LOCUS       NM_012703               1300 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus thyroid hormone responsive (Thrsp), mRNA.
ACCESSION   NM_012703
VERSION     NM_012703.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1300)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 1300)
  AUTHORS   Colbert,C.L., Kim,C.W., Moon,Y.A., Henry,L., Palnitkar,M.,
            McKean,W.B., Fitzgerald,K., Deisenhofer,J., Horton,J.D. and
            Kwon,H.J.
  TITLE     Crystal structure of Spot 14, a modulator of fatty acid synthesis
  JOURNAL   Proc Natl Acad Sci U S A 107 (44), 18820-18825 (2010)
   PUBMED   20952656
REFERENCE   3  (bases 1 to 1300)
  AUTHORS   Aipoalani,D.L., O'Callaghan,B.L., Mashek,D.G., Mariash,C.N. and
            Towle,H.C.
  TITLE     Overlapping roles of the glucose-responsive genes, S14 and S14R, in
            hepatic lipogenesis
  JOURNAL   Endocrinology 151 (5), 2071-2077 (2010)
   PUBMED   20233797
  REMARK    GeneRIF: Data support the hypothesis that both S14 and S14R are
            directly involved in supporting hepatic lipogenesis and that the
            two proteins play overlapping roles in this process.
REFERENCE   4  (bases 1 to 1300)
  AUTHORS   Zhi,J., Xu,G., Rubin,C.T. and Hadjiargyrou,M.
  TITLE     The lipogenic gene spot 14 is activated in bone by disuse yet
            remains unaffected by a mechanical signal anabolic to the skeleton
  JOURNAL   Calcif Tissue Int 82 (2), 148-154 (2008)
   PUBMED   18219437
  REMARK    GeneRIF: Anabolic mechanical stimulation (45 Hz, 10 min/day at 0.25
            g) did not show a statistically significant effect on S14
            expression.
REFERENCE   5  (bases 1 to 1300)
  AUTHORS   Zhu,Q., Anderson,G.W., Mucha,G.T., Parks,E.J., Metkowski,J.K. and
            Mariash,C.N.
  TITLE     The Spot 14 protein is required for de novo lipid synthesis in the
            lactating mammary gland
  JOURNAL   Endocrinology 146 (8), 3343-3350 (2005)
   PUBMED   15890771
REFERENCE   6  (bases 1 to 1300)
  AUTHORS   Campbell,M.C., Anderson,G.W. and Mariash,C.N.
  TITLE     Human spot 14 glucose and thyroid hormone response:
            characterization and thyroid hormone response element
            identification
  JOURNAL   Endocrinology 144 (12), 5242-5248 (2003)
   PUBMED   12960053
  REMARK    GeneRIF: significantly greater thyroid hormone response for the
            human promoter, compared with the rat
REFERENCE   7  (bases 1 to 1300)
  AUTHORS   Lee,A.K., Kang,K.W., Kim,Y.G., Cho,M.K., Lee,M.G., Shim,C.K.,
            Chung,S.J. and Kim,S.G.
  TITLE     Identification of genes enhanced by protein-calorie malnutrition by
            differential display polymerase chain reaction (expression of
            fibrinogen B beta chain, B cell translocation gene 1 and thyroid
            hormone responsive protein genes)
  JOURNAL   Mol Cell Biochem 231 (1-2), 163-171 (2002)
   PUBMED   11952159
  REMARK    GeneRIF: Identification of genes enhanced by protein-calorie
            malnutrition by differential display polymerase chain reaction
            (expression of fibrinogen B beta chain, B cell translocation gene 1
            and thyroid hormone responsive protein genes)
REFERENCE   8  (bases 1 to 1300)
  AUTHORS   MacDougald,O.A. and Jump,D.B.
  TITLE     Identification of functional cis-acting elements within the rat
            liver S14 promoter
  JOURNAL   Biochem J 280 (Pt 3) (Pt 3), 761-767 (1991)
   PUBMED   1764039
REFERENCE   9  (bases 1 to 1300)
  AUTHORS   Jump,D.B., Bell,A. and Santiago,V.
