LOCUS       NM_001395051            2759 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus TP53 induced glycolysis regulatory phosphatase
            (Tigar), transcript variant 1, mRNA.
ACCESSION   NM_001395051 XM_006237501
VERSION     NM_001395051.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Jiang,A., Du,P., Liu,Y., Pu,J., Shi,J. and Zhang,H.
  TITLE     Metformin regulates the Th17/Treg balance by glycolysis with TIGAR
            in hepatic ischemia-reperfusion injury
  JOURNAL   J Pharmacol Sci 146 (1), 40-48 (2021)
   PUBMED   33858654
  REMARK    GeneRIF: Metformin regulates the Th17/Treg balance by glycolysis
            with TIGAR in hepatic ischemia-reperfusion injury.
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Li,Z., Shao,Z., Chen,S., Huang,D., Peng,Y., Chen,S. and Ma,K.
  TITLE     TIGAR impedes compression-induced intervertebral disc degeneration
            by suppressing nucleus pulposus cell apoptosis and autophagy
  JOURNAL   J Cell Physiol 235 (2), 1780-1794 (2020)
   PUBMED   31317559
  REMARK    GeneRIF: TIGAR impedes compression-induced intervertebral disc
            degeneration by suppressing nucleus pulposus cell apoptosis and
            autophagy.
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Chen,C., Mei,Q., Wang,L., Feng,X., Tao,X., Qiu,C. and Zhu,J.
  TITLE     TIGAR suppresses seizures induced by kainic acid through inhibiting
            oxidative stress and neuronal apoptosis
  JOURNAL   Biochem Biophys Res Commun 515 (3), 436-441 (2019)
   PUBMED   31160088
  REMARK    GeneRIF: TIGAR has anti-epileptic, anti-oxidant and anti-apoptotic
            effects, and is therefore a promising therapeutictarget for
            epilepsy.
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Yu,H.P., Xie,J.M., Li,B., Sun,Y.H., Gao,Q.G., Ding,Z.H., Wu,H.R.
            and Qin,Z.H.
  TITLE     TIGAR regulates DNA damage and repair through pentosephosphate
            pathway and Cdk5-ATM pathway
  JOURNAL   Sci Rep 5, 9853 (2015)
   PUBMED   25928429
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2759)
  AUTHORS   Li,M., Sun,M., Cao,L., Gu,J.H., Ge,J., Chen,J., Han,R., Qin,Y.Y.,
            Zhou,Z.P., Ding,Y. and Qin,Z.H.
  TITLE     A TIGAR-regulated metabolic pathway is critical for protection of
            brain ischemia
  JOURNAL   J Neurosci 34 (22), 7458-7471 (2014)
   PUBMED   24872551
REFERENCE   6  (bases 1 to 2759)
  AUTHORS   Cheung,E.C., Ludwig,R.L. and Vousden,K.H.
  TITLE     Mitochondrial localization of TIGAR under hypoxia stimulates HK2
            and lowers ROS and cell death
  JOURNAL   Proc Natl Acad Sci U S A 109 (50), 20491-20496 (2012)
   PUBMED   23185017
REFERENCE   7  (bases 1 to 2759)
  AUTHORS   Hoshino,A., Matoba,S., Iwai-Kanai,E., Nakamura,H., Kimata,M.,
            Nakaoka,M., Katamura,M., Okawa,Y., Ariyoshi,M., Mita,Y., Ikeda,K.,
            Ueyama,T., Okigaki,M. and Matsubara,H.
  TITLE     p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage
            after ischemia
  JOURNAL   J Mol Cell Cardiol 52 (1), 175-184 (2012)
   PUBMED   22044588
REFERENCE   8  (bases 1 to 2759)
  AUTHORS   Kimata,M., Matoba,S., Iwai-Kanai,E., Nakamura,H., Hoshino,A.,
            Nakaoka,M., Katamura,M., Okawa,Y., Mita,Y., Okigaki,M., Ikeda,K.,
            Tatsumi,T. and Matsubara,H.
  TITLE     p53 and TIGAR regulate cardiac myocyte energy homeostasis under
            hypoxic stress
  JOURNAL   Am J Physiol Heart Circ Physiol 299 (6), H1908-H1916 (2010)
   PUBMED   20935145
  REMARK    GeneRIF: TIGAR inhibits glycolysis in hypoxic myocytes and
            inhibition of glycolysis is closely involved in apoptosis,
            suggesting that TIGAR significantly mediates cellular energy
            homeostasis and cell death under ischemic stress.
