LOCUS       NM_031340               4514 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus timeless circadian regulator (Timeless), mRNA.
ACCESSION   NM_031340 XM_346788
VERSION     NM_031340.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4514)
  AUTHORS   Liu,H., Zhang,H., Wu,X., Ma,D., Wu,J., Wang,L., Jiang,Y., Fei,Y.,
            Zhu,C., Tan,R., Jungblut,P., Pei,G., Dorhoi,A., Yan,Q., Zhang,F.,
            Zheng,R., Liu,S., Liang,H., Liu,Z., Yang,H., Chen,J., Wang,P.,
            Tang,T., Peng,W., Hu,Z., Xu,Z., Huang,X., Wang,J., Li,H., Zhou,Y.,
            Liu,F., Yan,D., Kaufmann,S.H.E., Chen,C., Mao,Z. and Ge,B.
  TITLE     Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
  JOURNAL   Nature 563 (7729), 131-136 (2018)
   PUBMED   30356214
REFERENCE   2  (bases 1 to 4514)
  AUTHORS   Xie,S., Mortusewicz,O., Ma,H.T., Herr,P., Poon,R.Y., Helleday,T.
            and Qian,C.
  TITLE     Timeless Interacts with PARP-1 to Promote Homologous Recombination
            Repair
  JOURNAL   Mol Cell 60 (1), 163-176 (2015)
   PUBMED   26344098
  REMARK    Erratum:[Mol Cell. 2016 Jan 7;61(1):181. Poon, Randy R Y [Corrected
            to Poon, Randy Y C]]
REFERENCE   3  (bases 1 to 4514)
  AUTHORS   Kang,T.H. and Leem,S.H.
  TITLE     Modulation of ATR-mediated DNA damage checkpoint response by
            cryptochrome 1
  JOURNAL   Nucleic Acids Res 42 (7), 4427-4434 (2014)
   PUBMED   24489120
REFERENCE   4  (bases 1 to 4514)
  AUTHORS   Shah,N., Inoue,A., Woo Lee,S., Beishline,K., Lahti,J.M. and
            Noguchi,E.
  TITLE     Roles of ChlR1 DNA helicase in replication recovery from DNA damage
  JOURNAL   Exp Cell Res 319 (14), 2244-2253 (2013)
   PUBMED   23797032
REFERENCE   5  (bases 1 to 4514)
  AUTHORS   Engelen,E., Janssens,R.C., Yagita,K., Smits,V.A., van der
            Horst,G.T. and Tamanini,F.
  TITLE     Mammalian TIMELESS is involved in period determination and DNA
            damage-dependent phase advancing of the circadian clock
  JOURNAL   PLoS One 8 (2), e56623 (2013)
   PUBMED   23418588
REFERENCE   6  (bases 1 to 4514)
  AUTHORS   Dunlap,J.C.
  TITLE     Molecular bases for circadian clocks
  JOURNAL   Cell 96 (2), 271-290 (1999)
   PUBMED   9988221
  REMARK    Review article
REFERENCE   7  (bases 1 to 4514)
  AUTHORS   Takumi,T., Nagamine,Y., Miyake,S., Matsubara,C., Taguchi,K.,
            Takekida,S., Sakakida,Y., Nishikawa,K., Kishimoto,T., Niwa,S.,
            Okumura,K. and Okamura,H.
  TITLE     A mammalian ortholog of Drosophila timeless, highly expressed in
            SCN and retina, forms a complex with mPER1
  JOURNAL   Genes Cells 4 (1), 67-75 (1999)
   PUBMED   10231394
REFERENCE   8  (bases 1 to 4514)
  AUTHORS   Koike,N., Hida,A., Numano,R., Hirose,M., Sakaki,Y. and Tei,H.
