LOCUS       NM_032618               1801 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus translocase of inner mitochondrial membrane 22
            (Timm22), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_032618 XM_001080619 XM_340856
VERSION     NM_032618.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1801)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1801)
  AUTHORS   Qi,L., Wang,Q., Guan,Z., Wu,Y., Shen,C., Hong,S., Cao,J., Zhang,X.,
            Yan,C. and Yin,P.
  TITLE     Cryo-EM structure of the human mitochondrial translocase TIM22
            complex
  JOURNAL   Cell Res 31 (3), 369-372 (2021)
   PUBMED   32901109
REFERENCE   3  (bases 1 to 1801)
  AUTHORS   Kang,Y., Stroud,D.A., Baker,M.J., De Souza,D.P., Frazier,A.E.,
            Liem,M., Tull,D., Mathivanan,S., McConville,M.J., Thorburn,D.R.,
            Ryan,M.T. and Stojanovski,D.
  TITLE     Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a
            Subunit of the Human TIM22 Protein Import Complex
  JOURNAL   Mol Cell 67 (3), 457-470 (2017)
   PUBMED   28712726
REFERENCE   4  (bases 1 to 1801)
  AUTHORS   Vukotic,M., Nolte,H., Konig,T., Saita,S., Ananjew,M., Kruger,M.,
            Tatsuta,T. and Langer,T.
  TITLE     Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the
            TIM22 Protein Translocase in Mitochondria
  JOURNAL   Mol Cell 67 (3), 471-483 (2017)
   PUBMED   28712724
REFERENCE   5  (bases 1 to 1801)
  AUTHORS   Callegari,S., Richter,F., Chojnacka,K., Jans,D.C., Lorenzi,I.,
            Pacheu-Grau,D., Jakobs,S., Lenz,C., Urlaub,H., Dudek,J.,
            Chacinska,A. and Rehling,P.
  TITLE     TIM29 is a subunit of the human carrier translocase required for
            protein transport
  JOURNAL   FEBS Lett 590 (23), 4147-4158 (2016)
   PUBMED   27718247
REFERENCE   6  (bases 1 to 1801)
  AUTHORS   Neupert,W. and Herrmann,J.M.
  TITLE     Translocation of proteins into mitochondria
  JOURNAL   Annu Rev Biochem 76, 723-749 (2007)
   PUBMED   17263664
  REMARK    Review article
REFERENCE   7  (bases 1 to 1801)
  AUTHORS   Muhlenbein,N., Hofmann,S., Rothbauer,U. and Bauer,M.F.
  TITLE     Organization and function of the small Tim complexes acting along
            the import pathway of metabolite carriers into mammalian
            mitochondria
  JOURNAL   J Biol Chem 279 (14), 13540-13546 (2004)
   PUBMED   14726512
REFERENCE   8  (bases 1 to 1801)
  AUTHORS   Bauer,M.F., Rothbauer,U., Muhlenbein,N., Smith,R.J., Gerbitz,K.,
            Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     The mitochondrial TIM22 preprotein translocase is highly conserved
            throughout the eukaryotic kingdom
  JOURNAL   FEBS Lett 464 (1-2), 41-47 (1999)
   PUBMED   10611480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM107575.1 and JAXUCZ010000010.1.
