LOCUS       NM_001014044            1662 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TRAF-interacting protein with forkhead-associated
            domain (Tifa), mRNA.
ACCESSION   NM_001014044 XM_227712
VERSION     NM_001014044.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1662)
  AUTHORS   Zhou,P., She,Y., Dong,N., Li,P., He,H., Borio,A., Wu,Q., Lu,S.,
            Ding,X., Cao,Y., Xu,Y., Gao,W., Dong,M., Ding,J., Wang,D.C.,
            Zamyatina,A. and Shao,F.
  TITLE     Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial
            ADP-heptose
  JOURNAL   Nature 561 (7721), 122-126 (2018)
   PUBMED   30111836
REFERENCE   2  (bases 1 to 1662)
  AUTHORS   Zimmermann,S., Pfannkuch,L., Al-Zeer,M.A., Bartfeld,S., Koch,M.,
            Liu,J., Rechner,C., Soerensen,M., Sokolova,O., Zamyatina,A.,
            Kosma,P., Maurer,A.P., Glowinski,F., Pleissner,K.P., Schmid,M.,
            Brinkmann,V., Karlas,A., Naumann,M., Rother,M., Machuy,N. and
            Meyer,T.F.
  TITLE     ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the
            Helicobacter pylori Type IV Secretion System
  JOURNAL   Cell Rep 20 (10), 2384-2395 (2017)
   PUBMED   28877472
REFERENCE   3  (bases 1 to 1662)
  AUTHORS   Milivojevic,M., Dangeard,A.S., Kasper,C.A., Tschon,T.,
            Emmenlauer,M., Pique,C., Schnupf,P., Guignot,J. and Arrieumerlou,C.
  TITLE     ALPK1 controls TIFA/TRAF6-dependent innate immunity against
            heptose-1,7-bisphosphate of gram-negative bacteria
  JOURNAL   PLoS Pathog 13 (2), e1006224 (2017)
   PUBMED   28222186
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1662)
  AUTHORS   Gaudet,R.G., Sintsova,A., Buckwalter,C.M., Leung,N., Cochrane,A.,
            Li,J., Cox,A.D., Moffat,J. and Gray-Owen,S.D.
  TITLE     INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite
            HBP activates TIFA-dependent innate immunity
  JOURNAL   Science 348 (6240), 1251-1255 (2015)
   PUBMED   26068852
REFERENCE   5  (bases 1 to 1662)
  AUTHORS   Huang,C.C., Weng,J.H., Wei,T.Y., Wu,P.Y., Hsu,P.H., Chen,Y.H.,
            Wang,S.C., Qin,D., Hung,C.C., Chen,S.T., Wang,A.H., Shyy,J.Y. and
            Tsai,M.D.
  TITLE     Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor
            necrosis factor alpha stimulation and NF-kappaB activation
  JOURNAL   Mol Cell Biol 32 (14), 2664-2673 (2012)
   PUBMED   22566686
  REMARK    Erratum:[Mol Cell Biol. 2012 Sep;32(18):3800]
REFERENCE   6  (bases 1 to 1662)
  AUTHORS   Kanamori,M., Suzuki,H., Saito,R., Muramatsu,M. and Hayashizaki,Y.
  TITLE     T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and
            AP-1 without TNF stimulation
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1108-1113 (2002)
   PUBMED   11798190
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083765.1.
