LOCUS       NM_001108073            2967 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tight junction protein 3 (Tjp3), mRNA.
ACCESSION   NM_001108073 XM_001069839 XM_234924
VERSION     NM_001108073.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2967)
  AUTHORS   Qiao,X., Roth,I., Feraille,E. and Hasler,U.
  TITLE     Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney
            collecting duct principal cell proliferation and adhesion
  JOURNAL   Cell Cycle 13 (19), 3059-3075 (2014)
   PUBMED   25486565
REFERENCE   2  (bases 1 to 2967)
  AUTHORS   Capaldo,C.T., Koch,S., Kwon,M., Laur,O., Parkos,C.A. and Nusrat,A.
  TITLE     Tight function zonula occludens-3 regulates cyclin D1-dependent
            cell proliferation
  JOURNAL   Mol Biol Cell 22 (10), 1677-1685 (2011)
   PUBMED   21411630
REFERENCE   3  (bases 1 to 2967)
  AUTHORS   Aho,S., Lupo,J., Coly,P.A., Sabine,A., Castellazzi,M., Morand,P.,
            Sergeant,A., Manet,E., Boyer,V. and Gruffat,H.
  TITLE     Characterization of the ubinuclein protein as a new member of the
            nuclear and adhesion complex components (NACos)
  JOURNAL   Biol Cell 101 (6), 319-334 (2009)
   PUBMED   18823282
REFERENCE   4  (bases 1 to 2967)
  AUTHORS   Adachi,M., Inoko,A., Hata,M., Furuse,K., Umeda,K., Itoh,M. and
            Tsukita,S.
  TITLE     Normal establishment of epithelial tight junctions in mice and
            cultured cells lacking expression of ZO-3, a tight-junction MAGUK
            protein
  JOURNAL   Mol Cell Biol 26 (23), 9003-9015 (2006)
   PUBMED   17000770
REFERENCE   5  (bases 1 to 2967)
  AUTHORS   Inoko,A., Itoh,M., Tamura,A., Matsuda,M., Furuse,M. and Tsukita,S.
  TITLE     Expression and distribution of ZO-3, a tight junction MAGUK
            protein, in mouse tissues
  JOURNAL   Genes Cells 8 (11), 837-845 (2003)
   PUBMED   14622136
REFERENCE   6  (bases 1 to 2967)
  AUTHORS   Unda,F.J., Perez-Nanclares,G., Le Morvan,V., Hernandez,C.,
            Vilaxa,A., De-la-Fuente,M. and Gorry,P.
  TITLE     Dynamic assembly of tight junction-associated proteins ZO-1, ZO-2,
            ZO-3 and occludin during mouse tooth development
  JOURNAL   Histol Histopathol 18 (1), 27-38 (2003)
   PUBMED   12507281
REFERENCE   7  (bases 1 to 2967)
  AUTHORS   Haskins,J., Gu,L., Wittchen,E.S., Hibbard,J. and Stevenson,B.R.
