LOCUS       NM_001012096            1435 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus TIA1 cytotoxic granule-associated RNA binding
            protein (Tia1), mRNA.
ACCESSION   NM_001012096 XM_232139
VERSION     NM_001012096.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1435)
  AUTHORS   Mahboubi,H., Koromilas,A.E. and Stochaj,U.
  TITLE     AMP Kinase Activation Alters Oxidant-Induced Stress Granule
            Assembly by Modulating Cell Signaling and Microtubule Organization
  JOURNAL   Mol Pharmacol 90 (4), 460-468 (2016)
   PUBMED   27430620
REFERENCE   2  (bases 1 to 1435)
  AUTHORS   Jefferson,M., Donaszi-Ivanov,A., Pollen,S., Dalmay,T., Saalbach,G.
            and Powell,P.P.
  TITLE     Host factors that interact with the pestivirus N-terminal protease,
            Npro, are components of the ribonucleoprotein complex
  JOURNAL   J Virol 88 (18), 10340-10353 (2014)
   PUBMED   24965446
REFERENCE   3  (bases 1 to 1435)
  AUTHORS   Zou,T., Rao,J.N., Liu,L., Xiao,L., Cui,Y.H., Jiang,Z., Ouyang,M.,
            Donahue,J.M. and Wang,J.Y.
  TITLE     Polyamines inhibit the assembly of stress granules in normal
            intestinal epithelial cells regulating apoptosis
  JOURNAL   Am J Physiol Cell Physiol 303 (1), C102-C111 (2012)
   PUBMED   22555848
REFERENCE   4  (bases 1 to 1435)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1435)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1435)
  AUTHORS   Kayali,F., Montie,H.L., Rafols,J.A. and DeGracia,D.J.
  TITLE     Prolonged translation arrest in reperfused hippocampal cornu
            Ammonis 1 is mediated by stress granules
  JOURNAL   Neuroscience 134 (4), 1223-1245 (2005)
   PUBMED   16055272
REFERENCE   7  (bases 1 to 1435)
  AUTHORS   Cok,S.J., Acton,S.J. and Morrison,A.R.
  TITLE     The proximal region of the 3'-untranslated region of
            cyclooxygenase-2 is recognized by a multimeric protein complex
            containing HuR, TIA-1, TIAR, and the heterogeneous nuclear
            ribonucleoprotein U
  JOURNAL   J Biol Chem 278 (38), 36157-36162 (2003)
   PUBMED   12855701
REFERENCE   8  (bases 1 to 1435)
  AUTHORS   Kimball,S.R., Horetsky,R.L., Ron,D., Jefferson,L.S. and
            Harding,H.P.
  TITLE     Mammalian stress granules represent sites of accumulation of
            stalled translation initiation complexes
  JOURNAL   Am J Physiol Cell Physiol 284 (2), C273-C284 (2003)
   PUBMED   12388085
REFERENCE   9  (bases 1 to 1435)
  AUTHORS   Forch,P., Puig,O., Kedersha,N., Martinez,C., Granneman,S.,
            Seraphin,B., Anderson,P. and Valcarcel,J.
  TITLE     The apoptosis-promoting factor TIA-1 is a regulator of alternative
            pre-mRNA splicing
  JOURNAL   Mol Cell 6 (5), 1089-1098 (2000)
   PUBMED   11106748
REFERENCE   10 (bases 1 to 1435)
  AUTHORS   Piecyk,M., Wax,S., Beck,A.R., Kedersha,N., Gupta,M., Maritim,B.,
            Chen,S., Gueydan,C., Kruys,V., Streuli,M. and Anderson,P.
  TITLE     TIA-1 is a translational silencer that selectively regulates the
            expression of TNF-alpha
  JOURNAL   EMBO J 19 (15), 4154-4163 (2000)
   PUBMED   10921895
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087064.1.