  TITLE     Identification of the mammalian homologues of the Drosophila
            timeless gene, Timeless1
  JOURNAL   FEBS Lett 441 (3), 427-431 (1998)
   PUBMED   9891984
REFERENCE   9  (bases 1 to 4514)
  AUTHORS   Sangoram,A.M., Saez,L., Antoch,M.P., Gekakis,N., Staknis,D.,
            Whiteley,A., Fruechte,E.M., Vitaterna,M.H., Shimomura,K.,
            King,D.P., Young,M.W., Weitz,C.J. and Takahashi,J.S.
  TITLE     Mammalian circadian autoregulatory loop: a timeless ortholog and
            mPer1 interact and negatively regulate CLOCK-BMAL1-induced
            transcription
  JOURNAL   Neuron 21 (5), 1101-1113 (1998)
   PUBMED   9856465
REFERENCE   10 (bases 1 to 4514)
  AUTHORS   Sakamoto,K., Nagase,T., Fukui,H., Horikawa,K., Okada,T., Tanaka,H.,
            Sato,K., Miyake,Y., Ohara,O., Kako,K. and Ishida,N.
  TITLE     Multitissue circadian expression of rat period homolog (rPer2) mRNA
            is governed by the mammalian circadian clock, the suprachiasmatic
            nucleus in the brain
  JOURNAL   J Biol Chem 273 (42), 27039-27042 (1998)
   PUBMED   9765215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 24, 2020 this sequence version replaced NM_031340.1.
            
            Summary: The protein encoded by this gene is highly conserved and
            is involved in cell survival after damage or stress, increase in
            DNA polymerase epsilon activity, maintenance of telomere length,
            and epithelial cell morphogenesis. The encoded protein also plays a
            role in the circadian rhythm autoregulatory loop, interacting with
            the Period genes (Per1, Per2, and Per3) and others to downregulate
            activation of Per1 by Clock/Arntl. Changes in this gene or its
            expression may promote prostate cancer, lung cancer, breast cancer,
            and mental disorders. [provided by RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB019576.1, SRR26643429.25350.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                JAXUCZ010000007.1  1239450-1239521
            73-181              JAXUCZ010000007.1  1249746-1249854
            182-335             JAXUCZ010000007.1  1249998-1250151
            336-450             JAXUCZ010000007.1  1250371-1250485
            451-513             JAXUCZ010000007.1  1250580-1250642
            514-615             JAXUCZ010000007.1  1251937-1252038
            616-771             JAXUCZ010000007.1  1252184-1252339
            772-905             JAXUCZ010000007.1  1252551-1252684
            906-993             JAXUCZ010000007.1  1252871-1252958
            994-1170            JAXUCZ010000007.1  1253233-1253409
            1171-1388           JAXUCZ010000007.1  1254806-1255023
            1389-1492           JAXUCZ010000007.1  1255252-1255355
            1493-1662           JAXUCZ010000007.1  1255483-1255652
            1663-1788           JAXUCZ010000007.1  1256725-1256850
            1789-1940           JAXUCZ010000007.1  1256940-1257091
            1941-2038           JAXUCZ010000007.1  1257789-1257886
            2039-2165           JAXUCZ010000007.1  1257974-1258100
            2166-2367           JAXUCZ010000007.1  1258187-1258388
            2368-2513           JAXUCZ010000007.1  1258654-1258799
            2514-2599           JAXUCZ010000007.1  1259770-1259855
            2600-2717           JAXUCZ010000007.1  1259944-1260061
            2718-2800           JAXUCZ010000007.1  1260148-1260230
            2801-2943           JAXUCZ010000007.1  1260397-1260539
