LOCUS       NM_012672               6243 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus thyroid hormone receptor beta (Thrb), transcript
            variant 1, mRNA.
ACCESSION   NM_012672
VERSION     NM_012672.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6243)
  AUTHORS   Mukherjee,S., Dasgupta,S., Adhikari,U. and Panja,S.S.
  TITLE     Molecular modeling and molecular dynamics simulation studies on
            thyroid hormone receptor from Rattus norvegicus: role of conserved
            water molecules
  JOURNAL   J Mol Model 27 (5), 126 (2021)
   PUBMED   33834296
  REMARK    GeneRIF: Molecular modeling and molecular dynamics simulation
            studies on thyroid hormone receptor from Rattus norvegicus: role of
            conserved water molecules.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6243)
  AUTHORS   Fernandez,M., Pannella,M., Baldassarro,V.A., Flagelli,A.,
            Alastra,G., Giardino,L. and Calza,L.
  TITLE     Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with
            the Retinoic Acid Pathway
  JOURNAL   Int J Mol Sci 21 (23), 8945 (2020)
   PUBMED   33255695
  REMARK    GeneRIF: Thyroid Hormone Signaling in Embryonic Stem Cells:
            Crosstalk with the Retinoic Acid Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6243)
  AUTHORS   Leach,P.T., Kenney,J.W., Connor,D.A. and Gould,T.J.
  TITLE     Thyroid receptor beta involvement in the effects of acute nicotine
            on hippocampus-dependent memory
  JOURNAL   Neuropharmacology 93, 155-163 (2015)
   PUBMED   25666034
  REMARK    GeneRIF: This study demonstrated that Thyroid receptor beta
            involvement in the effects of acute nicotine on
            hippocampus-dependent memory
REFERENCE   4  (bases 1 to 6243)
  AUTHORS   Frau,C., Loi,R., Petrelli,A., Perra,A., Menegon,S., Kowalik,M.A.,
            Pinna,S., Leoni,V.P., Fornari,F., Gramantieri,L.,
            Ledda-Columbano,G.M., Giordano,S. and Columbano,A.
  TITLE     Local hypothyroidism favors the progression of preneoplastic
            lesions to hepatocellular carcinoma in rats
  JOURNAL   Hepatology 61 (1), 249-259 (2015)
   PUBMED   25156012
  REMARK    GeneRIF: down-regulated in hepatocellular carcinoma
REFERENCE   5  (bases 1 to 6243)
  AUTHORS   Sharma,P., Thakran,S., Deng,X., Elam,M.B. and Park,E.A.
  TITLE     Nuclear corepressors mediate the repression of phospholipase A2
            group IIa gene transcription by thyroid hormone
  JOURNAL   J Biol Chem 288 (23), 16321-16333 (2013)
   PUBMED   23629656
  REMARK    GeneRIF: a novel inverse recruitment mechanism in which liganded
            TRbeta recruits corepressors to inhibit PLA2g2a expression.
REFERENCE   6  (bases 1 to 6243)
  AUTHORS   Horlein,A.J., Naar,A.M., Heinzel,T., Torchia,J., Gloss,B.,
            Kurokawa,R., Ryan,A., Kamei,Y., Soderstrom,M., Glass,C.K. et al.
  TITLE     Ligand-independent repression by the thyroid hormone receptor
            mediated by a nuclear receptor co-repressor
  JOURNAL   Nature 377 (6548), 397-404 (1995)
   PUBMED   7566114
REFERENCE   7  (bases 1 to 6243)
  AUTHORS   Ali,I.U., Lidereau,R. and Callahan,R.
  TITLE     Presence of two members of c-erbA receptor gene family (c-erbA beta
            and c-erbA2) in smallest region of somatic homozygosity on
            chromosome 3p21-p25 in human breast carcinoma
  JOURNAL   J Natl Cancer Inst 81 (23), 1815-1820 (1989)
   PUBMED   2573734
REFERENCE   8  (bases 1 to 6243)
  AUTHORS   Hodin,R.A., Lazar,M.A., Wintman,B.I., Darling,D.S., Koenig,R.J.,
            Larsen,P.R., Moore,D.D. and Chin,W.W.
