LOCUS       NM_001100558            7034 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TIAM Rac1 associated GEF 1 (Tiam1), mRNA.
ACCESSION   NM_001100558 XM_001072877 XM_221672
VERSION     NM_001100558.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7034)
  AUTHORS   Rao,S., Kay,Y. and Herring,B.E.
  TITLE     Tiam1 is Critical for Glutamatergic Synapse Structure and Function
            in the Hippocampus
  JOURNAL   J Neurosci 39 (47), 9306-9315 (2019)
   PUBMED   31597723
  REMARK    GeneRIF: Tiam1 plays a critical role in the development of
            glutamatergic perforant path-dentae gyrus synapses.
REFERENCE   2  (bases 1 to 7034)
  AUTHORS   Blanco-Suarez,E., Fiuza,M., Liu,X., Chakkarapani,E. and Hanley,J.G.
  TITLE     Differential Tiam1/Rac1 activation in hippocampal and cortical
            neurons mediates differential spine shrinkage in response to
            oxygen/glucose deprivation
  JOURNAL   J Cereb Blood Flow Metab 34 (12), 1898-1906 (2014)
   PUBMED   25248834
  REMARK    GeneRIF: We show that Rac1 and the Rac guanine nucleotide exchange
            factor (GEF) Tiam1 are differentially activated by oxygen-glucose
            deprivation in hippocampal and cortical neurons.
REFERENCE   3  (bases 1 to 7034)
  AUTHORS   Wang,B., Li,W., Liu,H., Yang,L., Liao,Q., Cui,S., Wang,H. and
            Zhao,L.
  TITLE     miR-29b suppresses tumor growth and metastasis in colorectal cancer
            via downregulating Tiam1 expression and inhibiting
            epithelial-mesenchymal transition
  JOURNAL   Cell Death Dis 5 (7), e1335 (2014)
   PUBMED   25032858
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7034)
  AUTHORS   Satoh,T.
  TITLE     Rho GTPases in insulin-stimulated glucose uptake
  JOURNAL   Small GTPases 5, e28102 (2014)
   PUBMED   24613967
  REMARK    Review article
REFERENCE   5  (bases 1 to 7034)
  AUTHORS   Xiao,L., Hu,C., Yang,W., Guo,D., Li,C., Shen,W., Liu,X., Aijun,H.,
            Dan,W. and He,C.
  TITLE     NMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte
            precursor cell migration
  JOURNAL   Glia 61 (12), 2078-2099 (2013)
   PUBMED   24123220
  REMARK    GeneRIF: our result suggests a critical role of NMDAR in regulation
            of oligodendrocyte precursor cells migration during CNS development
            by coupling to and activating the Tiam1/Rac1 pathway.
REFERENCE   6  (bases 1 to 7034)
  AUTHORS   Baumeister,M.A., Martinu,L., Rossman,K.L., Sondek,J., Lemmon,M.A.
            and Chou,M.M.
  TITLE     Loss of phosphatidylinositol 3-phosphate binding by the C-terminal
            Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation
            without affecting membrane targeting
  JOURNAL   J Biol Chem 278 (13), 11457-11464 (2003)
   PUBMED   12525493
REFERENCE   7  (bases 1 to 7034)
  AUTHORS   Otsuki,Y., Tanaka,M., Kamo,T., Kitanaka,C., Kuchino,Y. and
            Sugimura,H.
  TITLE     Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc
            and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts
  JOURNAL   J Biol Chem 278 (7), 5132-5140 (2003)
   PUBMED   12446731
REFERENCE   8  (bases 1 to 7034)
  AUTHORS   Buchsbaum,R.J., Connolly,B.A. and Feig,L.A.
  TITLE     Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a
            scaffold for the p38 mitogen-activated protein kinase cascade
  JOURNAL   Mol Cell Biol 22 (12), 4073-4085 (2002)
   PUBMED   12024021
  REMARK    GeneRIF: N-terminal region of both proteins binds to the scaffold
            protein IB2/JIP2. IB2/JIP2 is a scaffold for the p38
            mitogen-activated protein (MAP) kinase cascade because it binds to
            the Rac target MLK3.
