LOCUS       NM_001025287            1232 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus timeless interacting protein (Tipin), mRNA.
ACCESSION   NM_001025287 XM_039081744 XM_343407
VERSION     NM_001025287.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1232)
  AUTHORS   Gotter,A.L., Suppa,C. and Emanuel,B.S.
  TITLE     Mammalian TIMELESS and Tipin are evolutionarily conserved
            replication fork-associated factors
  JOURNAL   J Mol Biol 366 (1), 36-52 (2007)
   PUBMED   17141802
REFERENCE   2  (bases 1 to 1232)
  AUTHORS   Yoshizawa-Sugata,N. and Masai,H.
  TITLE     Human Tim/Timeless-interacting protein, Tipin, is required for
            efficient progression of S phase and DNA replication checkpoint
  JOURNAL   J Biol Chem 282 (4), 2729-2740 (2007)
   PUBMED   17102137
REFERENCE   3  (bases 1 to 1232)
  AUTHORS   Gotter,A.L.
  TITLE     Tipin, a novel timeless-interacting protein, is developmentally
            co-expressed with timeless and disrupts its self-association
  JOURNAL   J Mol Biol 331 (1), 167-176 (2003)
   PUBMED   12875843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Jul 27, 2021 this sequence version replaced
            XM_039081744.1, NM_001025287.1.
            
            Summary: The protein encoded by this gene is part of the replisome
            complex, a group of proteins that support DNA replication. It binds
            TIM and aids in protecting cells against DNA damage and stress.
            [provided by RefSeq, Feb 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM088552.1, SRR26360176.377688.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000008.1  73676091-73676153
            64-199              JAXUCZ010000008.1  73681339-73681474
            200-272             JAXUCZ010000008.1  73682120-73682192
            273-348             JAXUCZ010000008.1  73682417-73682492
            349-471             JAXUCZ010000008.1  73686708-73686830
            472-535             JAXUCZ010000008.1  73687060-73687123
            536-742             JAXUCZ010000008.1  73693257-73693463
            743-1232            JAXUCZ010000008.1  73696131-73696620
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1232
                     /gene="Tipin"
                     /gene_synonym="RGD1564084; UV98"
                     /note="timeless interacting protein"
                     /db_xref="GeneID:363076"
                     /db_xref="RGD:1564084"
     exon            1..63
                     /gene="Tipin"
                     /gene_synonym="RGD1564084; UV98"
                     /inference="alignment:Splign:2.1.0"
     exon            64..199
                     /gene="Tipin"
                     /gene_synonym="RGD1564084; UV98"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..900
                     /gene="Tipin"
                     /gene_synonym="RGD1564084; UV98"
                     /codon_start=1
                     /product="TIMELESS-interacting protein"
                     /protein_id="NP_001020458.1"
                     /db_xref="GeneID:363076"
                     /db_xref="RGD:1564084"
                     /translation="MLEQEENGLFEIPDYEHVEDETFPPFPPPGSPERDPAEAEPDEG
                     SGAPVPVPPKRIVKRNIPKLDATRLTSERGLPALRHVFDKTKFKGKGHEAEDLKTLIR
                     HMEHWAHRLFPKLQFEDFIDRVENLGNKKEVQTCLKRIRLDLPIVHEDFVNNNDEVEE
                     TNSLDAAATGFDAFVTSSSDSKRFASEASRNLTEEQQQRIEKNKQLALERRQAKLLSN
                     SQSLENDVTVEESSTGENQEESNGLISADGPHDVPSASTQEEGQLEAEETQLDHPNLD
                     "
     exon            200..272
                     /gene="Tipin"
                     /gene_synonym="RGD1564084; UV98"
                     /inference="alignment:Splign:2.1.0"
     exon            273..348
                     /gene="Tipin"
                     /gene_synonym="RGD1564084; UV98"
                     /inference="alignment:Splign:2.1.0"
     exon            349..471
                     /gene="Tipin"
                     /gene_synonym="RGD1564084; UV98"
                     /inference="alignment:Splign:2.1.0"
     exon            472..535
                     /gene="Tipin"
                     /gene_synonym="RGD1564084; UV98"
                     /inference="alignment:Splign:2.1.0"
     exon            536..742
                     /gene="Tipin"
                     /gene_synonym="RGD1564084; UV98"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1232
                     /gene="Tipin"
                     /gene_synonym="RGD1564084; UV98"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgtccgga gcctcgcgag aagtgctgtt ggcgcgcttg gcggcggccg ccgtttgggt
       61 gaggaaaaaa tgttggagca agaagaaaat ggcttgtttg aaataccaga ttatgaacat
      121 gtagaggatg aaacttttcc tcccttccca cctccaggct ctccagagag agatcctgca
      181 gaagctgaac ctgatgaagg gagtggagca cctgttcctg ttccgccaaa gagaatagtt
      241 aaaaggaata tacccaagct agatgctaca agattgactt cagagagagg gcttccagcc
      301 ttaaggcatg tatttgataa gacaaaattc aaggggaaag gtcatgaggc tgaagacttg
      361 aaaacgctaa tcagacacat ggagcactgg gcccataggc tattccccaa actgcaattt
      421 gaagatttta ttgacagagt tgaaaaccta ggaaataaaa aggaggttca gacctgttta
      481 aaacgaattc gacttgatct gcctattgta catgaagatt ttgttaacaa taacgatgaa
      541 gttgaggaaa ctaacagcct tgatgcagct gccactggat ttgatgcctt tgtgacaagt
      601 tcatctgaca gcaagaggtt tgcttctgaa gcgagtagaa acctaacaga agagcagcag
      661 cagagaattg agaaaaataa acaactggcc ttggaaagaa ggcaggcaaa gctattgagt
      721 aatagccagt ccctagaaaa tgacgtgaca gttgaagaga gcagtactgg tgagaatcaa
      781 gaagagtcaa atggattgat ctctgctgat ggtccacatg acgttccttc tgccagcaca
      841 caggaagaag gacagttgga agcagaggaa acacagctgg accatcctaa cttagactaa
      901 tccagaaatg ttctaagtag ccaaccctct acaacagaat cctacaggct tggagttatt
      961 tgtagttttt tctactttgt ataaatcctt aagtcttaag gcttctgtgg attcctgttt
     1021 aaaatacaat gactatttaa attgtttcct acttatttta gtaagtctat ttattatttt
     1081 tggtgttctg tataagtctg actttataag ctgttttgta gtttgcattg aattgtttct
     1141 tactaaattg ggtaatgatt aaaatgtaaa tatgccctga ctgttaggtc agtttttaat
     1201 aaagaaataa attattttgt aagcaactct ca
//
