LOCUS       NM_021989               1661 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus TIMP metallopeptidase inhibitor 2 (Timp2), mRNA.
ACCESSION   NM_021989
VERSION     NM_021989.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1661)
  AUTHORS   Tomaszewska,E., Rudyk,H., Swietlicka,I., Hulas-Stasiak,M.,
            Donaldson,J., Arczewska,M., Muszynski,S., Dobrowolski,P.,
            Mielnik-Blaszczak,M., Arciszewski,M.B., Kushnir,V., Brezvyn,O.,
            Muzyka,V. and Kotsyumbas,I.
  TITLE     Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF Expression
            and Immunolocalization in Bone and Cartilage in Newborn Offspring
            Prenatally Exposed to Fumonisins
  JOURNAL   Int J Mol Sci 22 (22), 12528 (2021)
   PUBMED   34830409
  REMARK    GeneRIF: Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF
            Expression and Immunolocalization in Bone and Cartilage in Newborn
            Offspring Prenatally Exposed to Fumonisins.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1661)
  AUTHORS   Zheng,X.Y., Lei,B.X., Lin,Y.Y., Sui,M.H., Zhang,M.L., Zhuang,Z.Q.,
            Dong,J.T., Jin,D.M. and Yan,T.B.
  TITLE     Long noncoding RNA MEG3 silencing protects against hypoxia-induced
            pheochromocytoma-12 cell injury through inhibition of TIMP2
            promoter methylation
  JOURNAL   J Cell Physiol 235 (2), 1649-1662 (2020)
   PUBMED   31392726
  REMARK    GeneRIF: Long noncoding RNA MEG3 silencing protects against
            hypoxia-induced pheochromocytoma-12 cell injury through inhibition
            of TIMP2 promoter methylation.
REFERENCE   3  (bases 1 to 1661)
  AUTHORS   Wang,L., Liu,M.Y., Yin,G., Li,N. and Wang,D.B.
  TITLE     Exogenous Tissue Inhibitor of Metalloproteinase-2 Affects Matrix
            Metalloproteinase-2 Expression in Conjunctival Filtering Blebs and
            Bleb Scarring in Rats
  JOURNAL   Biomed Res Int 2018, 9365950 (2018)
   PUBMED   29955613
  REMARK    GeneRIF: Exogenous TIMP-2 interfered with local MMP-2 expression,
            delaying peak expression of MMP-2 and slowing the scarring of
            filtering blebs during wound healing of subconjunctival tissue.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1661)
  AUTHORS   Liu,Y., Xiao,Y., Liu,J., Feng,L. and Kang,Y.J.
  TITLE     Copper-induced reduction in myocardial fibrosis is associated with
            increased matrix metalloproteins in a rat model of cardiac
            hypertrophy
  JOURNAL   Metallomics 10 (1), 201-208 (2018)
   PUBMED   29302675
  REMARK    GeneRIF: High TIMP2 expression is associated with myocardial
            fibrosis in cardiac hypertrophy.
REFERENCE   5  (bases 1 to 1661)
  AUTHORS   Chertok,V.M., Chertok,A.G., Zakharchuk,N.V. and Nevzorova,V.A.
  TITLE     Dynamics of Distribution of Capillaries with Matrix
            Metalloproteinase-2 and Its Tissue Inhibitor in Rat Brain during
            Development of Experimental Hypertension
  JOURNAL   Bull Exp Biol Med 164 (3), 397-401 (2018)
   PUBMED   29308554
  REMARK    GeneRIF: Dynamics of distribution of capillaries with MMP2 and
            TIMP2 expressed in rat brain during development of experimental
            hypertension has been reported.
REFERENCE   6  (bases 1 to 1661)
  AUTHORS   Remmers,E.F., Longman,R.E., Du,Y., O'Hare,A., Cannon,G.W.,
            Griffiths,M.M. and Wilder,R.L.
  TITLE     A genome scan localizes five non-MHC loci controlling
            collagen-induced arthritis in rats
  JOURNAL   Nat Genet 14 (1), 82-85 (1996)
   PUBMED   8782824
REFERENCE   7  (bases 1 to 1661)
  AUTHORS   Grima,J., Calcagno,K. and Cheng,C.Y.
  TITLE     Purification, cDNA cloning, and developmental changes in the
            steady-state mRNA level of rat testicular tissue inhibitor of
            metalloproteases-2 (TIMP-2)
  JOURNAL   J Androl 17 (3), 263-275 (1996)
   PUBMED   8792217
REFERENCE   8  (bases 1 to 1661)
  AUTHORS   Santoro,M., Battaglia,C., Zhang,L., Carlomagno,F., Martelli,M.L.,
            Salvatore,D. and Fusco,A.
  TITLE     Cloning of the rat tissue inhibitor of metalloproteinases type 2
            (TIMP-2) gene: analysis of its expression in normal and transformed
            thyroid cells
  JOURNAL   Exp Cell Res 213 (2), 398-403 (1994)
   PUBMED   8050496
REFERENCE   9  (bases 1 to 1661)
  AUTHORS   Cook,T.F., Burke,J.S., Bergman,K.D., Quinn,C.O., Jeffrey,J.J. and
            Partridge,N.C.