REFERENCE   9  (bases 1 to 7034)
  AUTHORS   Qi,H., Juo,P., Masuda-Robens,J., Caloca,M.J., Zhou,H., Stone,N.,
            Kazanietz,M.G. and Chou,M.M.
  TITLE     Caspase-mediated cleavage of the TIAM1 guanine nucleotide exchange
            factor during apoptosis
  JOURNAL   Cell Growth Differ 12 (12), 603-611 (2001)
   PUBMED   11751455
REFERENCE   10 (bases 1 to 7034)
  AUTHORS   Kunda,P., Paglini,G., Quiroga,S., Kosik,K. and Caceres,A.
  TITLE     Evidence for the involvement of Tiam1 in axon formation
  JOURNAL   J Neurosci 21 (7), 2361-2372 (2001)
   PUBMED   11264310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001100558.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643298.66050.1, SRR26360186.1937979.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JAXUCZ010000011.1  42645913-42646082   c
            171-1141            JAXUCZ010000011.1  42635195-42636165   c
            1142-1589           JAXUCZ010000011.1  42621337-42621784   c
            1590-1762           JAXUCZ010000011.1  42614834-42615006   c
            1763-1987           JAXUCZ010000011.1  42605347-42605571   c
            1988-2173           JAXUCZ010000011.1  42603175-42603360   c
            2174-2320           JAXUCZ010000011.1  42597582-42597728   c
            2321-2395           JAXUCZ010000011.1  42595318-42595392   c
            2396-2566           JAXUCZ010000011.1  42592810-42592980   c
            2567-2671           JAXUCZ010000011.1  42586954-42587058   c
            2672-2753           JAXUCZ010000011.1  42579819-42579900   c
            2754-2840           JAXUCZ010000011.1  42573217-42573303   c
            2841-3065           JAXUCZ010000011.1  42567511-42567735   c
            3066-3169           JAXUCZ010000011.1  42554545-42554648   c
            3170-3349           JAXUCZ010000011.1  42545503-42545682   c
            3350-3418           JAXUCZ010000011.1  42543938-42544006   c
            3419-3544           JAXUCZ010000011.1  42543529-42543654   c
            3545-3653           JAXUCZ010000011.1  42541138-42541246   c
            3654-3833           JAXUCZ010000011.1  42536882-42537061   c
            3834-3952           JAXUCZ010000011.1  42536513-42536631   c
            3953-4061           JAXUCZ010000011.1  42530773-42530881   c
            4062-4120           JAXUCZ010000011.1  42529290-42529348   c
            4121-4223           JAXUCZ010000011.1  42528755-42528857   c
            4224-4311           JAXUCZ010000011.1  42525449-42525536   c
            4312-4484           JAXUCZ010000011.1  42523321-42523493   c
            4485-7034           JAXUCZ010000011.1  42517528-42520077   c
FEATURES             Location/Qualifiers
     source          1..7034
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..7034
                     /gene="Tiam1"
                     /note="TIAM Rac1 associated GEF 1"
                     /db_xref="GeneID:304109"
                     /db_xref="RGD:1307455"
     exon            1..170
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            171..1141
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..4954
                     /gene="Tiam1"
                     /note="gene_id=rCG58779.0 transcript_id=rCT58779.0
                     protein_id=rCP35062.0; T-lymphoma invasion and
