LOCUS       XM_039088430            7515 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus TIAM Rac1 associated GEF 1 (Tiam1),
            transcript variant X2, mRNA.
ACCESSION   XM_039088430
VERSION     XM_039088430.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051346.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039088430.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..7515
                     /gene="Tiam1"
                     /note="TIAM Rac1 associated GEF 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 37 ESTs, 2 long SRA reads, 9 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 47 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:304109"
                     /db_xref="RGD:1307455"
     CDS             662..5434
                     /gene="Tiam1"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor TIAM1
                     isoform X2"
                     /protein_id="XP_038944358.1"
                     /db_xref="GeneID:304109"
                     /db_xref="RGD:1307455"
                     /translation="MGNAESQNVDHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASS
                     GKAIHRNSEVSTRSSSTPSIPQSLAENGLEPFSQEGALDDFGDPIWVDRVDMGLRPVS
                     YTDSSVTPSVDGSIVLTAASVQSMPDSEESRLYGDDAAYLAEGGRRQRPYTSNGPTFM
                     ETASFKKKRSKSADIWREDSLEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETGA
                     SPRQLSTCQRANSLGDLYAQKNSGVKANGGPRNRFSSYCRNLVSDIPDLAKHKMPPAA
                     VETPTYSNYNTLPCRKSHCLSEGATNPQISLSKSMQGRRAKTTQDVNTGEGSEFADSG
                     IEGATTDTDLLSRRSNATNSSYSPPTGRAFVGSDSGSSSTGDAARQGVYENFRRELEM
                     STTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKN
                     KKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSVPKHAVWVENSIVQAVPEHP
                     KKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACAAAVARHHHKEDTLRLLKSEI
                     KKLEQKIDMDEKMKKMGEMQLSSVTDAKKKKTILDQIFVWEQNLEQFQMDLFRFRCYL
                     ASLQGGELPNPKRLLGFASRPTKVAMGRLGIFSVSSFHALVAARTGEIGVRRRTQAMS
                     RSASKRRSRFSSLWGLDTTSKKKQGRPTINQVFGEGTDAVKRSLEGIFDDSVPDGKRE
                     KEVVLPSVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKAHQ
                     LDHSAHYLRLKFLMENKMQFYVPQPEEDIYELLYKEIEICPKVTQNIHIEKSDAAADN
                     YGFLLSSVDEDGVRRLYVNSVKETGLASKKGLKAGDEILQINNRAAGTLNSSMLKDFL
                     SQPSLGLLVRTYPEPEGGVELLENPPHRVDGPVDLGESPLTFLTSNPGHSLSSEQGSS
                     AETAPEEGEGPDLESSDETDHSSKSTEQVTAFCRSLHEMSPSDSSPSPQDATSPQLAT
                     TRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLT
                     EMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCA
                     SHTKVPKVLVKAKTDTAFKAFLDAQNPRQQHSSTLESYLIKPIQRVLKYPLLLRELFA
                     LTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLS
                     MGDLLLHTSVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLS
                     IYEEWDPFRFRHMIPTEALQVRALPSADAEANAVCEIVHVKSESEGRPERVFHLCCSS
                     PESRKDFLKSVHSILRDKHRRQLLKTESLPSAQQYVPFGGKRLCALKGARPAMSRAVS
                     APSKSLGRRRRRLARNRFTIDSDAISASSPEKEPQQPPGGGDTDRWVEEQFDLAQYEE
