LOCUS       NM_001106266            6614 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus tight junction protein 1 (Tjp1), mRNA.
ACCESSION   NM_001106266 XM_001058833 XM_218747
VERSION     NM_001106266.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6614)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 6614)
  AUTHORS   Lou,X., Mou,Q., Zhao,B., Huang,J., Yao,K., Luo,Z., Ye,M., Hu,Y.,
            Duan,Q., Li,X., Wen,Z., Chen,Z., Zhang,H. and Zhao,Y.
  TITLE     VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via
            Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation
  JOURNAL   Oxid Med Cell Longev 2021, 9397960 (2021)
   PUBMED   34552687
  REMARK    GeneRIF: VIP Stabilizes the Cytoskeleton of Schlemm's Canal
            Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal
            Degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6614)
  AUTHORS   Xu,X., Zhang,X., Gao,L., Liu,C. and You,K.
  TITLE     Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1
            Expression in Rat Kidney Accompanied by Impaired Proximal Tubular
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 2641461 (2020)
   PUBMED   33343804
  REMARK    GeneRIF: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and
            ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal
            Tubular Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6614)
  AUTHORS   Hou,Q., Huang,Y., Wang,Y., Liao,L., Zhu,Z., Zhang,W., Liu,Y.,
            Li,P., Chen,X. and Liu,F.
  TITLE     Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1
  JOURNAL   J Microbiol Biotechnol 30 (10), 1480-1487 (2020)
   PUBMED   32807750
  REMARK    GeneRIF: Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1.
REFERENCE   5  (bases 1 to 6614)
  AUTHORS   Ribeiro Hudson,A.S., Nascimento Soares,A.D., Coelho Horta,N.A.,
            Fuscaldi,L.L., Machado-Moreira,C.A., Soares,D.D., Coimbra,C.C., de
            Oliveira Poletini,M., Cardoso,V.N. and Wanner,S.P.
  TITLE     The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats
  JOURNAL   J Therm Biol 91, 102610 (2020)
   PUBMED   32716860
  REMARK    GeneRIF: The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats.
REFERENCE   6  (bases 1 to 6614)
  AUTHORS   Kawajiri,A., Itoh,N., Fukata,M., Nakagawa,M., Yamaga,M.,
            Iwamatsu,A. and Kaibuchi,K.
  TITLE     Identification of a novel beta-catenin-interacting protein
  JOURNAL   Biochem Biophys Res Commun 273 (2), 712-717 (2000)
   PUBMED   10873669
REFERENCE   7  (bases 1 to 6614)
  AUTHORS   Kidson,S.H., Kume,T., Deng,K., Winfrey,V. and Hogan,B.L.
  TITLE     The forkhead/winged-helix gene, Mf1, is necessary for the normal
            development of the cornea and formation of the anterior chamber in
            the mouse eye
  JOURNAL   Dev Biol 211 (2), 306-322 (1999)
   PUBMED   10395790
REFERENCE   8  (bases 1 to 6614)
  AUTHORS   Toyofuku,T., Yabuki,M., Otsu,K., Kuzuya,T., Hori,M. and Tada,M.
  TITLE     Direct association of the gap junction protein connexin-43 with
            ZO-1 in cardiac myocytes
  JOURNAL   J Biol Chem 273 (21), 12725-12731 (1998)
   PUBMED   9582296
REFERENCE   9  (bases 1 to 6614)
  AUTHORS   Haskins,J., Gu,L., Wittchen,E.S., Hibbard,J. and Stevenson,B.R.
  TITLE     ZO-3, a novel member of the MAGUK protein family found at the tight
            junction, interacts with ZO-1 and occludin
  JOURNAL   J Cell Biol 141 (1), 199-208 (1998)
   PUBMED   9531559
REFERENCE   10 (bases 1 to 6614)
  AUTHORS   Rajasekaran,A.K., Hojo,M., Huima,T. and Rodriguez-Boulan,E.