  TITLE     Cloning and regulation of rat tissue inhibitor of
            metalloproteinases-2 in osteoblastic cells
  JOURNAL   Arch Biochem Biophys 311 (2), 313-320 (1994)
   PUBMED   8203893
REFERENCE   10 (bases 1 to 1661)
  AUTHORS   Roswit,W.T., McCourt,D.W., Partridge,N.C. and Jeffrey,J.J.
  TITLE     Purification and sequence analysis of two rat tissue inhibitors of
            metalloproteinases
  JOURNAL   Arch Biochem Biophys 292 (2), 402-410 (1992)
   PUBMED   1309971
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_021989.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ409332.1, BC084714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840106, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000010.1  104088958-104089214 c
            258-358             JAXUCZ010000010.1  104054640-104054740 c
            359-467             JAXUCZ010000010.1  104052074-104052182 c
            468-592             JAXUCZ010000010.1  104044512-104044636 c
            593-1661            JAXUCZ010000010.1  104041604-104042672 c
FEATURES             Location/Qualifiers
     source          1..1661
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1661
                     /gene="Timp2"
                     /note="TIMP metallopeptidase inhibitor 2"
                     /db_xref="GeneID:29543"
                     /db_xref="RGD:61312"
     exon            1..257
                     /gene="Timp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..790
                     /gene="Timp2"
                     /note="tissue inhibitor of metalloproteinase 2;
                     metalloproteinase inhibitor 2; TIMP-2; tissue inhibitor of
                     metalloproteinases 2"
                     /codon_start=1
                     /product="metalloproteinase inhibitor 2 precursor"
                     /protein_id="NP_068824.1"
                     /db_xref="GeneID:29543"
                     /db_xref="RGD:61312"
                     /translation="MGAAARSLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVV
                     IRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPDKDIEFIYTAPSSAVCGVSL
                     DVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSITQKKSLNHRYQMGCECKITRCP
                     MIPCYISSPDECLWMDWVTEKSINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIE
                     DP"
     exon            258..358
                     /gene="Timp2"
                     /inference="alignment:Splign:2.1.0"
     exon            359..467
                     /gene="Timp2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..592
                     /gene="Timp2"
                     /inference="alignment:Splign:2.1.0"
     exon            593..1661
                     /gene="Timp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctcttcg ccccttgaca aagaggacag aaagtttgcg cgggggagcg ggccaggtga
       61 ggaggggcgt gcccggcgcc ccagcccgcg ccccagcagc cggacccagg cccctagcgc
      121 gcccgccatg ggcgccgcgg cccgcagcct ccggctggcg ctcggcctcc tgctgctggc
      181 cacgctgctg cgcccggccg acgcctgcag ctgctccccg gtgcacccgc aacaggcgtt
      241 ttgcaatgca gacgtagtga tcagggccaa agcagtgagc gagaaggagg tggattccgg
      301 gaatgacatc tatggcaacc ccatcaagag gattcaatat gagatcaagc agataaagat
      361 gttcaaagga cctgacaagg acatcgaatt tatctacacg gccccctcct cagcagtgtg
      421 cggggtctcg ctggacgttg gaggaaagaa ggaatatcta attgcaggga aggcggaagg
      481 agatggcaag atgcacatta ccctctgtga ctttattgtg ccctgggaca cgcttagcat
      541 cacccagaag aagagcctaa accacaggta ccagatgggc tgcgagtgca agatcacacg
      601 ctgccctatg atcccatgct acatctcctc cccggatgag tgcctctgga tggactgggt
      661 cacagagaag agcatcaatg ggcaccaggc caagttcttt gcctgcatca agagaagtga
      721 tggttcttgc gcgtggtacc gcggggcggc acccccgaag caggagtttc ttgacatcga
      781 ggacccgtaa gcaggctgac agagccccct gtggccaatt gaaaagcctc tgagggttca
      841 gactggtcca gctttgacat cccttcctgg aaacagcatg aataaaacat caatcatcca
      901 agtgggttca cgctagtgtg attctgcccc cccaccccca ttttccctaa acatggtagt
      961 gggtctagag ggacaggcgg gccagggtcc ctgccatacc ccctccctct gccggcctga
     1021 gcactgtgtg tctcagtctt tgatccttgg tacaggcagg agtagagcac aggctttacc
     1081 aggcctctct ggccctgttg cgtgcagcag acaggcagca ttaagggtcc cctagcaccg
     1141 ttagggcaga gcctgggaac gtgcattttg cagaaactct tgaaggttgt tataagactg
     1201 tgtagccggc ctaccaggtc cttttcatcc tgagagggtc atgtccctca ttttctgcag
     1261 tggccatccc tctggcccaa ggcccttgca aatgctcccc atccctcctg cacccagtct
     1321 ccctcaggtc taagaattgc cctccaacca gtgtttcatt tgcctaggag tcccagtcag
     1381 ccctacgaac ccacagacgt ccgtgaatgg aagccctccc tgagccgtgt ttctggcttc
     1441 atatttcttc cttcctctct cttcccctgt ctctacacac cccctcagtg gggatctgtg
     1501 aggtctcatg ctgagggcag gaacctgtgg tgaggggtgc ttggctgtcc tcgtaatcac
     1561 tctcaaggtt cccaagcttc ttcaccccct tccaagcttc aggcacctgg ggtgagcagc
     1621 acagctcatc tctctgtcgc gttatgccct cccgctgttg g
//
