LOCUS       NM_012673               1328 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Thy-1 cell surface antigen (Thy1), mRNA.
ACCESSION   NM_012673
VERSION     NM_012673.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1328)
  AUTHORS   Xu,C., Lu,H., Li,F. and Su,G.
  TITLE     Protein Expression Profile on Differentiation of Bone Marrow
            Mesenchymal Stem Cells into Retinal Ganglion-Like Cells
  JOURNAL   J Comput Biol 27 (8), 1329-1336 (2020)
   PUBMED   31841640
  REMARK    GeneRIF: Protein Expression Profile on Differentiation of Bone
            Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells.
REFERENCE   2  (bases 1 to 1328)
  AUTHORS   Cassaro,C.V., Justulin,L.A. Jr., de Lima,P.R., Golim,M.A.,
            Biscola,N.P., de Castro,M.V., de Oliveira,A.L.R., Doiche,D.P.,
            Pereira,E.J., Ferreira,R.S. Jr. and Barraviera,B.
  TITLE     Fibrin biopolymer as scaffold candidate to treat bone defects in
            rats
  JOURNAL   J Venom Anim Toxins Incl Trop Dis 25, e20190027 (2019)
   PUBMED   31723344
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1328)
  AUTHORS   Lagos-Cabre,R., Brenet,M., Diaz,J., Perez,R.D., Perez,L.A.,
            Herrera-Molina,R., Quest,A.F.G. and Leyton,L.
  TITLE     Intracellular Ca2+ Increases and Connexin 43 Hemichannel Opening
            Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte
            Migration
  JOURNAL   Int J Mol Sci 19 (8), 2179 (2018)
   PUBMED   30049932
  REMARK    GeneRIF: Intracellular Ca2+ signals and Cx43 hemichannel opening
            participate as key steps in the regulation of Thy-1-induced
            astrocyte migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1328)
  AUTHORS   Shen,D., Shen,M., Liang,H., Tang,J., Wang,B., Liu,C., Wang,P.,
            Dong,J., Li,L., Zhang,J. and Caranasos,T.G.
  TITLE     Therapeutic benefits of CD90-negative cardiac stromal cells in rats
            with a 30-day chronic infarct
  JOURNAL   J Cell Mol Med 22 (3), 1984-1991 (2018)
   PUBMED   29341439
  REMARK    GeneRIF: Therapeutic benefits of CD90-negative cardiac stromal
            cells in rats with a 30-day chronic infarct has been demonstrated.
REFERENCE   5  (bases 1 to 1328)
  AUTHORS   Horiguchi,K., Nakakura,T., Yoshida,S., Tsukada,T., Kanno,N.,
            Hasegawa,R., Takigami,S., Ohsako,S., Kato,T. and Kato,Y.
  TITLE     Identification of THY1 as a novel thyrotrope marker and THY1
            antibody-mediated thyrotrope isolation in the rat anterior
            pituitary gland
  JOURNAL   Biochem Biophys Res Commun 480 (2), 273-279 (2016)
   PUBMED   27765629
  REMARK    GeneRIF: THY1 is expressed in the anterior lobe of the rat
            pituitary gland.THY1 is a novel specific marker of thyrotropes,
            which produce TSH.
REFERENCE   6  (bases 1 to 1328)
  AUTHORS   Parekh,R.B., Tse,A.G., Dwek,R.A., Williams,A.F. and Rademacher,T.W.
  TITLE     Tissue-specific N-glycosylation, site-specific oligosaccharide
            patterns and lentil lectin recognition of rat Thy-1
  JOURNAL   EMBO J 6 (5), 1233-1244 (1987)
   PUBMED   2886334
REFERENCE   7  (bases 1 to 1328)
  AUTHORS   Kroczek,R.A., Gunter,K.C., Germain,R.N. and Shevach,E.M.
  TITLE     Thy-1 functions as a signal transduction molecule in T lymphocytes
            and transfected B lymphocytes
  JOURNAL   Nature 322 (6075), 181-184 (1986)
   PUBMED   2873512
REFERENCE   8  (bases 1 to 1328)
  AUTHORS   Seki,T., Chang,H.C., Moriuchi,T., Denome,R. and Silver,J.
  TITLE     Thy-1: a hydrophobic transmembrane segment at the carboxyl terminus
  JOURNAL   Fed Proc 44 (13), 2865-2869 (1985)
   PUBMED   2864289
REFERENCE   9  (bases 1 to 1328)
  AUTHORS   Seki,T., Chang,H.C., Moriuchi,T., Denome,R., Ploegh,H. and
            Silver,J.
  TITLE     A hydrophobic transmembrane segment at the carboxyl terminus of
            thy-1
  JOURNAL   Science 227 (4687), 649-651 (1985)
   PUBMED   2857501
REFERENCE   10 (bases 1 to 1328)
  AUTHORS   Seki,T., Moriuchi,T., Chang,H.C., Denome,R. and Silver,J.