  TITLE     Catenins and zonula occludens-1 form a complex during early stages
            in the assembly of tight junctions
  JOURNAL   J Cell Biol 132 (3), 451-463 (1996)
   PUBMED   8636221
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001058833.1, XM_218747.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..6614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6614
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="tight junction protein 1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
     exon            1..59
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..5213
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="zona occludens 1; zona occludens protein 1; zonula
                     occludens protein 1"
                     /codon_start=1
                     /product="tight junction protein ZO-1"
                     /protein_id="NP_001099736.1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
                     /translation="MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVI
                     SDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQI
                     PVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRSASRDRSLSPRSD
                     RRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVL
                     KINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDD
                     ISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERM
                     SKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQVGQPDVDLPVSPS
                     DGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
                     EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFY
                     IRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIVPNKN
                     RAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERV
                     VLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDHRSSGIIRLHTI
                     KQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSAR
                     KLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATS
                     DDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGT
                     PPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPGLKTASQQKAEAS
                     SPVPYLSPETNPASSASAVKHNVNLTNVNLEEPTPAPPTSHVSQADCLGAPSPEAPHT
                     MLRDEGVSLPSHVDPAKVYRKEPYPEEMMRQNHILKQPALGHPGQRLDKEPNPAYDPQ
                     LPYVEKQASRDLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYEDQWSYYDDKQPY
                     PTRPFDTQHPRDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYEQLPRTSTLRHEE
                     QPTSGYEVHNRYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPL
                     HGAAVVPPLIPSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQSVLTRVKMFENKR
                     SASLENKKDVNDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDKTLYRLPEPQKPQ
                     AKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGHHSEPAKPVHSQS
                     QPNFSSYSSKGKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQPVPPLSNSSLHIH
                     SKAAQSEGNSVSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKAS
                     VNGAEQTQKTITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKP
                     PPSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKAVPVSPSAVEEDE
                     DEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILP
                     PLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANCV
                     SVLIDHF"
     exon            60..184
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..287
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..564
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..668
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..837
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..985
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1125
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1231
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1382
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1491
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1711
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1896
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1992
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2075
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2286
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2387
