LOCUS       NM_019352               1098 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus translocase of inner mitochondrial membrane 23
            (Timm23), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_019352
VERSION     NM_019352.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1098)
  AUTHORS   Guarani,V., McNeill,E.M., Paulo,J.A., Huttlin,E.L., Frohlich,F.,
            Gygi,S.P., Van Vactor,D. and Harper,J.W.
  TITLE     QIL1 is a novel mitochondrial protein required for MICOS complex
            stability and cristae morphology
  JOURNAL   Elife 4, e06265 (2015)
   PUBMED   25997101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1098)
  AUTHORS   Wenz,L.S., Opalinski,L., Wiedemann,N. and Becker,T.
  TITLE     Cooperation of protein machineries in mitochondrial protein sorting
  JOURNAL   Biochim Biophys Acta 1853 (5), 1119-1129 (2015)
   PUBMED   25633533
  REMARK    Review article
REFERENCE   3  (bases 1 to 1098)
  AUTHORS   Schulz,C., Schendzielorz,A. and Rehling,P.
  TITLE     Unlocking the presequence import pathway
  JOURNAL   Trends Cell Biol 25 (5), 265-275 (2015)
   PUBMED   25542066
  REMARK    Review article
REFERENCE   4  (bases 1 to 1098)
  AUTHORS   Singh,K. and Hood,D.A.
  TITLE     Effect of denervation-induced muscle disuse on mitochondrial
            protein import
  JOURNAL   Am J Physiol Cell Physiol 300 (1), C138-C145 (2011)
   PUBMED   20943961
REFERENCE   5  (bases 1 to 1098)
  AUTHORS   Sinha,D., Joshi,N., Chittoor,B., Samji,P. and D'Silva,P.
  TITLE     Role of Magmas in protein transport and human mitochondria
            biogenesis
  JOURNAL   Hum Mol Genet 19 (7), 1248-1262 (2010)
   PUBMED   20053669
REFERENCE   6  (bases 1 to 1098)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1098)
  AUTHORS   Colavecchia,M., Christie,L.N., Kanwar,Y.S. and Hood,D.A.
  TITLE     Functional consequences of thyroid hormone-induced changes in the
            mitochondrial protein import pathway
  JOURNAL   Am J Physiol Endocrinol Metab 284 (1), E29-E35 (2003)
   PUBMED   12388124
REFERENCE   8  (bases 1 to 1098)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
REFERENCE   9  (bases 1 to 1098)
  AUTHORS   Ishihara,N., Komiya,T., Sakaguchi,M., Ito,A. and Mihara,K.
  TITLE     Characterization of the initial steps of precursor import into rat
            liver mitoplasts
  JOURNAL   J Biochem 124 (4), 824-834 (1998)
   PUBMED   9756630
REFERENCE   10 (bases 1 to 1098)
  AUTHORS   Ishihara,N. and Mihara,K.
  TITLE     Identification of the protein import components of the rat
            mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44
  JOURNAL   J Biochem 123 (4), 722-732 (1998)
   PUBMED   9538267
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB006451.1.
            
            On Feb 21, 2013 this sequence version replaced NM_019352.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006451.1, BC083559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1098              AB006451.1         1-1098
FEATURES             Location/Qualifiers
     source          1..1098
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1098
                     /gene="Timm23"
                     /note="translocase of inner mitochondrial membrane 23"
                     /db_xref="GeneID:54312"
                     /db_xref="RGD:3863"
     exon            1..207
                     /gene="Timm23"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..731
                     /gene="Timm23"
                     /function="mitochondrial precursor translocase"
                     /note="translocase of inner mitochondrial membrane 23
                     homolog"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim23"
                     /protein_id="NP_062225.1"
                     /db_xref="GeneID:54312"
                     /db_xref="RGD:3863"
                     /translation="MEGGGGSSNKSTGGLAGFFGAGGAGYSNADLAGVPLTGMNPLSP
                     YLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGALNGLRLGLKE
                     TQSMPWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDFNTVAA
                     GTMTGMLYKCTGGLRGIARGGLAGLTLTSVYALYNNWEHMKGSLLQQSL"
     exon            208..266
                     /gene="Timm23"
                     /inference="alignment:Splign:2.1.0"
     exon            267..360
                     /gene="Timm23"
                     /inference="alignment:Splign:2.1.0"
     exon            361..445
                     /gene="Timm23"
                     /inference="alignment:Splign:2.1.0"
     exon            446..504
                     /gene="Timm23"
                     /inference="alignment:Splign:2.1.0"
     exon            505..615
                     /gene="Timm23"
                     /inference="alignment:Splign:2.1.0"
     exon            616..1098
                     /gene="Timm23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaacgcggg tcttcccgct gttgctgtcg gggccacggc cgagcacacg accccggcct
       61 gaggtggtgg tgggaagccc gccgctgttt gctgcgacct catggagggt ggcggaggaa
      121 gtagcaacaa atccaccggc gggttagcgg gcttcttcgg agcgggagga gcgggttact
      181 cgaacgctga tttggccggc gtcccgctga ctggtatgaa ccccctgtct ccttacttaa
      241 atgtggaccc acgctatctc gttcaggata cagatgagtt tattttgcca actggagcta
      301 ataaaacccg aggcaggttt gaactagctt tcttcaccat tggaggatgc tgcatgacag
      361 gggctgcatt cggggcactg aacgggcttc gtttaggatt gaaggaaact cagagcatgc
      421 cctggtccaa accaagaaat gtacagattt tgaatatggt gactagacaa ggggcacttt
      481 gggctaatac tctaggttcc ctggctttgc tctatagtgc ttttggcgtt atcattgaga
      541 aaacacgggg tgcagaagac gacttcaaca cagtagcagc tggaaccatg acaggaatgt
      601 tatataaatg tacaggtggt cttcgaggaa tagcacgtgg tggcctggcg ggactgacac
      661 tgaccagtgt ctatgcactg tataacaact gggagcacat gaaaggttcc ctgctccaac
      721 agtcactctg aagatgtctg ccacctcagg aatgggggac acttcatagt catccagatc
      781 aaggaataag tcagtctgga gctgctttct ctcttgcacc tacaattact ttgaacaatt
      841 ggagactctg atttgctgtg acaaagatca tggatgctta gcctggactg cactgcttgc
      901 cctctgagtg gaagccaaac ccttggtggc tcactgagaa tgtgttctct tctcctttgg
      961 agatgacctc gcacctcctg cccccaaact ggaaaaccac ttactctcca aatttattac
     1021 catgttaatt catttaaaaa tctaaaactt aatattgccc tgttttccaa ataaagggtg
     1081 aaaatacaac caaagcta
//