            
            On or before Feb 8, 2013 this sequence version replaced
            XM_001080619.3, XM_340856.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM107575.1, AF223951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-642               FM107575.1         1-642
            643-1801            JAXUCZ010000010.1  61758286-61759444
FEATURES             Location/Qualifiers
     source          1..1801
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1801
                     /gene="Timm22"
                     /note="translocase of inner mitochondrial membrane 22"
                     /db_xref="GeneID:79463"
                     /db_xref="RGD:68406"
     exon            1..244
                     /gene="Timm22"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..591
                     /gene="Timm22"
                     /note="translocase of inner mitochondrial membrane 22
                     homolog"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim22"
                     /protein_id="NP_116007.1"
                     /db_xref="GeneID:79463"
                     /db_xref="RGD:68406"
                     /translation="MAAAKAGASAPEAAGSAEAPLQYSLLLQHLVGDKRQPRLLEPGS
                     LGGIPSPAKSEEQKMIERAMESCAFKAVLACVGGFVLGGAFGVFTAGIDTNVGFDPKD
                     PYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCIT
                     GGAIGFRAGVKAGAIGCGGFAAFSAAIDYYLR"
     exon            245..441
                     /gene="Timm22"
                     /inference="alignment:Splign:2.1.0"
     exon            442..514
                     /gene="Timm22"
                     /inference="alignment:Splign:2.1.0"
     exon            515..1801
                     /gene="Timm22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgtacag tcatggcggc cgccaaggct ggggcttcag ctcctgaggc ggcgggttcc
       61 gccgaagctc cgttgcagta cagccttctt cttcagcacc tggtgggcga caagcgtcag
      121 ccacggcttc tggagcctgg cagtctgggc gggatcccga gtcctgccaa gagcgaggag
      181 cagaagatga tcgagagggc gatggaaagt tgcgccttca aggctgtgct ggcctgtgtg
      241 ggaggatttg tcttgggagg cgcatttggt gtctttactg ctggcattga taccaacgtg
      301 ggctttgacc ccaaggaccc ttaccggaca ccaactgcaa gagaagtcct gaaggacatg
      361 ggacagagag gaatgtccta tgccaaaaat tttgccattg tgggtgccat gttttcctgt
      421 actgagtgtc tggtagagtc ttaccggggg aagtcagact ggaagaacag cgtcatcagc
      481 ggctgcatca ctggtggagc catcggcttc agagctggag taaaggccgg ggccataggt
      541 tgtggaggtt ttgctgcttt ctctgctgca atcgattatt acctacggtg aaagaaatag
      601 cctgaaagga agaggacgcc agccaccttc agggctgtcc tttggagcag ttcctgcaca
      661 cttgccattg cttcaggggt gaagccagtt gtttccctct acagtaggca gtgggaggga
      721 cactcctgtt gctctctctc tccagccatc tgagcaacca tgctgtctac ttctgaattc
      781 caaccaggtt tctcaggaga gatggtatgc gcaattgtct ccttgcagtg aacagatcag
      841 gaggcagtgt gtgcactgtt aaaagaatta agtgtgaacc aagctcagtt ctgaccttgt
      901 tcaactctcc agctgtgaac agggaggtgt cagtgttcgc ccatagccac ctcttccttc
      961 aaactgtgtt gtgcaagcat ccatcttgag ttccaggaca gggcaaagta aactcacgcc
     1021 acccaggcga ttatgtaatt ccagtatctt tgctgtcctt gttaaaaata tgtatatggg
     1081 ctggtaaggt ggctcgacag ttaataatag ttaatagctg ctattccaga ggtcccagat
     1141 ttggttccca gcacctactt tgtggcttcc aaccatctgt aactctagtt ccagggatct
     1201 aaggtcctct tctgacctct gaggacacca ggcacctgag tggtacacag acatacatac
     1261 ttgcacgcaa aatacccatt tttttaagag catatgtact gttataagga gctagttttt
     1321 cagatttcac acgtctgtca aaagatgcca actggcccaa agaccgataa gtccagtgga
     1381 aagatgagga aacctcaaag gaactcagga gtgctgctgt cagcatctgt ggaaactgtc
     1441 tttgttacca cagccattca gctaggcctc tccctagaaa gtctagccat gttcctggat
     1501 gtattgcgac atgctggtaa ctcctctgcc tcctcagagg cattgggttg gctgatggtc
     1561 atttctactg cttatgaccc cttagtctcg ggccccggcc cagttgaaag gtccatgtgt
     1621 gtcttgctgt agtcatcctg cggctgagtc atactgtagc tactggccca gatcagtggt
     1681 gaaggcctgt tcgccaccac ccttgttctc cattaagctt ttctttggct tttggtgggg
     1741 tttgttgttg ttcaacagtt cagcctaatt ataccatggc agaaaacgag ccttttatgt
     1801 c
//