  TITLE     Structural organization of the rat thy-1 gene
  JOURNAL   Nature 313 (6002), 485-487 (1985)
   PUBMED   2857477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB797376.1, X03150.1, CO561977.1 and CB741211.1.
            
            On Jun 13, 2010 this sequence version replaced NM_012673.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF975746.1, FQ098963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                CB797376.1         1-49
            50-699              X03150.1           1-650
            700-1229            CO561977.1         152-681
            1230-1328           CB741211.1         357-455
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1328
                     /gene="Thy1"
                     /gene_synonym="CD7"
                     /note="Thy-1 cell surface antigen"
                     /db_xref="GeneID:24832"
                     /db_xref="RGD:3860"
     exon            1..70
                     /gene="Thy1"
                     /gene_synonym="CD7"
                     /inference="alignment:Splign:2.1.0"
     exon            71..131
                     /gene="Thy1"
                     /gene_synonym="CD7"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..580
                     /gene="Thy1"
                     /gene_synonym="CD7"
                     /EC_number="3.1.26.4"
                     /note="thy-1 membrane glycoprotein; thy-1 glycoprotein;
                     Thy-1 protein; thy-1 antigen; Thymus cell surface antigen;
                     thymus cell antigen 1, theta; CD90"
                     /codon_start=1
                     /product="thy-1 membrane glycoprotein preproprotein"
                     /protein_id="NP_036805.1"
                     /db_xref="GeneID:24832"
                     /db_xref="RGD:3860"
                     /translation="MNPVISITLLLSVLQMSRGQRVISLTACLVNQNLRLDCRHENNT
                     NLPIQHEFSLTREKKKHVLSGTLGVPEHTYRSRVNLFSDRFIKVLTLANFTTKDEGDY
                     MCELRVSGQNPTSSNKTINVIRDKLVKCGGISLLVQNTSWLLLLLLSLSFLQATDFIS
                     L"
     exon            132..467
                     /gene="Thy1"
                     /gene_synonym="CD7"
                     /inference="alignment:Splign:2.1.0"
     exon            468..1328
                     /gene="Thy1"
                     /gene_synonym="CD7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttcgcgct gggtgcagca accagaggcg ttggtgcacc aagaggaggc tgcaagctag
       61 gggagcccag acccaggacg gagctattgg caccatgaac ccagtcatca gcatcactct
      121 cctgctttca gtcttgcaga tgtcccgagg acagagggtg atcagcctga cagcctgcct
      181 ggtgaaccag aaccttcgac tggactgccg tcatgagaat aacaccaact tgcccatcca
      241 gcatgagttc agcctgaccc gagagaagaa gaagcacgtg ctgtcaggca ccctgggggt
      301 tcccgagcac acttaccgct cccgcgtcaa ccttttcagt gaccgcttta tcaaggtcct
      361 tactctagcc aacttcacca ccaaggatga gggcgactac atgtgtgaac ttcgagtctc
      421 gggccagaat cccacaagct ccaataaaac tatcaatgtg atcagagaca agctggtcaa
      481 gtgtggtggc ataagcctgc tggttcaaaa cacttcctgg ctgctgctgc tcctgctttc
      541 cctctccttc ctccaagcca cggacttcat ttctctgtga ctggttgggc ccaaggagaa
      601 acaggaaacc tcaaggtctg ctgaagaggt cttgcttctc ccggtcagct gactccctcc
      661 ccaagacctt caaatatctc aaaacgcggg gagaaatggg gaccctgtcc ctcctaggga
      721 accccagtgc tgcatgccat cacccccacc ctcacccccg ccacttcacc ctcagtgcac
      781 accacgagct gccattttgt actctgtatt ccggggctgc ttctgattag tttgtcctgg
      841 agacccgatg gaacaccagg gtgtatgatg ggcagtgaag aggcaggata tcaccccccc
      901 gggtgagttc ctctttgcct tctaagccag atgcctgaaa gagatatgga tgagggaagt
      961 tggactgtgt ctgtgcctgg tatagtgata ctctgttgaa agtatcgccc agtaggcagg
     1021 gagggggagg ggcctcaaga taggagagcg ctgctgagcc tttgtggacc aaacaataag
     1081 gatgagaact tagattgtac caggtcattc tcagccccct tctatcaccg aagaagggcc
     1141 agggcacact caataaagat gcaggtccag ccagggaatg ttggggaaag gggtaggagg
     1201 tcagggacag atcacccccc ccctctaaaa catgatcctg ctgtttccaa aggccacact
     1261 gcctacagtg agggtagcag accagtcccc cttctctgcc tccaaggagc cagaactctg
     1321 actccagg
//
