LOCUS       XM_218829               6537 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus TOPBP1-interacting checkpoint and
            replication regulator (Ticrr), transcript variant X1, mRNA.
ACCESSION   XM_218829
VERSION     XM_218829.9
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_218829.10.
            
            On Jan 21, 2021 this sequence version replaced XM_218829.8.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6537
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6537
                     /gene="Ticrr"
                     /note="TOPBP1-interacting checkpoint and replication
                     regulator; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 6 ESTs, 2 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 31 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:308768"
                     /db_xref="RGD:1308541"
     CDS             179..5833
                     /gene="Ticrr"
                     /codon_start=1
                     /product="treslin isoform X1"
                     /protein_id="XP_218829.6"
                     /db_xref="GeneID:308768"
                     /db_xref="RGD:1308541"
                     /translation="MACCHKVMLLVDTAGDAARHSSARRAALRLLTYLSCRFGLARVH
                     WTFKFFDSQGARNRPSRVSDFRELGSRSWEDFEEELEARLGDRPPGAHLPGPTPRATH
                     THGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDADSEAKEAETALGGFGNAVFLL
                     APCPHSQRELLQFVSGCEAQAQRVPLTPKQLMEKVLPKRVQEVMIARNITLYWVDTTE
                     RSKLWASPDHTGYWTVCELLHHGGGTILPAETWNLGFTKARETVLPCGGELSPGPHLS
                     PWISALPIDATVNCLLYNSEYEASFPRVEGTLFLPVKGKEIQETWAICLEPLAMHQRH
                     FQKPVRIFLKGSVTQWSLPMSSALGTDNWMLQSPEEHKSTQRLLFQELVSRLTAEEFH
                     LVASVDPGDGWPPITGIISPFSANAMILTVLRAKEAEFQRHFLQTAVTEGSQDVTSLF
                     SDAVDSVLNQVHNSFEDPASSVSRVPEWVQQELSRTSPWSPALVEKWFPFSNVCGATS
                     DLMESFLLLHAASPDNNESSRTESELTRCLSELYQRRSHEESTVVNQERSRKKRGIPR
                     TPVRQKMNTMSRSLKMLNVARLNVKAQKLHPDGSPDMAVEKGLPKTVIGRTADKLEDR
                     GRVLRSSKLKEFKTEEELLAYIHDNYQKTVATGEITLHSCAQNTVSTIKIFLKSKDVK
                     ELEMTCMNHMNSNLLKTSKTLRQNLGGKTDKEDKVRECQLQVFLRLEMCQQCPSVLDR
                     TEEVEHVVEEVTDLLRVVCLTKDSAYLSEFLEEILGLYIDSIPGTIGQLYHSLGLKIP
                     QKLAGVLPTDFFSDDSMTQESMSPPPSSSTHRSVSAITESEQLEELRTRSAKKRRKNA
                     LIRHKSIAEISQALRQIEVPKVSKRATRSESAHPASVQLPLPRKDTVQEVTKVRRNLF
                     NQGMLSPSKRGLKKGLPRSRSVSTLECLQHKQDKLKKTKSSTFQGYKLLTKSVAETPV
                     HKQISRRLLHRQIKGRSSDPGPDIHVVEESPEKEDEMILRRSPRIKQLSFSRTNSGSF
                     YSVSQPKSRSVQRIHSSQQKSDQRENFPVQSIRSPKTLLFGALSETPSSSKKGSPGIK
                     RSSRSMLDSEISTAYETPKKNNQKSPSFSKTTPRSFPRTAQTLLYTPERLQNSSTEIT
                     SAEGTISEVAIKTPSSHGYNSPSASKVTPQKRASPAKEETSPLTELPSIPRESDVQPP
                     QCSSNSVSSSSEGPCCPASPPPLAGQARGQCLTPVRYSFRTPPRTALAVTSTYQEHQE
                     LPLRRASQAREPPQRLEEKALKIPKKPTDTSTSPLSPKEHFTSPGCNVSPHQPSISSL
