LOCUS       NM_001107679            3796 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus TCDD-inducible poly(ADP-ribose) polymerase
            (Tiparp), mRNA.
ACCESSION   NM_001107679 XM_001060648 XM_003749294 XM_003753596 XM_227217
VERSION     NM_001107679.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3796)
  AUTHORS   Hsu,C.N., Lin,I.C., Yu,H.R., Huang,L.T., Tiao,M.M. and Tain,Y.L.
  TITLE     Maternal Tryptophan Supplementation Protects Adult Rat Offspring
            against Hypertension Programmed by Maternal Chronic Kidney Disease:
            Implication of Tryptophan-Metabolizing Microbiome and Aryl
            Hydrocarbon Receptor
  JOURNAL   Int J Mol Sci 21 (12), 4552 (2020)
   PUBMED   32604820
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3796)
  AUTHORS   Gomez,A., Bindesboll,C., Satheesh,S.V., Grimaldi,G., Hutin,D.,
            MacPherson,L., Ahmed,S., Tamblyn,L., Cho,T., Nebb,H.I., Moen,A.,
            Anonsen,J.H., Grant,D.M. and Matthews,J.
  TITLE     Characterization of TCDD-inducible poly-ADP-ribose polymerase
            (TIPARP/ARTD14) catalytic activity
  JOURNAL   Biochem J 475 (23), 3827-3846 (2018)
   PUBMED   30373764
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3796)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   4  (bases 1 to 3796)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3796)
  AUTHORS   Watson,J.D., Prokopec,S.D., Smith,A.B., Okey,A.B., Pohjanvirta,R.
            and Boutros,P.C.
  TITLE     TCDD dysregulation of 13 AHR-target genes in rat liver
  JOURNAL   Toxicol Appl Pharmacol 274 (3), 445-454 (2014)
   PUBMED   24355419
REFERENCE   6  (bases 1 to 3796)
  AUTHORS   MacPherson,L., Tamblyn,L., Rajendra,S., Bralha,F., McPherson,J.P.
            and Matthews,J.
  TITLE     2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase
            (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of
            aryl hydrocarbon receptor transactivation
  JOURNAL   Nucleic Acids Res 41 (3), 1604-1621 (2013)
   PUBMED   23275542
REFERENCE   7  (bases 1 to 3796)
  AUTHORS   Schmahl,J., Rizzolo,K. and Soriano,P.
  TITLE     The PDGF signaling pathway controls multiple steroid-producing
            lineages
  JOURNAL   Genes Dev 22 (23), 3255-3267 (2008)
   PUBMED   19056881
REFERENCE   8  (bases 1 to 3796)
  AUTHORS   Schmahl,J., Raymond,C.S. and Soriano,P.
  TITLE     PDGF signaling specificity is mediated through multiple immediate
            early genes
  JOURNAL   Nat Genet 39 (1), 52-60 (2007)
   PUBMED   17143286
REFERENCE   9  (bases 1 to 3796)
  AUTHORS   Ma,Q., Baldwin,K.T., Renzelli,A.J., McDaniel,A. and Dong,L.
  TITLE     TCDD-inducible poly(ADP-ribose) polymerase: a novel response to
            2,3,7,8-tetrachlorodibenzo-p-dioxin
  JOURNAL   Biochem Biophys Res Commun 289 (2), 499-506 (2001)
   PUBMED   11716501
REFERENCE   10 (bases 1 to 3796)
  AUTHORS   Matsuo,R., Murayama,A., Saitoh,Y., Sakaki,Y. and Inokuchi,K.