                     metastasis-inducing protein 1; T-cell lymphoma invasion
                     and metastasis 1"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor TIAM1"
                     /protein_id="NP_001094028.1"
                     /db_xref="GeneID:304109"
                     /db_xref="RGD:1307455"
                     /translation="MGNAESQNVDHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASS
                     GKAIHRNSEVSTRSSSTPSIPQSLAENGLEPFSQEGALDDFGDPIWVDRVDMGLRPVS
                     YTDSSVTPSVDGSIVLTAASVQSMPDSEESRLYGDDAAYLAEGGRRQRPYTSNGPTFM
                     ETASFKKKRSKSADIWREDSLEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETGA
                     SPRQLSTCQRANSLGDLYAQKNSGVKANGGPRNRFSSYCRNLVSDIPDLAKHKMPPAA
                     VETPTYSNYNTLPCRKSHCLSEGATNPQISLSKSMQGRRAKTTQDVNTGEGSEFADSG
                     IEGATTDTDLLSRRSNATNSSYSPPTGRAFVGSDSGSSSTGDAARQGVYENFRRELEM
                     STTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKN
                     KKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSVPKHAVWVENSIVQAVPEHP
                     KKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACAAAVARHHHKEDTLRLLKSEI
                     KKLEQKIDMDEKMKKMGEMQLSSVTDAKKKKTILDQIFVWEQNLEQFQMDLFRFRCYL
                     ASLQGGELPNPKRLLGFASRPTKVAMGRLGIFSVSSFHALVAARTGEIGVRRRTQAMS
                     RSASKRRSRFSSLWGLDTTSKKKQGRPTINQVFGEGTDAVKRSLEGIFDDSVPDGKRE
                     KEVVLPSVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKAHQ
                     LDHSAHYLRLKFLMENKMQFYVPQPEEDIYELLYKEIEICPKVTQNIHIEKSDAAADN
                     YGFLLSSVDEDGVRRLYVNSVKETGLASKKGLKAGDEILQINNRAAGTLNSSMLKDFL
                     SQPSLGLLVRTYPEPEGGVELLENPPHRVDGPVDLGESPLTFLTSNPGHSLSSEQGSS
                     AETAPEEGEGPDLESSDETDHSSKSTEQVTAFCRSLHEMSPSDSSPSPQDATSPQLAT
                     TRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLT
                     EMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCA
                     SHTKVPKVLVKAKTDTAFKAFLDAQNPRQQHSSTLESYLIKPIQRVLKYPLLLRELFA
                     LTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLS
                     MGDLLLHTSVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLS
                     IYEEWDPFRFRHMIPTEALQVRALPSADAEANAVCEIVHVKSESEGRPERVFHLCCSS
                     PESRKDFLKSVHSILRDKHRRQLLKTESLPSAQQYVPFGGKRLCALKGARPAMSRAVS
                     APSKSLGRRRRRLARNRFTIDSDAISASSPEKEPQQPPGGGDTDRWVEEQFDLAQYEE
                     QDDIKETDILSDDDEFCESAKGASVDIDLQEQLQAASISQRARGRKTLDSHASRMTQL
                     KKQAALSGINGGLESASEEVIWVRREDFAPSRKLNTEI"
     exon            1142..1589
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1762
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1987
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2173
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2320
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2395
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2566
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2671
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2753
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2840
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..3065
