LOCUS       NM_031133               1406 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus thrombopoietin like 1 (Thpol1), mRNA.
ACCESSION   NM_031133
VERSION     NM_031133.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1406)
  AUTHORS   Chang,C., Yang,J., Li,X., Zhao,W., Li,Y., Guo,P., Wang,G. and Xu,C.
  TITLE     Thrombopoietin Signaling Pathway Regulates Hepatocyte Activation in
            Rat Liver Regeneration
  JOURNAL   Biochem Genet 53 (9-10), 244-259 (2015)
   PUBMED   26116151
  REMARK    GeneRIF: Fourteen channels of thrombopoietin signaling pathway
            participated in regulating hepatocyte activation during rat liver
            regeneration.
REFERENCE   2  (bases 1 to 1406)
  AUTHORS   Dasouki,M.J., Rafi,S.K., Olm-Shipman,A.J., Wilson,N.R.,
            Abhyankar,S., Ganter,B., Furness,L.M., Fang,J., Calado,R.T. and
            Saadi,I.
  TITLE     Exome sequencing reveals a thrombopoietin ligand mutation in a
            Micronesian family with autosomal recessive aplastic anemia
  JOURNAL   Blood 122 (20), 3440-3449 (2013)
   PUBMED   24085763
REFERENCE   3  (bases 1 to 1406)
  AUTHORS   Wang,X., Muramatsu,H., Sakaguchi,H., Xu,Y., Narita,A., Tsumura,Y.,
            Doisaki,S., Tanaka,M., Ismael,O., Shimada,A., Hama,A., Takahashi,Y.
            and Kojima,S.
  TITLE     Mutation in the THPO gene is not associated with aplastic anaemia
            in Japanese children
  JOURNAL   Br J Haematol 158 (4), 553-555 (2012)
   PUBMED   22686250
REFERENCE   4  (bases 1 to 1406)
  AUTHORS   Kostyak,J.C., Naik,M.U. and Naik,U.P.
  TITLE     Calcium- and integrin-binding protein 1 regulates megakaryocyte
            ploidy, adhesion, and migration
  JOURNAL   Blood 119 (3), 838-846 (2012)
   PUBMED   22128142
REFERENCE   5  (bases 1 to 1406)
  AUTHORS   Marcucci,R. and Romano,M.
  TITLE     Thrombopoietin and its splicing variants: structure and functions
            in thrombopoiesis and beyond
  JOURNAL   Biochim Biophys Acta 1782 (7-8), 427-432 (2008)
   PUBMED   18433726
  REMARK    Review article
REFERENCE   6  (bases 1 to 1406)
  AUTHORS   Yang,C., Li,Y.C. and Kuter,D.J.
  TITLE     The physiological response of thrombopoietin (c-Mpl ligand) to
            thrombocytopenia in the rat
  JOURNAL   Br J Haematol 105 (2), 478-485 (1999)
   PUBMED   10233424
REFERENCE   7  (bases 1 to 1406)
  AUTHORS   Ishikawa,T., Ichida,T., Matsuda,Y., Sugitani,S., Sugiyama,M.,
            Kato,T., Miyazaki,H. and Asakura,H.
  TITLE     Reduced expression of thrombopoietin is involved in
            thrombocytopenia in human and rat liver cirrhosis
  JOURNAL   J Gastroenterol Hepatol 13 (9), 907-913 (1998)
   PUBMED   9794189
REFERENCE   8  (bases 1 to 1406)
  AUTHORS   Kondo,T., Okabe,M., Sanada,M., Kurosawa,M., Suzuki,S.,
            Kobayashi,M., Hosokawa,M. and Asaka,M.
  TITLE     Familial essential thrombocythemia associated with one-base
            deletion in the 5'-untranslated region of the thrombopoietin gene
  JOURNAL   Blood 92 (4), 1091-1096 (1998)
   PUBMED   9694695
REFERENCE   9  (bases 1 to 1406)
  AUTHORS   Wiestner,A., Schlemper,R.J., van der Maas,A.P. and Skoda,R.C.
  TITLE     An activating splice donor mutation in the thrombopoietin gene
            causes hereditary thrombocythaemia
  JOURNAL   Nat Genet 18 (1), 49-52 (1998)
   PUBMED   9425899
REFERENCE   10 (bases 1 to 1406)
  AUTHORS   Ogami,K., Shimada,Y., Sohma,Y., Akahori,H., Kato,T., Kawamura,K.
            and Miyazaki,H.
  TITLE     The sequence of a rat cDNA encoding thrombopoietin
  JOURNAL   Gene 158 (2), 309-310 (1995)
   PUBMED   7607561
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D32207.1.