  TITLE     Identification and cataloging of genes induced by long-lasting
            long-term potentiation in awake rats
  JOURNAL   J Neurochem 74 (6), 2239-2249 (2000)
   PUBMED   10820183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001107679.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1378859.1,
                                           SRR26360194.2541695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000002.1  152063769-152063982
            215-1175            JAXUCZ010000002.1  152066636-152067596
            1176-1344           JAXUCZ010000002.1  152081567-152081735
            1345-1505           JAXUCZ010000002.1  152082931-152083091
            1506-1781           JAXUCZ010000002.1  152087818-152088093
            1782-3796           JAXUCZ010000002.1  152088400-152090414
FEATURES             Location/Qualifiers
     source          1..3796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..3796
                     /gene="Tiparp"
                     /gene_synonym="RM1"
                     /note="TCDD-inducible poly(ADP-ribose) polymerase"
                     /db_xref="GeneID:310467"
                     /db_xref="RGD:1306171"
     exon            1..214
                     /gene="Tiparp"
                     /gene_synonym="RM1"
                     /inference="alignment:Splign:2.1.0"
     exon            215..1175
                     /gene="Tiparp"
                     /gene_synonym="RM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2229
                     /gene="Tiparp"
                     /gene_synonym="RM1"
                     /EC_number="2.4.2.30"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase TIPARP"
                     /protein_id="NP_001101149.2"
                     /db_xref="GeneID:310467"
                     /db_xref="RGD:1306171"
                     /translation="MDMETTDPEPDCVVQPPSPPDDFSCQMRISEKITPLKTCFKKKQ
                     EQKRLGTGTLRSLRPILNTLLESGSLDGVFRARDQNGDESSLHEHIVKKPLDINPACP
                     PAENSMPVLIPDGTNVEGQLPEAHPSTDAPEQVVPIQDHSFPPETINGTVADSTTGHF
                     QTDLLHPVSGDVPTSPDCIDKVMDYVPGAFQDNSFTIQYILDTSDKLSTELFQDKSEE
                     ASLDLVFELVNQLQYHTHQETGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTT
                     QKWQSVSNDSQEHLERFYCNPENDRMRMKYGGQDFWADLNAMTVFETTEFDQLRRLST
                     PPCSSTNSIYHTFWKFFCRDHFGWREYPESVVRLIEEANSRGLKEVRFMMWNNHYILH
                     NSFFRREIKRRPLFRSCFILIPYLQTLGGVPTQASLPLEATSSQIICPDGVTSANFYP
                     ETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYK
                     RKKEYMNRKMSGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFA
                     KKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVD
                     NFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI"
     exon            1176..1344
                     /gene="Tiparp"
                     /gene_synonym="RM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1505
                     /gene="Tiparp"
                     /gene_synonym="RM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1781
                     /gene="Tiparp"
                     /gene_synonym="RM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..3796
                     /gene="Tiparp"
                     /gene_synonym="RM1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcagagct ggagctgaca ggcgagcgag ctggaacccg gagagcagtt gcggctttct
       61 gcgcccaagt ccgcggaatg gcccgtgccc cgctcgccga gtcggccgcc cacgaaccct
      121 agacaccggc acttgccctc ggctcagacc gctggcgcag agccggacct tccacgccgc
      181 gcctgtgctg cgttctgagg gcagcttgcc tgaggatttg tagatactga ggcgcaattg
      241 gagctaatcc acatcatgga catggaaacc accgaccctg agccagactg tgtagtacag
      301 cctccttctc ctcctgatga cttttcatgc caaatgagaa tttctgagaa gatcactcca
      361 ttgaaaactt gttttaagaa aaagcaggaa cagaaaagat tgggaactgg aacattgaga
      421 tccttaaggc caatattaaa tactttgcta gaatctgggt cgcttgacgg agtttttaga
      481 gccagagacc aaaatggaga tgagagcagc ttacatgaac atatagtgaa aaaacctctg
      541 gatatcaacc cagcatgccc accagcagaa aacagtatgc ctgtcctgat tcctgatggg