            2944-3121           JAXUCZ010000007.1  1260693-1260870
            3122-3190           JAXUCZ010000007.1  1260956-1261024
            3191-3309           JAXUCZ010000007.1  1261134-1261252
            3310-3529           JAXUCZ010000007.1  1261916-1262135
            3530-3628           JAXUCZ010000007.1  1262256-1262354
            3629-4514           JAXUCZ010000007.1  1262458-1263343
FEATURES             Location/Qualifiers
     source          1..4514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..4514
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /note="timeless circadian regulator"
                     /db_xref="GeneID:83508"
                     /db_xref="RGD:620939"
     exon            1..72
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            73..181
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..3702
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /note="timeless-like protein; timeless homolog; timeless
                     circadian clock"
                     /codon_start=1
                     /product="protein timeless homolog"
                     /protein_id="NP_112630.2"
                     /db_xref="GeneID:83508"
                     /db_xref="RGD:620939"
                     /translation="MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRH
                     EDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFGSVPK
                     DPTVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERIL
                     LLVRNILHVPANLEQEKRIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHV
                     LEIISLMFRDQKPEQLAGVGQGRLAQERSTDLAELEVLRQREVAEKRARALQRGNRHS
                     RFGGSYVVQGLKSIGERDVVFHKGLHNLQNYSSDLGKQPRRVPKRRQAAQELSVHRRS
                     VLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLREKAQQHDETYYMWAMAFFMAFNRAA
                     AFRPGFVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATV
                     NEMDMCPDDAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLCDLVETTHL
                     FLKMLERFCRSRGNLMVQNKRKKRKKKKKAQEQGVAFSRSPEELQAMWSALAERLLQC
                     AQEPELSVDSIIPFDAASEVPVEEQRVEAMVRIQDCLVAGQAPQALALLRSAREVWPE
                     GNVFGSPVISPGEEMQLLKQILSATLPRQQEPVEGDAEEEDEEEEEEEEEELQVVQVS
                     EKEFKFLDYLKRFACSTIVRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHDLGMEALLF
                     QLSLFCLFNQLLSDPAAAAYKELVTFAKYILGKFFALAAVNQKAFVELLFWKNTSVVR
                     EMTQGYGSLDSGSCSHRAPVWSSEEEAQLQELYLAHKDVEGQDVVETILAHLKAVPRT
                     RKQVIHHLVRMGLADSVKDFQRKGTQIVLWTEDQELELQRLFEEFQDSDDVLGHIMKN
                     ITAKRSRARVVDKLLALGLVSERRQLHKKRRKKLAPSCMQNGEESQRDAWQEDPEEEE
                     EKEGLPESEGEENEEDLLAGQVQGSSSLSAENLRQSLCQDGLSAPLLWLQSSLIRAAD
                     DREEDGCSQAIPLVPLTEENEEAMENKQFQHLLRKLGIRAPCSGQETFWRIPAKLSST
                     QLRRVAASLSEQENKEEREEEPEPNPGVPGEQSPSEEHQVRAPRALLSARKRKAGLVF
                     PKEEATGEEEWKSVPKKQQLLDSDEEDTDDERGGQAAVSGTLRIHKKKRFLVEDEDED
                     Y"
     exon            182..335
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            336..450
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            451..513
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            514..615
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            616..771
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            772..905
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            906..993