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2738
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2978
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3848
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..3946
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4174
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4341
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4342..4816
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4817..5034
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5035..5118
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5119..6614
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcacagc aatggaggaa acagctatat gggaacagca cacagtgacg cttcacaggg
       61 ctcctgggtt tggatttgga attgcaatat ctggtggaag agataatcct cattttcaga
      121 gtggggaaac ctccatagtg atttctgatg tgctaaaagg agggccagct gaaggacagc
      181 tacaggaaaa tgaccgagtc gcaatggtta acggagtttc aatggataat gttgaacatg
      241 cttttgctgt tcagcagcta aggaaaagtg ggaaaaacgc aaaaattacc atccgaagaa
      301 agaagaaagt tcagattcct gtaagtcacc cagaccctga cccagtgtct gataatgaag
      361 atgatagcta tgacgaggat gtgcacgatc caagaagtgg ccgaggtgcc ctagctaaca
      421 gaaggggtga gaagagctgg gcaagggata gaagcgcaag cagggaccgg agcctgtccc
      481 ctcgctcaga caggcgatca gtggcctcca gtcagcccgc caaacccacc aaggtcacat
      541 tggtgaagtc tcggaaaaat gaagaatatg gtcttcgatt ggccagccat atatttgtaa
      601 aggaaatttc acaagatagt ttggcagcaa gagatggtaa cattcaagaa ggggatgttg
      661 tcctgaagat aaatggtact gtgacagaaa atatgtcact gacagatgca aaaacattga
      721 tagaaaggtc taaaggcaag ttaaaaatgg tagtgcaaag agatgagcgg gctaccttat
      781 tgaatgtccc tgatctttca gatagtatcc attctgctaa tgcctctgaa agagatgaca
      841 tttcagaaat tcagtcacta gcatcagacc attcagttcg ctcccatgac aggcctcccc
      901 gccgaagcca gtcacgatct cccgaccaac gttcagagcc ctctgatcat tccacacagt
      961 ctccacagca gcccagcaat ggcagtctcc ggagcagaga ggaagagcgc atgtctaaac
     1021 ccggggctgt ctcaactcct gtaaaacatg tagatgatca tacacccaaa gcagtggaag
     1081 aagttacagt tgaaaaacat gagaagcaga cacccactct tccagaacca aaacctgtat
     1141 atgctcaagt cggacagcca gatgtggatt tacctgtcag cccttctgat ggtgttctgc
     1201 caaattcaac acatgaagat gggattctta ggcccagcat gaaactggta aaattcagaa
     1261 aaggagatag tgtgggtttg cgactagctg gtggaaatga tgtcggaata tttgtagctg
     1321 gcgttctaga agatagccct gcagccaaag aaggcttaga ggaaggtgat caaattctca
     1381 gggtgaacaa tgtagatttc acaaatatca taagagaaga agctgttctt ttcctcctcg
     1441 acctccctaa aggtgaagaa gtgaccatat tggctcagaa gaaaaaggac gtttatcgcc
     1501 gcattgtaga gtcagatgta ggagactcgt tctatattag aacacatttt gaatatgaga
     1561 aagaatctcc ttatggactc agttttaaca aaggagaggt gttccgggtc gtggacaccc
     1621 tgtacaacgg gaagctgggc tcctggctgg ccattcgaat tggcaaaaat cacaaggagg
     1681 tagagcgagg catcgttcct aataagaaca gagccgagca gttagccagt gtacagtaca
     1741 cacttccaaa gacagcaggt ggcgatcggg cagacttctg gaggtttcga ggtcttcgta
     1801 gctccaagag aaatcttcga aaaagcagag aggacctgtc agcgcagcca gttcaaacaa
     1861 agttcccagc ttatgaaagg gttgttcttc gagaagctgg attcctaaga cctgtaacca
     1921 tctttggacc gattgctgat gttgccagag aaaagttagc aagggaggag ccagacattt
     1981 atcagattgc aaaaagtgaa ccacgagatg ctggaactga ccatcggagc tcgggcatta
     2041 ttcgccttca tacaataaag caaatcatag atcaagataa acatgcttta ttagatgtca
     2101 caccaaatgc agtcgatcgc cttaattatg cacagtggta tccgattgtt gtgttcctta
     2161 accctgactc taagcagggt gtaaaaacaa tgaggatgag gctatgtcca gagtctcgga
     2221 aaagtgccag gaagctatat gaacggtctc ataaacttcg taaaaataat caccatcttt
     2281 ttacaaccac aattaactta aactcaatga atgatggttg gtatggtgcc ctgaaagaag
     2341 cgattcagca gcaacagaac cagctggtgt gggtctctga ggggaaggcg gatggtgcta
     2401 caagtgatga ccttgatttg catgatgatc gtctgtccta cctgtcagcc ccaggtagtg
     2461 agtactcaat gtatagcacg gacagtagac acacttctga ctatgaagac acagatacag
     2521 aaggcggggc ctacactgat caagaactag atgaaactct taatgatgag gtggggactc
     2581 caccggagtc tgctattaca cggtcctctg agcctgtaag agaggattcc tctggaatgc
     2641 atcatgaaaa ccaaacatat cctccttact caccacaagc gcagccacaa gctattcata
     2701 gaatagactc ccctggactt aagacagcct ctcaacagaa agcagaagcc tcatctccag
     2761 tcccttacct ttcgcctgaa acaaacccag catcatcagc ctctgcagtt aagcataatg
     2821 taaatttaac taatgtcaac ctggaggagc ccaccccagc tcctcccacc tcgcacgtat
     2881 cacaagctga ttgtttagga gcaccaagtc ctgaggcacc tcacacgatg ctcagagacg
     2941 aaggagtgtc attgccgtcg catgtagacc cagcaaaggt atataggaag gagccatatc
     3001 ctgaggaaat gatgagacaa aaccatattt taaaacagcc agctcttggt catccagggc
