LOCUS       NM_001414504            4699 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus tight junction protein 2 (Tjp2), transcript
            variant 1, mRNA.
ACCESSION   NM_001414504 XM_006231181
VERSION     NM_001414504.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4699)
  AUTHORS   Gonzalez-Gonzalez,L., Gallego-Gutierrez,H., Martin-Tapia,D.,
            Avelino-Cruz,J.E., Hernandez-Guzman,C., Rangel-Guerrero,S.I.,
            Alvarez-Salas,L.M., Garay,E., Chavez-Munguia,B.,
            Gutierrez-Ruiz,M.C., Hernandez-Melchor,D., Lopez-Bayghen,E. and
            Gonzalez-Mariscal,L.
  TITLE     ZO-2 favors Hippo signaling, and its re-expression in the steatotic
            liver by AMPK restores junctional sealing
  JOURNAL   Tissue Barriers 10 (2), 1994351 (2022)
   PUBMED   34689705
  REMARK    GeneRIF: ZO-2 favors Hippo signaling, and its re-expression in the
            steatotic liver by AMPK restores junctional sealing.
REFERENCE   2  (bases 1 to 4699)
  AUTHORS   Li,J., Cong,X., Zhang,Y., Xiang,R.L., Mei,M., Yang,N.Y., Su,Y.C.,
            Choi,S., Park,K., Zhang,L.W., Wu,L.L. and Yu,G.Y.
  TITLE     ZO-1 and -2 Are Required for TRPV1-Modulated Paracellular
            Permeability
  JOURNAL   J Dent Res 94 (12), 1748-1756 (2015)
   PUBMED   26464396
  REMARK    GeneRIF: crucial roles in basal salivary epithelial barrier
            function and TRPV1-modulated paracellular transport
REFERENCE   3  (bases 1 to 4699)
  AUTHORS   Kazmierczak,M., Harris,S.L., Kazmierczak,P., Shah,P.,
            Starovoytov,V., Ohlemiller,K.K. and Schwander,M.
  TITLE     Progressive Hearing Loss in Mice Carrying a Mutation in Usp53
  JOURNAL   J Neurosci 35 (47), 15582-15598 (2015)
   PUBMED   26609154
REFERENCE   4  (bases 1 to 4699)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4699)
  AUTHORS   Qiao,X., Roth,I., Feraille,E. and Hasler,U.
  TITLE     Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney
            collecting duct principal cell proliferation and adhesion
  JOURNAL   Cell Cycle 13 (19), 3059-3075 (2014)
   PUBMED   25486565
  REMARK    GeneRIF: ZO-2 suppression decreased cyclin D1 abundance and the
            depletion of which restored cell cycle progression.
REFERENCE   6  (bases 1 to 4699)
  AUTHORS   Carlton,V.E., Harris,B.Z., Puffenberger,E.G., Batta,A.K.,
            Knisely,A.S., Robinson,D.L., Strauss,K.A., Shneider,B.L., Lim,W.A.,
            Salen,G., Morton,D.H. and Bull,L.N.
  TITLE     Complex inheritance of familial hypercholanemia with associated
            mutations in TJP2 and BAAT
  JOURNAL   Nat Genet 34 (1), 91-96 (2003)
   PUBMED   12704386
REFERENCE   7  (bases 1 to 4699)
  AUTHORS   Unda,F.J., Perez-Nanclares,G., Le Morvan,V., Hernandez,C.,
            Vilaxa,A., De-la-Fuente,M. and Gorry,P.
  TITLE     Dynamic assembly of tight junction-associated proteins ZO-1, ZO-2,
            ZO-3 and occludin during mouse tooth development
  JOURNAL   Histol Histopathol 18 (1), 27-38 (2003)
   PUBMED   12507281
REFERENCE   8  (bases 1 to 4699)
  AUTHORS   Morita,K., Furuse,M., Yoshida,Y., Itoh,M., Sasaki,H., Tsukita,S.
            and Miyachi,Y.
  TITLE     Molecular architecture of tight junctions of periderm differs from
            that of the maculae occludentes of epidermis
  JOURNAL   J Invest Dermatol 118 (6), 1073-1079 (2002)
   PUBMED   12060405
REFERENCE   9  (bases 1 to 4699)
  AUTHORS   Duffy,H.S., John,G.R., Lee,S.C., Brosnan,C.F. and Spray,D.C.
  TITLE     Reciprocal regulation of the junctional proteins claudin-1 and
            connexin43 by interleukin-1beta in primary human fetal astrocytes
  JOURNAL   J Neurosci 20 (23), RC114 (2000)
   PUBMED   11090614
REFERENCE   10 (bases 1 to 4699)
  AUTHORS   Adams,L.D., Lemire,J.M. and Schwartz,S.M.