            
            On Feb 11, 2005 this sequence version replaced XM_232139.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132279, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1435
                     /gene="Tia1"
                     /note="TIA1 cytotoxic granule-associated RNA binding
                     protein"
                     /db_xref="GeneID:312510"
                     /db_xref="RGD:1305742"
     exon            1..207
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1309
                     /gene="Tia1"
                     /note="cytotoxic granule-associated RNA binding protein 1;
                     nucleolysin TIA-1"
                     /codon_start=1
                     /product="cytotoxic granule associated RNA binding protein
                     TIA1"
                     /protein_id="NP_001012096.1"
                     /db_xref="GeneID:312510"
                     /db_xref="RGD:1305742"
                     /translation="MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAG
                     NDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDL
                     SPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQW
                     LGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVSQSSPGNCTVYCGGVTSGLTEQL
                     MRQTFSPFGQIMEIRVFPDKGYSFIRFSSHESAAHAIVSVNGTTIEGHVVKCYWGKET
                     LDMINPVQQQNQIGYPPAYGQWGQWYGNAQQIGQYVPNGWQVPAYGMYGQPWSQQGFN
                     QTQSSAPWMGPNYSVPPPQGQNGGMLPNQPAGYRVAGYETQ"
     exon            208..304
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..403
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..458
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..546
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..622
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..731
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..827
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..912
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1036
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1182
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1401
                     /gene="Tia1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtttcatt gttcgcggtg ggacgggcat ttttgtgtaa tcgctgccaa agaagaaagc
       61 gaagtagcct ccagtcaagc gaggaggccg gctcttccgc agccatagcc acctcaacga
      121 tttgggaggt agcgaagggc agggagctgg accctgaggt gccgccgcga ctgcagcagc
      181 catggaggac gagatgccca agactctata cgtcggtaac ctttctcgag atgtgacaga
      241 agctctcatc ctccagctct ttagccagat cggaccttgt aaaaactgca aaatgattat
      301 ggatacggca ggaaatgacc cgtactgttt cgtggagttc catgagcatc gccacgcagc
      361 tgcagccctg gctgctatga atgggcggaa gataatgggt aaggaagtga aagtgaattg
      421 ggcaacaacc cctagcagtc aaaagaaaga tacaagcaat catttccatg tgtttgttgg
      481 tgacctcagt ccagaaatca caactgaaga catcaaagca gcttttgcac catttggaag
      541 aatttcagat gcccgtgtgg taaaagacat ggctaccggg aagtctaagg gatatggctt
      601 tgtctccttt ttcaacaaat gggatgcaga aaatgccatt cagcagatgg gtggccagtg
      661 gcttggtgga agacaaatca gaactaactg ggcaacccga aagcctccag ctccaaagag
      721 tacatatgag tcaaacacca aacagctgtc atacgatgag gttgtgagtc agtctagtcc
      781 cggcaactgt accgtgtact gtggaggagt gacgtcagga ctgacagaac aactaatgcg
      841 tcagactttt tctccatttg gacaaataat ggaaatccga gtctttccag ataaagggta
      901 ctcattcatt cggttcagtt cccatgaaag tgcggcacat gcaattgttt ctgttaacgg
      961 tactaccatt gaagggcatg tggtgaaatg ttactggggc aaagagactc ttgacatgat
     1021 aaaccccgtg cagcagcaaa atcaaattgg atatccacca gcatatggcc agtggggcca
     1081 gtggtatgga aatgcacaac agattggcca gtatgtacct aatggttggc aagtacctgc
     1141 ctatggaatg tatggccagc catggagcca gcagggattc aatcagaccc agtcttctgc
     1201 accatggatg ggacccaatt acagtgtgcc gccacctcaa gggcagaacg gcggcatgct
     1261 gcctaatcag cctgctgggt atcgagtggc agggtatgaa acccagtaaa aacagacgac
     1321 agaatggaag ccagtggctt gaagccacag ggagggtagg aaagccgatg tttacttcaa
     1381 gatttatcaa atcagtcagt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
