LOCUS       NM_019351                898 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus translocase of inner mitochondrial membrane 17A
            (Timm17a), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_019351
VERSION     NM_019351.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 898)
  AUTHORS   Wenz,L.S., Opalinski,L., Wiedemann,N. and Becker,T.
  TITLE     Cooperation of protein machineries in mitochondrial protein sorting
  JOURNAL   Biochim Biophys Acta 1853 (5), 1119-1129 (2015)
   PUBMED   25633533
  REMARK    Review article
REFERENCE   2  (bases 1 to 898)
  AUTHORS   Schulz,C., Schendzielorz,A. and Rehling,P.
  TITLE     Unlocking the presequence import pathway
  JOURNAL   Trends Cell Biol 25 (5), 265-275 (2015)
   PUBMED   25542066
  REMARK    Review article
REFERENCE   3  (bases 1 to 898)
  AUTHORS   Sinha,D., Joshi,N., Chittoor,B., Samji,P. and D'Silva,P.
  TITLE     Role of Magmas in protein transport and human mitochondria
            biogenesis
  JOURNAL   Hum Mol Genet 19 (7), 1248-1262 (2010)
   PUBMED   20053669
REFERENCE   4  (bases 1 to 898)
  AUTHORS   Hinojos,C.A., Boerwinkle,E., Fornage,M. and Doris,P.A.
  TITLE     Combined genealogical, mapping, and expression approaches to
            identify spontaneously hypertensive rat hypertension candidate
            genes
  JOURNAL   Hypertension 45 (4), 698-704 (2005)
   PUBMED   15710778
REFERENCE   5  (bases 1 to 898)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 898)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
REFERENCE   7  (bases 1 to 898)
  AUTHORS   Ishihara,N., Komiya,T., Sakaguchi,M., Ito,A. and Mihara,K.
  TITLE     Characterization of the initial steps of precursor import into rat
            liver mitoplasts
  JOURNAL   J Biochem 124 (4), 824-834 (1998)
   PUBMED   9756630
REFERENCE   8  (bases 1 to 898)
  AUTHORS   Ishihara,N. and Mihara,K.
  TITLE     Identification of the protein import components of the rat
            mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44
  JOURNAL   J Biochem 123 (4), 722-732 (1998)
   PUBMED   9538267
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB006450.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_019351.2.
            
            Sequence Note: This sequence has been modified as follows: removed
            46 bp suspected to be vector contamination from the 3' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006450.1, DV715276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-898               AB006450.1         1-898
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..898
                     /gene="Timm17a"
                     /gene_synonym="Tim17; Timm17"
                     /note="translocase of inner mitochondrial membrane 17A"
                     /db_xref="GeneID:54311"
                     /db_xref="RGD:3862"
     exon            1..30
                     /gene="Timm17a"
                     /gene_synonym="Tim17; Timm17"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..520
                     /gene="Timm17a"
                     /gene_synonym="Tim17; Timm17"
                     /function="mitochondrial precursor translocase"
                     /note="inner membrane preprotein translocase Tim17a;
                     translocase of inner mitochondrial membrane 17 homolog A;
                     translocator of inner mitochondrial membrane 17a;
                     translocator of inner mitochondrial membrane 17 kDa, a"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim17-A"
                     /protein_id="NP_062224.1"
                     /db_xref="GeneID:54311"
                     /db_xref="RGD:3862"
                     /translation="MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAFKGFRNSPVGV
                     NHRLRGSLTAIKTRAPQLGGSFAVWGGLFSTIDCGMVQIRGKEDPWNSITSGALTGAI
                     LAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASAQFPNGPQFAEDHSQLPSSQLP
                     SSPFGDYRQYQ"
     exon            31..130
                     /gene="Timm17a"
                     /gene_synonym="Tim17; Timm17"
                     /inference="alignment:Splign:2.1.0"
     exon            131..194
                     /gene="Timm17a"
                     /gene_synonym="Tim17; Timm17"
                     /inference="alignment:Splign:2.1.0"
     exon            195..323
                     /gene="Timm17a"
                     /gene_synonym="Tim17; Timm17"
                     /inference="alignment:Splign:2.1.0"
     exon            324..434
                     /gene="Timm17a"
                     /gene_synonym="Tim17; Timm17"
                     /inference="alignment:Splign:2.1.0"
     exon            435..898
                     /gene="Timm17a"
                     /gene_synonym="Tim17; Timm17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagatggag gagtacgcga gagagccgtg cccctggaga attgtggatg actgtggcgg
       61 tgcctttacc atgggtacca taggtggtgg catcttccag gccttcaaag gttttcgaaa
      121 ttctccagtg ggagtaaacc acagactccg agggagttta acagctatta aaaccagggc
      181 cccacaattg ggaggtagct ttgcagtttg gggaggcctg ttttccacga ttgactgtgg
      241 tatggttcag ataagaggca aagaagaccc ctggaactcc atcactagcg gtgccttaac
      301 aggagccatc ctggcagcaa gaaatggacc ggtagccatg gttgggtcag ctgcgatggg
      361 cggcattctc ctagctttaa ttgaaggagc tggtatcctg ttgaccaggt ttgcctctgc
      421 acagtttcct aatggccctc agtttgctga agaccactcc cagttgcctt caagccagtt
      481 gccgtcctca ccatttggag actaccgaca gtatcagtag gacttggtcc ccgggattcc
      541 tggacctggg tggactgcag tttggtaggg tttcagaaga tcaagttaca gtctgttgaa
      601 agccttaggt gggacaccgg cggccaagca ggccatcaag agacatttag cacatttttc
      661 tatttaaaag agactcagag tgtggaaaag ataccgagtt tatttattca tgcttggatt
      721 gcgtctgtga tcaaaataaa tgtctaatac catttaaaga atgtatatga acttagaaga
      781 taaaggacca aaggccacat aacagtgaaa ttcgactgtc cttccttcgg gacttttttg
      841 cctggtgttt atgtacagtt gttcagacaa taaaaggctt ttgggacttg acctttcc
//
