LOCUS       NM_001007682            2538 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus thiamine triphosphatase (Thtpa), mRNA.
ACCESSION   NM_001007682 XM_224183
VERSION     NM_001007682.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2538)
  AUTHORS   Song,J., Bettendorff,L., Tonelli,M. and Markley,J.L.
  TITLE     Structural basis for the catalytic mechanism of mammalian 25-kDa
            thiamine triphosphatase
  JOURNAL   J Biol Chem 283 (16), 10939-10948 (2008)
   PUBMED   18276586
REFERENCE   2  (bases 1 to 2538)
  AUTHORS   Lakaye,B., Makarchikov,A.F., Antunes,A.F., Zorzi,W., Coumans,B., De
            Pauw,E., Wins,P., Grisar,T. and Bettendorff,L.
  TITLE     Molecular characterization of a specific thiamine triphosphatase
            widely expressed in mammalian tissues
  JOURNAL   J Biol Chem 277 (16), 13771-13777 (2002)
   PUBMED   11827967
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081978.1.
            
            On Nov 29, 2004 this sequence version replaced XM_224183.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081978.1, CO398180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2538
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..2538
                     /gene="Thtpa"
                     /note="thiamine triphosphatase"
                     /db_xref="GeneID:305889"
                     /db_xref="RGD:727917"
     exon            1..909
                     /gene="Thtpa"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..1037
                     /gene="Thtpa"
                     /EC_number="3.6.1.28"
                     /note="thTPase"
                     /codon_start=1
                     /product="thiamine-triphosphatase"
                     /protein_id="NP_001007683.1"
                     /db_xref="GeneID:305889"
                     /db_xref="RGD:727917"
                     /translation="MAQGLIEVERKFTPGPDTEERLQKLGATLEHRVTFRDTYYDTSE
                     LSLMLSDHWLRQREGSGWEFKCPGVTGVSGPHNEYVEVTSESAIVTQLFELLGSGEQE
                     TAGVAAVLGRLKLQEVASFITTRSSWKLALSGAHEEESLLTVDLDSTDFGYAVGEVEA
                     VVHEKAEVPAALEKIISVSSMLGVPAQEKAPAKLLVYLQRFRPQDYQRLLEADSSGEA
                     TGDSVP"
     exon            910..2509
                     /gene="Thtpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctggggtc ttgaagagtg tccggaggtt ccgctgtatg gtgcttaggc gaagaatggc
       61 aggccctcct gggcagtgaa ttctggcctt gggtagcaag gtgtaaagag aagataggtc
      121 atcagcatca cggcctgttt tctagggagc ctttcgggtt atcagtagta ggatttaact
      181 ggagacttgt caccattgtt gcagcccggt gagaccttga agtagagcct tgtgtcactg
      241 gagcagggct ctgagacagt gtatatgcat cttaaattca tccaggacta gtgggtcttt
      301 gatgactagt cctcaccttg agcacgcagt gaattcttca caaaagtgtg ttgcaggtta
      361 acatggccca gggcttgatt gaggtggagc gaaagtttac tccagggcct gacacagagg
      421 aaaggctgca gaagttgggg gccaccctgg agcaccgggt caccttccga gacacgtact
      481 atgatacctc tgagttaagc cttatgctgt ctgaccactg gctgcgacaa cgagaaggta
      541 gtggatggga gttcaaatgt cctggagtaa caggtgtctc aggacctcac aatgagtatg
      601 tggaagtcac atcggaatct gcaattgtga cccagctctt tgaactgctg gggtctgggg
      661 agcaggagac tgcaggtgtg gctgctgtcc tgggccgact gaagctgcag gaagtagcta
      721 gttttataac tacacgaagt tcctggaagc tggccttatc tggagcccat gaagaggagt
      781 cactgctcac agtggacttg gattcaacgg atttcggtta tgccgtgggt gaggtagagg
      841 ccgtggtgca tgagaaggct gaagtcccgg ctgccctaga gaagatcatc agcgtcagta
      901 gcatgcttgg agtgccagca caggagaagg cacctgctaa gctcctggtc tacctacagc
      961 gcttcaggcc tcaggactat cagcgcctgc tagaagcaga cagttccggt gaggccacag
     1021 gggactcagt accgtgacaa cagtgcatgg aagcagggtt cacttcctca aaaggatggt
     1081 aaccctgaag ctgccatcca cacccggacc cactgcgccc cttccctttc agcagagcta
     1141 cttttctctc cagctctgcc tggtctttca cccacactga gctatccttc ctggagccct
     1201 ccctcactgc ttccctcatc cgtcagatgc aatctgtggg ccgcccctct cccctggccg
     1261 ctaagcagcc tccattgatt tccgctcgtg tttataggat ttccacttag ccgtgatcag
     1321 tagttaagca cagggaaatc ccttgccacc ccccctcccc tggtcgatgc cattgattct
     1381 gccagaggct ctgaagccgc cttacagctg agttagggat gaggggaaac agtggggatt
     1441 cccctgcctt ggggtgcagg aagagtaaga aggtggagaa atggttggga actccttaag
     1501 ggatctagac attctgggcc tgtcactgtg cctggagggt agagtgccct gtgtggcagt
     1561 tcagacatac atttgctctc caacccagag aggggagaaa gcaaacggtc aatgttgaga
     1621 caggttccta ggattccggg aagtcattct tgtggagaag gctccgccct cggctcttag
     1681 acactgtttc tctcagctag gcctttctgc cctcctcagg cttcatagac attttttgtt
     1741 gggcaggagg caggctgtcc atattgcggt gacaaataaa gggtccgagt gccacctgct
     1801 ggtggccctc agggctgtgt cccaagctga gggcgcagaa agatttcagg tgagctgagg
     1861 cagtgatgag acaggcaagc ttagcagccc gcaactccac ttgcttcaag ccatacatgc
     1921 ctctccgcta actgccactt ggtgccctag gatcctcagc tgcatgtact gcggacacac
     1981 acttttaaca gtgcacccag gaccccagcc atattgagta gcagtcatgt cccacttcga
     2041 acgacggaat aaatctctcc ttccccggtg gccatcaaaa actccccttt tgtggacagt
     2101 cttattcaaa cattttagaa cataccccaa agtagggggc tggttaggcc tagactggtt
     2161 tcgggtgcaa gcacagtaag gtaaactgtg tcctttgggt gaacttttaa ggagaaccct
     2221 attgaccatc ctgtgtctat gaagaatgag ttagcatgtg attaaaaaaa tcagctgcat
     2281 catgggaagg gtcatgcaca gtcaggaaag gcttatagaa tccaagtctg tcagcgaaaa
     2341 tagaaaatta tgctactttg caactaacac ctttccctga gactttatca aagggacact
     2401 gggcaatgac cctgggccct tgagtactgt gatcatcacc cgtttgcagc acatttctaa
     2461 tctgtatggt cactgtgctt ttaaataaag tttccttgct acttcgcaaa aaaaaaaaaa
     2521 aaaaaaaaaa aaaaaaaa
//