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1170
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1388
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1492
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1662
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1788
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1940
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2038
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2165
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2367
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2513
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2599
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2717
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2800
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2943
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3121
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3190
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3309
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3529
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3628
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..4514
                     /gene="Timeless"
                     /gene_synonym="rTIM; rTLP; Tim"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggaaagt ctgcgacccc gcacctcacg gccactggcc ctgcgagcct tcagaggact
       61 catggatagt ggggcctctg gtgtatggac ttgtacatga tgaactgtga acttctagcc
      121 acttgtagcg cccttgggta cttggaagga ggcacttacc acaaggagcc ggactgcttg
      181 gagagtgtga aggatttgat ccgatacctg aggcatgagg acgagactcg agatgtgcgg
      241 cagcagctgg gagccgcgca gatcctgcag agtgatctcc tgccaatcct cacccagcac
      301 cgccaggaca agcctctctt tgatgctgtg atcaggctga tggtaaattt gactcagcca
      361 gccttgctct gttttggcag cgtgcctaag gaccccactg tacgacacca ttttctgcag
      421 gttctaacct acctgcaggc ctacaaagag gcctttgcca gtgaaaaggc atttggagtc
      481 ctcagcgaaa ccttgtatga gctactgcag ctgggctggg aggatcggca agaagaagac
      541 aacttgctga ttgaacggat ccttctgttg gtcagaaata ttctccatgt cccagccaac
      601 cttgagcagg agaagaggat cgatgacgat gccagcattc atgaccggct tctgtgggca
      661 attcacctca gtggcatgga cgacttgctc ctcttcctgt ccagctcatc cgctgagcag
      721 cagtggagcc tccatgtgct ggagatcatc tccctcatgt tccgagacca gaagcctgag
      781 cagctggcag gagtagggca gggacgcttg gctcaggagc gaagcacaga tttggcagaa
      841 ttggaagtgc tgcgccaacg ggaggtggcc gagaagagag cccgagccct gcagcgagga
      901 aacaggcact ctcgatttgg gggctcctat gttgtccagg ggttgaaatc tattggggag
      961 agggatgtcg tctttcacaa aggccttcac aacctccaga actacagctc agatctagga
     1021 aagcagcccc ggagggtgcc taagcgtcgt caggctgccc aggagctgtc tgtccatcgc
     1081 cgctctgtcc tgaatgtgag gctcttcctc agagacttct gctctgagtt cctggagaac
     1141 tgttacaacc cactcatggg tgcagtcaag gatcacctgc ttcgggagaa agctcagcaa
     1201 catgatgaga cgtactacat gtgggcgatg gctttcttta tggccttcaa ccgagctgct
     1261 gccttccgcc ctggctttgt ctctgagacc ctcagtatcc ggacctttca ctttgtggag
     1321 cagaacctca ccaactacta tgagatgatg ctgacagacc gcaaggaggc cgcctcctgg
     1381 gcacgcagga tgcacctggc tctgaaggcc tatcaggagc tgctggccac agtgaatgag
     1441 atggacatgt gcccagacga cgctgtcagg gagagcagtc gcatcatcaa aaacaacatt
     1501 ttctacatga tggagtaccg agaactattt ctggcactct ttcgaaaatt cgatgagaga
     1561 taccatccac gttcattcct ttgtgacctg gtggagacca ctcacctctt cctcaaaatg
     1621 ttggagcgct tctgtcggag ccgagggaac ctgatggtgc agaacaaaag aaagaagaga
     1681 aaaaagaaaa agaaggccca ggagcagggt gttgctttct cacgtagccc tgaggagctg
