LOCUS       NM_001006962            1679 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus TERF1 interacting nuclear factor 2 (Tinf2), mRNA.
ACCESSION   NM_001006962 XM_214178
VERSION     NM_001006962.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Kappei D, Butter F, Benda C, Scheibe M, Draskovic I, Stevense M,
            Novo CL, Basquin C, Araki M, Araki K, Krastev DB, Kittler R,
            Jessberger R, Londono-Vallejo JA, Mann M and Buchholz F.
  TITLE     HOT1 is a mammalian direct telomere repeat-binding protein
            contributing to telomerase recruitment
  JOURNAL   EMBO J 32 (12), 1681-1701 (2013)
   PUBMED   23685356
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Grolimund L, Aeby E, Hamelin R, Armand F, Chiappe D, Moniatte M and
            Lingner J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   3  (bases 1 to 1679)
  AUTHORS   Choi KH, Farrell AS, Lakamp AS and Ouellette MM.
  TITLE     Characterization of the DNA binding specificity of Shelterin
            complexes
  JOURNAL   Nucleic Acids Res 39 (21), 9206-9223 (2011)
   PUBMED   21852327
REFERENCE   4  (bases 1 to 1679)
  AUTHORS   Abreu E, Aritonovska E, Reichenbach P, Cristofari G, Culp B, Terns
            RM, Lingner J and Terns MP.
  TITLE     TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
  JOURNAL   Mol Cell Biol 30 (12), 2971-2982 (2010)
   PUBMED   20404094
REFERENCE   5  (bases 1 to 1679)
  AUTHORS   Dejardin J and Kingston RE.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   6  (bases 1 to 1679)
  AUTHORS   Chiang YJ, Kim SH, Tessarollo L, Campisi J and Hodes RJ.
  TITLE     Telomere-associated protein TIN2 is essential for early embryonic
            development through a telomerase-independent pathway
  JOURNAL   Mol Cell Biol 24 (15), 6631-6634 (2004)
   PUBMED   15254230
REFERENCE   7  (bases 1 to 1679)
  AUTHORS   Ye JZ and de Lange T.
  TITLE     TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length
            control complex
  JOURNAL   Nat Genet 36 (6), 618-623 (2004)
   PUBMED   15133513
REFERENCE   8  (bases 1 to 1679)
  AUTHORS   Loayza D and De Lange T.
  TITLE     POT1 as a terminal transducer of TRF1 telomere length control
  JOURNAL   Nature 423 (6943), 1013-1018 (2003)
   PUBMED   12768206
REFERENCE   9  (bases 1 to 1679)
  AUTHORS   Kim SH, Parrinello S, Kim J and Campisi J.
  TITLE     Mus musculus and Mus spretus homologues of the human
            telomere-associated protein TIN2
  JOURNAL   Genomics 81 (4), 422-432 (2003)
   PUBMED   12676566
REFERENCE   10 (bases 1 to 1679)
  AUTHORS   Kim SH, Kaminker P and Campisi J.
  TITLE     TIN2, a new regulator of telomere length in human cells
  JOURNAL   Nat Genet 23 (4), 405-412 (1999)
   PUBMED   10581025
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083766.1.
