LOCUS       NM_012886               4509 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Rattus norvegicus TIMP metallopeptidase inhibitor 3 (Timp3), mRNA.
ACCESSION   NM_012886 XM_001075779 XM_006241162
VERSION     NM_012886.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4509)
  AUTHORS   Wumiti,T., Wang,L., Xu,B., Ma,Y., Zhu,Y., Zuo,X., Qian,W., Chu,X.
            and Sun,H.
  TITLE     lncTIMP3 promotes osteogenic differentiation of bone marrow
            mesenchymal stem cells via miR-214/Smad4 axis to relieve
            postmenopausal osteoporosis
  JOURNAL   Mol Biol Rep 51 (1), 719 (2024)
   PUBMED   38824271
  REMARK    GeneRIF: lncTIMP3 promotes osteogenic differentiation of bone
            marrow mesenchymal stem cells via miR-214/Smad4 axis to relieve
            postmenopausal osteoporosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4509)
  AUTHORS   Wang,C., Lin,Y., Fu,Y., Zhang,D. and Xin,Y.
  TITLE     MiR-221-3p regulates the microvascular dysfunction in diabetic
            retinopathy by targeting TIMP3
  JOURNAL   Pflugers Arch 472 (11), 1607-1618 (2020)
   PUBMED   32648125
  REMARK    GeneRIF: MiR-221-3p regulates the microvascular dysfunction in
            diabetic retinopathy by targeting TIMP3.
REFERENCE   3  (bases 1 to 4509)
  AUTHORS   Li,X. and Yu,H.M.
  TITLE     Overexpression of HOXA-AS2 inhibits inflammation and apoptosis in
            podocytes via sponging miRNA-302b-3p to upregulate TIMP3
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (9), 4963-4970 (2020)
   PUBMED   32432759
  REMARK    GeneRIF: Overexpression of HOXA-AS2 inhibits inflammation and
            apoptosis in podocytes via sponging miRNA-302b-3p to upregulate
            TIMP3.
REFERENCE   4  (bases 1 to 4509)
  AUTHORS   He,M., Pang,J., Sun,H., Zheng,G., Lin,Y. and Ge,W.
  TITLE     Overexpression of TIMP3 inhibits discogenic pain by suppressing
            angiogenesis and the expression of substance P in nucleus pulposus
  JOURNAL   Mol Med Rep 21 (3), 1163-1171 (2020)
   PUBMED   31922222
  REMARK    GeneRIF: Overexpression of TIMP3 inhibits discogenic pain by
            suppressing angiogenesis and the expression of substance P in
            nucleus pulposus.
REFERENCE   5  (bases 1 to 4509)
  AUTHORS   Jiang,C., Xia,W., Wu,T., Pan,C., Shan,H., Wang,F., Zhou,Z. and
            Yu,X.
  TITLE     Inhibition of microRNA-222 up-regulates TIMP3 to promotes
            osteogenic differentiation of MSCs from fracture rats with type 2
            diabetes mellitus
  JOURNAL   J Cell Mol Med 24 (1), 686-694 (2020)
   PUBMED   31691506
REFERENCE   6  (bases 1 to 4509)
  AUTHORS   Fager,N. and Jaworski,D.M.
  TITLE     Differential spatial distribution and temporal regulation of tissue
            inhibitor of metalloproteinase mRNA expression during rat central
            nervous system development
  JOURNAL   Mech Dev 98 (1-2), 105-109 (2000)
   PUBMED   11044612
REFERENCE   7  (bases 1 to 4509)
  AUTHORS   Salzmann,J., Limb,G.A., Khaw,P.T., Gregor,Z.J., Webster,L.,
            Chignell,A.H. and Charteris,D.G.
  TITLE     Matrix metalloproteinases and their natural inhibitors in
            fibrovascular membranes of proliferative diabetic retinopathy
  JOURNAL   Br J Ophthalmol 84 (10), 1091-1096 (2000)
   PUBMED   11004090
REFERENCE   8  (bases 1 to 4509)
  AUTHORS   Felbor,U., Benkwitz,C., Klein,M.L., Greenberg,J., Gregory,C.Y. and
            Weber,B.H.
  TITLE     Sorsby fundus dystrophy: reevaluation of variable expressivity in
            patients carrying a TIMP3 founder mutation
  JOURNAL   Arch Ophthalmol 115 (12), 1569-1571 (1997)
   PUBMED   9400791
REFERENCE   9  (bases 1 to 4509)
  AUTHORS   Esposito,C., Liu,Z.H., Striker,G.E., Phillips,C., Chen,N.Y.,
            Chen,W.Y., Kopchick,J.J. and Striker,L.J.
  TITLE     Inhibition of diabetic nephropathy by a GH antagonist: a molecular
            analysis
  JOURNAL   Kidney Int 50 (2), 506-514 (1996)
   PUBMED   8840279
REFERENCE   10 (bases 1 to 4509)
  AUTHORS   Wu,I. and Moses,M.A.
