LOCUS       NM_022541                493 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus translocase of inner mitochondrial membrane 8
            homolog B (Timm8b), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_022541
VERSION     NM_022541.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Hohr,A.I., Straub,S.P., Warscheid,B., Becker,T. and Wiedemann,N.
  TITLE     Assembly of beta-barrel proteins in the mitochondrial outer
            membrane
  JOURNAL   Biochim Biophys Acta 1853 (1), 74-88 (2015)
   PUBMED   25305573
  REMARK    Review article
REFERENCE   3  (bases 1 to 493)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   4  (bases 1 to 493)
  AUTHORS   Farkas,R.H., Qian,J., Goldberg,J.L., Quigley,H.A. and Zack,D.J.
  TITLE     Gene expression profiling of purified rat retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2503-2513 (2004)
   PUBMED   15277470
REFERENCE   5  (bases 1 to 493)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 493)
  AUTHORS   Bauer,M.F., Rothbauer,U., Muhlenbein,N., Smith,R.J., Gerbitz,K.,
            Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     The mitochondrial TIM22 preprotein translocase is highly conserved
            throughout the eukaryotic kingdom
  JOURNAL   FEBS Lett 464 (1-2), 41-47 (1999)
   PUBMED   10611480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF977529.1 and AF196315.1.
            
            On Nov 15, 2007 this sequence version replaced NM_022541.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217135.1, FQ212447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                CF977529.1         11-35
            26-493              AF196315.1         27-494
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..493
                     /gene="Timm8b"
                     /gene_synonym="Ddp2"
                     /note="translocase of inner mitochondrial membrane 8
                     homolog B"
                     /db_xref="GeneID:64372"
                     /db_xref="RGD:619840"
     exon            1..97
                     /gene="Timm8b"
                     /gene_synonym="Ddp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..265
                     /gene="Timm8b"
                     /gene_synonym="Ddp2"
                     /note="deafness dystonia protein 2 homolog; small zinc
                     finger-like protein DDP2"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim8 B"
                     /protein_id="NP_071986.1"
                     /db_xref="GeneID:64372"
                     /db_xref="RGD:619840"
                     /translation="MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKP
                     GSRLDSRTENCLSSCVDRFIDTTLAITGRFAQIVQKGGQ"
     exon            98..487
                     /gene="Timm8b"
                     /gene_synonym="Ddp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgacgctg accatggccg agcttggtga agcggacgaa gcggagttac aacgcctggt
       61 ggccgccgaa cagcagaagg cacagttcac tgcgcaggtg catcacttca tggaactatg
      121 ttgggataag tgtgtggaga agccaggaag tcggctagac tcccgaactg aaaactgcct
      181 ctctagctgt gtggatcgat tcattgacac tactcttgcc atcaccggtc gttttgccca
      241 gatcgtacag aaaggagggc agtaggccat accttggaat gacggaagac caaaagactt
      301 gttactaagc agactgaatg gccagtggtg aaagacttgt caacatgtca ggttagcgtc
      361 aggcagttac caagtctgtt ggtgttaaga agtaacaaag caaatgttca agtgaaattt
      421 tatttattgg aattcagtaa ttccaagttg tatcacacca gttaataaat gtgaagtctc
      481 cgatcaaaaa aaa
//
