LOCUS       NM_001108878            4305 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus thrombospondin type 1 domain containing 1
            (Thsd1), mRNA.
ACCESSION   NM_001108878 XM_001064856 XM_344542
VERSION     NM_001108878.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4305)
  AUTHORS   Gao L, Zhang Y, Qiu W, Xu W, Feng X, Ren J, Jiang X, Wang H, Zhao D
            and Wang Y.
  TITLE     Effects of PI3-k/Akt short hairpin RNA on proliferation,
            fibronectin production and synthesis of thrombospondin-1 and
            transforming growth factor-beta1 in glomerular mesangial cells
            induced by sublytic C5b-9 complexes
  JOURNAL   Cell Prolif 42 (1), 83-93 (2009)
   PUBMED   19143766
  REMARK    GeneRIF: C5b-9 can promote proliferation of GMCs and secretion of
            fibronectin as well as synthesis of thrombospondin-1 and
            transforming growth factor-beta(1)
REFERENCE   2  (bases 1 to 4305)
  AUTHORS   Takayanagi S, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J,
            Eto K, Motohashi T, Shiomi K, Keino-Masu K, Masu M, Oike Y, Mori S,
            Yoshida N, Iwama A and Nakauchi H.
  TITLE     Genetic marking of hematopoietic stem and endothelial cells:
            identification of the Tmtsp gene encoding a novel cell surface
            protein with the thrombospondin-1 domain
  JOURNAL   Blood 107 (11), 4317-4325 (2006)
   PUBMED   16455951
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473970.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344542.3, XM_001064856.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760384
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4305
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..4305
                     /gene="Thsd1"
                     /note="thrombospondin type 1 domain containing 1"
                     /db_xref="GeneID:364630"
                     /db_xref="RGD:1306998"
     exon            1..113
                     /gene="Thsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            114..257
                     /gene="Thsd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2752
                     /gene="Thsd1"
                     /note="thrombospondin type-1 domain-containing protein 1;
                     thrombospondin, type I, domain 1; thrombospondin, type I,
                     domain containing 1"
                     /codon_start=1
                     /product="thrombospondin type-1 domain-containing protein
                     1 precursor"
                     /protein_id="NP_001102348.1"
                     /db_xref="GeneID:364630"
                     /db_xref="RGD:1306998"
                     /translation="MKPMLKDFSNLLLVVLCDYVLGEADYLVLREPVHVALSDRTVSV
                     GFHYLGDVNGTLRNVTVMLWEANTNRTLTTKYLLTNQAQGTLQFECFYFKEAGDYWFV
                     MIPEETDNGTRVPLWEKSASLKVEWPVFHIDLNRTAKAAEGTFQVGIFTSQPLCLFPV
                     DKPDLLVDVIFKDSLPEARTSLGQPLEIRASKRTRLTQGQWVEFGCAPLGVEAYVTVM
                     LRLLGQDSVIASTGPIDLAQKFGYKLMMAPEVRCESVLEVMVLPPPCVFVQGVLAVYK
                     EAPKAPEERTFQMAENRLPLGERRSVFNCTLFDVGKNKYCFNFGILKKSHFSAKGCML