  TITLE     Cloning and expression of the cDNA encoding rat tissue inhibitor of
            metalloproteinase 3 (TIMP-3)
  JOURNAL   Gene 168 (2), 243-246 (1996)
   PUBMED   8654952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Mar 12, 2021 this sequence version replaced
            XM_006241162.4, NM_012886.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.26000.1,
                                           SRR26643299.30029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840106, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               JAXUCZ010000007.1  19459139-19459558   c
            421-503             JAXUCZ010000007.1  19419205-19419287   c
            504-615             JAXUCZ010000007.1  19413842-19413953   c
            616-737             JAXUCZ010000007.1  19413227-19413348   c
            738-4509            JAXUCZ010000007.1  19408539-19412310   c
FEATURES             Location/Qualifiers
     source          1..4509
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..4509
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /note="TIMP metallopeptidase inhibitor 3"
                     /db_xref="GeneID:25358"
                     /db_xref="RGD:3865"
     exon            1..420
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..935
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /note="metalloproteinase inhibitor 3; tissue inhibitor of
                     metalloproteinases 3; tissue inhibitor of
                     metalloproteinase 3 (Sorsby fundus dystrophy,
                     pseudoinflammatory)"
                     /codon_start=1
                     /product="metalloproteinase inhibitor 3 precursor"
                     /protein_id="NP_037018.2"
                     /db_xref="GeneID:25358"
                     /db_xref="RGD:3865"
                     /translation="MTPWLGLVLLLSCWSLGHWGTEACTCSPSHPQDAFCNSDIVIRA
                     KVVGKKLVKEGPFGTLVYTIKQMKMYRGFSKMPHVQYIHTEASESLCGLKLEVNKYQY
                     LLTGRVYEGKMYTGLCNFVERWDHLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSK
                     NECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSISNATDP"
     exon            421..503
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            504..615
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            616..737
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..4509
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtgggca gcgggcagcc gccagcgcca aggagcttct tctcttgctt ctccgcttcc
       61 cgatccttct cccggaggcc actcactggc tccgcggact cgtgcgccag acacccttgg
      121 ccacttggtc acatcccgcc gggctacttg gaaggcactt ccccggagct caaagttgcc
      181 caccgtgcac agtgcacggt taaacccggc gagtgagctc ggactgcagc accggcgcta
      241 gcgctcggca actttgagga aaagagcggc agtccccgca gcggaccaca gcagctacca
      301 tgactccctg gcttgggctt gtcctgctcc tgagctgctg gagccttggg cactggggaa
      361 cggaagcgtg cacatgctcg cccagccatc cccaggatgc cttctgcaac tccgacatcg
      421 tgatccgggc caaagtggtg ggaaagaagc tggtgaagga agggcccttt ggcactctgg
      481 tctacactat taagcaaatg aagatgtacc gaggattcag taagatgccc catgtgcagt
      541 acattcacac agaagcctct gaaagtctct gtggccttaa gctagaagtc aacaaatacc
      601 agtacctgct gacagggcgc gtgtatgaag gcaagatgta cacagggctg tgcaactttg
      661 tggagaggtg ggaccacctc acactgtccc agcgcaaggg cctcaattac cgctaccacc
      721 tgggttgcaa ttgcaagatc aagtcctgct actacttgcc ttgctttgtg acctccaaga
      781 atgaatgtct ctggaccgac atgctctcca atttcgggta ccctggctat cagtccaaac
      841 actacgcctg catccggcag aagggtggct actgcagctg gtaccgagga tgggcccccc
      901 cagacaagag catcagcaat gccacagacc cctgaaccca gacctgtccc acctcacctc
      961 cttcccatcc cgctgagcgt cccggacact aactcttccc agatgatgac aatgaaatta
     1021 gtgcctgttt tcttgcaaat ttagcactgg gggacagtta aagtctctgc cgtttatgga
     1081 gttgatttgg aaataccttc ctggtcccgc ccccttatac cccgtctttt tggttttgac
     1141 atcacccatt tccaactgtg gatctctggt gccaagccag aaagaatgag gcatgtatac
     1201 acacctcttc ttcatgatat ataatctata tttttttagg aaaacagaaa ttgaaaaatc
     1261 taccccattg gggcatttaa tagctactct tctttcttct tcctctcttg accacatcct