  TITLE     Identification of a thyroid hormone receptor that is
            pituitary-specific
  JOURNAL   Science 244 (4900), 76-79 (1989)
   PUBMED   2539642
REFERENCE   9  (bases 1 to 6243)
  AUTHORS   Murray,M.B., Zilz,N.D., McCreary,N.L., MacDonald,M.J. and
            Towle,H.C.
  TITLE     Isolation and characterization of rat cDNA clones for two distinct
            thyroid hormone receptors
  JOURNAL   J Biol Chem 263 (25), 12770-12777 (1988)
   PUBMED   2457590
REFERENCE   10 (bases 1 to 6243)
  AUTHORS   Koenig,R.J., Warne,R.L., Brent,G.A., Harney,J.W., Larsen,P.R. and
            Moore,D.D.
  TITLE     Isolation of a cDNA clone encoding a biologically active thyroid
            hormone receptor
  JOURNAL   Proc Natl Acad Sci U S A 85 (14), 5031-5035 (1988)
   PUBMED   2899322
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Aug 4, 2012 this sequence version replaced NM_012672.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000015.1  10461376-10461446   c
            72-132              JAXUCZ010000015.1  10325462-10325522   c
            133-211             JAXUCZ010000015.1  10313598-10313676   c
            212-275             JAXUCZ010000015.1  10205577-10205640   c
            276-536             JAXUCZ010000015.1  10181503-10181763   c
            537-637             JAXUCZ010000015.1  10146731-10146831   c
            638-745             JAXUCZ010000015.1  10141914-10142021   c
            746-893             JAXUCZ010000015.1  10140339-10140486   c
            894-1099            JAXUCZ010000015.1  10137062-10137267   c
            1100-1246           JAXUCZ010000015.1  10127633-10127779   c
            1247-1505           JAXUCZ010000015.1  10124144-10124402   c
            1506-6243           JAXUCZ010000015.1  10115954-10120691   c
FEATURES             Location/Qualifiers
     source          1..6243
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..6243
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /note="thyroid hormone receptor beta"
                     /db_xref="GeneID:24831"
                     /db_xref="RGD:3858"
     exon            1..71
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            72..132
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            133..211
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            212..275
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1747
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thyroid hormone receptor, beta (avian erythroblastic
                     leukemia viral (v-erb-a) oncogene homolog 2);
                     TRbeta2Delta; thyroid hormone receptor beta2delta; nuclear
                     receptor subfamily 1 group A member 2; thyroid hormone
                     receptor beta 3"
                     /codon_start=1
                     /product="thyroid hormone receptor beta isoform 1"
                     /protein_id="NP_036804.2"
                     /db_xref="GeneID:24831"
                     /db_xref="RGD:3858"
                     /translation="MTPNSMTENGLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVE
                     RRGALKNEQTSSHLIQATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLD
                     KDELCVVCGDKATGYHYRCITCEGCKPSHTRDEKTGIWFHTDTSSTSLHSVWMLSSRQ
                     WDPEGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVLDD
                     SKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
                     QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPC
                     EDQIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDL
                     GMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHV
                     THFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED"
     exon            276..536
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            537..637
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            638..745
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            746..893
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1099
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1246
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1505
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..6243
                     /gene="Thrb"
                     /gene_synonym="c-erbA-2; C-erba-beta; ERBA2; Nr1a2;
                     RATT3REC; T3rec; TRbeta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaccggct gctcggccgc agctcgcccg cgcgccgcct cggggcgcca ccgccaggct
       61 ccagcgctcc ggttcaagag gagccacact ggggagtccc aaggaagcag ccaggcagat
      121 ggggagccca ggatccgtgg tttccctctc cttagtctgc tggaggacgc gcgtggtggt
      181 accaagttcc acacatgact taatgaataa gggaatgcca gagctgaaga ggacccagca
      241 tgactactaa cctatgactc ctaacagtat gacagaaaat ggccttccag cctgggacaa
      301 acagaagccc catccagacc gaggccagga ctggaagctg gtaggaatgt ccgaagcctg
      361 cctgcacagg aagagccatg tggagaggcg tggtgcattg aagaatgagc aaacatcctc
      421 acacctcatc caggccactt gggcgagctc tatattccat ctggatccag acgatgtgaa
      481 cgatcagagc gtctcaagcg cccagacttt ccagaccgaa gagaagaaat gtaaagggta
      541 tatccccagc tatctagaca aggatgagct ctgcgtagtg tgcggggaca aagccacggg
      601 gtaccactat cgctgcatca cctgtgaagg ctgcaagcct tctcacacca gagacgagaa
      661 gacagggatt tggttccata cagacaccag ttctacctct ctgcattcgg tctggatgtt
      721 gtcctcaagg cagtgggacc ctgagggttt ctttagaaga accattcaga aaagtctcca
      781 tccatcttac tcctgtaaat atgaagggaa gtgcatcata gacaaagtca cccgtaacca
      841 gtgccaggaa tgtcgcttta agaaatgcat ctatgttggc atggcaacag acctggtgct
      901 ggatgacagc aagaggctag ccaagaggaa gctgatagaa gagaaccgtg agaagaggcg
      961 gcgggaagag ctacagaaat ccattgggca taagccagag cccacggatg aggaatggga
     1021 gctcatcaag acagtcaccg aggcccacgt ggccaccaat gcccagggca gccactggaa
     1081 gcagaagcgg aaatttctgc ctgaagacat tggacaagca cccattgtga acgccccgga
     1141 aggtggcaag gttgatctgg aagccttcag ccattttaca aaaatcatca caccagcaat
     1201 caccagagtg gtggatttcg ccaaaaagtt gcccatgttt tgtgagctgc cctgtgaaga
     1261 ccagatcatc ctcctcaaag gctgctgcat ggagatcatg tccctccgag ctgctgtgcg
     1321 ctatgaccca gacagcgaga ctctaacctt gaatggggaa atggcagtga cacggggcca