  TITLE     A systematic analysis of 40 random genes in cultured vascular
            smooth muscle subtypes reveals a heterogeneity of gene expression
            and identifies the tight junction gene zonula occludens 2 as a
            marker of epithelioid 'pup' smooth muscle cells and a participant
            in carotid neointimal formation
  JOURNAL   Arterioscler Thromb Vasc Biol 19 (11), 2600-2608 (1999)
   PUBMED   10559001
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 29, 2022 this sequence version replaced XM_006231181.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.6176.1,
                                           SRR26643297.4912.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000001.1  231264575-231264750 c
            177-297             JAXUCZ010000001.1  231233544-231233664 c
            298-351             JAXUCZ010000001.1  231178406-231178459 c
            352-476             JAXUCZ010000001.1  231174080-231174204 c
            477-579             JAXUCZ010000001.1  231172134-231172236 c
            580-1198            JAXUCZ010000001.1  231170606-231171224 c
            1199-1302           JAXUCZ010000001.1  231165972-231166075 c
            1303-1456           JAXUCZ010000001.1  231164840-231164993 c
            1457-1565           JAXUCZ010000001.1  231162743-231162851 c
            1566-1699           JAXUCZ010000001.1  231162503-231162636 c
            1700-1766           JAXUCZ010000001.1  231161325-231161391 c
            1767-1917           JAXUCZ010000001.1  231160598-231160748 c
            1918-2026           JAXUCZ010000001.1  231154835-231154943 c
            2027-2237           JAXUCZ010000001.1  231153797-231154007 c
            2238-2425           JAXUCZ010000001.1  231152273-231152460 c
            2426-2521           JAXUCZ010000001.1  231151744-231151839 c
            2522-2601           JAXUCZ010000001.1  231150074-231150153 c
            2602-2812           JAXUCZ010000001.1  231148987-231149197 c
            2813-2913           JAXUCZ010000001.1  231143491-231143591 c
            2914-3126           JAXUCZ010000001.1  231142263-231142475 c
            3127-3237           JAXUCZ010000001.1  231141069-231141179 c
            3238-3552           JAXUCZ010000001.1  231139583-231139897 c
            3553-3638           JAXUCZ010000001.1  231138220-231138305 c
            3639-4699           JAXUCZ010000001.1  231136218-231137278 c
FEATURES             Location/Qualifiers
     source          1..4699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..4699
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /note="tight junction protein 2"
                     /db_xref="GeneID:115769"
                     /db_xref="RGD:619807"
     exon            1..176
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            177..297
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..351
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..3807
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /note="isoform 1 is encoded by transcript variant 1; tight
                     junction protein ZO-2"
                     /codon_start=1
                     /product="tight junction protein ZO-2 isoform 1"
                     /protein_id="NP_001401433.1"
                     /db_xref="GeneID:115769"
                     /db_xref="RGD:619807"
                     /translation="MEEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVIS
                     DVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVA
                     PLQGSPPLSHDDRGFEMMDEFDGRSFRSGYSERSRHSSHDMLSHSWEDSRERGRPHQR
                     AQSRERERSRGRSLERGLDHEDYGRSHERSRGRSLERGLDRDFVSRDYSRGRSIDRDY
                     DRDYERSYHQAYEPDYEGRYSPSYDRRAHPETRYERSRSREHLRSRSPTPESRSRQEH
                     KGQHDPDRPIGVLLTKSKANEEYGLRLGSQIFIKEMTRTGLATKDGNLHEGDIILKIN
                     GTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIPSLNDSDSEVEDISEIESNR
                     SFSPEERRQQYSDQEYHSSTEKLKERPSSREETSGRMSRMGATPTPFKSTGDITAAGV
                     TEANKEPRSQEESPVPQPRTASRVFLRPSPEDEAIYGPNTKMVKFKKGDSVGLRLAGG
