LOCUS       NM_001109393            1701 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus TIMP metallopeptidase inhibitor 4 (Timp4), mRNA.
ACCESSION   NM_001109393 XM_001056766
VERSION     NM_001109393.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1701)
  AUTHORS   Zhou,W., Jiang,Z., Yi,Z., Ouyang,J., Li,X., Zhang,Q. and Wang,P.
  TITLE     Defect of TIMP4 Is Associated with High Myopia and Participates in
            Rat Ocular Development in a Dose-Dependent Manner
  JOURNAL   Int J Mol Sci 24 (23), 16928 (2023)
   PUBMED   38069250
  REMARK    GeneRIF: Defect of TIMP4 Is Associated with High Myopia and
            Participates in Rat Ocular Development in a Dose-Dependent Manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1701)
  AUTHORS   Guerra Cde,S., Carla Lara Pereira,Y., Issa,J.P., Luiz,K.G.,
            Guimaraes,E.A., Gerlach,R.F. and Iyomasa,M.M.
  TITLE     Histological, histochemical, and protein changes after induced
            malocclusion by occlusion alteration of Wistar rats
  JOURNAL   Biomed Res Int 2014, 563463 (2014)
   PUBMED   25028660
  REMARK    GeneRIF: The immunohistochemistry demonstrated greater expression
            of MMP-2 than MMP-9 and MMP-14 in all masseter muscles and there
            were few differences in the staining of 4 TIMPs.
REFERENCE   3  (bases 1 to 1701)
  AUTHORS   Feng,Z.Y., He,Z.N., Zhang,B. and Chen,Z.
  TITLE     Osteoprotegerin promotes the proliferation of chondrocytes and
            affects the expression of ADAMTS-5 and TIMP-4 through MEK/ERK
            signaling
  JOURNAL   Mol Med Rep 8 (6), 1669-1679 (2013)
   PUBMED   24126801
  REMARK    GeneRIF: OPG regulated the proliferation of chondrocytes via
            MEK/ERK signaling, and directly affected chondrocytes by
            influencing the expression profile of ADAMTS-5 and TIMP-4.
REFERENCE   4  (bases 1 to 1701)
  AUTHORS   Tong,W., Xiong,F., Li,Y. and Zhang,L.
  TITLE     Hypoxia inhibits cardiomyocyte proliferation in fetal rat hearts
            via upregulating TIMP-4
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 304 (8), R613-R620 (2013)
   PUBMED   23427085
  REMARK    GeneRIF: These findings provide evidence of a novel causal role of
            TIMP-4 and TIMP-3 in the direct inhibitory effect of hypoxia on
            cardiomyocyte proliferation in the developing heart
REFERENCE   5  (bases 1 to 1701)
  AUTHORS   Fouillade,C., Baron-Menguy,C., Domenga-Denier,V., Thibault,C.,
            Takamiya,K., Huganir,R. and Joutel,A.
  TITLE     Transcriptome analysis for Notch3 target genes identifies Grip2 as
            a novel regulator of myogenic response in the cerebrovasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (1), 76-86 (2013)
   PUBMED   23117660
REFERENCE   6  (bases 1 to 1701)
  AUTHORS   Li,Y.Y., McTiernan,C.F. and Feldman,A.M.
  TITLE     Proinflammatory cytokines regulate tissue inhibitors of
            metalloproteinases and disintegrin metalloproteinase in cardiac
            cells
  JOURNAL   Cardiovasc Res 42 (1), 162-172 (1999)
   PUBMED   10435007
REFERENCE   7  (bases 1 to 1701)
  AUTHORS   Dollery,C.M., McEwan,J.R., Wang,M., Sang,Q.A., Liu,Y.E. and
            Shi,Y.E.
  TITLE     TIMP-4 is regulated by vascular injury in rats
  JOURNAL   Circ Res 84 (5), 498-504 (1999)
   PUBMED   10082471
REFERENCE   8  (bases 1 to 1701)
  AUTHORS   Mujumdar,V.S. and Tyagi,S.C.
  TITLE     Temporal regulation of extracellular matrix components in
            transition from compensatory hypertrophy to decompensatory heart
            failure
  JOURNAL   J Hypertens 17 (2), 261-270 (1999)
   PUBMED   10067796
REFERENCE   9  (bases 1 to 1701)
  AUTHORS   Wu,I. and Moses,M.A.
  TITLE     Molecular cloning and expression analysis of the cDNA encoding rat
            tissue inhibitor of metalloproteinase-4
  JOURNAL   Matrix Biol 16 (6), 339-342 (1998)
   PUBMED   9503367
REFERENCE   10 (bases 1 to 1701)
  AUTHORS   Wang,M., Liu,Y.E., Greene,J., Sheng,S., Fuchs,A., Rosen,E.M. and
            Shi,Y.E.
  TITLE     Inhibition of tumor growth and metastasis of human breast cancer
            cells transfected with tissue inhibitor of metalloproteinase 4
  JOURNAL   Oncogene 14 (23), 2767-2774 (1997)
   PUBMED   9190892
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473964.2.