      601 acaaatgttg agggccaatt accagaagct catccttcta ctgatgctcc agaacaggtg
      661 gttccaatcc aggatcacag ttttccacca gaaaccatca atggcacagt agcagattct
      721 acaacaggac acttccaaac tgaccttttg catcctgttt caggtgatgt tcctacaagt
      781 cctgactgca tagataaagt tatggattat gtgccaggag ctttccaaga caatagtttt
      841 acaatccaat acattttgga taccagtgac aagttgagta ctgagctctt ccaagacaaa
      901 agtgaggaag cttcccttga ccttgtgttt gagcttgtaa accagctaca gtaccatact
      961 caccaagaga ctggaattga aatttgtatg gactttctgc aaggcacttg catttatggc
     1021 agggattgtt tgaaacatca caccgtattg ccctatcatt ggcagatcaa aaggacaacc
     1081 actcaaaagt ggcagagtgt ttccaatgat tctcaggagc acttggaaag attttattgt
     1141 aatccagaaa atgatagaat gagaatgaag tatggaggtc aagacttttg ggcagatttg
     1201 aatgccatga ctgtatttga aacaactgaa tttgaccaac tacgaaggct gtctacacca
     1261 ccttgtagta gtacaaactc tatttaccac acattttgga aattcttctg tagagaccac
     1321 tttggatgga gagagtatcc tgagtctgtt gttcgactaa ttgaagaagc caactctcgg
     1381 ggtctgaaag aagttagatt tatgatgtgg aacaaccatt acatcctcca caactcattc
     1441 ttccggagag aaataaaacg gagacccctt tttcgttcct gtttcatact gattccatat
     1501 ttacagacac ttggtggggt tcccactcag gcttctctgc ctcttgaagc aacttcatca
     1561 caaatcatct gtccagatgg agtaacttca gcaaactttt accctgaaac atgggtttat
     1621 atgcatccat ctcaggactt catccaagtg cctgtttctg cagaggataa aagttatcga
     1681 atcatttaca acctttttca taaaactgta cctgaattta aatacagaat tttacaaata
     1741 ttgagagtcc aaaaccaatt tctttgggag aaatataaaa ggaaaaaaga gtatatgaat
     1801 agaaaaatgt ctggccgtga cagaataata aatgagagac acttatttca tggaacatca
     1861 caagatgtgg tagatggaat ttgcaagcac aactttgacc ctcgtgtctg tggaaagcat
     1921 gctacaatgt ttggacaagg cagttacttc gcgaagaagg caagctactc tcataacttt
     1981 tctaagaagt cctccaaagg agtccatttc atgtttttgg ccaaagtgtt aactggcaga
     2041 tacacaatgg gcagtcatgg catgagaagg ccccctccgg tcaacccagg cagtgtcacc
     2101 agtgacttgt atgactcttg tgtggataat ttttttgagc ctcagatttt tgtcattttt
     2161 aatgatgacc agagttaccc ttattttgtt atccaatatg aagaagtcag taacactgtt
     2221 tccatttgaa atcttggtac tactaagtta tttgatatga actcaatcca gcatttgtag
     2281 caggtttggg tggggctggg agggaaacag catatgacag aaattggata cttttcagac
     2341 ccaatttttt aataagtgct agaaagtaat tttttaaaag aaaaaaaagg ggttttaaaa
     2401 tggccactta ttatttaatt gtttactaat tattagtgta cttggtgtgg aaaagactaa
     2461 agtgcatatt cttcattcac acttgtacat atagtcagca gcaatattag tagaagtatt
     2521 tggagaaaaa tcaaaaactg actagcctaa ttaaatgtcg cttgggtctg gtagaagttt
     2581 ggtcaaaaca aatagaggct gcgagcaaag tgaggattct gtttacttaa cattgataaa
     2641 accacctgga actgatacta ccatgcttat tacctatcca aagcattatg tattgtactt
     2701 tggggtagaa tacattcgtg taattctaat aggtgggaag aaattttcat tctgtgatca
     2761 ggactgaaat atatcaccca ctcaaacctc tagaattttc ctgagaactc agggtctgtt
     2821 cagaggaagt aaaataataa taaagaaccc atttggggaa aaaaatgtca ccagcagaat
     2881 tccctggttg tgaagtgtga tacatgtgtt aaaattagcc atgaaaaact cagcctcttt
     2941 cattgttgcc taccatcgtt tcagagttgg gcacctaggt tggttaaagc cagtcttaag
     3001 ggttaaaagt atttcttttg ggattccaga cctacccttg ggctggtatt agataataga
     3061 agacatctac aaccaaagtg gagaggttga gaactgtgcc tggcacaaaa cagactctta
     3121 gccatatctg ctgagttgaa ttgttaaaga caacaagctc accccatgcc tgctttgcca
     3181 gatgcactag atttcttggc tgactctgta ccttacacta cttactttaa tagaaacaca
     3241 gacttggaaa ttgtgccact ggcccagcaa aagcactgtt gggtgaatgt tctgttgcct
     3301 caattcagag cagtagtaag tacttgtaag caaagcaaaa gcctgagtaa agtgaaaagt
     3361 ggttgttgat aaaataaacc acagaagtcc ttcagatacc aagctctcct tgtatgtttg
     3421 tggttatctc atttacccaa actttacagg aacttctttg ttatttaaag caagatatag
     3481 ctgtacagat gtctcagtga atcggtctgt ttaagcactt atcagggctt ccacacagtt
     3541 atttattttg ctccagttga tcctgttgtt tgctgccatt ggcaggagga aatgggcaac
     3601 tgtagcaatc attcattcag ttataacttg taaaccagtg atccccaatc gttttcaagt
     3661 tagacatgtt accattgctt gtttgatttt atggaacttg ttcctttttt tctccctaaa
     3721 ggaaacaaaa gctttatgac atatttattt ttttaataaa actaagcaaa aataaaagtt
     3781 aattctttaa aacttc
//