                     QDDIKETDILSDDDEFCESAKGASVDIDLQEQLQAASISQRARGRKTLDSHASRMTQL
                     KKQAALSGINGGLESASEEVIWVRREDFAPSRKLNTEI"
ORIGIN      
        1 gaggccgctg gcccaggagc cctgacagtt cccattggca gaccgcgagc ggccgaaggg
       61 ctgagcagcg ccgctgccgt cgggttcgta gctttgcagc gccgctaagg cttcggcgcc
      121 cgcagcctca ggggcccagc ggctccgctt tgtgccgggc caggtctccg agatcctgga
      181 tgaacgtcac aggttgatgg ctgcttctgg atgttgaccc tgttggaaac ttgagctccc
      241 aatggcacag tttgacgatg cggtccagtg ttgagaagac cagcgtgccc caccgaggta
      301 gaaccactgt ggattgaaac ccacctttcc agatctgaaa ggaagaccga ggaaaaggaa
      361 gggagcatca gtccccaaga ctatgatgtt ctgaattcca gtccctcact cttgacttga
      421 acagcgcctt tccgatggca cctttggaga tcctgaccaa ggcacttctg tttggcctgg
      481 ggtttttggc acattctccc agactcaggt gagaccccga tggacacccc gtggggcagg
      541 tgctgacaca cgccccaact ccagccactg acaccatctc cagcctcagt atctaaatgc
      601 cacagtgctc tcggggccag ttgggctggg caccactgtt gcctttgaag accataaaac
      661 catgggaaac gcagaaagcc aaaatgtaga ccacgagttt tatggagaaa agcatgccag
      721 cctggggcgg aagcacacat cacgctccct gcgactgtca cacaagaccc ggaggacgcg
      781 gcatgcttcc tctgggaagg caatccacag gaactctgaa gtgagcacgc ggtccagcag
      841 cacccctagc atcccccagt ccctggccga aaatggcttg gagccctttt cccaagaagg
      901 cgccctagac gacttcgggg accccatctg ggtggaccga gtggatatgg gcttgagacc
      961 cgtgtcttac acggattctt ctgtcactcc cagcgtagac ggcagcatcg tcctcacggc
     1021 agcctctgtg cagagcatgc cagactcgga ggagagccgg ctttacgggg atgacgctgc
     1081 gtacttggct gagggaggca ggaggcagcg tccctataca tccaacgggc ccacgttcat
     1141 ggagacagcg agctttaaga agaaacgctc taaatctgca gacatctggc gggaggacag
     1201 cctggagttc tcactctcag atctgagcca agaacattta acaagcaacg aagaaatctt
     1261 gggctccgcg gaagagaagg attgcgagga ggctcggggg atggaaacag gggcgagccc
     1321 ccggcagctc agcacctgtc agcgagccaa ctccctgggt gacttgtatg ctcagaagaa
     1381 ctccggggtg aaggctaacg gaggaccgag aaacagattt tcgagctact gccggaattt
     1441 ggtgtcggat attcccgatc ttgcaaagca taagatgcca ccggctgctg tagagactcc
     1501 gacgtacagt aattataaca cgcttccctg taggaagtcg cactgtcttt ccgagggtgc
     1561 caccaaccca caaattagcc ttagcaagag catgcaaggc agaagagcga aaaccaccca
     1621 ggatgttaac acaggcgagg gcagtgagtt tgcagacagt gggatcgaag gggccaccac
     1681 ggacacggac ctcctgtcca ggagatccaa tgccaccaac tccagctact cgcctcccac
     1741 aggccgagcc tttgtgggca gcgacagcgg cagcagttcg actggggatg ctgcacgcca
     1801 gggggtgtac gagaacttca ggcgggaact ggagatgagc accaccaaca gcgagagcct
     1861 ggaggaggct ggctctgcgc acagcgacga gcagagcagc ggaaccctca gctccccggg
     1921 ccagtcggac atcctgctga cggctgcgca gggcactgtg cggaaggctg gcgcgctggc
     1981 agtcaagaac ttcctggtac ataagaagaa taagaaggtg gagtcggcta cccggaggaa
     2041 gtggaagcac tactgggtgt ccctgaaagg ttgcacgctc tttttctacg agagtgatgg
     2101 caggtctggg atagaccaca acagtgtccc caagcatgct gtctgggtgg agaacagcat
     2161 cgtgcaggcc gtacctgagc accccaagaa agattttgtc ttctgcctca gcaactccct
     2221 gggcgatgcc ttcctcttcc agaccaccag ccagacagag ctggagaact ggatcacggc
     2281 catccactct gcctgcgcag ctgcggtcgc aaggcaccac cacaaggaag acacgctccg
     2341 cctcctcaag tcggaaatca agaagctgga gcaaaagatt gacatggacg agaaaatgaa
     2401 gaagatgggc gagatgcagc tgtcctccgt cacggacgcg aagaagaaga agaccatact
