LOCUS       NM_053370               1424 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus translocase of inner mitochondrial membrane 8A1
            (Timm8a1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_053370
VERSION     NM_053370.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1424)
  AUTHORS   Hohr,A.I., Straub,S.P., Warscheid,B., Becker,T. and Wiedemann,N.
  TITLE     Assembly of beta-barrel proteins in the mitochondrial outer
            membrane
  JOURNAL   Biochim Biophys Acta 1853 (1), 74-88 (2015)
   PUBMED   25305573
  REMARK    Review article
REFERENCE   2  (bases 1 to 1424)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   3  (bases 1 to 1424)
  AUTHORS   Bahmad,F. Jr., Merchant,S.N., Nadol,J.B. Jr. and Tranebjaerg,L.
  TITLE     Otopathology in Mohr-Tranebjaerg syndrome
  JOURNAL   Laryngoscope 117 (7), 1202-1208 (2007)
   PUBMED   17471106
REFERENCE   4  (bases 1 to 1424)
  AUTHORS   Ezquerra,M., Campdelacreu,J., Munoz,E., Tolosa,E. and Marti,M.J.
  TITLE     A novel intronic mutation in the DDP1 gene in a family with
            X-linked dystonia-deafness syndrome
  JOURNAL   Arch Neurol 62 (2), 306-308 (2005)
   PUBMED   15710860
REFERENCE   5  (bases 1 to 1424)
  AUTHORS   Muhlenbein,N., Hofmann,S., Rothbauer,U. and Bauer,M.F.
  TITLE     Organization and function of the small Tim complexes acting along
            the import pathway of metabolite carriers into mammalian
            mitochondria
  JOURNAL   J Biol Chem 279 (14), 13540-13546 (2004)
   PUBMED   14726512
REFERENCE   6  (bases 1 to 1424)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1424)
  AUTHORS   Blackstone,C., Roberts,R.G., Seeburg,D.P. and Sheng,M.
  TITLE     Interaction of the deafness-dystonia protein DDP/TIMM8a with the
            signal transduction adaptor molecule STAM1
  JOURNAL   Biochem Biophys Res Commun 305 (2), 345-352 (2003)
   PUBMED   12745081
REFERENCE   8  (bases 1 to 1424)
  AUTHORS   Swerdlow,R.H. and Wooten,G.F.
  TITLE     A novel deafness/dystonia peptide gene mutation that causes
            dystonia in female carriers of Mohr-Tranebjaerg syndrome
  JOURNAL   Ann Neurol 50 (4), 537-540 (2001)
   PUBMED   11601506
REFERENCE   9  (bases 1 to 1424)
  AUTHORS   Ujike,H., Tanabe,Y., Takehisa,Y., Hayabara,T. and Kuroda,S.
  TITLE     A family with X-linked dystonia-deafness syndrome with a novel
            mutation of the DDP gene
  JOURNAL   Arch Neurol 58 (6), 1004-1007 (2001)
   PUBMED   11405816
  REMARK    Review article
REFERENCE   10 (bases 1 to 1424)
  AUTHORS   Bauer,M.F., Rothbauer,U., Muhlenbein,N., Smith,R.J., Gerbitz,K.,
            Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     The mitochondrial TIM22 preprotein translocase is highly conserved
            throughout the eukaryotic kingdom
  JOURNAL   FEBS Lett 464 (1-2), 41-47 (1999)
   PUBMED   10611480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1 and BC060552.1.
            
            On Mar 15, 2021 this sequence version replaced NM_053370.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ229817.1, BC060552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               JAXUCZ010000021.1  102015193-102015444 c
            253-1424            BC060552.1         6-1177
FEATURES             Location/Qualifiers
     source          1..1424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..1424
                     /gene="Timm8a1"
                     /gene_synonym="DDP; Ddp1; Timm8a"
                     /note="translocase of inner mitochondrial membrane 8A1"
                     /db_xref="GeneID:84383"
                     /db_xref="RGD:621801"
     exon            1..410
                     /gene="Timm8a1"
                     /gene_synonym="DDP; Ddp1; Timm8a"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..572
                     /gene="Timm8a1"
                     /gene_synonym="DDP; Ddp1; Timm8a"
                     /note="deafness dystonia protein 1 homolog; translocase of
                     inner mitochondrial membrane 8 homolog a; translocase of
                     inner mitochondrial membrane 8 homolog A1"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim8 A"
                     /protein_id="NP_445822.1"
                     /db_xref="GeneID:84383"
                     /db_xref="RGD:621801"
                     /translation="MESSSSSSGSALAAVDPQLQHFIEVETQKQRFQQLVHQMTELCW
                     EKCMDKPGPKLDSRAEACFVNCVERFIDTSQFILNRLEQTQKSKPVFSESLSD"
     exon            411..1424
                     /gene="Timm8a1"
                     /gene_synonym="DDP; Ddp1; Timm8a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccacagcgc ggcagcgctc cagggaaagg ccggacgtta ccgcggtttg cagcggggag
       61 cagatcccgc tcgcagagac tgcggagcgc ggtggcccga ggggagcggg cagagccggc
      121 agggacaaca gccccgcgcc gacgcggtga gctcacaggg cggtccccga ggcgggggcg
      181 gggggcgggg gaggttgtag ttccggttcc gtcacccaga cacgtgaagg tcggcgagtc
      241 ggttctttgc tcgcttcggc ccgcgtggtc gtgccgggat ggagtcctcc tcgtcctctt
      301 cgggctcggc tttggccgcc gtggaccctc agctgcagca tttcatcgag gtggagacac
      361 agaagcagcg cttccagcag ctggtgcacc agatgacgga actttgctgg gagaagtgca
      421 tggataagcc tgggcctaag ttggacagtc gggctgaggc ctgttttgtg aactgcgttg
      481 aacgcttcat tgatacaagc cagttcatct taaatcgact ggagcagacc cagaagtcca
      541 aacctgtctt ctcagaaagc ctttctgact gatctcagca ttacctcttt ggaaaagtag
      601 ttcaagaagg gaagagctgc tgctgagtcg gttaaagaaa tggctatggg gggattaact
      661 cccaattctc ttcatcatct tgggacatat tgtcacctga gaatgaacaa agaccaattt
      721 ttatgtatgg gagttgagag tcacgtgtat ttggttgtgt tttttaagct aactgtgtgg
      781 taataattta gataaatgga agtatgagac gcgtattgct gtgtattggg acggcgcttt
      841 ctcaaggtcc cttattaact actttataga atttggacag tggaactgct ttctagaatt
      901 ggatagtggg accacgtagg gggaatctcg atttgtatgg gtttatatct gaattttttt
      961 agggagagct ttatggcaga aaaattggca gtggggaaat accctggcac tgatgaactg
     1021 tgagctttct cacagtttga cttagagctg aaaaaaagtc ctatggagga ttcatataat
     1081 ccaccttctt agattgtccc tctgccctat actgtgactt acttaaatgt caaattgaaa
     1141 atacggtctc aaggtagaac aggaagcgtg agaatccaaa gggctttagt catataggaa
     1201 cctagttcat gaacattatt cttatcacca gacagccaca ggaagaagtt aacttacttc
     1261 gtatatcagg atacaaaaca ttcacagatg tgcctaaaga aataacgact taggccagtt
     1321 taaaactaac aacagattca ggtagaggtg catgcctgaa tgttagtcat aaattccatt
     1381 aactgcattc ttttggtcac ggaaataaaa gctcgccaga tcaa
//