     1381 gctgaaaaac ggaggtcttg gggtggtgtc agatgcgatc tttgacctgg gcatgtctct
     1441 gtcgtctttc aacctggatg acacggaggt tgccctgctt caagccgtcc tgctgatgtc
     1501 ttcagatcgc ccagggctag cttgtgttga gagaattgag aaataccaag acagtttcct
     1561 gttggccttt gaacactata tcaattaccg gaagcaccat gtgacacact tttggcccaa
     1621 actcctgatg aaggtgacgg acctgcggat gattggagcg tgccacgcca gccgcttcct
     1681 gcacatgaag gtggagtgcc ccaccgagct cttcccgcct ctcttcttgg aagtctttga
     1741 ggactgaacg gactggacag gttcttgtca ttcctgcagc acgactgggt gtcgctgcat
     1801 tccacctgta gctctttctg ttgtcgtttc ttcgtttctt tgtgtcaagt gagctcatca
     1861 gtgggtcagc gggtcatcag tggcatagac ttggatgaag tggtcctttg aatgtgggtc
     1921 tttgtaacca ttgcgtttcg ttctccagtc cttagtgtga cggctttgag gggttcacag
     1981 cagtgcaggc cgagtggggg cgatcatctc accagcacca cgtcgtcacc agctcccatc
     2041 tgtccctggg cagactcaag caagccaaat ggcattacag aagactaaag aagccttaaa
     2101 accgagacga cagtcatctt gatccaatgc gatccagttc tgttgtttgt aaggtgaagc
     2161 tggcagagct caggccacct caggttgggc gtggcttttg gcgcgtgagg ggaggagccg
     2221 ttccagcttc aggaactcac agctactcag gagcttaccg cttccagcac ccttactctc
     2281 caagcaggct gacttggaat gtgcaggata cccacaccat aacaaatcga cgttactttc
     2341 catggccttc tgtaaccttg tgatttactt caagttgcgc aagagtagaa cttggagact
     2401 tgactggttt gaggccacaa ggaaagtctc cttttcagga tgcccataga gcttggaaat
     2461 catccatgtt acagcatagt ttccaaaaat ggtgttacct caagcaggaa ggcacctttg
     2521 cagcttagat agattcacaa gccattccca cagagctcaa acctgtttac agagtgccgt
     2581 ccctcttccg atggcctatg aaccagccct ctccccagcc tgtggctgtt gagctggtga
     2641 tgtttccctg tacattgaat cttccaatca gagagagacg tgttgaaact ccagtcttgt
     2701 tttggaaaaa tccctggaaa agatcaatgc aggaacaatc agattcaaag gaaaagaact
     2761 actcatgctg taggctgtcc aattagggag aatgctcccc gtggatcggc aagcgcttta
     2821 cccattcaca aatgtctccc agtcccatcc cgtctctgct cccaaaccca cctcctcaga
     2881 ttctgagaca ctaaatagct tctcttctct tctcttctct tctcttctct tctcttctct
     2941 tctcttctct tctcttccct tctcttctct ctctcaacac taactcttct gtagcttata
     3001 cactattacc ttggcaaata gtcctcataa aatatagcag accatgcata ggaaacacca
     3061 ttacgctgcc ccatccccag tgaccgtgta gagtagatgt ctctaagcaa ccagtagtga
     3121 caacttaccc aaaaatgggc agactgtacc catgcaactg aatgtacgac tcttcactga
     3181 tgtcacagat gtgaactact tcttgtctgc ctttcactgc cttagcctgg aaatgctggg
     3241 aaaaacaagc catatcagtg agaattacct aaaagcaaag gaagtcactg tgaaaagcaa
     3301 gggaactcac ttcttcccac cgggctcggt agagcatctt tggcctcaca gcaagtcagg
     3361 gtgcctgcgg cctgggtcat ttaggacctt acagtgttag ttttcttacc tcctagtaaa
     3421 tgagttgatc tccagaaacc cctcttccct tctctagtgt ttgacttttc agctaaggag
     3481 ggggcgtctt tgaaagattc cttttctatt caaacttcta gcttcggaaa cggaatgcat
     3541 gtgggtgctc atggagtgag aatgaggatt tgattcagag gaaggcagaa tgacctcgga
     3601 agcagagagg tacagccctg aaagtctttg gaaataactg aggaaaaggg aacagtctgt
     3661 gcagggaact aaagatttag cctgatgttt tagcagataa aacatcgctg tagacttggt
     3721 gtggagatta aatagaaaca agaagcccca gagagtcaag ttcaagcatc tgtctgagat
     3781 ttgctttccc aggcaacctg tacccagcct cctccctcag gaatttcatt aaaacatctg