                     SASPSGELSWKENQTSPSVTTSVSCPVPSTPPRTPQRMICPIPPSPPSKLRRPCRKKS
                     CLPQDFPECQPGPCAVPVLGTTTSPGTVRGSREEQSQPSEGHSYLGTSFGSDWHVSSP
                     MLIASDTECLPLIDEAQLHRLENQEVKSGVLPGEEGEEPETTTAEPPSVSDLGILVPA
                     PSSVSNSPELLSYTLCRVADGRQSHDAAQQESPPASEATDSPQTYDVELEMQASGLPK
                     LRIKKIDPGVLLEPEALGRETLLGEEGTFPALSMPKASKSSGRSEHTYLSPPCLLPSH
                     STPGKSGGQTFICQSCTPSRCPPSTPSPFQADVGVSWTPSPKQSGKTTPEIIKDWPRR
                     KRAVDCSAGPSAGRGEASMDLPGSLSLLEPEPEGKEQSLEQDLCKVLILEDFELEGVC
                     QLPDQSPPKHSVSMAEETSWEQFGLGRKRLLSAKEESEYNGKRLCDSPSEDPQASEHK
                     ECSPCWSAPPVPSVGDDEVFVSGSTPPSGYMVRSCLSASGLQALTQSPLLFQGRTPSS
                     HSKDTRDEDVDVFPSTAEESPFSQTLSRKRPFRTYTRKKLIS"
ORIGIN      
        1 ccaataggag cggagcttgg aaaccagctc ctccaatagc agcagttgtc ggagagcgcg
       61 ggagccttcg gagcagggcc tcagaggagc gggcaatggc gctggttctc tgaagagagt
      121 gctttacccc aggaagggca acgcggggcc gggcggaggg agtcccgtgg cggccgagat
      181 ggcctgctgt cacaaagtga tgctgctggt ggacactgcg ggcgacgctg ctcgccatag
      241 ctccgcccgg cgcgccgccc tccgtctcct aacttacctg agctgccgct tcggcctggc
      301 cagggtccac tggaccttca agttcttcga ctctcagggg gcgcgaaacc ggccctcccg
      361 cgtgtccgac ttccgcgaac tggggagccg ctcctgggag gacttcgagg aggagctgga
      421 ggccaggctc ggggatcgcc ctcccggagc tcacctgccc ggccccacgc ccagggccac
      481 ccacacgcac ggtgccctga tggagacgct gctcgattac cagtgggacc ggccggagat
      541 cacgtcgccc actaagccga tcctgcgaag tagcgggagg aggttgctgg acgccgacag
      601 cgaggccaag gaggccgaga ccgcgctcgg gggctttggg aacgccgtct tcctcctggc
      661 gccctgtccg cactcacaga gggagctgct tcagttcgtg tccgggtgcg aggcccaggc
      721 tcaacgcgtg ccgctcaccc ccaagcagct gatggaaaag gtgttgccca agagagtcca
      781 ggaggtcatg atcgcccgaa atataacctt gtactgggtg gacaccaccg agcgatctaa
      841 gttgtgggct tccccagacc acactggata ctggacagtt tgtgaactgc tccaccacgg
      901 aggaggcacc atcttgcctg ctgaaacttg gaacctgggt tttactaaag ccagggaaac
      961 agtgctgcca tgtggtggcg agctgtcacc tggacctcac ctctccccat ggatctcagc
     1021 tctgccaata gatgccactg taaactgttt gctatataat tctgagtatg aagcctcatt
     1081 tccacgagtt gaaggaacat tatttctccc tgttaaaggc aaagaaattc aagaaacatg
     1141 ggcaatctgc ctggagcctt tagctatgca tcagagacat tttcaaaagc ccgtcagaat
     1201 tttcctaaaa ggctcagtga cacagtggtc tctcccaatg agcagtgctt taggcactga
     1261 caactggatg ctacaaagtc cagaggaaca caagtcaact caaaggctgc tgtttcagga
     1321 gctggtaagc aggctgactg ctgaagaatt ccatctggtg gccagtgtgg atcctggtga
     1381 cggctggccc cccatcacgg gaattatctc cccattctct gccaatgcca tgattctcac
     1441 agtgctccga gccaaagaag ctgaatttca aagacatttt ctccagacag ctgtgactga
     1501 aggttcccag gatgtaactt ccctgttctc agatgccgtg gatagtgtac tgaatcaggt
     1561 tcataattca tttgaagatc ctgcttcttc tgtctcccgt gttccagaat gggtccagca
     1621 ggagcttagt cgtaccagtc cctggagtcc agctcttgtc gaaaagtggt ttcctttctc
     1681 caatgtctgt ggtgccactt cagacttgat ggaatcattt ttgttgttgc acgctgcctc