            
            On Aug 31, 2012 this sequence version replaced NM_031133.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D32207.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1406              D32207.1           2-1407
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1406
                     /gene="Thpol1"
                     /gene_synonym="Thpo"
                     /note="thrombopoietin like 1"
                     /db_xref="GeneID:81811"
                     /db_xref="RGD:11455920"
     exon            1..33
                     /gene="Thpol1"
                     /gene_synonym="Thpo"
                     /inference="alignment:Splign:2.1.0"
     exon            34..184
                     /gene="Thpol1"
                     /gene_synonym="Thpo"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1152
                     /gene="Thpol1"
                     /gene_synonym="Thpo"
                     /note="thrombopoietin"
                     /codon_start=1
                     /product="thrombopoietin precursor"
                     /protein_id="NP_112395.1"
                     /db_xref="GeneID:81811"
                     /db_xref="RGD:11455920"
                     /translation="MELTDLLLVAILLLTARLTLSSPVPPACDPRLLNKLLRDSYLLH
                     SRLSQCPDVNPLSIPVLLPAVDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQL
                     EPSCLSSLLGQLSGQVRLLLGALQGLLGTQLPPQGRTTAHKDPSALFLSLQQLLRGKV
                     RFLLLVEGPALCVRRTLPTTAVPSRTSQLLTLNKFPNRTSGLLETNFSVVARTAGPGL
                     LNRLQGFRAKIIPGQLNQTSGSLDQIPGYLNGTHEPVNGTHGLFAGTSLQTLEAPDVV
                     PGAFNKGSLPLNLQSGLPPIPSLAADGYTLFPPSPTFPTPGSPPQLPPVS"
     exon            185..312
                     /gene="Thpol1"
                     /gene_synonym="Thpo"
                     /inference="alignment:Splign:2.1.0"
     exon            313..399
                     /gene="Thpol1"
                     /gene_synonym="Thpo"
                     /inference="alignment:Splign:2.1.0"
     exon            400..567
                     /gene="Thpol1"
                     /gene_synonym="Thpo"
                     /inference="alignment:Splign:2.1.0"
     exon            568..1406
                     /gene="Thpol1"
                     /gene_synonym="Thpo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtacctgg gtcctgaagc ccttcttcac ctggatagat tccttggccc acctgtcccc
       61 accccactct gtgcagaggt acaaaagctc aagccgtctc catggcccca ggaaagattc
      121 aggggagagg ccccacacag ggagccactg cagtcagaca ccctgggcag aatggagctg
      181 actgatttgc tcctggtggc catacttctc ctcaccgcaa gactaactct gtccagccca
      241 gttcctcccg cctgtgaccc cagactccta aataaactgc ttcgtgactc ctacctcctt
      301 cacagccgac tgagtcagtg tcctgacgtc aaccctttgt ctatccctgt cctgctgcct
      361 gctgtggact ttagcctggg agaatggaaa acccagacgg aacagagcaa ggcacaggac
      421 attctagggg cagtgtccct tctactggag ggggtgatgg cagcacgagg acagttggaa
      481 ccctcctgcc tctcatccct cctgggacag ctttctggtc aggttcgcct cctcttggga
      541 gccctgcagg gcctcctagg aacccagctt cctccacagg gcaggaccac agctcacaag
      601 gaccccagtg ccctcttctt gagcttgcaa caactgcttc ggggaaaggt gcgcttcctg
      661 ctgctggtag aaggtcccgc cctctgtgtc agacggaccc ttcccaccac agctgtccca
      721 agcagaacct ctcaactcct cacactaaac aagttcccaa acaggacttc tggattgttg
      781 gagacgaact tcagtgttgt agccagaact gctggccctg gacttctgaa caggcttcaa
      841 ggattcagag ccaagattat tcctggtcag ctaaatcaaa cctccgggtc cttagaccaa
      901 atccctggat acctgaacgg gacacacgaa cctgtgaatg gaactcatgg gctctttgct
      961 gggacctcac tacagaccct ggaagcccca gacgttgtgc caggagcttt caacaaaggc
     1021 tccttgccac tcaacctcca gagtggactt cctcctatcc caagccttgc tgctgatgga
     1081 tacacacttt tccctccttc acctaccttc cccacccctg ggtctccacc ccagctcccc
     1141 cccgtttcct gacccctcca ccaccatacc taactctacc aaccctcatc caggacttgg
     1201 tctcagtaag cgtcccgtgc actggcacgg agagcgatcg tctgcaacat ctctcagggg
     1261 caagcttcct caggaaggct ctgaggcagc tcactagaca tcctgctctc gcctaacggg
     1321 ccctgggaaa gggatacaca ggccaggaca ctgtacaacc ttaggagcga tttttttctt
     1381 aacctatcaa caatattcat cagagc
//