                     IQRNIETWGPWQPWSPCSTTCGDAVRERRRTCVTSFPSRPSCSGKPSETSPCSLEECA
                     VFRPPDPSPDPEKYNNVVTVTGISLCLFIIFATVLITLWRRFGRAPKCSTPARHNSIH
                     SPGFRKNSDEENICELSEPRGSFSDAGDGPRGSPGDTGIPLTYRCSASAPPEDEASGS
                     ESFQSNAQKIIPPLFSYRLAQQQLKEMKKKGLTETTKVYHVSQSPLTDTVVDATASPP
                     LDLECPEEAAASKFRIKSPFLDQPGAGPGERPPSRLDGVLPPPSCAVSPSQTLIRKSQ
                     MRSTGGRDGSSERGHCRSSLFRRTASFHETKQARPFRERSLSALTPRQAPAYSSRMRT
                     WEQMEDRGRPPSRSAHLLPERPEHFQGAAGRASSPLGPLSKSYTVGHPRRKPDPGDRQ
                     AGLVAGAAAEKMEPHRAHRGPSPSHRSASRKQTSPVFLKDSYQKVSQLSPSHFRKDKC
                     QSFPIHPEFAFYDNTSFRLTEAEQRMLDLPGYFGSNEEDETTSTLSVEKLVI"
     exon            258..1217
                     /gene="Thsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1376
                     /gene="Thsd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..4305
                     /gene="Thsd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagctctg gatctgggcg tgcagctgcg ggaccggaga tgctcggcca gtcaccctgt
       61 ggtcgctgag gctctcctct catttccgcc gtgccagaca gacccgacca gaggtgcttt
      121 tggaaaggaa aaacaaccca caattttggt gtgagaaagg acatgaggag actacaggcc
      181 tgggttcttc ccgatcagaa tgaaacccat gttgaaagac ttttcaaatc tcttgctggt
      241 ggtgctctgt gactatgtcc ttggagaagc cgactacctc gtcttacgag agccagtcca
      301 cgtggcgctg agcgaccgaa cggtgtcagt gggtttccac tacctcggtg acgtcaacgg
      361 gacactgagg aatgtgactg tcatgctgtg ggaggccaac accaaccgga ctcttaccac
      421 taagtacctc ctgaccaacc aggcccaggg aacactccag tttgaatgct tctacttcaa
      481 ggaggctggt gactactggt ttgtgatgat cccagaagag acagacaatg gcacacgagt
      541 tcccctctgg gagaaaagtg cctctctgaa ggtcgaatgg cccgtctttc acatcgattt
      601 aaataggaca gccaaggcgg cagaaggcac cttccaagtg ggtattttta cctcccaacc
      661 gctctgcctg tttcctgtgg acaagccaga cctgctggtg gatgtcatct tcaaggacag
      721 ccttcctgag gcaagaacaa gtttgggaca gccgctggag atccgagcca gcaaaaggac
      781 aagactcact caaggccagt gggtcgagtt tggctgtgca cccctagggg tggaagccta
      841 cgttacggtg atgctgaggc ttttgggtca agactcagtc attgcttcga cgggacctat
      901 tgacctggcc caaaagttcg gatacaaatt gatgatggca ccggaagtca ggtgtgagtc
      961 tgtcctggag gtgatggtac tgccacctcc ttgtgtcttt gtccaaggag tgctggctgt
     1021 ttacaaagaa gcccccaaag ccccggagga gaggaccttc cagatggctg aaaacaggct
     1081 gcccctggga gagaggagat cggtgtttaa ctgcactttg tttgatgtgg ggaagaacaa
     1141 gtattgcttt aactttggaa ttttgaagaa aagccatttt tctgcaaagg gatgcatgct
     1201 aattcagaga aatatagaaa cttggggacc atggcagccg tggagcccgt gtagcaccac
     1261 gtgcggggat gctgtccgag agcgtcgccg cacgtgcgtc acttccttcc cctccagacc
     1321 cagctgctct ggaaagccct cagagacctc tccatgctcc ctggaggagt gtgctgtttt
     1381 ccggccacca gacccatcgc cggacccgga gaagtacaac aacgtggtga ccgtcacagg
     1441 gatatccctg tgcttgttca tcatctttgc caccgtgctc atcaccctct ggaggagatt
     1501 cggcagagcc cccaaatgca gcacgccggc ccgccacaac tccatccatt cccccggctt
     1561 ccggaagaac tcggatgagg agaacatctg cgagctgagc gagcctcgcg gaagcttctc
     1621 ggatgcgggg gacgggccca ggggaagccc aggggacacg ggcatcccgt tgacttaccg
     1681 gtgcagtgcg tcagcgcctc ctgaggacga ggcctccggc agtgagagct ttcagtccaa
     1741 cgctcagaag atcatcccgc ccctgtttag ctaccgcctg gcccagcagc agctgaagga