     2461 tgaccagatc ttcgtttggg agcagaacct cgaacagttc cagatggacc ttttccggtt
     2521 ccgctgttac cttgccagcc tccagggcgg ggagctgcca aaccccaaac gactcctagg
     2581 ttttgccagc cggcccacca aggtggccat gggccgcctt ggcatctttt cggtatcatc
     2641 ttttcacgcc ctggtggcgg cccgcactgg cgagatcggg gtgagaaggc gtactcaggc
     2701 tatgtccagg tctgcgagca agcggaggag caggttttct tctctctggg gcctagacac
     2761 tacctccaaa aagaagcagg ggcgcccaac catcaaccag gtgtttggag aggggaccga
     2821 tgctgtaaag agatctttag agggaatatt tgatgactct gttccagacg gcaagaggga
     2881 gaaggaagtg gtcttaccca gtgtccacca gcacaatcct gactgtgaca tttgggtcca
     2941 tgaatatttc actccatcct ggttctgtct acccaataat cagccagcct tgacggttgt
     3001 ccggccgggg gacactgcga gggacacctt ggagctcatt tgcaaggcgc accaactgga
     3061 tcattctgcc cattacctgc gcctgaaatt tctgatggag aacaagatgc agttctatgt
     3121 cccgcaaccc gaggaggaca tttacgagct gctttacaaa gaaatcgaaa tctgtccgaa
     3181 agtcacccag aacatccaca ttgagaagtc cgacgcggcc gccgataatt acgggttttt
     3241 gctttcttct gtggacgaag atggcgttcg aaggctctac gtgaacagcg tcaaggaaac
     3301 cgggctagct tccaagaaag gcctgaaggc gggggacgag attcttcaga tcaataaccg
     3361 tgccgctggt accctgaact catctatgct caaagatttc ctctcacagc cctctctggg
     3421 cctcctggtg aggacctacc ctgagccaga gggaggagtg gagctgctag agaacccacc
     3481 ccaccgagtg gacggccctg tggaccttgg cgagagcccc ctcaccttcc tcaccagcaa
     3541 cccagggcac agcctctcca gcgagcaggg cagcagtgct gagacagctc cggaagaggg
     3601 cgaaggaccg gacttggagt cttccgatga gacagatcac agcagcaaga gcacagaaca
     3661 ggtcacagcg ttttgccgga gtctgcacga gatgagcccc tctgactcga gcccgtcccc
     3721 tcaggatgcc acgagccctc agctggcaac cacacgacag ctatcggacg cagataaact
     3781 gcgcaaggtg atctgtgagc tcctagagac cgaacgcacc tatgtgaagg acttaaactg
     3841 cctcatggag agatacctga agccccttca gaaggagacc tttctcaccc aggatgagct
     3901 cgatgtactc tttggaaatt taaccgaaat ggtggagttt caagttgagt tccttaaaac
     3961 tctagaagat ggagttagac tggtccctga cttggaaaag cttgagaagg ttgaccagtt
     4021 taagaaagtg ctgttctctc tggggggatc cttcctgtac tacgcggacc gcttcaagct
     4081 ctacagtgcc ttctgtgcga gccatacgaa agtccccaag gtcctggtga aagccaagac
     4141 ggacacagcc ttcaaggcat tcctagatgc ccagaacccg aggcagcagc actcgtccac
     4201 actagagtct tacctcatca agcccatcca gagggtcctc aagtacccgc ttctgctcag
     4261 ggagctgttt gcgctgaccg acgcggagag tgaggagcat taccacctgg atgtggccat
     4321 caagactatg aacaaggttg ccagtcacat caatgagatg cagaagatcc acgaagaatt
     4381 tggtgctgtg ttcgaccagc tgattgctga gcagacagga gagaagaaag aggtcgcgga
     4441 tctgagcatg ggtgacctgc tgttgcacac cagtgtcatc tggctgaacc cacccgcctc
     4501 gctgggaaag tggaaaaagg agccggaact ggcagccttc gtcttcaaaa ctgccgtggt
     4561 ccttgtgtat aaagatggtt ccaagcagaa gaagaagctc gttggctctc acaggctgtc
     4621 aatctacgag gagtgggacc ctttccggtt tcgccacatg atccctaccg aagctttgca
     4681 agtccgagct ctgcccagtg cagatgcaga ggcaaatgcc gtgtgtgaaa ttgtccacgt
     4741 gaaatcagag tcagagggga ggccggagcg ggttttccac ctctgctgca gctccccgga
     4801 gagccgaaag gattttctga agtctgtaca ctccatcctg cgagataagc acagaaggca
     4861 gctcctcaaa acggaaagtc ttccctcagc ccagcagtat gtcccttttg gaggcaagag
     4921 attgtgtgcg cttaaaggcg ccaggccagc catgagcagg gcagtgtctg ccccaagcaa
