LOCUS       NM_053545               3848 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus tyrosine kinase with immunoglobulin-like and
            EGF-like domains 1 (Tie1), mRNA.
ACCESSION   NM_053545 XM_001069541 XM_233462
VERSION     NM_053545.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3848)
  AUTHORS   Economides AN, Frendewey D, Yang P, Dominguez MG, Dore AT, Lobov
            IB, Persaud T, Rojas J, McClain J, Lengyel P, Droguett G,
            Chernomorsky R, Stevens S, Auerbach W, Dechiara TM, Pouyemirou W,
            Cruz JM Jr, Feeley K, Mellis IA, Yasenchack J, Hatsell SJ, Xie L,
            Latres E, Huang L, Zhang Y, Pefanis E, Skokos D, Deckelbaum RA,
            Croll SD, Davis S, Valenzuela DM, Gale NW, Murphy AJ and
            Yancopoulos GD.
  TITLE     Conditionals by inversion provide a universal method for the
            generation of conditional alleles
  JOURNAL   Proc Natl Acad Sci U S A 110 (34), E3179-E3188 (2013)
   PUBMED   23918385
REFERENCE   2  (bases 1 to 3848)
  AUTHORS   Su D and Gudas LJ.
  TITLE     Retinoic acid receptor gamma activates receptor tyrosine kinase
            Tie1 gene transcription through transcription factor GATA4 in F9
            stem cells
  JOURNAL   Exp Hematol 36 (5), 624-641 (2008)
   PUBMED   18439490
REFERENCE   3  (bases 1 to 3848)
  AUTHORS   Zhang H, Lawson WE, Polosukhin VV, Pozzi A, Blackwell TS,
            Litingtung Y and Chiang C.
  TITLE     Inhibitor of differentiation 1 promotes endothelial survival in a
            bleomycin model of lung injury in mice
  JOURNAL   Am J Pathol 171 (4), 1113-1126 (2007)
   PUBMED   17717145
REFERENCE   4  (bases 1 to 3848)
  AUTHORS   Zheng W, Christensen LP and Tomanek RJ.
  TITLE     Stretch induces upregulation of key tyrosine kinase receptors in
            microvascular endothelial cells
  JOURNAL   Am J Physiol Heart Circ Physiol 287 (6), H2739-H2745 (2004)
   PUBMED   15548727
  REMARK    GeneRIF: Mechanical stretch induces upregulation of the key
            tyrosine kinase receptors Flk-1, Tie-2, and Tie-1 in vascular
            endothelial cells
REFERENCE   5  (bases 1 to 3848)
  AUTHORS   Shyu KG, Liang YJ, Chang H, Wang BW, Leu JG and Kuan P.
  TITLE     Enhanced expression of angiopoietin-2 and the Tie2 receptor but not
            angiopoietin-1 or the Tie1 receptor in a rat model of myocardial
            infarction
  JOURNAL   J Biomed Sci 11 (2), 163-171 (2004)
   PUBMED   14966366
  REMARK    GeneRIF: Ang2 and Tie2 expressions significantly increased both
            spatial and temporal patterns after myocardial infarction in the
            rat ventricular myocardium, while Ang1 and Tie1 receptor expression
            did not.
REFERENCE   6  (bases 1 to 3848)
  AUTHORS   Loughna S and Sato TN.
  TITLE     A combinatorial role of angiopoietin-1 and orphan receptor TIE1
            pathways in establishing vascular polarity during angiogenesis
  JOURNAL   Mol Cell 7 (1), 233-239 (2001)
   PUBMED   11172728
REFERENCE   7  (bases 1 to 3848)
  AUTHORS   Fujikawa K, Presman E, Isner JM and Varticovski L.
  TITLE     Expression of tie1 and tie2 proteins during reendothelialization in
            balloon-injured rat carotid artery
  JOURNAL   J Vasc Res 36 (4), 272-281 (1999)
   PUBMED   10474040
  REMARK    Erratum:[J Vasc Res 1999 Nov-Dec;36(6):509]
REFERENCE   8  (bases 1 to 3848)
  AUTHORS   Patan S.
  TITLE     TIE1 and TIE2 receptor tyrosine kinases inversely regulate
            embryonic angiogenesis by the mechanism of intussusceptive
            microvascular growth
  JOURNAL   Microvasc Res 56 (1), 1-21 (1998)
   PUBMED   9683559
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169020.1.