     1741 ccctgataat aatgaatcct ccagaactga aagtgagcta acacgctgcc tctctgagct
     1801 ctaccagaga agatctcacg aagagtctac tgtagttaat caagaacgca gcagaaagaa
     1861 acgtggcatc cctcgaactc cggtgagaca gaagatgaat accatgtccc gctccttgaa
     1921 gatgctgaat gtggcgaggc taaatgtaaa ggctcagaag ttacatccag atgggagtcc
     1981 agacatggct gtggagaagg ggctcccaaa gactgtcatt ggcagaacag cagacaaatt
     2041 ggaagataga ggaagagtat taagaagttc taaacttaaa gaatttaaaa ctgaagagga
     2101 gcttctggct tacatacatg acaactacca aaagactgtg gctacaggag aaattacatt
     2161 acattcatgt gctcaaaata cggtctcaac cattaaaatt ttcctgaagt ccaaggacgt
     2221 caaggaatta gaaatgactt gcatgaatca tatgaatagt aacctcttaa aaaccagcaa
     2281 gaccctccga cagaacctag ggggaaagac ggataaagaa gacaaagtca gagagtgcca
     2341 gctccaggta tttcttcgtc tggagatgtg tcagcagtgc ccctcagtcc tggaccggac
     2401 ggaggaggta gagcacgtgg tggaggaggt gacagatctg ctgcgtgtgg tgtgtctcac
     2461 taaggactca gcatacctgt cagagtttct ggaggagatt ttgggattgt atattgactc
     2521 catcccaggg acaattggac aactttacca cagcctgggg ttaaagattc ctcagaagct
     2581 ggctggagtt cttcctacag actttttcag tgatgattct atgactcaag agagcatgtc
     2641 accacctccc tcatcaagca ctcacagatc agtgtcggcc attactgagt ctgagcagct
     2701 ggaggagctt cggaccagat cagccaagaa gagaaggaaa aatgcactaa taagacataa
     2761 aagtattgca gagatttccc aggctcttcg acaaattgaa gttcccaaag tgtccaagag
     2821 agctacaagg agtgagagcg cccaccctgc ttccgtacag ctaccactcc cgagaaaaga
     2881 cacagtacag gaagtgacaa aagttcgaag aaaccttttc aaccagggaa tgctttctcc
     2941 ttcaaagagg gggttgaaga aagggctgcc tcggagccgt tctgtttcaa ctttggaatg
     3001 tctacagcat aagcaggaca agttgaagaa aaccaaaagc agtacattcc agggttataa
     3061 actgctgact aagagtgtgg ctgagacccc agtccataag caaatctcca ggaggctgct
     3121 ccacagacaa atcaagggca ggtcttctga tcctggtcct gatattcatg tagttgaaga
     3181 gtctcctgaa aaagaggatg agatgatttt gagaagaagt cctcgaatca agcagctgtc
     3241 atttagcaga acaaattctg gctccttcta ttctgtatct cagccaaagt ctcgaagtgt
     3301 gcaaagaatc cactcctccc agcagaagtc agaccaaaga gaaaattttc cagttcaaag
     3361 tattcggtct cctaaaacac ttctttttgg ggcattgtct gagacaccta gctcctccaa
     3421 gaaaggttca cccggaatta agagatcctc aagaagcatg ttggattctg agatctctac
     3481 agcttacgag actcccaaaa agaataacca aaaatctcca agcttttcta aaactacacc
     3541 aagaagtttc cctcgtacag cacaaacctt actgtacact ccagaaagac tacagaactc
     3601 ctctacagaa ataacatcag ctgaggggac catttctgaa gtagccataa aaaccccctc
     3661 ttcccacggt tacaactcac catctgcatc aaaagtcact cctcagaaga gagcctcccc
     3721 agcaaaagag gagacttctc ccctcacaga gctacccagc atacccagag agtctgatgt
     3781 ccaaccacct cagtgctcgt caaactcagt gagctccagt tcagaaggtc cctgttgtcc
     3841 agcatcccca cctcctttgg ctggccaggc caggggtcag tgtctaaccc ctgtaagata
     3901 ctccttcaga actcctccac gtacagccct tgctgtcaca tctacgtatc aggagcacca
     3961 agagctccct ctccgcaggg cctctcaggc acgagaacct ccacagagac tggaggagaa
     4021 agctctcaaa atcccaaaga aaccaacaga cacaagtact tcacctcttt ctccaaagga
     4081 acattttact tctcctggat gtaatgtctc cccacatcaa cctagcatct cttctttgtc
