LOCUS       XM_017589892            6478 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus TIAM Rac1 associated GEF 2 (Tiam2),
            transcript variant X4, mRNA.
ACCESSION   XM_017589892
VERSION     XM_017589892.2
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 25, 2024 this sequence was replaced by
            NM_001427473.1.
            
            On Jan 21, 2021 this sequence version replaced XM_017589892.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6478
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6478
                     /gene="Tiam2"
                     /note="TIAM Rac1 associated GEF 2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 6
                     ESTs, 4 long SRA reads, 14 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 31 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:100362710"
                     /db_xref="RGD:2324148"
     CDS             882..6026
                     /gene="Tiam2"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor TIAM2
                     isoform X1"
                     /protein_id="XP_017445381.1"
                     /db_xref="GeneID:100362710"
                     /db_xref="RGD:2324148"
                     /translation="MGNSESQYTFQGSKNQSNTVTGAKQKPCSLKIRSIHAKDEKSLH
                     GWAHGSGGAGYKSRSLARSCLSHFKSHQPYATRLNGPTCKVSKGTAYSKHRANAPGND
                     FQGNNGAFLPENGFHYVGRESGESHITSRDCNGHLLTCYGRHDSIASTPPGEDRRSPR
                     VLIKTLGKLDGCLRVEFHNGGNPHKGPSEDPSEPVQLLRYSPTLAAETCPVPESRRLS
                     GAGSSASQRPSPTDSCLRSSKGSSLSSESSWYDSPWGNAGEASEVDGTFLAPSALDPS
                     LPSSFPPSDTKKPFNQSSSLSSLRELYKDANLGCRSPSGTCLSSNEYISSQVGLNNRV
                     SFASDMDVPSRVDHRDTMQYSSFTLPCRKSKALTEDAAKKDTLKARMRRFSDWTGSLS
                     RKKRKLQEPRSTEGSEYFDSHSDGLNADVQGPTQTSALLWSGGSAQTLPHRSESTHAI
                     GSDPLQQNIYENFMRELEMSRTNMENAETSTETVESSSESLSSLEQLDLLFEKEQGVV
                     RKAGWLFFKPLVTLQKERKLELVARRKWKQYWVTLKGCTLMFYETYGKNSTDQNSAPR
                     CALFAEDSIVQSVPEHPKKEHVFCLSNSYGDVYLFQATSQTDLENWITAIHSACASLF
                     AKKHGKEDTVRLLKSQTRGLLQKIDMDSKMKKMAELQLSVVSDPKNRKAIENQIRQWE
                     QNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAATSRPSKLALGRLGVLSVSSFHALV
                     CSRDDSALRKRTLSFTQRAKSKKGLFSSLKGLDTLARKGREKRASITQMFDSSHSHGY
                     LGTQLPQNSTNSSEVHDLHLYGSSADSTLRDSTWEVQTYVHFQDNEGVTVIIKPEHRV
                     EDVLALACKMRHLEPTRYGLQLRKVVDESVEWCVPALYEYMQEQVYDEIEVFPLSVYD
                     VQLTKTGDMTDFGFAVTAQVDEHQHLSRIFISDVLPDSLAYGGGLRKGNEIRSLNGEA
                     VSDLDLKQMEALFSEKSVGLTLVARPADTRASLCTSCSDSDLFSRDQKSLLPSPNQCQ
                     LLEEFLDNFKKTSTNDFSNVPDVTTGLKRSHTEGTLDQVPHREKMEQTFRSAEQIVEL
                     CRGTTSMEAPTDSRDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLE
                     PLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFSVLETPSQFRKLLF
                     SLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDRAFKAFLDARNPTKQHSSTLES
                     YLIKPVQRVLKYPLLLKELVSLTDHESEEHYHLTEALKAMEKVASHINEMQKIYEDYG
                     TVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDIELTVFVFKRAV
                     ILVYKENCKLKKKLPSNSRPAHNSADLDPFKFRWLIPISALQVRLGNTAGTENNSTWE
                     LIHTKSEIEGRPETIFQLCCSDSESKTSIVKVIRSILRENFRRHIKCELPMEKTCKDR
                     LVPLKNRVPVSAKLASSRSLKVLRTSSSSEWPSDPSKGNSLDSDECSLSSGTQSSGCP
                     VAESRQDCKSTVLEKDAHEVLAEFPDGLIKESDILSDEEEDFHHPLKQGSPTKDIELQ
                     FQRLRISEEPDMHSTGQQPPLTGPGEQPKLVRGHFCPIKRKANSTKRGRGTLLKAQTR
                     HQSLDSHPETASIDLNLVLEREFSVQSLTSVVNEECFYETQSHGKS"
ORIGIN      
        1 tgcctccatt gtatgacctt aatttacagt aatgtaacac atactctcga taaaatgcct
       61 ccacatttag tctcccagga cttggagtgt aagactctgc tgctgcgcta acttaagggg
      121 gaaaagcccg attccaaaag gaacgctgag tgagggtata tccgatattc tgcaaatcgc
      181 agccttgttt ccaggggccg ctctgaaggc agcttttctg accatagcat tccatctgtg
      241 gttttgactg cttccccaaa cacaaggaca gtaggtgtgt actccccgtg ctccggggct
      301 ttataaaggc gaccagagca gccctggtga gtaaggcttt attctgtagc cctcagagcc
      361 agactcctgt ggaacttcgg tggtcatggt agattgctgg cccaacaaga gcctagtcat
      421 gggcagcccg gtgtctctga ggcatgcatg gtggcaggct gtcccgggta atcactccag
      481 gcagcccacg gaaaaaccgc tttctggtta agtctgcctc atagagttcc atcaatggaa
      541 aaaattgaac atgatgaggg tgtgtaacga gcagacaaat atatccagca ttgcacagga
      601 tccgttttta gctctcaacg gctgagcagt caaagtgtta gacaccgttt cctggctcag
      661 cagggcagaa ggaaggcaga gcatagcttc tagctgggtg gaactttgtt aaccgtaggt
      721 tccagagaac cactggccac agccaccttt ctgaccaagg gccacttcat ggactttccc
      781 tgcacaccta cacttgttaa atacctgctt tgttcccaag accatgtaaa acccgctgag
      841 cattaaccac cctcccagcg aaagccaggc tgcaggttaa gatggggaac tccgagagtc
      901 aatatacctt ccaaggatcc aagaatcaaa gcaatactgt cactggtgct aagcagaagc
      961 cgtgctctct gaagatacgc agcattcatg caaaagatga gaagtccttg catggttggg
     1021 ctcacgggag cggcggagca ggctacaagt ccagatccct agccaggagc tgcctttctc
     1081 actttaagag tcaccagcct tacgccacca gactcaatgg acccacgtgt aaagtctcaa
     1141 agggcactgc ctactctaag cacagagcaa atgccccagg aaatgatttt cagggcaaca
     1201 atggtgcttt cttacccgag aatggcttcc actatgttgg gcgcgagtca ggggagagcc
     1261 acatcacctc cagggactgc aatggacacc ttctcacctg ctatgggaga cacgacagca
     1321 ttgcctccac tcctccaggt gaggaccgca ggagccccag ggtgctcatc aagacactgg
     1381 ggaagctaga tgggtgttta agagttgagt tccacaatgg cggcaacccc cacaaagggc
     1441 cctcagagga ccccagtgaa cctgtacagc tgctaagata ctcccctacg ttagcagcgg
     1501 aaacctgccc ggtgccggaa agtaggcggc tttcgggtgc aggctcctca gccagccagc
     1561 gcccttctcc cactgactct tgcctgcgct ccagtaaagg cagctccctg agctcggagt
     1621 cctcctggta tgactccccc tggggcaacg caggggaggc gagtgaagtg gacggcacct
     1681 tcctggctcc cagtgctcta gaccccagcc tccccagcag cttcccaccc agtgacacca
     1741 aaaagccttt caaccaaagc tcttccctct cctctctccg ggaactgtac aaagatgcca