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3169
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3349
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3418
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3544
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3653
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..3833
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            3834..3952
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4061
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            4062..4120
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4223
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4311
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            4312..4484
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..7034
                     /gene="Tiam1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtttttggc acattctccc agactcaggt gagaccccga tggacacccc gtggggcagg
       61 tgctgacaca cgccccaact ccagccactg acaccatctc cagcctcagt atctaaatgc
      121 cacagtgctc tcggggccag ttgggctggg caccactgtt gcctttgaag accataaaac
      181 catgggaaac gcagaaagcc aaaatgtaga ccacgagttt tatggagaaa agcatgccag
      241 cctggggcgg aagcacacat cacgctccct gcgactgtca cacaagaccc ggaggacgcg
      301 gcatgcttcc tctgggaagg caatccacag gaactctgaa gtgagcacgc ggtccagcag
      361 cacccctagc atcccccagt ccctggccga aaatggcttg gagccctttt cccaagaagg
      421 cgccctagac gacttcgggg accccatctg ggtggaccga gtggatatgg gcttgagacc
      481 cgtgtcttac acggattctt ctgtcactcc cagcgtagac ggcagcatcg tcctcacggc
      541 agcctctgtg cagagcatgc cagactcgga ggagagccgg ctttacgggg atgacgctgc
      601 gtacttggct gagggaggca ggaggcagcg tccctataca tccaacgggc ccacgttcat
      661 ggagacagcg agctttaaga agaaacgctc taaatctgca gacatctggc gggaggacag
      721 cctggagttc tcactctcag atctgagcca agaacattta acaagcaacg aagaaatctt
      781 gggctccgcg gaagagaagg attgcgagga ggctcggggg atggaaacag gggcgagccc
      841 ccggcagctc agcacctgtc agcgagccaa ctccctgggt gacttgtatg ctcagaagaa
      901 ctccggggtg aaggctaacg gaggaccgag aaacagattt tcgagctact gccggaattt
      961 ggtgtcggat attcccgatc ttgcaaagca taagatgcca ccggctgctg tagagactcc
     1021 gacgtacagt aattataaca cgcttccctg taggaagtcg cactgtcttt ccgagggtgc
     1081 caccaaccca caaattagcc ttagcaagag catgcaaggc agaagagcga aaaccaccca
     1141 ggatgttaac acaggcgagg gcagtgagtt tgcagacagt gggatcgaag gggccaccac
     1201 ggacacggac ctcctgtcca ggagatccaa tgccaccaac tccagctact cgcctcccac
     1261 aggccgagcc tttgtgggca gcgacagcgg cagcagttcg actggggatg ctgcacgcca
     1321 gggggtgtac gagaacttca ggcgggaact ggagatgagc accaccaaca gcgagagcct
     1381 ggaggaggct ggctctgcgc acagcgacga gcagagcagc ggaaccctca gctccccggg
     1441 ccagtcggac atcctgctga cggctgcgca gggcactgtg cggaaggctg gcgcgctggc
     1501 agtcaagaac ttcctggtac ataagaagaa taagaaggtg gagtcggcta cccggaggaa
     1561 gtggaagcac tactgggtgt ccctgaaagg ttgcacgctc tttttctacg agagtgatgg
     1621 caggtctggg atagaccaca acagtgtccc caagcatgct gtctgggtgg agaacagcat
     1681 cgtgcaggcc gtacctgagc accccaagaa agattttgtc ttctgcctca gcaactccct
     1741 gggcgatgcc ttcctcttcc agaccaccag ccagacagag ctggagaact ggatcacggc
     1801 catccactct gcctgcgcag ctgcggtcgc aaggcaccac cacaaggaag acacgctccg