     1741 caggccatgt ggtcagcgct ggcagagcgg ctgctgcagt gcgcccagga acctgagctc
     1801 agtgtggact ccatcattcc ctttgatgcg gcctcagagg tgccagtgga ggagcagcgg
     1861 gtagaagcta tggtgaggat ccaagactgc cttgtggctg gccaggcccc gcaagccttg
     1921 gcccttctgc ggtctgcccg ggaagtgtgg cctgaaggaa atgtgtttgg ctctccagtc
     1981 atttccccag gggaagaaat gcagttgcta aaacaaatcc tctctgcaac ccttccccgg
     2041 cagcaggagc cagtagaagg agatgcagag gaggaagatg aagaggagga ggaggaggaa
     2101 gaggaggagt tacaggtggt ccaggtgtca gagaaggagt ttaagttttt ggactacttg
     2161 aaacgctttg catgctcaac cattgtgcga gcctatgtgc ttctcctgcg gagctaccgg
     2221 cagaacagcg ctcacaccaa ccactgcatc gccaagatgc tgcaccggct ggcccatgac
     2281 ctggggatgg aagccctgct tttccagctc tccctgttct gcctcttcaa ccagctactc
     2341 agtgacccag ccgctgcagc ctacaaagag ctagtgactt ttgccaaata catcctcggc
     2401 aagttctttg cgttggctgc agtgaaccag aaagcatttg tggagctgct gttctggaag
     2461 aacacctcgg tggttcggga aatgacccag ggatatggct cccttgacag tgggtcttgc
     2521 agccacagag cccctgtgtg gagctctgag gaagaggccc agcttcaaga actatacctc
     2581 gcccacaagg atgtagaagg tcaggatgta gtggagacca tcttggcaca cctgaaagct
     2641 gtccctcgga cacgcaagca ggtcatccac catctggtac gcatgggcct ggccgacagt
     2701 gtcaaggact tccagaggaa agggacccag attgtcttgt ggacagagga tcaggagctg
     2761 gagttacagc ggctctttga ggagttccag gattccgatg atgttcttgg tcatatcatg
     2821 aagaatatca cagccaaacg ttcacgggct cgagtagtgg acaaactgtt ggccctggga
     2881 ctcgtgtccg agcgcaggca actgcacaag aaacggagga agaagctggc gccctcttgc
     2941 atgcagaatg gggaagagtc ccagagagat gcttggcagg aagatccaga agaagaagag
     3001 gaaaaagaag gcttgccaga gagtgagggt gaggagaacg aggaagactt gttagcagga
     3061 caggtccagg gcagctcatc tctttctgct gaaaacctcc gtcagagcct ttgtcaggac
     3121 ggcctctctg ctcccctcct gtggctccag agctccctga ttcgcgcagc agatgaccga
     3181 gaagaggatg gctgctccca ggccatccct ctggtgcctc tgacggaaga aaatgaggaa
     3241 gcaatggaga acaaacagtt tcagcatctg ctacgtaagc taggaatccg ggccccctgc
     3301 tcaggacagg aaaccttctg gcgaattcca gccaaactga gctccaccca gcttcggaga
     3361 gtggctgctt ctctgagtga gcaagaaaac aaggaggaaa gagaggagga gccagagccg
     3421 aatccaggag tccctggaga gcagagtccc agtgaggagc accaagtgag agccccgaga
     3481 gcccttttgt cagctcgtaa aaggaaagca ggcctggtgt ttccaaaaga ggaggccact
     3541 ggggaggaag aatggaaatc ggtgcctaag aagcagcaac tgctggacag cgacgaagag
     3601 gacaccgacg acgagagggg agggcaagca gcagtgtcgg gaaccctgag aatccacaag
     3661 aagaaacggt ttctggttga ggatgaagat gaggattact gaagcctttg acagatgcca
     3721 gttggaaggc acagaagcta tttcaccttg cctgcattca aagcaatctc ctctaggagt
     3781 tttaggcacc agtgagaaga gcagggagat gctaaggtgg ccgggactcc tctctgggct
     3841 gtcttcacac agggagcttc ataccacatg acacgtgtgt tcataccatc ctcaccaggt
     3901 actggactca ttttctctca gtggttgaac ccaggacaca tgattgtgcc cgttactgca
     3961 gttgggtaga gttgggatac actactctca agctgacaag catccttgat ttgtgtttct
     4021 tattaaacgt gtaaaattaa caattgctga tctcaaaggg accaaccagt cttctgttgt
     4081 gtctctggaa cagaagaagg ttaagtgctc gcttcggcag cacatatact aaaattggac
     4141 caatacagag aagatgagca tggcccctgc acaaggacga cacacaaatt catgacacgt
     4201 tccatattta aaaaaaaaaa aaaaagaggg ggctggggat ttagctcagt ggtagagcgc
     4261 ttggctagga agcgcaaggc cctgggttca gtccccagct ccgaaaaaaa gaaccaaaaa
     4321 aaaaaaaaag aggaaagtta aaagacattt cctgaactga gcgtggtagc atgaccttct
     4381 actcccagaa tgtggaagag agaagcaaga ggattgattt cctgaggggg aggggaaaga
     4441 gtgacatacc ctctgcctgg gccaataaat gtaataaaaa aaatcagcct gacaataaat
     4501 gtgattttaa aaag
//