     3841 tcccctctgt cagctctcct ggaatgcctc tgtccagaca attaaaacac acttgctgtg
     3901 agaccagttc tccgtccaaa gagggagaga gggaggtgac aggtaggtga gtcccacaca
     3961 ggcatacaaa cttctggggc accagagttt ctgaggaagt ttcctgatgc tgacagtttt
     4021 caaatggcat cggaaaccct ggcattagtg cagggtttga cccagggtca ttcagagcgc
     4081 tgtaaagatt aagcgctggg cactagcccg gtcctcacaa tccagccagc cacagcacag
     4141 tgaccctccc tctgtagagg ctcacctttc agggacgaac caggctgtag caaccgtgga
     4201 gactgagtac tgaacaagac aagcaagctt cagtcttctg gcgggaagga acaagaacgg
     4261 taggcattca gaatggcctt cgagaaactc attttatgca ctagattgtg agggatttgc
     4321 tcccaatgtt tttttttttc ttcttcttct tcttcttttt caaagtcatt cccttctaat
     4381 cttgtccaga ctttcaattc aagtgtggac gcggtgacaa gaacctttac acctgctcca
     4441 ccgtggggag actttccagt caaggagaac acgctcatcc tgctggggca ctcactgaca
     4501 aatggtattc atgaacgaga aggctgtgca catgcaaccg acatgtgcgt gtgcacacat
     4561 gtgcgtacat ccggtcgttg cctcaagtgt actttgcact tcagttaaaa tgtgcagaac
     4621 ttccagaaac tggaagaaga agaagaagaa aaaaaaaaaa aaactctcta actctgctct
     4681 aacaccatgt gccacctctg agctttttct agtcccttga gcctcagtcc tcagtgatgc
     4741 gcttaagtga tgaagcctca gcccagtgca ttcctcctcc tgtggcccca gggccacctc
     4801 tgtcccagtg caatctccga gagggctggg cctggctctg ctctgcagcg tccttctcac
     4861 attgacctgc aggccgggcg tgcaagcctt ctcctcctca cactcagctc tccccagtcc
     4921 agcctcatga cctgctgagc ctcctcagag cgcttcattg tcagtgagac ctctacgttc
     4981 tgtggaactc agacccatcc atgtcatact gacctttttg ctgcatgagt cataaattat
     5041 gaagtcagtc ttatggtttc tgagatgtaa ccagcgtttt gtaaggctaa acctttttca
     5101 cgaacttgat ttaagtggat aaccaaacca caggccctcc tccaaatgag agatgacaag
     5161 acaattgact ctctgccctt tgcagtggcg atggcatcag gtcctaaaat aagctcataa
     5221 ttttccttat tttaataata tggaaatatt agcatagtgt ttcttttgat agcgatagac
     5281 cgatccgtat ttaaatttta tagagaagaa attttattgt actgtgatgt agatatttat
     5341 tacccaggta aggatttgcc cggtgtgtat tttttacaat tgagacattt tactttaatc
     5401 tttaaaagag aaaaaaagac tattaaaaac atatacgtat taaaaaaaaa aaaggctagg
     5461 gagaaaaaaa ggtttggcct tatcacagga tttttactgt gtcgtataaa tgtttgcaaa
     5521 tgaaaaaaga aatcgcacat ttttggtgtg ttttccacat taattagtgc cgcctccagg
     5581 agcgatattg tgcagtaaac actgtttgtg gctttctgtc gcacagctcg aactggcccc
     5641 accttatgca caagacaatc agacgtgagt ctttcctctg aggacacaga ccatacgcaa
     5701 cagagcacaa tgtgacgcca agaacgagac ttgtaggcgt gcggctgaca gaggtggtca
     5761 gggcgtgtgc gcactcgagt ggccttgggc cactgcctcc ctttggctgt cctttgtggc
     5821 gttggcacct ttcgcttgac atcaaatagc caaagtagtt ctctgtgttt tcttcagaga
     5881 agaccgttct ttttccagta atgttttcat gccctgtgaa tcagaaaaaa aaaaaaaaaa
     5941 caacaacaac aacaaaaaaa aggtacgggt ggagtagaga ggttcatagt aagtggaagg
     6001 tttgtgtttt gcaaacagtg ttaagtgata ttgctgttgc tagattggta atattttttc
     6061 agcctaaaat tgttgaaatc tgtgatcaaa tgttttaaac tatccaaaag gaaaatttgt
     6121 atatttggga aaatggattt ttacatagct ttttgtatgc aaatattaaa ttgtaattat
     6181 gaatatagtg ggcgtaggta ctcataagct taaattctaa aaaaagaaaa ggcttacaat
     6241 gga
//
