LOCUS       NM_017267               1785 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus translocase of inner mitochondrial membrane 44
            (Timm44), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_017267
VERSION     NM_017267.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1785)
  AUTHORS   Schulz C, Schendzielorz A and Rehling P.
  TITLE     Unlocking the presequence import pathway
  JOURNAL   Trends Cell Biol 25 (5), 265-275 (2015)
   PUBMED   25542066
  REMARK    Review article
REFERENCE   2  (bases 1 to 1785)
  AUTHORS   Santos JM and Kowluru RA.
  TITLE     Impaired transport of mitochondrial transcription factor A (TFAM)
            and the metabolic memory phenomenon associated with the progression
            of diabetic retinopathy
  JOURNAL   Diabetes Metab Res Rev 29 (3), 204-213 (2013)
   PUBMED   23255365
REFERENCE   3  (bases 1 to 1785)
  AUTHORS   Zhong Q and Kowluru RA.
  TITLE     Diabetic retinopathy and damage to mitochondrial structure and
            transport machinery
  JOURNAL   Invest Ophthalmol Vis Sci 52 (12), 8739-8746 (2011)
   PUBMED   22003103
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1785)
  AUTHORS   Sinha D, Joshi N, Chittoor B, Samji P and D'Silva P.
  TITLE     Role of Magmas in protein transport and human mitochondria
            biogenesis
  JOURNAL   Hum Mol Genet 19 (7), 1248-1262 (2010)
   PUBMED   20053669
REFERENCE   5  (bases 1 to 1785)
  AUTHORS   Matsuoka T, Wada J, Hashimoto I, Zhang Y, Eguchi J, Ogawa N,
            Shikata K, Kanwar YS and Makino H.
  TITLE     Gene delivery of Tim44 reduces mitochondrial superoxide production
            and ameliorates neointimal proliferation of injured carotid artery
            in diabetic rats
  JOURNAL   Diabetes 54 (10), 2882-2890 (2005)
   PUBMED   16186389
REFERENCE   6  (bases 1 to 1785)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1785)
  AUTHORS   Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA and
            Martinou JC.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 1785)
  AUTHORS   Colavecchia M, Christie LN, Kanwar YS and Hood DA.
  TITLE     Functional consequences of thyroid hormone-induced changes in the
            mitochondrial protein import pathway
  JOURNAL   Am J Physiol Endocrinol Metab 284 (1), E29-E35 (2003)
   PUBMED   12388124
REFERENCE   9  (bases 1 to 1785)
  AUTHORS   Bauer MF, Gempel K, Reichert AS, Rappold GA, Lichtner P, Gerbitz
            KD, Neupert W, Brunner M and Hofmann S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
REFERENCE   10 (bases 1 to 1785)
  AUTHORS   Ishihara N and Mihara K.
  TITLE     Identification of the protein import components of the rat
            mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44
  JOURNAL   J Biochem 123 (4), 722-732 (1998)
   PUBMED   9538267
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000223.1.
            
            [WARNING] On Mar 30, 2024 this sequence was replaced by
            NM_017267.3.
            
            On Nov 26, 2020 this sequence version replaced NM_017267.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006452.1, SRR8487230.122501.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JACYVU010000223.1  2629221-2629286     c
            67-165              JACYVU010000223.1  2627589-2627687     c
            166-336             JACYVU010000223.1  2623009-2623179     c
            337-417             JACYVU010000223.1  2621541-2621621     c
            418-567             JACYVU010000223.1  2621110-2621259     c
            568-707             JACYVU010000223.1  2620884-2621023     c
            708-793             JACYVU010000223.1  2620505-2620590     c
            794-886             JACYVU010000223.1  2619805-2619897     c
            887-1011            JACYVU010000223.1  2619592-2619716     c
            1012-1062           JACYVU010000223.1  2618228-2618278     c
            1063-1152           JACYVU010000223.1  2614870-2614959     c
            1153-1263           JACYVU010000223.1  2613365-2613475     c
            1264-1785           JACYVU010000223.1  2612581-2613102     c
FEATURES             Location/Qualifiers
     source          1..1785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..1785
                     /gene="Timm44"
                     /note="translocase of inner mitochondrial membrane 44"