     1861 cctcctcaag tcggaaatca agaagctgga gcaaaagatt gacatggacg agaaaatgaa
     1921 gaagatgggc gagatgcagc tgtcctccgt cacggacgcg aagaagaaga agaccatact
     1981 tgaccagatc ttcgtttggg agcagaacct cgaacagttc cagatggacc ttttccggtt
     2041 ccgctgttac cttgccagcc tccagggcgg ggagctgcca aaccccaaac gactcctagg
     2101 ttttgccagc cggcccacca aggtggccat gggccgcctt ggcatctttt cggtatcatc
     2161 ttttcacgcc ctggtggcgg cccgcactgg cgagatcggg gtgagaaggc gtactcaggc
     2221 tatgtccagg tctgcgagca agcggaggag caggttttct tctctctggg gcctagacac
     2281 tacctccaaa aagaagcagg ggcgcccaac catcaaccag gtgtttggag aggggaccga
     2341 tgctgtaaag agatctttag agggaatatt tgatgactct gttccagacg gcaagaggga
     2401 gaaggaagtg gtcttaccca gtgtccacca gcacaatcct gactgtgaca tttgggtcca
     2461 tgaatatttc actccatcct ggttctgtct acccaataat cagccagcct tgacggttgt
     2521 ccggccgggg gacactgcga gggacacctt ggagctcatt tgcaaggcgc accaactgga
     2581 tcattctgcc cattacctgc gcctgaaatt tctgatggag aacaagatgc agttctatgt
     2641 cccgcaaccc gaggaggaca tttacgagct gctttacaaa gaaatcgaaa tctgtccgaa
     2701 agtcacccag aacatccaca ttgagaagtc cgacgcggcc gccgataatt acgggttttt
     2761 gctttcttct gtggacgaag atggcgttcg aaggctctac gtgaacagcg tcaaggaaac
     2821 cgggctagct tccaagaaag gcctgaaggc gggggacgag attcttcaga tcaataaccg
     2881 tgccgctggt accctgaact catctatgct caaagatttc ctctcacagc cctctctggg
     2941 cctcctggtg aggacctacc ctgagccaga gggaggagtg gagctgctag agaacccacc
     3001 ccaccgagtg gacggccctg tggaccttgg cgagagcccc ctcaccttcc tcaccagcaa
     3061 cccagggcac agcctctcca gcgagcaggg cagcagtgct gagacagctc cggaagaggg
     3121 cgaaggaccg gacttggagt cttccgatga gacagatcac agcagcaaga gcacagaaca
     3181 ggtcacagcg ttttgccgga gtctgcacga gatgagcccc tctgactcga gcccgtcccc
     3241 tcaggatgcc acgagccctc agctggcaac cacacgacag ctatcggacg cagataaact
     3301 gcgcaaggtg atctgtgagc tcctagagac cgaacgcacc tatgtgaagg acttaaactg
     3361 cctcatggag agatacctga agccccttca gaaggagacc tttctcaccc aggatgagct
     3421 cgatgtactc tttggaaatt taaccgaaat ggtggagttt caagttgagt tccttaaaac
     3481 tctagaagat ggagttagac tggtccctga cttggaaaag cttgagaagg ttgaccagtt
     3541 taagaaagtg ctgttctctc tggggggatc cttcctgtac tacgcggacc gcttcaagct
     3601 ctacagtgcc ttctgtgcga gccatacgaa agtccccaag gtcctggtga aagccaagac
     3661 ggacacagcc ttcaaggcat tcctagatgc ccagaacccg aggcagcagc actcgtccac
     3721 actagagtct tacctcatca agcccatcca gagggtcctc aagtacccgc ttctgctcag
     3781 ggagctgttt gcgctgaccg acgcggagag tgaggagcat taccacctgg atgtggccat
     3841 caagactatg aacaaggttg ccagtcacat caatgagatg cagaagatcc acgaagaatt
     3901 tggtgctgtg ttcgaccagc tgattgctga gcagacagga gagaagaaag aggtcgcgga
     3961 tctgagcatg ggtgacctgc tgttgcacac cagtgtcatc tggctgaacc cacccgcctc
     4021 gctgggaaag tggaaaaagg agccggaact ggcagccttc gtcttcaaaa ctgccgtggt
     4081 ccttgtgtat aaagatggtt ccaagcagaa gaagaagctc gttggctctc acaggctgtc
     4141 aatctacgag gagtgggacc ctttccggtt tcgccacatg atccctaccg aagctttgca
     4201 agtccgagct ctgcccagtg cagatgcaga ggcaaatgcc gtgtgtgaaa ttgtccacgt
     4261 gaaatcagag tcagagggga ggccggagcg ggttttccac ctctgctgca gctccccgga
     4321 gagccgaaag gattttctga agtctgtaca ctccatcctg cgagataagc acagaaggca
     4381 gctcctcaaa acggaaagtc ttccctcagc ccagcagtat gtcccttttg gaggcaagag