     1321 agaccgcact tccatagaca cttcttcatc caagtacaca ggaagcatgg ataaggaagt
     1381 tggcagaagt ccaactgttt ccccgatcag ccaagggcag caagcagaca gacgccaggt
     1441 atttgaaggc cttatacaca gaggatatac aactgtgtgt ctggatcaga cagtctgtct
     1501 atgtctgcat gtcagattga gggagggaag ggacagactg taggagtggg tcacacagtt
     1561 tcccagtcct gtgattcttg ggttgacccg ctgtttcagg tcctggaaca agcatccaag
     1621 agtagcagaa ctttctgagt tggcaaagac ttaaacatct gcccgagttc agcaggcaac
     1681 ctgcctgttt gtataaaaaa actcagacga agggctgaga cgaacgtctt tcctctcctg
     1741 cctcccatga gacagtctcc tgggaatcct aggctggaag cttgcaaaca tgtgagctgg
     1801 agaaacacac acctgacacc atccacagat atagtcaagt agatttgggt agagaatact
     1861 atttccaaag tagtgtttag ctcatctagg gggatgtgtt tatatataca tttgcatata
     1921 cccacagggg attatgagct aattttttta taggacacag aattctattc aatgctgtta
     1981 aatatgcaaa tagtttaatc tcttttgttg ttgtttgatg ggaaattgtg acattccaag
     2041 ttgacttttt ttttttatct gaattaaaat ttgaaactct gaccacactc agcaccctct
     2101 tgtccctatc actggggttg tttgaccctt catctccttt ttccttctgc tttgtgtttg
     2161 gggtgccctt cacttagttg ccttactagc cggctgatgg caggtgagtg tgagtgttag
     2221 ggcaggggct gtctcatgaa agggacagtt gcacatcatc ctacatcagt ggaatgactc
     2281 ctctcctgga tctggggaca gcatatactt cttccccagc tcagtcatgg gtgaacgtca
     2341 cctcctgaga tggtcacctc agagaaggaa cacggttggt tactgaggga gccaggctct
     2401 gccaacaaac tgtaggcctt ttgttgtgta gtatttttgt tttttaaata aaagtatagt
     2461 ataaattttc ctattaaata agattatttt aagttttact gtcaaaattg caatgcccat
     2521 tgtaggtaag ggtgtactat acagatttgg agatggtaag gtggtgacat ttaacacaat
     2581 tacactgtct tttttcaggt tatgggtata tatcctctat tagtatcata tctttttcat
     2641 tccactttag gaaacacagt taccagttat aagtagagag agagagagag agaaagacaa
     2701 gttctagtct gcctctaccc cacacatacc acttctttgt ccaggggttt gacagaatag
     2761 caggcccgga agacagttga ggagatgggt gtcaagtttc ctctgggtag atttcattcc
     2821 ccggcatcct tcccctgtgc tgacagggag cagaaggcgc aacgctttcc atggtgtggg
     2881 gcagaaggag ccgaggtcag caagccagtg gttcttaaga ggtaaacctc tgacttactg
     2941 ttggaagttg tctctttcaa cctcagagtc tcctaatatg gcgctcctga tctaccctgc
     3001 tcaatgctct cccgtatgta caccccagcc tctttcccaa gaagtctctg gccattctca
     3061 gtccctgtgt gatcagcctc cctcctaccc ggacagactt gaggtgaggc ctaagtatga
     3121 ggcacctgaa gttaacctga agataaaacc attggcagaa ccacggcccc aggtggctgt
     3181 tgaggtcttg gcgagaagtc ctgggcaagg aaggtctttc gtaaagtcac atcattggag
     3241 agccgttttt gcgctttcaa taagctatag ctttgtttct ttctcctgtt cacttactgt
     3301 ataatttaaa gtcatttatg tagctgagac actttgttat ttcaatcata tcgtgaatgt
     3361 tttattttgc taaatcatgt gccatgtgta ggctgtcgtg tgtacactgt gtctaagaga
     3421 agaagaaaag aaagaaagaa aaaaaacccc acatgccatt tttttttcct gattcaaatt
     3481 ctacagtaga atggaaggca gaatactggg gctcgagcac tcagctggaa taaagattca
     3541 aggaaatgga aagtactaga aacagactcc tccagcctcc tccccatggg atcctaaggg
     3601 tgggaaggag aaaaagaaca aaagtacact gatgtccttg tcctgtatca actatccctg
     3661 ggtcatctgc cacccacttt ccaagacctt tctcctactc aaccaggaag ccgtggtttc
     3721 tgcaatccag ggccatggca actgtgactc caagctctct ctgtctcatc cagtcaactt
     3781 ttctgcctcc taaccaagga attcctctac gcaggctctt gttgcccagg ctagccctct
     3841 ttttcagcca ggatgtggag ctgaaggaga ccctagtgtt tactttctcc agtcctagct
     3901 ctgccatata aacactgttt catgctgtgc ttcttaaatg ataaaggaca cagtgacttt
     3961 tggggataga tttgtctggg agatgatgtg agtccgggag gcattactct tccctgcctc
     4021 acatcaaggt gccattcagg tatttggctc ctagctactt aaagttaaaa ataatcactc
     4081 taatatttgt atcatagaaa ctcaaaaaaa aaaaaaaaag aaaagtcaca gaaacataat
     4141 caaatgggag aaggcaggag agaatggtct caacagattt aagttggctg ttgggactga
     4201 ggaggagagg acctgatgaa aagaccatgc tctggggaca gggatacctt agattctctg
     4261 tctacttttc ttctaacaag tcagctgtgc tgaagcccag tagtgatgaa gagactccag
     4321 ccagagaaaa acccatctag aaggaatgta tttgttgcta aattttgtag cactgtttac
     4381 agttttcctc catgttattt atgaatttta tattccgtga atgtatattg tcttgtaatg
     4441 ttgcataatg ttcacttttt atagtgtgtc ctttattcta aacagtaaag tggttttatt
     4501 tctatcaca
//