  TITLE     Thyroid hormone and dietary carbohydrate interact to regulate rat
            liver S14 gene transcription and chromatin structure
  JOURNAL   J Biol Chem 265 (6), 3474-3478 (1990)
   PUBMED   2303455
REFERENCE   10 (bases 1 to 1300)
  AUTHORS   Liaw,C.W. and Towle,H.C.
  TITLE     Characterization of a thyroid hormone-responsive gene from rat
  JOURNAL   J Biol Chem 259 (11), 7253-7260 (1984)
   PUBMED   6327713
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089061.1.
            
            On Jan 27, 2005 this sequence version replaced NM_012703.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089061.1, FQ214269.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1300
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1300
                     /gene="Thrsp"
                     /gene_synonym="Lpgp; S14; SPOT14"
                     /note="thyroid hormone responsive"
                     /db_xref="GeneID:25357"
                     /db_xref="RGD:3859"
     exon            1..477
                     /gene="Thrsp"
                     /gene_synonym="Lpgp; S14; SPOT14"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..458
                     /gene="Thrsp"
                     /gene_synonym="Lpgp; S14; SPOT14"
                     /note="spot 14 protein; thyroid hormone responsive SPOT14
                     homolog; Lipogenic protein S14"
                     /codon_start=1
                     /product="thyroid hormone-inducible hepatic protein"
                     /protein_id="NP_036835.2"
                     /db_xref="GeneID:25357"
                     /db_xref="RGD:3859"
                     /translation="MQVLTKRYPKNCLLKVMDRYSAVVRNMEQVVMIPSLLRDVELSG
                     YGGSVQDGAPDLYTYFTMLKSICVEVDHGLLPREEWQAKVAGNEGSEAENEAAETEEA
                     EEDRLSEELDLEAQFHLHFSSLHHILTHLTQKAQEVTQKYQEMTGQVL"
     exon            478..1234
                     /gene="Thrsp"
                     /gene_synonym="Lpgp; S14; SPOT14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccatgca agtgctaacg aaacgctacc ccaagaattg cctgctgaag gtcatggatc
       61 ggtactcggc tgtggtgcgg aacatggagc aagtggtgat gatccccagc cttctgaggg
      121 atgtggagct gagtgggtac ggaggctcgg tccaggacgg agcccccgat ctctatacct
      181 acttcaccat gctcaagagc atctgtgtag aagtggacca cgggctgctg ccgcgggagg
      241 aatggcaggc caaggtggca ggcaatgaag gcagtgaggc tgagaatgag gctgctgaaa
      301 cagaggaggc tgaggaagac aggctttcgg aggagctgga cctagaagcc cagttccacc
      361 tgcacttctc cagcctccat cacatcctta cccacctgac ccagaaagca caggaggtga
      421 cgcagaaata ccaggaaatg acggggcagg tcctgtaggt cttcgactct atggaagatc
      481 actttacacg agagggaaga cgatgaggac ccagcggtgc atcagccccg agaccaggaa
      541 ggaagacctg gacccaggtg gatgcaaagg cggctcctgt ccctgggtgt cccccacctc
      601 cctctgagcg catctgtgga cttggctgca ggctcacctt taagatgtct gttgtgattc
      661 ccaacttctc ttccatgtct tagcagtttg aggttcacag gcagcaagga tcagtagaag
      721 gcagaggtaa tagcaagcgg ccagagttca catcccatcc ctgggatgtc ctttagtgcc
      781 tggggtcaca gttactcttt catgtataaa gcagggacgc tgtatttacc tcacaaggtt
      841 actaaacgga cacggaatca aaggcacctg tcacgtgcgg atgtctgaac agctggtgtt
      901 tctcttacct tcctcagaga gcatgctctg tgtagctctt gcttttgacc cccaacccca
      961 ggaaaaggtt gaggtagttg agtgtgtggg atgagcttct catcctgttg gatctgatga
     1021 ggctgagcac aagtgaacta tgcaactatt atagtagcaa ttaaaaaata catggcatgc
     1081 tgatcttttt tttttcttct tcttattgat tcttcatgaa tttcacatca tgacccccag
     1141 tcccattcat cttcgtccct ccatatctgc cctccaccct tgcaacttcc tccacaaaag
     1201 aaaacaaaca aataaacaaa actttgctgt ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1261 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