     1801 gatgaagaag aaagggctga cagagaccac caaagtgtac cacgtgtctc agagccccct
     1861 gacagacacg gtagtggatg ccactgccag ccccccctta gacctggagt gccccgaaga
     1921 ggcagcagca agcaagttcc ggatcaagtc tccttttctg gaccagcctg gggcaggtcc
     1981 cggggaaagg cccccctcca ggctggatgg cgtcctgcct ccgcccagct gtgcggtcag
     2041 ccccagccag acgctgatcc gcaagtccca gatgaggtcg actggtggga gagatggctc
     2101 gtcggagcgg ggccactgca gaagttccct cttccggagg actgctagtt ttcacgaaac
     2161 caagcaggct cgccctttca gggagaggag tttgtcagcc ctgactcccc gccaggcccc
     2221 cgcctacagt tccaggatga ggacctggga gcagatggag gataggggtc ggcctcccag
     2281 tcgaagtgct cacctgcttc cagagaggcc ggaacacttc caaggggcgg caggtcgggc
     2341 cagcagtcct ttgggtccac tctccaaatc ctacactgtg gggcatccca ggaggaaacc
     2401 cgacccgggg gatcgccagg ctgggttggt ggcaggagct gctgcggaga aaatggagcc
     2461 tcaccgagct cacaggggac cgtcccccag tcacaggagt gcgtcaagga agcagacttc
     2521 ccccgttttc ctcaaggaca gctaccagaa agtcagtcag cttagccctt ctcacttcag
     2581 gaaagataaa tgccagagct tccccatcca ccctgagttc gccttctacg acaacacctc
     2641 tttccgcctc accgaggctg agcagagaat gctggacctc ccgggatact ttggctccaa
     2701 cgaagaggac gaaaccacta gtacactgag cgtggagaag ttagtaatct aggctaggaa
     2761 gcggcagggc tcacccaggt ccttccccca gctggcaata tcccttgctc gctagtgctg
     2821 tacaaccgtg ggtacaaccg tgggaattag tcggggagat gggatttatc ctgaactttc
     2881 cttttgttac cccttttcta ttggcttatt actactaata aaattgaaag aaggcaaatg
     2941 tatgatgcat tttgaacgct acacatgatg tttccaattt aggcatctgg gagattttcc
     3001 caaggggtag gagcctccca gtgcctgatg ggtatgcaga accattatac aagtgacctt
     3061 gcttagcatc ttgctttgtt ttgaagcagg aaccaaacaa aggagcctaa atgtggggct
     3121 gcttcttttg aagtttgtta ccaagattcc gagtggccta aggactaatc agcatacaca
     3181 gaaatagcta cgtgtttgtg gtgacctcca gctaccacac ccatcctgcc tttagattga
     3241 tttccttctt ttagagtttt atcaggacgt caggcagcca gggaggtttc agacaggggg
     3301 aaatcagaaa tgtaaacatg gtagttccaa aagttaatat ttgttcaact gtcacttgtg
     3361 actttttgtt ttttaaatta aaatgtgctt cctttggaac tgtttcagca atgactgcgg
     3421 gctcttcagg aacaggaggg gtgggttgtc cagagctgtg tggcaactcc tatgcatgga
     3481 tgaaagaaga gccaggcgtg ttactcccca gtctctttat ttacctcacc agaaagcttt
     3541 gttctctacc caagttcaca ggcctgtggg ccagcctttg acacaggggc acatgattgc
     3601 ttgtcccaga ggtttaccca gcagtgtcac tctgagacca aaacagcttt ggaaaagtgg
     3661 aaattcatgt gggctgagac ttttcctgtc aagtgatact cactaacagt ctacccagcc
     3721 cagtgttctg gggctctcac taacagcgaa acccctgcct ccaggaaaaa agatgcttcc
     3781 ccgcaggctt taatgtggga gttgtaaatt tcagtgcaca gatttttggt atcttaccac
     3841 tgtgtctgcg tgttctagtc ccagtagctg ctatagaata ggggctcaat aaagacacgg
     3901 caagtggcca gctagcaaaa tgccttaaaa ccagttgtgg ttgaagtaga atgactcttc
     3961 ataacacttt acattgcaca tcattataaa ggaaatgcat tcgtgagaca tcatgaggtt
     4021 tcagtttata gaggcctcac ctcacaaaca taagtacttt tttttttttt tttttttttt
     4081 tttgcagtca ccagtttgtg catttccagc catcctgaga acaaccaatg atgcttggcc
     4141 agcgttttgc tggttccgtg tttcagatta tcttagtgta tgtaacttca cgaagctggg
     4201 tgagcacgcc acatttatat gtttattgtg tgtgtcctga ccagtaatgt gtccgtgctc
     4261 accttgctga gaagaaatgt tctttttaaa tatagttttt aatct
//