  TITLE     ZO-3, a novel member of the MAGUK protein family found at the tight
            junction, interacts with ZO-1 and occludin
  JOURNAL   J Cell Biol 141 (1), 199-208 (1998)
   PUBMED   9531559
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_234924.4, XM_001069839.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132268 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2967
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2967
                     /gene="Tjp3"
                     /note="tight junction protein 3"
                     /db_xref="GeneID:314640"
                     /db_xref="RGD:1309247"
     exon            1..150
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2868
                     /gene="Tjp3"
                     /codon_start=1
                     /product="tight junction protein ZO-3"
                     /protein_id="NP_001101543.1"
                     /db_xref="GeneID:314640"
                     /db_xref="RGD:1309247"
                     /translation="MAVADMEELTIWEQHTATLYKDPRRGFGIAVSGGHDRAGGPVVV
                     SDVVPGGPAEGRLQTGDHIVMVNGVSVENVTSAFAIQILKTCTKTANITVKRPRRVQL
                     PATKASPASGHQLSDQEEADHGRGYEGDSSSGSGRSWGERSRRSRAGRRVRMGSHGRR
                     SSCGGSEANGLDLVSGYKRLPKQDVLMRPLKSVLVKRRNSEEFGVKLGSQIFIKHITE
                     SGLAARNRGLQEGDLILQINGVSSANLSLSDTRRLIEKSEGQLTLLVLRDSGQFLVNI
                     PPAVSDSDSSLMEDISDLTSELSQAPPSHIPPPPLKSRRSPEDSQTDSPVETPQPQRR
                     ERSVDSRAIAEPESPGESRYDIYRVPSRQSLEDRGYSPDTRVVRFPKGVSIGLRLAGG
                     NDVGIFVSGVQAGSPADGQGIQEGDEILQVNDMPFRNLTREEAVQFLLGLPAGEDVEL
                     VIQSKQDIFRKMVQSRVGDSFYIRTHFELEPSPPYGLGFTRGDVFHVVDTLYRGSGSG
                     HGHSSHGGLWLAARMGRDLREQERGVIPNQSRAEQLASLEAAQRAAGLGPGASTGSNP
                     RAEFWRLRGLRRGAKKTMTQRSREDLSALTRQGHYPPYERVVLREASFKRPVVILGPV
                     ADIAMKRLTTEVPEQFEIAESVSRTDSPSKIIKLDTVRVIAERDKHALLDVTPSAIER
                     LNYVQYYPVVIFCAPESRSALKALREWLAPASRRSSRRLYAQAQKLQKHSGHLFTATI
                     PLNGTSDSWYQEVKAVIQQQQARPIWTAEDQLNGSSEDLDLPGHGLAASSGDLSCDSR
                     ANSDYEDTDGEGTYTDREGEPQDFDEEAPPTALARSSEPVWVDDHQGLMGHGRIAAAE
                     VQADSHYTPDQRRQDSMRTYKHEALRKKFTRARDIESSDEEGYDWGPATDL"
     exon            151..207
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            208..317
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            318..420
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..748
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            749..852
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1012
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1121
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1183
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1250
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1407
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1516
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1763
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1978
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2074
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2145
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2356
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2457
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2718
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2765
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2967
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcagagc cggagaaagg cgggagcgcg gcccggaccc cgccgccacc acctccggcc
       61 caaagtgggg gtcggttgtt tccaggcgcc tccaggtcca aggtgggggc tgccctaccg