            
            On Oct 4, 2007 this sequence version replaced XM_001056766.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213131.1, FQ214060.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1701
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1701
                     /gene="Timp4"
                     /gene_synonym="Timp-4"
                     /note="TIMP metallopeptidase inhibitor 4"
                     /db_xref="GeneID:680130"
                     /db_xref="RGD:69077"
     exon            1..503
                     /gene="Timp4"
                     /gene_synonym="Timp-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..1039
                     /gene="Timp4"
                     /gene_synonym="Timp-4"
                     /note="metalloproteinase inhibitor 4; tissue inhibitor of
                     metalloproteinases 4; tissue inhibitor of
                     metalloproteinase 4"
                     /codon_start=1
                     /product="metalloproteinase inhibitor 4 precursor"
                     /protein_id="NP_001102863.1"
                     /db_xref="GeneID:680130"
                     /db_xref="RGD:69077"
                     /translation="MPWSPLAALSWALVLRLLALLWPPGRGEACSCAPAHPQQHVCHS
                     ALVIRAKISSEKVVPASEDPADTQKMIRYEIKQIKMFKGFEKAKDIQYVYTPFDSSLC
                     GVKLETNSQKQYLLTGQILSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHQNCGCQI
                     TTCYAVPCTISAPDECLWTDWLLERKLYGYQAQHYVCMKHVDGICSWYRGHLHLRKEY
                     VDIVQP"
     exon            504..601
                     /gene="Timp4"
                     /gene_synonym="Timp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            602..716
                     /gene="Timp4"
                     /gene_synonym="Timp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            717..841
                     /gene="Timp4"
                     /gene_synonym="Timp-4"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1701
                     /gene="Timp4"
                     /gene_synonym="Timp-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgctcttgc tcttaatgct ggagccccaa accctcatct ttctgccttt tctagtctct
       61 tcactggttt ttgcttttct ctctctgccc ctagcgccca gtcttcctct acttctaggc
      121 tcttttcgga aatctgcatg tttccctctg cgttgactgg gtcttgttgg tctggtcagg
      181 agggcctcag gtcctgcggc tgtgggtggc cgggcgccaa aggagggagg agcccatggg
      241 ggcgggattg gccctaaagc cacctcataa agactgggac tgacaagctt tctggaggag
      301 tcctggaggg gctgtttgtt tcgacaggca gaccccacga gctcagctgg ggctctgcag
      361 tgtcatgccc tggagtcccc tggctgcgct gagctgggcg ctggtgctga ggctgctggc
      421 tttgctgtgg ccccctggac ggggtgaggc gtgcagctgc gcgcctgcgc acccccagca
      481 gcacgtctgc cactctgctt tagtaatacg ggccaaaata tccagtgaga aggtagtccc
      541 tgccagtgaa gaccccgctg acactcaaaa aatgatccgg tatgaaatca aacagataaa
      601 gatgtttaaa gggttcgaga aggccaagga tattcagtat gtctacacgc catttgactc
      661 ttctctctgt ggtgtgaaac tagaaaccaa cagtcagaag cagtatctgt tgactggcca
      721 gattctcagt gatggaaaag tcttcatcca tctgtgcaac tacattgagc cctgggagga
      781 cctgtccttg gtgcagaggg agagcctgaa tcatcactac caccagaact gtggctgcca
      841 aatcaccact tgctatgcag tgccgtgtac catctcagcc cccgatgagt gtctctggac
      901 agactggctg ctggaacgga agctctatgg gtaccaggcc cagcactatg tctgcatgaa
      961 gcatgttgat ggcatctgca gctggtaccg aggacaccta cacctccgga aggagtacgt
     1021 tgacatcgtc cagccctaga agggaccggc aaccatatcc ttggaagagt tctgaagacc
     1081 aagccagttc tctgtggtac tctgatcacc accacttgcc atgttgctgc cagataatga
     1141 gaagtgacaa gtggatggcc tggccagtaa attggaggct gtggggcatg tggcagcctg
     1201 ggtctgctgt tcacatctcc agctcacaac ctgtcaaggg ttgggaagga agtatcttat
     1261 ctgccttgcc ctcagcccct ctcccctgtc tcccaaacct tgttagtcta gcttataccc
     1321 attactcagt ttttattctg gctttgttta actggctttt cttaactcgt aagggagaag
     1381 ctgtgactgt cataaaatgg tacagccttg cgatgtgcgc tatggaaggt gggctgacta
     1441 tatcctgagt gggctggttg gctgaaagga aaagattgcc taaagctcca ttatctccta
     1501 ctcccactgt ctcaacttag cctaatcctc tgacacactt ttatctgctt gaaggacgca
     1561 gtgggagctg aacagcacac tcttccttgg tgtcctgcaa gtcttctgat acttgtcctg
     1621 gcagaaggtc tggcccagtt ggcatacatc tttggaaaag aaaacttaca tactagaaca
     1681 cgcattttcc cctccaggtt a
//
