LOCUS       NM_001108890            3315 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TIR domain containing adaptor molecule 2
            (Ticam2), mRNA.
ACCESSION   NM_001108890 XM_001054397 XM_344681
VERSION     NM_001108890.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3315)
  AUTHORS   Skjesol,A., Yurchenko,M., Bosl,K., Gravastrand,C., Nilsen,K.E.,
            Grovdal,L.M., Agliano,F., Patane,F., Lentini,G., Kim,H., Teti,G.,
            Kumar Sharma,A., Kandasamy,R.K., Sporsheim,B., Starheim,K.K.,
            Golenbock,D.T., Stenmark,H., McCaffrey,M., Espevik,T. and
            Husebye,H.
  TITLE     The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative
            bacteria by interacting with the Rab11-family interacting protein 2
  JOURNAL   PLoS Pathog 15 (3), e1007684 (2019)
   PUBMED   30883606
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3315)
  AUTHORS   Liao,J., Jijon,H.B., Kim,I.R., Goel,G., Doan,A., Sokol,H.,
            Bauer,H., Herrmann,B.G., Lassen,K.G. and Xavier,R.J.
  TITLE     An image-based genetic assay identifies genes in T1D susceptibility
            loci controlling cellular antiviral immunity in mouse
  JOURNAL   PLoS One 9 (9), e108777 (2014)
   PUBMED   25268627
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3315)
  AUTHORS   Ohnishi,H., Tochio,H., Kato,Z., Kawamoto,N., Kimura,T., Kubota,K.,
            Yamamoto,T., Funasaka,T., Nakano,H., Wong,R.W., Shirakawa,M. and
            Kondo,N.
  TITLE     TRAM is involved in IL-18 signaling and functions as a sorting
            adaptor for MyD88
  JOURNAL   PLoS One 7 (6), e38423 (2012)
   PUBMED   22685567
REFERENCE   4  (bases 1 to 3315)
  AUTHORS   Kumar,H., Kawai,T. and Akira,S.
  TITLE     Pathogen recognition by the innate immune system
  JOURNAL   Int Rev Immunol 30 (1), 16-34 (2011)
   PUBMED   21235323
  REMARK    Review article
REFERENCE   5  (bases 1 to 3315)
  AUTHORS   Palsson-McDermott,E.M., Doyle,S.L., McGettrick,A.F., Hardy,M.,
            Husebye,H., Banahan,K., Gong,M., Golenbock,D., Espevik,T. and
            O'Neill,L.A.
  TITLE     TAG, a splice variant of the adaptor TRAM, negatively regulates the
            adaptor MyD88-independent TLR4 pathway
  JOURNAL   Nat Immunol 10 (6), 579-586 (2009)
   PUBMED   19412184
REFERENCE   6  (bases 1 to 3315)
  AUTHORS   Kagan,J.C., Su,T., Horng,T., Chow,A., Akira,S. and Medzhitov,R.
  TITLE     TRAM couples endocytosis of Toll-like receptor 4 to the induction
            of interferon-beta
  JOURNAL   Nat Immunol 9 (4), 361-368 (2008)
   PUBMED   18297073
REFERENCE   7  (bases 1 to 3315)
  AUTHORS   Yamamoto,M., Sato,S., Hemmi,H., Uematsu,S., Hoshino,K., Kaisho,T.,
            Takeuchi,O., Takeda,K. and Akira,S.
  TITLE     TRAM is specifically involved in the Toll-like receptor 4-mediated
            MyD88-independent signaling pathway
  JOURNAL   Nat Immunol 4 (11), 1144-1150 (2003)
   PUBMED   14556004
REFERENCE   8  (bases 1 to 3315)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473971.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344681.3, XM_001054397.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BF286065.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760476,
                                    SAMN12840112 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3315
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3315
                     /gene="Ticam2"
                     /note="TIR domain containing adaptor molecule 2"
                     /db_xref="GeneID:364867"
                     /db_xref="RGD:1308258"
     exon            1..313
                     /gene="Ticam2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..416
                     /gene="Ticam2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..3315
                     /gene="Ticam2"
                     /inference="alignment:Splign:2.1.0"
     CDS             475..1173
                     /gene="Ticam2"
                     /note="toll-like receptor adaptor molecule 2"
                     /codon_start=1
                     /product="TIR domain-containing adapter molecule 2"
                     /protein_id="NP_001102360.1"
                     /db_xref="GeneID:364867"
                     /db_xref="RGD:1308258"
                     /translation="MGVGKSKLDKCPLSWHKRDSVDGDQGCHESDSKNSENASSPAFV
                     VHSNGVEQPIGEQDRPEAKGEGHEEQAEEEFLKFVILHAEDDTNEALRVQNLLQNDFG
                     IRPGIVFAEMPCGRLHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNSVNR
                     QHKYNSVIPMRPLNSPLPRERTPLALQTINALEEESQGFSTQVERIFRESVYERQQSV
                     WKETRSVTQRQFIA"
ORIGIN      
        1 tctgcttcct cctggggaca gtacacccca tcctgtagct ggtggcccag tctggcgaga
       61 cccgtggacc cgcagagcac gcagagcacg acttccgaag gcgaagtcca ccgccctgag
      121 ggctccatgg ccagtcctgg actctgcagg ctcagtgggc gtggcgtgcg gagccacact
      181 gcctttggga cacgatctac gacagtaaca tcctaacttt caaagttctg tggcaagccg
      241 cttgtcaaca agggctcgct cagtgggaga gcaagaccaa agagcctcgt ggccgcgcag
      301 caccgcttcc cagctgactg ctttctcctg tgctcctacc cactgctgac ttaggcttct
      361 caaccactga atggtaaggt gtcacagagc ccggtataag atgagttctt tttaatattg
      421 aaaagaaaca ttgattctca aataaagctc cctcttctgc cccgtcagtc cgtcatgggt
      481 gttgggaagt ctaaactaga taagtgccct ctttcttggc ataaaagaga cagtgtggat
      541 ggcgatcaag gctgccatga gtcagactcc aagaactctg agaatgcgtc ctcgcctgct
      601 tttgtggtgc atagcaatgg agtagaacag ccaatagggg agcaggacag acccgaggca
      661 aagggggagg ggcatgagga gcaagctgaa gaagagttcc tcaaatttgt gatactgcac
      721 gcagaagatg acaccaacga ggccctccga gtccagaatc tactgcaaaa cgactttggt
      781 atcaggcctg ggatagtctt cgccgagatg ccatgcggaa gactgcactt gcagaatcta
      841 gacgatgcgg taaatgggtc cgcctggacg atcttgttac tgactgagaa cttcttaaga
      901 gacacctggt gcaacttcca gttctacact tccctgatga attctgtgaa caggcaacac
      961 aagtacaatt ccgtcatacc tatgcggccc ctgaacagtc ctcttcccag ggaaaggact
     1021 ccgttggcgc tgcaaaccat caatgcctta gaggaagaaa gccaaggctt ttccacacaa
     1081 gtggagagga ttttccggga atctgtgtat gagaggcaac aaagtgtatg gaaggagaca
     1141 cgaagtgtga cacagagaca gttcattgcc tgaaatggag catgcacccg gctcctgttt
     1201 tgtaaacaaa atggctcacc ttcacttaag agagtggttt ctaagaaatg cttagatgtg
     1261 agtctgcttc caagaaatct gtggctcgca agaaaggtac atttctgcag ccttaggatt
     1321 gtggtacttt caaatgataa actcaagact gtcagagttt ctggcacttt tcttatagtt
     1381 ttcacagttc atgaatattc ttaactcatt tcttgtgttg aaccaggcat tttcaaaata
     1441 cgatattgaa aattctcaaa agacatgatg aaaatggctc tggctggagc aggtctgacc
     1501 acctcccttc ctgcttctct catgaatttt aaataccaca aagcatccta gcgctgtcac
     1561 acagaaacat gggtggccag aatgggacat gtgcagtata ggagtagtaa ataggagatc
     1621 agatatagac ttcgggctgg gcacaagtag cactcgcctt tagtcccagc actcaggagg
     1681 cagaggcagg aagatctctc gagttcattc gccagcctgg cctatagagt gagttccagg
     1741 atatccagag ctacatagag aaacaatatc ttgaaaaaaa attagaatta gtcaaaacag
     1801 tcaggttttg ggaaataatc cagccatgtg tggttttatt tctgctggaa ttcggaacta
     1861 gatcctacca caaattggca atcctttcga gaatgtgata gagggactct ggggagatgg
     1921 gtccccatct tgttaggtgt cttctgtgac cagggcttta attcttgtga atttaaagct
     1981 tgtgaaaaat atgcaactca tcagctcttt gcttttaaaa tcaataacct ctcacgttag
     2041 cctttagaat gtcccttgag tgtttaactc agggaatgtt tcttagctag ggcagtgtgt
     2101 gtgtatgtgt gtgtgtttgt gtgtgtgtgt gtgtgctcgc acactcgcac gtgcgtgcac
     2161 acgcgtgtgc cagggagggc cacatagacc tgtacctttc cctcatagaa cttcaaccca
     2221 tttgagactg tcaaacaagt acagactggg agtgtgacta ggggtgagtc acatcaaata
     2281 atgaggaagt gctgcttggg gagcaggaga cctacttgca gtccaatctc tgccactgag
     2341 gatgaatgtg ccagtgggca gctattctcc tttgtctgtg aaataaaagg gttggattaa
     2401 tggatctcta aaggcttttg tcctttccca agatgggaaa aaccgaagcc agaaagcaat
     2461 aagcagagcc ttaaactttt atgaggtgac acacaatgta atcattgtag aagacataat
     2521 gcatgtttac aacaagtaga tatttttgta tatttgcatc ctcattgata tttactgcag
     2581 tcacaggaaa gaattactat atatccctac ttgggtcttt gggttcagtt ttgtacagca
     2641 tctcatatgt agtcctggct ggcctgaaac tgacaataga ccagtttggc atcaaactca
     2701 cagatccacc tgacaatgct gagattaaag gtgtgcacca ccacatcctg ctactcaggt
     2761 ttttaaaaga catatatttt tataggaact cacgaacaaa caccttcttc ctagtttgtg
     2821 tgtctcctga tcctcttctc tgaatccgca gctgctgctg ttcgtttctt atagctgaaa
     2881 gctactgtgc cacacagtca gacctcttgt tcagttctca gagaggtgac tgctttcata
     2941 gcattttctt gaccttcttt gccatggtaa cttactactt agctttgagt ctgttgttgt
     3001 tattattatt gttattatta ttattattac taccacaatg cttactacat ctcaagcgtc
     3061 aggtaatgat aaaacattaa ccacccatcc ttcacatgcc tgccaaactg agactgatgc
     3121 tcgccgtcac ttcttcaata aatgttttta ttctttatgg ttgactaacc atcattctca
     3181 tctccagtga agactgtgaa aaagtattct gagaaatgtc aacccgtgcc tgtcagataa
     3241 tgtggcatga tgtcccaggc aatctggagt tccgcatttt ttcttgcgat gaaaaagtaa
     3301 attttaggtg ctgag
//