     1801 acctggggtg ccgctcacct tccggcacct gcctttcttc caacgagtac attagctccc
     1861 aagtcggcct gaacaaccga gtctcctttg cttctgacat ggatgtgccc tccagggtgg
     1921 atcacaggga caccatgcag tacagctcct ttactctccc gtgtcgcaag tccaaagcct
     1981 taactgagga tgcagctaag aaagacaccc tcaaagccag aatgcggcgc ttcagtgact
     2041 ggacaggaag cctttccagg aagaagagga aattgcagga acccagatcc acggagggca
     2101 gtgagtactt cgatagccac tcggatggac tgaatgcaga tgtgcagggg cccacgcaga
     2161 catctgcctt actgtggtca gggggctcag ctcagaccct gcctcacaga agcgaatcca
     2221 ctcacgcaat cggcagcgat cccctccaac agaacatcta cgagaatttc atgcgagagc
     2281 tggaaatgag caggaccaac atggagaacg cggaaacgtc cacagagact gtggagtcca
     2341 gcagcgagtc cctcagctcg ctggagcagc tggatctgct ctttgagaag gagcaggggg
     2401 tggtccgaaa agctgggtgg ctcttcttca aaccccttgt caccttgcag aaggagagga
     2461 aactggagct ggtggctcgg aggaagtgga aacagtactg ggtgaccctg aaaggctgta
     2521 ctctgatgtt ttatgagacc tacggaaaga attccacaga ccagaatagc gccccacggt
     2581 gtgccctctt tgcagaggac agcattgtgc agtctgtccc agagcatccc aagaaggagc
     2641 acgtgttctg cctgagtaac tcctatggag atgtctacct tttccaggcc actagccaga
     2701 cggatctgga aaactggatc actgccatac actcggcgtg cgcatccctc tttgcaaaga
     2761 agcatgggaa agaagacacg gtgcggctgc tgaagagcca gaccagaggc ctgcttcaga
     2821 agatagacat ggacagcaag atgaagaaga tggcagagct gcagctgtct gtggtgagcg
     2881 accccaagaa caggaaggcc atcgaaaacc agatccggca atgggagcag aacctggaaa
     2941 aattccacat ggacctgttc cgcatgcgct gctatttggc aagcttacaa ggtggggagt
     3001 taccaaaccc caagagtctc cttgcagcca ccagccgccc ctccaagctg gctcttggca
     3061 gactgggcgt cctgtctgtt tcatctttcc atgctctggt atgttccaga gacgattctg
     3121 ctctcaggaa aagaacactt tcctttaccc agagagcaaa aagcaagaaa ggcctatttt
     3181 cttcattgaa aggtctggac actctagcaa gaaaagggag ggagaagaga gcttctataa
     3241 ctcagatgtt tgattcgagc cacagccatg gatatcttgg aactcaacta cctcaaaact
     3301 ccactaactc cagtgaggtc catgacctgc atctgtatgg ctcctcagca gacagcactc
     3361 tccgagacag cacgtgggaa gtacagactt atgtccactt ccaggataac gaaggagtca
     3421 ctgtgatcat caagccagag cacagggtgg aagatgttct ggctttggca tgcaagatga
     3481 ggcacttgga acccactcgc tatggtcttc agctccgaaa ggtggtggat gaaagtgtgg
     3541 agtggtgtgt gcccgcgttg tatgagtaca tgcaggagca ggtttatgat gaaattgaag
     3601 tcttcccact cagtgtgtat gacgtgcagc taaccaagac gggggacatg actgactttg
     3661 ggtttgcagt cacagcccag gtggacgagc accagcatct cagccggata tttatcagcg
     3721 atgttctccc tgacagcctg gcgtatggag gaggactgag aaagggcaat gaaatcagga
     3781 gcttaaatgg ggaagcagtg tctgaccttg acctcaagca gatggaggct ttgttttctg
     3841 agaagagcgt tggactcact ctagtcgccc ggcctgcaga cacaagagca agcctgtgta
     3901 cttcctgctc agacagtgac ctgttctcca gggaccagaa aagtctgctg ccctctccca
     3961 accagtgcca actgctggag gaattcctgg ataactttaa aaaaacctcc acaaacgatt
     4021 tcagcaatgt ccctgacgtc acaactggcc tgaagaggag ccatacagaa ggcaccctgg
     4081 atcaggtgcc ccacagggag aagatggagc agacattccg gagtgctgag cagattgtgg