     4141 agcctccccg tctggagaac tgagttggaa agaaaaccag acatcaccta gtgtaactac
     4201 atctgtctct tgtcctgttc cttcaactcc tcccagaacg ccacagagaa tgatctgccc
     4261 tataccccct tctccaccat ctaagcttcg gagaccatgt agaaagaagt cctgtcttcc
     4321 ccaggacttc ccagagtgcc agcctggacc ctgtgctgtt ccagtgcttg gcacaaccac
     4381 cagcccaggg actgtcagag gctctagaga ggagcagtct caaccttctg aagggcacag
     4441 ttacctgggc actagcttcg ggagtgactg gcatgtgtcc tctcctatgc tcattgcaag
     4501 tgacacggag tgccttcctc tgattgatga agcccaactc cataggcttg aaaaccaaga
     4561 ggtaaaaagt ggcgtcttgc caggggaaga aggtgaggaa ccagagacca ccactgctga
     4621 gcctccctct gtgtctgacc ttgggattct tgtacctgct ccttcctctg tgtctaactc
     4681 ccctgagctg ctgtcctaca ccctgtgccg cgtagcagat ggaaggcaga gtcacgatgc
     4741 tgctcagcag gagagtccac cagcctcaga ggccactgac agccctcaga cctatgacgt
     4801 tgagctggag atgcaagctt ctggccttcc caagctccga attaaaaaaa tagaccccgg
     4861 agttcttttg gaacctgagg ccctaggaag ggaaaccctc ctgggagagg agggcacttt
     4921 ccctgctctc tccatgccca aggccagtaa gtcctctggt agaagtgagc acacttactt
     4981 gtcaccccct tgtctcctcc cctcacacag cacgcctggc aagagtgggg gtcaaacctt
     5041 catctgccaa tcttgtactc cctcccgctg cccacccagt accccctctc catttcaagc
     5101 agatgttggg gtttcttgga caccatcccc taagcaaagt ggaaagacca ctcctgaaat
     5161 catcaaagac tggccccgaa ggaagagggc agtggactgc agtgccggac cctcagctgg
     5221 aagaggcgag gccagtatgg accttcctgg gtctttgtca ctacttgagc ctgagcctga
     5281 gggaaaagag caaagccttg aacaagacct ctgtaaggtt ctcatcttgg aggattttga
     5341 actagagggt gtgtgtcaat tgccagacca gtcacctccc aaacacagtg tgtctatggc
     5401 tgaggaaacc tcctgggaac aatttggctt aggcagaaag agactcttgt ctgccaagga
     5461 agaatctgaa tataacggca aaaggctctg tgattccccg agcgaggatc cccaagctag
     5521 tgagcataaa gagtgctctc catgttggag tgcaccacca gtcccttctg taggggatga
     5581 tgaggtgttt gtttctggct ccactccacc ctctggctac atggttcgga gctgcctctc
     5641 tgcgagtggt ctgcaggccc tgacccagtc tccactgctg ttccagggaa gaacgccctc
     5701 ctctcatagc aaagacacca gagatgagga tgtggatgtg tttccctcca ctgctgaaga
     5761 atctcctttc agccaaaccc tgtctcggaa acggcctttc agaacttaca caaggaagaa
     5821 gcttattagc tagctctggt acaacatcac cggaggactc aaaacaagga acactgtgag
     5881 cctggccaga ctcatcgcat caatccagca atgcgcccag aacaagagta gccaggactt
     5941 catgggactg agaaagttca caagtaaagg ttgacagcag ctcggttcct gtggacttta
     6001 agaaactgga gactatgcag ggtatggtag taagcctatc tatagtccta gcacttggga
     6061 gatggagacg gaagcatcag aagattctga ctacgtagca tgtacagcct gggctatatg
     6121 agaccctgtc tcaaaaacaa caaaagacat taagggcctt aggccttttc cccatagcca
     6181 ttgttcagat taccactgga atgcctcatg gtcttcaaat ctttcttgtg gtcttcatat
     6241 gaggccaggc cctgaccctt ttgggggaag gttggaaatc aggtgggcag ctgatactat
     6301 atataactca gacagcccag gagtctgatc ccaatcaaag atcccattcc aggccttggt
     6361 ggttcagagg accactgcca cactgtgaaa tggacaaaag aaacccttga catagtctct
     6421 tgaggtgtta accaaagctt gagtgctttg acacaagcgg tccttcataa agtaagaccc
     6481 ctaaatgaaa gactacagca agaagcgagg taacaataaa gtcatcctgg taactta
//