            
            On or before Sep 5, 2008 this sequence version replaced
            XM_233462.4, XM_001069541.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169020.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3848
                     /gene="Tie1"
                     /note="tyrosine kinase with immunoglobulin-like and
                     EGF-like domains 1"
                     /db_xref="GeneID:89806"
                     /db_xref="RGD:621642"
     exon            1..108
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..3464
                     /gene="Tie1"
                     /EC_number="2.7.10.1"
                     /note="tyrosine-protein kinase receptor Tie-1; tyrosine
                     kinase receptor 1"
                     /codon_start=1
                     /product="tyrosine-protein kinase receptor Tie-1
                     precursor"
                     /protein_id="NP_445997.1"
                     /db_xref="GeneID:89806"
                     /db_xref="RGD:621642"
                     /translation="MVWWGSPFLLPILFLASHVGASVDLTLLANLRITEPQRFFLTCV
                     SGEAGAGRSSDVWGPPLLLEKDDRIVRTFPPGQPLHLTRNGSHQVTLRGFSKPSDLVG
                     VFSCVGGAGTRRTRVLYVHNSPGAHLFPDKVTHTVNKGDTAVLSARVHKEKQTDVIWK
                     NNGSYFHTLDWHEAHDGRFQLQLQNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCEA
                     GRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGT
                     AGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGC
                     VCPSGWHGVHCEKSDRIPQILNVATELEFNLGTMPRINCAAAGNPFPVRGSMELRKPD
                     GTMLLSTKAIVEPDRTTAEFEVPRLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPPVP
                     LTAPRLLAKQSRQLVVSPLVSFGGDGPISSVRLHYRPQDSMITWSAIVVDPSENVTLM
                     NLKPRTGYNVRVQLSRPGEGGEGAWGPSTLMTTDCPEPLLQPWVESWNVEGPDRLRVS
                     WSLPSVPLSGDGFLLRLWDGARGQERRENISSPQARTALLTGLTPGTHYQLDVRLYHC
                     TLLGPASPSAHVHLPLSGPPAPRHLRAQALSDSEIRLMWQHPEAPPGPISKYIVEIQV
                     AGGSGDPQWMDVDKPEETSTTVRGLNASTRYLFRVRASVQGLGDWSNTVEETTLGNGL
                     QSASPVQESRVAEDGLDQQLVLAVVGSVSATCLTILAALLALVCIRRSCLHRRHTFTY
                     QSGSGEETILQFSSGTLTLTRRPKPQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAM
                     IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYI
                     AIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEK
                     QFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYT
                     TKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQC
                     WRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA"
     exon            109..426
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..537
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..693
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..825
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..966
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1095
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1241
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1386
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1545
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1683
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1974
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2265
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2456
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2667
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2778
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2969
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3083
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3154
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3195
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3292
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3392
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3819
                     /gene="Tie1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaccccgg gcccagccgg cctcggctgg cccaggtcag cctccggagt atggtctggt
       61 ggggatcccc tttcctgctc cccattcttt ttctggcctc tcatgttggt gcatccgtgg
      121 atttaacact gctggccaat ctgcgtatca ccgaacccca gcgtttcttc ctgacctgtg
      181 tgtctggtga ggcgggagca gggaggagct ccgacgtctg gggcccgccc ctgctgctgg
      241 aaaaggatga tcgcatagtg cgcaccttcc cacccgggca gcccctgcac ctcactcgca
      301 acggttcaca ccaggtcacg ctgcggggct tctccaagcc ctcggattta gtaggcgtct