     4981 gtctcttggg aggaggaggc ggcgactggc ccgaaacagg tttaccattg attcagacgc
     5041 catctcagcc agcagcccgg agaaagagcc ccagcagccc cccggtggcg gggacactga
     5101 ccgatgggta gaggaacagt ttgatcttgc tcagtatgag gagcaggatg acatcaagga
     5161 gacagacatc ctcagtgacg atgatgaatt ctgtgagtct gcgaagggcg cctcagtgga
     5221 catagacctg caggagcagc ttcaggctgc ctctatcagt cagcgcgccc gaggccggaa
     5281 aacccttgat agccacgcct cccgcatgac acagctcaag aagcaagcgg ccctttcggg
     5341 catcaacgga ggcctggaga gtgcgagcga ggaggtcatt tgggttaggc gcgaagactt
     5401 tgccccctcc aggaaactga acacagagat atgactttct tgtcccttta gagaatgtgt
     5461 gtagatacga tgccggcccc accctcactc tgcccaccct cctgtgccgt ccacgagaat
     5521 gtcctcttag gtcgcactct tgcacacaga ttttggcagc tgactcgggt ctgaagccat
     5581 gtggccaccc accttcatca ttcttaatga catcagagag aatcgttcag aatcccaaca
     5641 agcttgagtc ctatcctctg tgcccagggc tctttattct caattcatcg gggcctgaag
     5701 atttagaaca aaaaatcgat agcactggaa attaaaccgt ccccacccca gcagtcaaag
     5761 caaagtatcg gagtgacagg acagcgttca cataggtgtc ccagctccac ctccctgagt
     5821 ccagtctcga cagctgggga accttcaaac acacattaaa aaaaaaaaaa aaatccagaa
     5881 cagatcgaaa catctgtaca gcttgcagtg ttctgactcc ctcttcagca tcgaagaata
     5941 tctgtgtatc ttaagaatgc gtgaggaaag ggtggtcgtc tctgtttgat gagcctttat
     6001 tcttttttct tctgtttatg tctgtagctg gtcttactct gtgtcagtgt ttggaagctc
     6061 tagttttgca gagaattata aagccgccac actcttggga aagagatcca aatttatcat
     6121 ttagagggag agagaagaaa aaaaaaacac tatttttttt gtattttcct tgagatgcag
     6181 gggcacaaat agatgagaat tttacagtgt taggagtaac tcagtctgaa aatgagtata
     6241 taaccctttt gcagagcgag cagggcacga tgactttata tttatatata aacagccaag
     6301 aagaagctca tgctaagaat aaacttttct tttctgagaa acagattttt tttaaatgta
     6361 tgaatctata tttgagatgg gaatttggtt ggattacagg ggcagggaat ggggctctgt
     6421 gtgtgtgtgc gcatatgtga gtgagtgagt gcatgtgtgt gtgtgtgtgt gtgtgtgtgt
     6481 gtgtgtgtgt gtgttgtaca tggcggggga ggggagcctc ctcatggggt tgccatggcg
     6541 accattggtt ttctcatcca gcttgcatct tcatccacag atgactcccc cttccctgac
     6601 agtccatggc tgaatcttag aacctcttca gaaacgtcct ttgtggtcaa tatttccttc
     6661 atgccaatga gacagggtaa acttgcctac ggggcctaac cttctaaatg gatgtccaga
     6721 caggaagaac aaaacccatt atagcacttt catcttttaa aaaaataaaa ggtttatagc
     6781 tttttgttcc ccctccccct ccccatttca tgatgtccat tccttaagaa gggtttaaat
     6841 aatatgaaaa ctttcttttt ggaaataaaa aaatatatat ctatatatct atatatatct
     6901 atttggtgtt tgatacatcg gtaggtactt taaagacctg aattttatag tagctttagc
     6961 gattatattt tataagaatc agttatgact ttatatttcc agatagagag ttcagaacac
     7021 gatgctctaa gcccccctcc tctgcccctc ctcggcttgc ttttcctgct ctcccgacct
     7081 ctacccctcc cccctccggg ttcccagggc tttgagcttg atcttttgaa agttttattc
     7141 tattgaagtt tttgctatat cttctggttt tcttaagaag ctttagagtg gtttctatgc
     7201 cctttgtacc actgcactgt tcatatcatc tcggggtcga ttgtgactgc gtccggatgg
     7261 gaaaccgagg cagaggcgtc gatagtcacg ttttctggtc tccctgcaac atgtccatgg
     7321 ggggtggggg gatcctggaa agtctggtgc ttagagaggg tgccattgtc tcttgtatat
     7381 acggtcatga tgtgtctatg tcaaaagttc ttatatattt cttttataag ctgaaagaag
     7441 gtctattttt atgtttttag gtctatgaat ggaacgttgt aaatgcttgt ccaacaataa
     7501 aaatactgaa aaggg
//