     4141 agctctgcag aggcaccacc agtatggaag caccgacaga cagccgcgac ccgcctccca
     4201 ggcctctggc tcgtcacctc tcagatgcag accgcctccg aaaagtcatc caggagcttg
     4261 tagacaccga gaagtcttac gtgaaggatc tgagctgcct ctttgaactg tacttggagc
     4321 cccttcagaa cgagaccttt cttacccaag atgagatgga gtcacttttt gggagcttgc
     4381 cagagatgct ggaatttcaa aaggtgttcc tggagactct ggaggatggg atctctgctt
     4441 cctcagactt tagtgtcctg gaaaccccct cacagtttcg gaaattgctg ttctctctcg
     4501 gaggctcttt cctctactac gcagatcact ttaaactgta cagtggattc tgcgccaacc
     4561 acattaaagt acagaaggtc ctagagcgag ctaaaaccga cagagctttc aaggcttttc
     4621 tggacgcgcg gaaccccacg aagcagcact cctccacgct ggagtcatat ctcatcaagc
     4681 ctgttcagag agtgctcaag tatcctctgc tcctcaagga gctcgtgtca ctgactgacc
     4741 atgagagcga agaacactat cacctgacag aagctctaaa ggccatggaa aaagtagcca
     4801 gtcacatcaa tgagatgcag aagatctacg aggactatgg gacggtgttt gaccagctgg
     4861 tggcagagca gagtggcaca gagaaggagg taacagagct gtccatgggg gaacttctga
     4921 tgcactctac agtttcctgg ttgaatccgt tcctgtctct gggaaaagcc aggaaggaca
     4981 ttgagctcac agtgtttgtt tttaagagag ctgtcatact ggtttataaa gaaaactgca
     5041 agctgaaaaa gaaactgccc tccaattccc ggcctgctca caactctgct gacttggacc
     5101 catttaaatt ccgctggttg atccccatat ctgcgcttca agttagactg gggaacacgg
     5161 cagggactga aaacaattcc acctgggagc tgattcatac caagtcagaa attgaaggac
     5221 ggccagagac catctttcaa ctgtgctgca gtgacagcga gagcaaaacc agcatcgtta
     5281 aggtgatccg ttctattctg agagagaact tcaggcgcca cataaagtgt gagttaccaa
     5341 tggagaagac atgtaaggac cggctggtac ctcttaagaa ccgagttcct gtttcagcca
     5401 aattagcctc atccaggtct ttgaaggtcc tcagaacatc ctccagcagc gagtggccca
     5461 gcgaccccag caagggcaac tcactggact cggatgagtg cagcctgagc agtggcaccc
     5521 agagcagtgg ctgcccagta gctgagagca gacaagactg taagagcacc gtgctggaga
     5581 aagacgctca tgaggtcctg gcagagtttc cagatggtct catcaaagaa agcgacattc
     5641 taagtgatga agaggaggac ttccaccacc ctctgaaaca gggcagccct actaaggaca
     5701 ttgagcttca gttccagaga ctgcgaatct ctgaggaacc cgatatgcac tcaactgggc
     5761 agcagccgcc tctcacaggg ccgggtgaac agcccaagct ggtcaggggc cacttttgcc
     5821 ccattaagcg taaagcaaac agcactaaga ggggccgagg aactttgctc aaggcgcaga
     5881 cacgtcacca gtccctggac agccacccgg aaaccgccag catcgatcta aatttggttc
     5941 tggagagaga attcagtgtc cagagcttaa cttcagttgt taatgaggag tgtttttatg
     6001 aaacacagag ccatggcaaa tcctagtgtg atctgtatgg cgtggttaca atgctcattt
     6061 tcaaattggt ggaaaataga aactgcagga aaactgttca tgtttgggtt ttatgcagta
     6121 tataattttc cacaaaacct gtaaagattt aagttatttt aatttattgt gaatcagaaa
     6181 actagattta gttggtcaga atctgtaaat tactagcttc tatccctttt gagcaggaat
     6241 caaatgattt ttagtcttgt aataaaattg cattctaatt attttaagtt atgtgggata
     6301 agattgggaa cgttgtgatt aatagctttt aaaggcccct ccccccagtc ctttgggcat
     6361 tttctttgcg ctgttagttt ttgcttcatt taaagcacat ttatgtttac atggtttagg
     6421 ggcacaatgt gcagacattt cattttggaa ggttgtaata aatgctgttt atactaaa
//