                     NDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGETVTI
                     LAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGH
                     WLAVRIGNELEKGLIPNKSRAEQMASVQNAQRENAGDRADFWRMRGQRSGVKKNIRKS
                     REDLAAAVSVSTKFPAYEKVLLREAGFKRPVVLFGPIADIAMERLTTELPDLFQTAKT
                     EPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSR
                     QGIKTIRQRLNPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKDSIQ
                     QQQNEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTD
                     NELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASRDQLRDGSPPPAFK
                     PEPPKVRNQNREDSFNYSKSNLSAMAGSEIPGGSTKGCPPPIAVKPAFGRSILKPSTP
                     VPMPESEEVGESTEEQEEAPKSVLGRVKIFEKMDHKAKLQRMQELQEAQNARIEIAQK
                     HPDIYAVPIKAPKPDAGLPQHMSSRPPEPQKAPSRLYQDTRGSYGSDPEEEEEYRQQL
                     AAHSKRGYYSQPSRYRDTEL"
     exon            352..476
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..579
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            580..1198
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1302
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1456
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1565
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1699
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1766
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1917
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2026
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2237
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2425
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2521
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2601
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2812
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2913
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3126
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3237
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..3552
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3638
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..4699
                     /gene="Tjp2"
                     /gene_synonym="ZO-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtcacaac aatacccagg aacggccggt ggcggaggtc actggctccc gcctgctggg
       61 gcagcccgcg gcactccgcc tccggacagg cgctgctcgc gctgtgccgc cggacgccgg
      121 ggaccgtcgc ctcctgcgcg ctgacactgc tggctgccgc cgcccccctt ctccagggcc
      181 cggagtcctg ccttgctctc ttctccctgt cagtgggact ggcacccagg atacagctcc
      241 aggcccaagc actctgcagc gcacagaccg gtgtccacct acagcctgct ctcccagggc
      301 ccaggcatgg aggaggtgat atgggaacag tacactgtga ccctgcagaa ggattccaaa
      361 agaggatttg gaatcgcagt gtcaggaggc agagacaacc cccactttga aaatggggag
      421 acgtcaatcg tcatttcaga tgtactccca ggtggacccg ctgatggctt gcttcaagaa
      481 aatgacaggg tggtcatggt caatggcacc cccatggagg atgtgctcca ttcatttgcc
      541 gttcagcagc ttaggaaaag tgggaagatc gcagccattg tggtcaagag gcctcggaag
      601 gttcaggtgg ccccgctgca gggcagcccc cctctcagtc atgatgaccg aggttttgag
      661 atgatggatg aatttgatgg cagaagtttc cgcagcggct acagtgagag gagccggcac
      721 agcagccacg atatgctcag ccacagctgg gaggacagca gggagagggg gcgtccccat
      781 cagcgcgcac agagccggga gcgggagcgc agccgtggcc ggagcctgga acgtggcctg
      841 gaccatgaag actacgggcg cagccatgag cgcagccgcg gccggagcct ggagcgcggt
      901 ctagaccgcg actttgtgtc ccgggactac agccgtggac ggagcatcga cagggactac
      961 gaccgagact atgagcgctc ctatcaccaa gcctatgagc ctgactacga aggccgctac
     1021 agcccatctt atgaccgcag agcccatcca gagacccgct atgaacggag ccgcagccga
     1081 gaacacctac ggtcccgaag ccccaccccc gagtctaggt cccggcagga acacaagggc
     1141 cagcatgatc ccgacaggcc catcggggtc cttctgacca aaagcaaagc aaacgaagag
     1201 tacgggctcc ggctgggaag tcagatcttc attaaggaaa tgaccagaac aggactggca
     1261 acaaaagatg gcaaccttca tgagggggac ataattctca agatcaatgg aactgttact
     1321 gagaacatgt ctttaaccga tgctcggaag ttaatagaaa agtctcgagg aaaactgcag
     1381 ctggtggtgt tgagagacag caagcagacc ctcatcaaca tcccatctct gaatgacagc