            
            On Apr 20, 2005 this sequence version replaced XM_227712.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083765.1, DN933168.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132295, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1662
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..1662
                     /gene="Tifa"
                     /gene_synonym="Ab2-389; T2bp"
                     /note="TRAF-interacting protein with forkhead-associated
                     domain"
                     /db_xref="GeneID:310877"
                     /db_xref="RGD:1359151"
     exon            1..207
                     /gene="Tifa"
                     /gene_synonym="Ab2-389; T2bp"
                     /inference="alignment:Splign:2.1.0"
     exon            208..264
                     /gene="Tifa"
                     /gene_synonym="Ab2-389; T2bp"
                     /inference="alignment:Splign:2.1.0"
     exon            265..1638
                     /gene="Tifa"
                     /gene_synonym="Ab2-389; T2bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..835
                     /gene="Tifa"
                     /gene_synonym="Ab2-389; T2bp"
                     /note="TRAF2-binding protein; Traf2 binding protein"
                     /codon_start=1
                     /product="TRAF-interacting protein with FHA
                     domain-containing protein A"
                     /protein_id="NP_001014066.1"
                     /db_xref="GeneID:310877"
                     /db_xref="RGD:1359151"
                     /translation="MSTFEDADTEETVTCLQMTIYHPGQLQSGIFKSIRFCSKEKFPS
                     IEVVKFGRNSNMCQYTFQDKQVSRVQFALQPFKQFNSSVLSFEIKNMSKKTSLMVDNQ
                     ELGYLNKMDLPYKCMLRFGEYQFLLQKEDGESVESFETQFILSPRPLLQENNWPTQSP
                     IPEDGVYSSYFTHRSSPAEMDENEL"
ORIGIN      
        1 cgcgagggct ttgctgaggt cactcgcgcg aggccgctct tggcgcgccc gtgggaggct
       61 cggtggcacg ggaggactgg cgacctgcgg gttcggcgag ctcgtacggc gctggtcgcg
      121 acgacggtcc cccaccgagg ccgcgccccg ccgcttccac cgaaggctcc gcaaggctca
      181 cggaccaccc agccctccca gccccaggag aagagacaag gcccaagagt cctgatctag
      241 ctgtggccac tggaagactc tcaggccggg gagcgtcatg tccacctttg aagacgctga
      301 tacagaagag acggtcactt gtctccagat gaccatttac catcctggcc agctgcaaag
      361 tggaatattt aaatcgataa ggttttgcag caaggagaaa ttcccttcca ttgaagtggt
      421 gaaatttgga cggaattcca atatgtgcca gtacacgttt caggacaaac aggtttcccg
      481 agttcagttt gctttacagc cgtttaaaca attcaacagc tcggttctgt cgtttgaaat
      541 aaaaaacatg agcaagaaga cgagtctgat ggtggacaac caggagctcg gctacctcaa
      601 taaaatggac ctgccttaca agtgcatgct ccggttcgga gagtatcagt tcctgctgca
      661 gaaggaagat ggagagtcag tagaatcttt tgagactcaa tttatcttgt ctccaagacc
      721 tctcttgcaa gaaaacaact ggccaacgca gagccccata cccgaggatg gggtgtattc
      781 ttcctacttc acccatagaa gttctcctgc agaaatggat gaaaacgagc tgtgaagagg
      841 gtccacccgg agacacgtga aggatgagga cgcatgggta gacactcctg cttccctgga
      901 gttcgtgagt gtagcataac acagacgtcc gcgtgctgac ttcagttttg gcagtggcat
      961 ttggaagtct gtacactggg ttagtcatca acttagtcaa ctgtttgagt ttcggctcta
     1021 gcaagaatta agtgtgcgga ggtggcgcgt aagacacgcc ttccgcgtaa tgacgtcact
     1081 ctcgttgctt ctctgcttga cgccaccccc acgctatgtc ttggtagcag ccatcttgtc
     1141 ctggtcacgt catttcgcgg cagcctttgt ttttcaagtt tagagcctgg gcagattgtt
     1201 cgctgctggt gtcttcggca tgctagtgct tgtagagcca gagtcctggg ctaagctcta
     1261 gagtgctgag tccctgagtc actgtggctc cattatggaa agacttgaga aatagctcct
     1321 tggttttctt tctatggaac tgtcatgtcc atccctaaga cggcagcttt gctttcttat
     1381 gtgtaggccc ttcagctaac atgtaaagaa ccaaaatggt tttctcctga agtcgaaagt
     1441 gaattttttt gtatcttaac agatttagaa atggcagaaa tcaaaacggt ttagcagcct
     1501 cttcgcatat gatgaagtcg gagctcagtt cctcagctgc ttctttgaaa cttcttaaag
     1561 ggaaacatct gttcttaggc cgctctacag aagtcagtat atgtgaatat ttataataaa
     1621 tgcttaacta tttctaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