            
            On Nov 22, 2004 this sequence version replaced XM_214178.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083766.1, SRR8487231.116968.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1679
                     /gene="Tinf2"
                     /note="TERF1 interacting nuclear factor 2"
                     /db_xref="GeneID:290232"
                     /db_xref="RGD:1359192"
     exon            1..446
                     /gene="Tinf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1448
                     /gene="Tinf2"
                     /note="TERF1 (TRF1)-interacting nuclear factor 2"
                     /codon_start=1
                     /product="TERF1-interacting nuclear factor 2"
                     /protein_id="NP_001006963.1"
                     /db_xref="GeneID:290232"
                     /db_xref="RGD:1359192"
                     /translation="MAPPPGVGPASLRFAAAASWLVVRRRQVEHFPRVVQFLESLRAA
                     VPGLVCYRHHERLCMGLKAKVVVELIVQERPWTQILNALNLHFPESRTTEQDRKLLEA
                     QENFCLLVKQLSEDPASSPQELEQDYGEPFLVAMEKLLFEYLCQLERVLPTVRAQELQ
                     DVLSWIQPGCSVTSSVALRQYGMDMGWPFPESPSGSVSPPQQTKPASHSPLPKAKLGP
                     LQPASQEHPEHLAGNRFNLAPLGKRKCPSQWTSAKACHKERPTVMLFPFRNTGLPSQD
                     IPNPKSKEEHEPEPVCTEKSKTPSQTLGKRALEETPPDSPATKQKENCVNCMDPLGYS
                     SPPSRVKKPVLSPSLCSSVITIGDLVLDSDEEENNQKEGKESLKNYQKTKLDTYIPMF
                     CDYIP"
     exon            447..530
                     /gene="Tinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..620
                     /gene="Tinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..728
                     /gene="Tinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..825
                     /gene="Tinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1219
                     /gene="Tinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1284
                     /gene="Tinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1376
                     /gene="Tinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1656
                     /gene="Tinf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcccagt cggaagtgac gtaccctcgc gctccgcgca gtggcggcat tttaagcttt
       61 gccgtctgga caggttgaca cactcagtca cggtctggga ggagactcta ggattccggt
      121 ggctccccga aactggctaa agccagtccg ccggtcttcc ggtgcagacg agagaaccga
      181 agctccgcct acgggagcgt ctaggaagtc tgcgctgagg gaaagcggcg cggaggaaag
      241 ggcgcccgcg agccatggcc ccacctccag gggtgggtcc cgcgtctctg cggtttgctg
      301 ctgccgccag ctggctagtt gtccgccgtc gccaagtaga gcacttcccg agagtggtcc
      361 agtttttgga gtcccttcgc gctgctgtcc ctggcttggt ttgctaccgg caccatgaac
      421 gcctatgtat gggcctaaag gccaaggtgg tggtggagct gatcgtgcaa gagcgaccct
      481 ggacccagat cctcaatgcc ctgaatcttc actttccaga gtccagaaca acagaacaag
      541 ataggaagct tttggaggca caggaaaatt tttgcctgct tgtgaagcag ctgtcagagg
      601 acccggcttc gagcccgcag gaactagaac aagactatgg ggaacccttt ctggttgcca
      661 tggaaaagct gttgtttgaa tacttgtgtc agctagaaag agtactgcct acagtcagag
      721 cacaagagct tcaggatgtt ctaagttgga ttcagccggg ctgctccgtt acttcttctg
      781 ttgctttgcg ccagtatggt atggacatgg ggtggccgtt tccagagagt ccttctggtt
      841 cagtgagtcc tcctcagcaa acaaaaccag catcccacag tcctctgcct aaagctaagc
      901 ttggccctct ccaaccagct tcacaggagc atccagaaca tttagctggc aaccgcttta
      961 atctggcccc tttgggaaag cgaaaatgcc catcccagtg gacatccgca aaggcctgcc
     1021 acaaagagcg gcccacagtc atgctgttcc ccttcaggaa cacaggccta ccatctcaag
     1081 acatacctaa ccccaaaagc aaggaagaac atgaaccaga accagtctgc actgagaagt
     1141 ccaagactcc atcacaaacc ttagggaaaa gggcattaga ggagaccccg cctgactcac
     1201 cggctacaaa gcaaaaggag aactgtgtga attgcatgga tcctctagga tactcatcac
     1261 caccttctag agtcaagaaa ccagtgctat ccccgtccct atgtagctct gttattacca
     1321 taggggactt ggttttggac tctgatgagg aagaaaataa ccagaaagaa gggaaggagt
     1381 ctttgaaaaa ctatcagaag acgaagcttg acacctatat ccccatgttt tgtgactaca
     1441 ttccatagtg tcctgactat tcctttctgg ctacataaac agttctcact caggtcctct
     1501 ggaataccct ctgcactctg tccatccacc cctgcagctc tgcacgcaaa agtttagtgg
     1561 aaaagaagag gaagctgaga cctcagttgc ctggctacat tgctaaaagc tttgtaacac
     1621 ttgaaaatta aatcttgatt tctttcagtg tcttgaaaaa aaaaaaaaaa aaaaaaaaa
//