                     /db_xref="GeneID:29635"
                     /db_xref="RGD:3864"
     exon            1..66
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1383
                     /gene="Timm44"
                     /note="translocator of inner mitochondrial membrane 44"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit TIM44"
                     /protein_id="NP_058963.2"
                     /db_xref="GeneID:29635"
                     /db_xref="RGD:3864"
                     /translation="MAAAALRGGWCRCPRRCLGSGIQFLSSHNLPRGGSSYQISRPGG
                     ELTLTKSYSSGSRKGFLSGLLDNIKQELAKNKEMKESIKKFRDEAKKLEESDALQEAR
                     RKYKTIESETVRTSEAIKKKLGELTGTVKESLDEVSKSDLGRKIKEGVEEAARTAKQS
                     AESVSKGGEKLGKTAAFKAISQGVESVKKEIDESVLGHTGTYRRPERLRKRTEFAGAK
                     FKESKVFEANEEALGVVLHKDSKWYQQWKDFKDNNVVFNRFFEMKMKYDESDNVLIRA
                     SRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPTFDKDRFLHQCETDIIPNILEAMIS
                     GELDILKDWCYEATYNQLAHSIQQAKALGLQFHSRILDISNVDLAMGKMMEQGPVLIV
                     TFQAQLVMVIKNPKGEVFDGDPDKVLRMLYVWALCRDQEELNPYAAWRLLDISASSTE
                     QIL"
     exon            67..165
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     exon            166..336
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     exon            337..417
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     exon            418..567
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     exon            568..707
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     exon            708..793
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     exon            794..886
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1011
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1062
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1152
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1263
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1785
                     /gene="Timm44"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcacacgg gcttttccaa catggcggcc gcagctctgc ggggcggctg gtgccgctgt
       61 ccgcggaggt gcctaggcag cggaatacaa tttctctcca gtcacaacct accccgtggt
      121 ggttcaagct accagataag ccggccagga ggagagctga cgctgactaa atcttattct
      181 tctgggagca gaaaagggtt tttgtcaggc ttgctagata acatcaaaca agaattagcc
      241 aaaaacaaag agatgaaaga aagtataaag aagttccgag atgaggccaa gaaactagaa
      301 gagtcggatg cccttcagga agccagaaga aaatataaaa ccatcgaatc agaaactgtg
      361 cgaactagtg aagcaataaa gaagaagctc ggagaattga caggcacagt gaaggagagt
      421 cttgatgaag tcagtaagag tgaccttggc cgcaagatca aggaaggagt agaagaggct
      481 gccaggacag ccaagcagtc agcagagtca gtgtccaagg gcggggagaa gctgggcaag
      541 acggcggcct tcaaagccat ctcccagggt gtagagtcgg tgaagaagga gattgatgag
      601 agcgtgctcg gacacacagg gacataccgc cggcctgagc ggctccggaa aaggacagag
      661 tttgctggag caaagttcaa agaaagcaaa gtgttcgagg ctaatgagga agcattaggg
      721 gttgtgctac acaaggactc caagtggtac cagcagtgga aggacttcaa agataacaat
      781 gttgtattca accgcttctt tgagatgaag atgaagtatg atgaaagtga caatgttctt
      841 atccgggcat cccgggcctt aaccgacaag gtcactgact tgctgggagg tcttttctca
      901 aagacagaaa tgtcagaggt gctcacggag atcctgagag tggacccaac ctttgacaag
      961 gaccgctttc ttcatcagtg tgagactgac attatcccca acatcctaga ggccatgatt
     1021 tccggggaac ttgacattct caaagactgg tgctatgaag ctacctacaa ccaactggcc
     1081 cactctatcc agcaggccaa ggctctgggc ctccagttcc actcccggat cctggatatc
     1141 agcaatgtgg acctggccat gggcaagatg atggagcagg gccccgtgct gattgttacc
     1201 ttccaggccc agctggtgat ggtgatcaag aaccccaaag gcgaggtgtt tgacggtgac
     1261 ccggacaagg tgctgcgaat gctgtatgtg tgggcactct gcagagacca ggaggagctc
     1321 aacccttacg ctgcctggcg ccttctggac atctcagcct ctagcacaga gcagatcctc
     1381 tgagggcagc aatggagtct aggcagctcc gggctagacc atcatggggc agacacacag
     1441 aaacacttgg gcacatctga tacagctgtg aactggcttc tgccccaagt tcttcacgac
     1501 agctgtgaaa ccagctggac aaggaaagag cttggggtgt ctagcaggag ggggaatgtt
     1561 tccccgagtg tcacaggggg gatactggca gtgtcagaag gccccagccc aggactcctg
     1621 tggggtgagg cctggcctgc tgttctgagt agtccactgg ctttgcttgc caagccactt
     1681 taggtccttt tttttttttt tttttttttt tttaaatcag tgctcttact tcctgtacat
     1741 agcctaagat ctgaacataa taaaacacca gagcgcagaa gagca
//