      361 tctcctgcgt gggtggagct ggcacgaggc gcactcgagt cctctatgtg cacaacagcc
      421 cgggggcaca cctgtttcca gacaaggtca cacacacggt gaacaaaggt gataccgctg
      481 tgctttctgc acgagtgcac aaggaaaagc agactgatgt gatttggaag aacaatggat
      541 cctacttcca taccctagac tggcatgagg cccatgatgg gcggtttcaa ctgcagctcc
      601 aaaatgtaca gccaccatcg agtggcatct acagcgccac ctacctagag gccagcccct
      661 tgggcagtgc cttctttcgg ctcatcgtgc gaggctgtga ggctggacgc tgggggccgg
      721 gatgtgtcaa ggattgccca ggctgcctgc atggaggtgt ctgtcatgac cacgatggcg
      781 aatgtgtgtg cccccctgga ttcactggca cccgctgtga gcaggcctgc agagaaggtc
      841 gttttggaca gagctgccag gaacagtgcc caggcacagc aggctgtcgg ggtctcacct
      901 tctgcctccc agatccctat ggctgttctt gtggatctgg ctggagggga agccagtgcc
      961 aggaagcatg tgcacctggt cattttgggg cagattgtcg cctccagtgt cagtgtcaaa
     1021 atggtggtac ttgtgatcgg ttcagcggct gcgtctgccc ctccgggtgg catggagtcc
     1081 actgtgaaaa gtcagaccgg atcccccaga tcctcaatgt ggccacagag ctggagttca
     1141 acttagggac aatgccccgg atcaactgtg cagctgccgg gaatcccttc ccagtacggg
     1201 gcagcatgga actccgcaag ccagacggca ccatgctcct gtctaccaaa gccattgtgg
     1261 agccagatag gaccacagct gagttcgagg tgccccgttt gactcttggg gacagcgggt
     1321 tctgggaatg ccgtgtatcg acgtctggtg gccaagatag ccggcgcttc aaggtcaatg
     1381 tcaaagtacc cccagtgcct ctgactgcac ctcggctcct ggccaagcag agccgccagc
     1441 ttgtggtctc cccactggtc tccttcggtg gggatggacc catctcctct gtccgcctgc
     1501 actaccggcc ccaggacagc atgattacct ggtctgccat tgtggtggat cccagtgaga
     1561 atgtgacatt aatgaacctg aagccaagga caggatacaa cgttcgggtg cagctgagcc
     1621 ggccagggga aggaggagaa ggagcctggg gtccttcgac tctcatgact acggactgtc
     1681 ctgagccttt gctgcagccg tgggtagaga gctggaacgt ggagggtcct gacaggctac
     1741 gggtgagctg gtctctaccc tcggtgccac tgtctgggga tggtttcctg ctgcgtctgt
     1801 gggatggggc ccggggacag gagaggcggg agaacatctc atccccccag gcccgcactg
     1861 ccctcctgac tggactcacg cctggcacgc actaccaact ggatgtgcgg ctgtatcact
     1921 gcaccctcct gggccctgcc tcaccctctg cgcatgtgca cctgcccctc agcgggcctc
     1981 cagctccccg ccacctccgt gcccaggccc tctcagactc tgagatccgt ctgatgtggc
     2041 agcatcctga ggctccgcct ggacctatat ccaagtacat tgtggagatt caggtggccg
     2101 ggggctcagg agaccctcag tggatggatg tagacaaacc cgaggagacg agcaccaccg
     2161 tccgtggtct caatgccagc acacgctacc tcttccgtgt gcgggccagt gtgcagggtc
     2221 tcggcgactg gagcaacaca gtggaagaga ccacgctggg taatgggctg cagagtgcga
     2281 gcccagtcca agagagccgg gtggctgaag acggtctgga tcagcagctg gtcctggctg
     2341 tggtaggctc cgtctctgcc acctgcctca ccatcctggc tgccctttta gccctggtgt
     2401 gtatccgaag aagctgccta catcggagac ataccttcac ctaccagtca ggatcgggtg
     2461 aagagaccat cctgcagttc agctcaggga ccttgacatt gacccgacgg ccaaagccac
     2521 agcctgagcc tttgagttac cctgtgctgg agtgggagga catcaccttt gaggacctca
     2581 tcggggaggg gaacttcggc caagtgatcc gggccatgat caagaaggac ggactcaaga
     2641 tgaacgcagc catcaagatg ctgaaagagt atgcgtctga aaatgaccac cgagactttg
     2701 caggggaact agaagttctg tgcaaactag gacaccaccc caatattatc aacctcttgg
     2761 gggcctgtga gaaccgaggc tacttgtata ttgcgatcga atatgccccg tatggaaacc
     2821 tgctagattt cctgagaaag agcagggtcc tggagactga tccagctttt gctcgagagc
     2881 atggaacagc ctccacactc agctcccggc agctgctgcg ctttgccagt gatgcagcca
     2941 acgggatgca gtaccttagt gagaagcagt tcattcacag ggacctggct gcccgaaatg
     3001 ttctggtcgg agagaacctg gcctccaaga ttgcagactt tggcctttct cggggggagg
     3061 aagtatatgt gaagaagacg atgggccgtc ttcctgtgcg ttggatggcc attgagtccc
     3121 tcaactacag cgtctacact accaagagtg acgtctggtc atttggggtc ctcctctggg
     3181 agatagtgag ccttggaggc acgccctact gtggcatgac ctgtgctgag ctctacgaga
     3241 aactgcctca aggctatcgc atggagcagc ctcgaaactg tgatgatgaa gtgtacgagc
     3301 tgatgcggca gtgctggcgg gaccgtccct atgagcgccc cccttttgcc cagattgcac
     3361 tacagttggg ccgcatgctg gaagccagga aggcctacgt gaacatgtca ctgtttgaga
     3421 actttaccta tgcaggcatc gatgccacag ctgaggaggc ctaggctgcc ccccaccaga
     3481 acctggctct gctggccgga gcaaactgct tccacctgtg actctgaacc cttccaacct
     3541 ctgacccaag ctgtctcaag aaagtctttt aatttaaagg agaaaggaaa ggatccagga
     3601 aacatggggt ggagggaaac ggggatcccc atttttggca gctgctccta tagctacccc
     3661 ttcatattct tccttctaca aatgtgttcc ccactctgat gctgcccaaa cccaaacccc
     3721 acttctgatc ctctaccaaa agcagcatgc atgttactaa caccccgttt agctacccta
     3781 ctctctgctc gtactcaaaa aataaatgct tggaacagca aaaaaaaaaa aaaaaaaaaa
     3841 aaaaaaaa
//