     4441 attgtgtgcg cttaaaggcg ccaggccagc catgagcagg gcagtgtctg ccccaagcaa
     4501 gtctcttggg aggaggaggc ggcgactggc ccgaaacagg tttaccattg attcagacgc
     4561 catctcagcc agcagcccgg agaaagagcc ccagcagccc cccggtggcg gggacactga
     4621 ccgatgggta gaggaacagt ttgatcttgc tcagtatgag gagcaggatg acatcaagga
     4681 gacagacatc ctcagtgacg atgatgaatt ctgtgagtct gcgaagggcg cctcagtgga
     4741 catagacctg caggagcagc ttcaggctgc ctctatcagt cagcgcgccc gaggccggaa
     4801 aacccttgat agccacgcct cccgcatgac acagctcaag aagcaagcgg ccctttcggg
     4861 catcaacgga ggcctggaga gtgcgagcga ggaggtcatt tgggttaggc gcgaagactt
     4921 tgccccctcc aggaaactga acacagagat atgactttct tgtcccttta gagaatgtgt
     4981 gtagatacga tgccggcccc accctcactc tgcccaccct cctgtgccgt ccacgagaat
     5041 gtcctcttag gtcgcactct tgcacacaga ttttggcagc tgactcgggt ctgaagccat
     5101 gtggccaccc accttcatca ttcttaatga catcagagag aatcgttcag aatcccaaca
     5161 agcttgagtc ctatcctctg tgcccagggc tctttattct caattcatcg gggcctgaag
     5221 atttagaaca aaaaatcgat agcactggaa attaaaccgt ccccacccca gcagtcaaag
     5281 caaagtatcg gagtgacagg acagcgttca cataggtgtc ccagctccac ctccctgagt
     5341 ccagtctcga cagctgggga accttcaaac acacattaaa aaaaaaaaaa aaatccagaa
     5401 cagatcgaaa catctgtaca gcttgcagtg ttctgactcc ctcttcagca tcgaagaata
     5461 tctgtgtatc ttaagaatgc gtgaggaaag ggtggtcgtc tctgtttgat gagcctttat
     5521 tcttttttct tctgtttatg tctgtagctg gtcttactct gtgtcagtgt ttggaagctc
     5581 tagttttgca gagaattata aagccgccac actcttggga aagagatcca aatttatcat
     5641 ttagagggag agagaagaaa aaaaaaacac tatttttttt gtattttcct tgagatgcag
     5701 gggcacaaat agatgagaat tttacagtgt taggagtaac tcagtctgaa aatgagtata
     5761 taaccctttt gcagagcgag cagggcacga tgactttata tttatatata aacagccaag
     5821 aagaagctca tgctaagaat aaacttttct tttctgagaa acagattttt tttaaatgta
     5881 tgaatctata tttgagatgg gaatttggtt ggattacagg ggcagggaat ggggctctgt
     5941 gtgtgtgtgc gcatatgtga gtgagtgagt gcatgtgtgt gtgtgtgtgt gtgtgtgtgt
     6001 gtgtgtgtgt gtgttgtaca tggcggggga ggggagcctc ctcatggggt tgccatggcg
     6061 accattggtt ttctcatcca gcttgcatct tcatccacag atgactcccc cttccctgac
     6121 agtccatggc tgaatcttag aacctcttca gaaacgtcct ttgtggtcaa tatttccttc
     6181 atgccaatga gacagggtaa acttgcctac ggggcctaac cttctaaatg gatgtccaga
     6241 caggaagaac aaaacccatt atagcacttt catcttttaa aaaaataaaa ggtttatagc
     6301 tttttgttcc ccctccccct ccccatttca tgatgtccat tccttaagaa gggtttaaat
     6361 aatatgaaaa ctttcttttt ggaaataaaa aaatatatat ctatatatct atatatatct
     6421 atttggtgtt tgatacatcg gtaggtactt taaagacctg aattttatag tagctttagc
     6481 gattatattt tataagaatc agttatgact ttatatttcc agatagagag ttcagaacac
     6541 gatgctctaa gcccccctcc tctgcccctc ctcggcttgc ttttcctgct ctcccgacct
     6601 ctacccctcc cccctccggg ttcccagggc tttgagcttg atcttttgaa agttttattc
     6661 tattgaagtt tttgctatat cttctggttt tcttaagaag ctttagagtg gtttctatgc
     6721 cctttgtacc actgcactgt tcatatcatc tcggggtcga ttgtgactgc gtccggatgg
     6781 gaaaccgagg cagaggcgtc gatagtcacg ttttctggtc tccctgcaac atgtccatgg
     6841 ggggtggggg gatcctggaa agtctggtgc ttagagaggg tgccattgtc tcttgtatat
     6901 acggtcatga tgtgtctatg tcaaaagttc ttatatattt cttttataag ctgaaagaag
     6961 gtctattttt atgtttttag gtctatgaat ggaacgttgt aaatgcttgt ccaacaataa
     7021 aaatactgaa aagg
//