     3061 agaggctgga taaagagcca aatccagcct atgatcccca acttccatat gtagaaaaac
     3121 aagccagcag agaccttgag cagccaccat acaggtatga gtcctcaagc tacacagacc
     3181 agttttctcg gaactatgac catcgcctac gatttgaaga ccgagtccct acctatgaag
     3241 accagtggtc atattatgat gacaaacagc cctacccaac tcggcccttt gatactcagc
     3301 atcctcgaga cttggactcc agacagcatc ctgaagaggc ttcagaacga ggctatttcc
     3361 agcgttttga agagcccgcc cctctgccat atgacagtag accacgctac gagcagctgc
     3421 ctcgaacctc tactctccga catgaagaac agccaaccag tggatatgag gtgcacaaca
     3481 ggtacaggcc agaagcacag ccctatgctc cagcaggtcc taagtcatct gagccgaagc
     3541 agtactttga ccagtaccca cgaagttatg agcaagtacc accaccagga tttacctcca
     3601 aaacaggcca ttacgagcct ctccatggtg ctgcagttgt tcctcctctg ataccttcct
     3661 ctcaacataa gccagaagtt ctgccctcag ctaccaagcc acagcctccg cccccagccc
     3721 taactgagga agaggaggat ccagcaatga aaccacagtc tgtgctcacc agggtcaaaa
     3781 tgtttgaaaa caaaagatct gcgtctctgg agaacaagaa ggatgtgaat gacactgcca
     3841 gctttaagcc tccagaagta gcatctaaac ctccaagtgc ttctcttgtt ggccctaaac
     3901 ctgtttctca gactcagttt agtgagcatg acaaaacact ctacaggctc ccagagcctc
     3961 agaaacctca agcgaagcca cctgaagata ttgttcgatc aaatcattac gatcctgaag
     4021 aggatgaaga gtattaccgg aaacagctct cttactttga ccggagaagt ttcgagagca
     4081 agcctcctgc acatattcct gctggccatc actcagagcc tgccaagcca gtccattctc
     4141 agagtcagcc gaatttctct agttattctt caaaggggaa acccgaaact gatgctatgg
     4201 atagatcatt cagtgagaaa cgttatgatc caacccaggc catgcctcct cctcctccgt
     4261 tgccctcaca gtacagccag ccagttccgc ctctgtccaa ctcttctctc cacatacatt
     4321 ccaaggccgc ccagagtgaa ggcaattccg tatcgttgga ttttcagaac tcatatatat
     4381 ccaaaccaga cccaccccca tctcagagca aaccagcaac ttttagacca ccaacccggg
     4441 aggaccctcc tcagaccttc tatccccaga aaagtttccc agacaaagct tcagttaatg
     4501 gagctgagca gactcagaaa accatcactc cagcatacaa ccgattcaca ccaaagccgt
     4561 acacgagctc tgcccggcca tttgaacgca agtttgaaag tccaaagttc aaccataatc
     4621 ttctgccaag tgaaactgta cataaacctg aattgtcttc aaaacctccc ccttctccaa
     4681 aaactctcat gaaggctcat agttccacac agccgcctga gtttgacagt ggagtcgaga
     4741 ctttctctgt tcacacagat aagcctaaat atcaaataaa taatatcagc accatgccta
     4801 aagctgttcc tgtgagtcct tcagctgtgg aagaagatga agatgaggat ggtcatactg
     4861 tagtggctac agcccgcggc atttttaaca gcaatggcgg tgtgttgagt tccatagaaa
     4921 ctggtgttag tataattatc ccacaaggag ccattcctga aggaattgag caagaaatct
     4981 atttcaaagt ctgcagagac aatagcatcc tcccaccttt agataaagag aaaggtgaaa
     5041 ctctgctgag ccccctagtg atgtgcgggc cccatggcct caagttcctg aagcctgtgg
     5101 agctacgctt gccacactgt gaccctaaaa cttggcaaaa caagtgtctt cctggagatc
     5161 cgaattacct tgttggagcc aactgtgttt ctgtcctgat tgaccacttt taattcttag
     5221 agtctagcag ctggactaag cagtgtgaac atggattgaa cttactgaat ggaaccactc
     5281 taatgagtat tctattttct tagaatttat actgcagtta gtagtattaa acatttgttg
     5341 gaactgataa aggttagtga gcatgcccct gaaccacgat cagaaaacat gctacaagct
     5401 gtgtgttatt gagtggagaa ctgtcaggca ttggctagag gttcaaagat attttgcttt
     5461 gtaatgattt ttgtactttt ttatggtcac tgcttaactt cacatactga tttccgttaa
     5521 aaataccagc cagtaaatgg gggtgcattt gagttttgtt ctttccaaag tacactcaac
     5581 ctttactatg gccttggcct agcatacaca tttattttat tatgcatgag gtaatgtgca
     5641 cacatttttt acaaatgcac ctggaatata taaccagtgt agtggattta acagaaatgt
     5701 acagcagggg gatttataac ttggggaggg aggggcaaat gaagacaatt ccttattgta
     5761 tatgaaaaca catttctctt agggaaggac accaaagcat gtgagcccag ttccatggcc
     5821 gctgaatcta taaattaaca tatcaccaca gacatccaac cagcaggaat gccttaccct
     5881 catggttttc attcttagat catttcgctc tgtagtacta agtttttatg agtttgtgcg
     5941 tacctagata ctgtatcatg gaaaagactg aggaaattgt ggacttgatg gtttcggaaa
     6001 tgtgtaaatc acctggaaga aagtaatggt gtgacttaaa atattttttt ttgacaaggg
     6061 agagtggttg gtggtcttct gttctttggg ctatgcatct gagatgtttg atgtgttcag
     6121 gacgcatgta cataatgcgt gcataccact tttgttcttg gtttgtaaat taacttttat
     6181 aaactttacc tttttataca taaacagaac cgagtttcta aggctacctt tgtattctct
     6241 cctgtacctc ttgagccttg aactttgacc tctgcagcaa taaagcagca tttctacaca
     6301 tataaggtca tttttttaag aaaaagaatg cacagagttg ttacattttt aagtgctgca
     6361 tttaaaagat acagttactc tagtttgatt aaattcttgc aaagtatccc ttctgtaaaa
     6421 tttgtgatac aatgctgtgc cctaaagtgt atttttttac taatagttta ttatggcaca
     6481 tcagcacgat ttctgtttag ataatacacc actacattct gttaataatc attaggtgtg
     6541 aaaggatttc ttttgtggtt attaaaaatc tcaaatttct aaatctgcaa gaataaaact
     6601 ttttaaaata cagt
//