      121 tttccaggac gcctgttgta caccatggcg gtggcagaca tggaagagtt gaccatctgg
      181 gaacagcaca cagccacact gtacaaggac ccccgccgag gctttggcat agctgtgtct
      241 ggaggtcatg accgagctgg tggacctgtg gtcgtgtctg atgtggtacc tggaggcccc
      301 gctgagggca ggcttcagac tggggaccac atcgtcatgg tgaatggtgt ctctgtggag
      361 aatgtcacat ctgcttttgc catccagatc cttaagacct gcaccaaaac agccaacatt
      421 acagtgaagc gtccccgaag ggtccaactg cctgccacca aggctagccc agcttctggc
      481 caccagctct cagaccagga ggaagctgac catggccggg gctatgaggg ggactcctcc
      541 agtggctcag gtcgatcttg gggtgagcgt tctcgccggt ccagggctgg tcgccgcgtc
      601 aggatgggca gccatgggcg ccggagctct tgtggaggtt ctgaggccaa tggtctggac
      661 ctggtatctg gctacaagcg cttgcctaag caggatgtgc taatgagacc gctaaagtcc
      721 gtgctggtga aacgaagaaa cagcgaagag tttggagtga agctaggcag tcagatcttc
      781 ataaaacaca tcacagagtc cggcctcgct gctcggaacc gtgggctgca ggagggagac
      841 cttatcttac agatcaacgg agtgtccagt gctaatctat ccctgagtga cacacggagg
      901 ctcattgaga agtcagaggg gcagctaacc ctgctggtgc tgagggacag tgggcagttc
      961 ctggtgaaca tccctccagc agtgagtgac agcgacagct ccctaatgga agacatctca
     1021 gacctgacct cggaattgtc ccaggcgccc ccttcccaca ttccaccgcc acctctgaag
     1081 agtcggcgga gccctgagga cagccagacg gattccccag tggagacccc acagccccag
     1141 aggcgggaac ggtcggtgga ttcaagagcc atcgctgaac cagagtctcc tggagaaagc
     1201 cgctatgaca tttaccgggt ccctagtcgg cagagcctgg aggaccgtgg ctacagcccc
     1261 gacacccgtg tcgtgcgctt ccccaagggt gtgagcattg gtctgcggct ggccggcggc
     1321 aacgacgtgg gcatcttcgt gtccggggtg caggcaggca gccccgccga cgggcaaggc
     1381 atccaggaag gggatgagat cttgcaggtg aatgatatgc catttcggaa cctgactcgg
     1441 gaggaggctg tgcagtttct gttagggctg cctgcagggg aagacgtgga gctggtgata
     1501 cagagcaagc aggacatctt caggaagatg gtccagtccc gcgtgggtga ctccttctac
     1561 atccgcacac actttgagct ggagccaagc ccgccctacg gcctgggctt cactcgcggt
     1621 gatgtgttcc acgtggtgga cacgttgtac cggggctctg ggtcaggcca cgggcacagc
     1681 agccatgggg gtctctggct ggcggcccga atgggcagag atctccgaga gcaagaacga
     1741 ggcgtcattc ccaaccagag cagggccgag cagctggcca gtttggaggc cgcgcagcgg
     1801 gccgcgggcc tggggccagg cgcctcaaca ggctccaacc cacgggccga gttctggcga
     1861 ctccgaggtc tccggcgagg ggccaagaag acaatgaccc agcggagccg cgaggacctg
     1921 tcggcgctga ccaggcaggg acactaccca ccctacgagc gagtcgtgct acgagaagcc
     1981 agttttaagc gccccgtggt gatcctagga cccgtggcag acattgctat gaagagactg
     2041 acaacagagg tgccagagca gtttgagatt gcagaaagcg tgtcccggac tgacagccca
     2101 tccaagatca tcaaattgga cacagtgcgg gtgatcgcag agagggacaa gcacgcactc
     2161 ctggatgtca ccccctctgc catcgagcgc ctcaactacg tgcagtacta ccctgtcgtc
     2221 atcttctgtg ctccggagag ccggtcagcg ctcaaggccc ttcgcgagtg gctggccccc
     2281 gcctctcgcc gcagcagccg ccgcctgtat gcgcaggccc agaagctgca gaaacacagt
     2341 ggccacctct tcaccgccac cattcccctg aatggcacta gtgactcctg gtaccaggaa
     2401 gtcaaggctg tcatacagca acagcaggcg cgaccgatct ggactgcgga ggaccagctg
     2461 aatggctcat ccgaggacct tgacctgccg ggccatgggc tggccgccag ctctggagac
     2521 ctcagctgtg acagtcgggc taacagcgac tacgaagaca ccgatgggga gggcacctat
     2581 acggatagag agggcgaacc ccaggatttc gatgaggaag ccccacccac ggccctggcc
     2641 cggtcctcag agcctgtgtg ggtagatgac caccaggggc tgatgggtca tgggaggatc
     2701 gcagccgcgg aggtgcaggc cgacagccac tacaccccgg accagcggcg ccaagacagc
     2761 atgcggacct acaagcatga ggccctgaga aagaagttca caagagcccg ggacatcgaa
     2821 tcctctgacg aagaaggcta tgactggggc ccagccaccg acctgtgacc tgtgcagtcc
     2881 accagcctgc cacaagccct caagcttctg accatttaat aaacctttaa aagtattttt
     2941 tacattagaa aatagcacaa gactgag
//