     1441 gactcggaag tggaggatat ctcggaaatc gagtccaacc gatctttttc tccagaggag
     1501 aggcgccagc agtattctga tcaggagtat cattcctcca ctgagaagct gaaggagagg
     1561 ccaagctcaa gagaggagac ctcaggcaga atgtccagga tgggtgccac acccacgccg
     1621 ttcaagtcca cgggggacat cacagctgca ggtgtcacag aggccaacaa ggagcccagg
     1681 tcccaggagg aatccccagt tcctcaaccc agaacagcat caagagtctt tcttcgtcct
     1741 agtcccgaag atgaagcaat atatggccct aacaccaaaa tggtgaagtt caagaaggga
     1801 gacagcgtgg gcctccggtt ggctggtgga aatgatgttg gcatatttgt ggctggcatt
     1861 caggagggca cctctgcaga gcaggagggc ctacaagaag gggaccagat tctgaaggtg
     1921 aacacacaag atttcagagg gctggtccgg gaagatgccg tcctctacct gttagaaatc
     1981 cctaaaggtg aaaccgtgac cattttggct cagagccgag cagacgtgta tagagacatc
     2041 ctggcctgtg gcaggggaga ctcgttcttc ataaggagcc actttgaatg tgagaaggag
     2101 actccgcaga gcttggcctt caccagggga gaggtcttcc gagtggtaga cacgctgtac
     2161 gatggcaaac tgggccactg gctggctgtg aggattggaa atgagctgga gaagggctta
     2221 atccctaaca aaagcagagc tgagcagatg gccagtgtcc agaatgccca gcgagagaat
     2281 gctggggaca gagcagactt ctggcggatg cgtggccaga gatccggggt caagaagaac
     2341 attcgcaaga gccgggaaga cctggcagct gctgtgtcgg ttagcaccaa gttccccgcc
     2401 tacgagaagg ttctgcttcg ggaagctggc ttcaagagac ccgtggttct gtttggcccc
     2461 atagcagata tagcaatgga aaggctgact actgagctac ccgacctgtt tcaaactgca
     2521 aaaacagaac ccaaagatgc gggatctgag aaatccagtg gagtggttcg gttgaatact
     2581 gtgaggcaaa ttattgagca ggacaagcat gccctgctcg acgttacccc caaagctgtg
     2641 gacctgctca attatactca gtggttccca atcgtgattt tcttcaaccc ggattccaga
     2701 caaggcatta aaaccataag gcagaggttg aacccaacat ccaataaaag ttctcgcaag
     2761 ttattcgatc aagccaacaa gctcaaaaaa acctgttctc atctttttac agctaccatc
     2821 aacgtgaatt cagccaatga tggctggttt ggcagcctga aggacagcat tcagcagcag
     2881 caaaacgaag cagtgtgggt ctctgaagga aagatggagg ggatggatga tgacgctgaa
     2941 gaccgcatgt cctacttaac cgccatgggt gcggactatc tgagttgtga cagccgtctc
     3001 atcagtgact ttgaagatac ggacggcgag ggaggcgcct acactgacaa tgagctggat
     3061 gagccagctg aggagccgct ggtgtcttcc atcacccgct cctcagagcc ggtgcagcat
     3121 gaggagagca taaggaagcc cagcccagag ccacgcgctc agatgaggag ggcagctagc
     3181 agagaccagc ttagggatgg tagcccgccc ccagcattca agccagagcc gcccaaggtc
     3241 agaaaccaaa acagagagga ctctttcaac tactccaagt caaacctctc tgccatggct
     3301 ggcagtgaaa tcccgggggg atccaccaaa gggtgtcctc cccctattgc ggtgaaacct
     3361 gcctttgggc gatccatcct gaagccttct actccagtcc ccatgcctga gagtgaggag
     3421 gttggggaga gcaccgagga gcaggaagag gctcccaaat cagtcctggg cagagtgaaa
     3481 atcttcgaga agatggacca caaggcgaaa ttacagagga tgcaggagct ccaagaagca
     3541 cagaatgcga ggattgaaat agctcagaag catcctgaca tctatgcggt tccaatcaaa
     3601 gcccccaagc cagatgctgg cctgccccag cacatgagtt ctagaccccc agagccacag
     3661 aaagctcctt ctaggcttta ccaggacacc agaggaagct acggcagtga tcccgaggaa
     3721 gaggaggagt accgccaaca gttggcagca cactcgaagc gtggttacta cagccagccc
     3781 tcccggtacc gagacaccga attatagagg gccacttgtg gactcctgcg agactccctg
     3841 gaggtcttct ccagttaaaa tgcactgcag agatacggtg gggatccagg caacagacag
     3901 ctcgaattat caaccgaagg ctctgttcgt gggactggag taaagttggt tatgactttt
     3961 tgaatgaaga gaaacactat agcctgataa tggttacttg ctttggtgtg gaccaaaaat
     4021 ctgtattaat ctctctgtat ttgtaatatg tatattgagc aataactcct tctcctcgtt
     4081 cagagctgcc ttccagagct gcttcgatgt gaagcaaatg tgaacaggga gtaaaaaaaa
     4141 aaaaagtact ccatctcaaa ctaaatccag aagtaattta tcacgactcc ctaagtgcct
     4201 ttgacaagat gtgtcttagt ttgcttccct gaagctttat gcaaagctat aatggactaa
     4261 aacttttatt ttgactaaat ttttatacca gtttagcagc tgtaactgcc ctcagcacca
     4321 tgccaccttt tcagggcatt atcttgggag tgtggctatt agttctacat agctcggagg
     4381 ccaagatttt attagagtgt ttgtccttgt ttgtctgaaa ccacgtgctc cacaaagtca
     4441 gaggcttgag aaaagggtat tttatttcct tcctatcagc atatgtactg acatcaggtg
     4501 gttttataat ttaataaaaa ggagtacctt gtggtcaaga atgagctttg tgctgaatct
     4561 ctacacacct tccttttggg ctgtgtgggg tggaatccaa gatcctcatg cattcagagt
     4621 gctgctccac cgctgaacta taccccagac ttcctgattt attttatttt aattaaaaaa
     4681 attaaaaaga cttaaaaaa
//