REFERENCE   9  (bases 1 to 2759)
  AUTHORS   Li,H. and Jogl,G.
  TITLE     Structural and biochemical studies of TIGAR (TP53-induced
            glycolysis and apoptosis regulator)
  JOURNAL   J Biol Chem 284 (3), 1748-1754 (2009)
   PUBMED   19015259
REFERENCE   10 (bases 1 to 2759)
  AUTHORS   Bensaad,K., Tsuruta,A., Selak,M.A., Vidal,M.N., Nakano,K.,
            Bartrons,R., Gottlieb,E. and Vousden,K.H.
  TITLE     TIGAR, a p53-inducible regulator of glycolysis and apoptosis
  JOURNAL   Cell 126 (1), 107-120 (2006)
   PUBMED   16839880
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On May 28, 2021 this sequence version replaced XM_006237501.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217296.1, SRR22399481.2939566.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000004.1  161632108-161632229 c
            123-160             JAXUCZ010000004.1  161623340-161623377 c
            161-282             JAXUCZ010000004.1  161619180-161619301 c
            283-360             JAXUCZ010000004.1  161617734-161617811 c
            361-471             JAXUCZ010000004.1  161616209-161616319 c
            472-2759            JAXUCZ010000004.1  161613306-161615593 c
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2759
                     /gene="Tigar"
                     /note="TP53 induced glycolysis regulatory phosphatase"
                     /db_xref="GeneID:502894"
                     /db_xref="RGD:1560038"
     exon            1..122
                     /gene="Tigar"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..897
                     /gene="Tigar"
                     /EC_number="3.1.3.46"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TP53-induced glycolysis and apoptosis regulator;
                     fructose-2,6-bisphosphatase TIGAR"
                     /codon_start=1
                     /product="fructose-2,6-bisphosphatase TIGAR isoform 1"
                     /protein_id="NP_001381980.1"
                     /db_xref="GeneID:502894"
                     /db_xref="RGD:1560038"
                     /translation="MPRFALTIIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAATGQ
                     FLSNVHFTHAFSSDLTRTKQTIHGILEKSRFCKDIAVKYDSRLRERMYGVAEGKPLSE
                     LRAMAKAAGEECPMFTPPGGETVEQVKMRGKDFFDFICQLILGKAGQRENFLPGAPDN
                     CLESSLAEVFPVGKHGSLGTDPKHGALGLTASILVVSHGAYMRSLFGYFLSDLRCSLP
                     ATIDKFELSSITPNTGISVFIIDCEEARKPTVQCVCMNLQEHLNKGVEKH"
     exon            123..160
                     /gene="Tigar"
                     /inference="alignment:Splign:2.1.0"
     exon            161..282
                     /gene="Tigar"
                     /inference="alignment:Splign:2.1.0"
     exon            283..360
                     /gene="Tigar"
                     /inference="alignment:Splign:2.1.0"
     exon            361..471
                     /gene="Tigar"
                     /inference="alignment:Splign:2.1.0"
     exon            472..2759
                     /gene="Tigar"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggaagt agtgcaggca aagtggacct gcagtcagtc gcagcaaggt gctgcagagt
       61 cgggttgtgg ctcacgtgcc ttggaccaag atgccgcgct tcgccttgac catcatccgc
      121 catggcgaaa caagacttaa caaggagaaa atcattcaag ggcaaggagt agacgcgccc
      181 ctttccgaga ctgggtttag gcaagcagcc gccactggtc agtttctgag caacgtgcac
      241 tttacccacg ccttctccag tgatctcacg aggactaagc agaccataca tggcattctg
      301 gagaaaagca gattttgcaa agacatagca gtgaagtatg actccagact tcgggaaagg
      361 atgtacgggg ttgcagaagg caagccgcta agtgagcttc gggccatggc caaagccgct
      421 ggagaagagt gtcccatgtt caccccgcct ggaggagaga cagtagagca ggtaaaaatg
      481 cgtggaaagg atttctttga tttcatttgt cagttgattc tgggcaaggc aggccagaga
      541 gaaaacttcc tccccggagc gccagacaac tgtttggaaa gctctttggc ggaggttttc
      601 cccgtgggaa aacacggcag cttggggaca gaccccaagc atggtgccct gggtttaacc
      661 gccagcatct tggtcgtgag ccacggggct tacatgagaa gcctctttgg ttatttcctg
      721 agtgacctca gatgctcact gccagccaca atagacaaat tcgaactttc ctccatcact
      781 cccaacactg gcatcagtgt cttcatcatc gactgtgagg aagcacgcaa gccaaccgtc
      841 cagtgtgttt gtatgaacct ccaggagcat ctaaacaaag gggttgaaaa gcactgagtc
      901 caaagccccc aaccgtgggg ctccgaatgg agggccttgg cctcttgtgt tttcatcctc
      961 tgcccctgct gtttagaagc aggtgagact tgtgccataa agccccactg gggtcctgac
     1021 tgtatccgct gttagtggga atccactcag agtcagcctg gtttttctga gacaccattt
     1081 tctaccatga ttttgtcacc ctgtgctgtt atgtctgtga actattaact tatgaggaca
     1141 ctcagcattg cacacggggg atgaagcctt ttctccacat tctcctttca ttggcctctt
     1201 cgatgtctag atggtgttgg ctgttgaaga tcatttaatg tttttccact cactcaccaa
     1261 gtgcttgcaa gaaagaatgg tttaaataat tctcccgcat ttgcagtgat tgtgtcagag
     1321 tccacagtgt tcagactgaa gcttcttact gtcatccgtg tgtaaaggga aatggctgaa
     1381 tgctctagcg tcctctggag aaactggctc ttgggaatta ttattatcat tgttattgtt
     1441 attattgcct caaatacagc tgagggactg aagggactag gagtacttcc agttaccctg
     1501 agaaccccag ttcagatccc tttacccata ttgggcagct cacagcttcc tggaactcca
     1561 gcatcaggga ggcagtgccc gctctgggcc tctgcagaca cttgcacaca tgcacacaaa
     1621 taaaagtagt aaaagcagcc tgggggaagg aaggaacaca ctgcctgatc agacacatta
     1681 cgatcctctg agaagaaggc aaacacagct ttccagcaaa agcggtgggg gtggggaatg
     1741 ctcaagttac cctcgctttg tatccaagct gcctgtgaag actggttgac ccatccaaag
     1801 aagaggtgct gaaaactggt acgcagaagg ctcagaggag tgaccttcct ccaggtggcg
     1861 ctgtcggaaa gggattttga ttgctgctca agagtcctca attaggaaac tggactgcta
     1921 aaaatgccag gcccacacta cagcctcagg aaaatgtaac actgggccca gatatagagg
     1981 agtttgacca ggaagagctg gtaggattga gagcttactg aacagtaggt gacaaactta
     2041 agaaacctag aaatacagtt cacctgcaaa gggaggtgta ggtcaaggct caccacagtt
     2101 gacttgcctg ctgtaaagtg ctactaggtc cttctgtcta gacactttgt gggggcgctg
     2161 ccaacacttt gggtactggt ggccccacac tagggattta cttgaggttc caaatgcacg
     2221 tgtaccttga acaaagacat cactgacatg agtccaaagt gtgaccatgt tctgagaaac
     2281 caaaggacat gattataaag gccgtagaaa agtctcccta tgggtgacag tgaacttcag
     2341 ttcaaaagtc atgtcggcat ttggggtgag tgttgggttg tgtgaatctg agaggaaagt
     2401 tataaaaacc tgaggagttt ggaggtgtcg ctcagtgggc cctggcttcc atcacaagtg
     2461 gagaaaaatc agaacagaaa cctgcttttt taagagaaat ccagtgttag gtcactccct
     2521 ccgtgtagag caccactgga agtcctggtg cggagctgct gtgagacaga gcagagctca
     2581 taagcagagt gggtgagcag cagtattgtt ctactgcctt tcaaatgcac ataaataccc
     2641 agctctgtag tcttcctttt acccgtactg tttgagggta tttatttggg aatgtatggc
     2701 tctacttaat tgtaaccagt attctaccga atgaataaag atctttggtt tatagaggg
//
