LOCUS       NM_024384               1475 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Rattus norvegicus THO complex subunit 6 (Thoc6), mRNA.
ACCESSION   NM_024384
VERSION     NM_024384.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1475)
  AUTHORS   Beaulieu,C.L., Huang,L., Innes,A.M., Akimenko,M.A.,
            Puffenberger,E.G., Schwartz,C., Jerry,P., Ober,C., Hegele,R.A.,
            McLeod,D.R., Schwartzentruber,J., Majewski,J., Bulman,D.E.,
            Parboosingh,J.S. and Boycott,K.M.
  CONSRTM   FORGE Canada Consortium
  TITLE     Intellectual disability associated with a homozygous missense
            mutation in THOC6
  JOURNAL   Orphanet J Rare Dis 8, 62 (2013)
   PUBMED   23621916
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1475)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   3  (bases 1 to 1475)
  AUTHORS   Katahira,J.
  TITLE     mRNA export and the TREX complex
  JOURNAL   Biochim Biophys Acta 1819 (6), 507-513 (2012)
   PUBMED   22178508
  REMARK    Review article
REFERENCE   4  (bases 1 to 1475)
  AUTHORS   Boyne,J.R., Colgan,K.J. and Whitehouse,A.
  TITLE     Recruitment of the complete hTREX complex is required for Kaposi's
            sarcoma-associated herpesvirus intronless mRNA nuclear export and
            virus replication
  JOURNAL   PLoS Pathog 4 (10), e1000194 (2008)
   PUBMED   18974867
REFERENCE   5  (bases 1 to 1475)
  AUTHORS   Cheng,H., Dufu,K., Lee,C.S., Hsu,J.L., Dias,A. and Reed,R.
  TITLE     Human mRNA export machinery recruited to the 5' end of mRNA
  JOURNAL   Cell 127 (7), 1389-1400 (2006)
   PUBMED   17190602
REFERENCE   6  (bases 1 to 1475)
  AUTHORS   Masuda,S., Das,R., Cheng,H., Hurt,E., Dorman,N. and Reed,R.
  TITLE     Recruitment of the human TREX complex to mRNA during splicing
  JOURNAL   Genes Dev 19 (13), 1512-1517 (2005)
   PUBMED   15998806
REFERENCE   7  (bases 1 to 1475)
  AUTHORS   Guo,S., Hakimi,M.A., Baillat,D., Chen,X., Farber,M.J.,
            Klein-Szanto,A.J., Cooch,N.S., Godwin,A.K. and Shiekhattar,R.
  TITLE     Linking transcriptional elongation and messenger RNA export to
            metastatic breast cancers
  JOURNAL   Cancer Res 65 (8), 3011-3016 (2005)
   PUBMED   15833825
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079149.1.
            
            On Oct 4, 2005 this sequence version replaced NM_024384.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079149.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1475
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /note="THO complex subunit 6"
                     /db_xref="GeneID:79227"
                     /db_xref="RGD:708553"
     exon            1..278
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1265
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /note="WD repeat-containing protein 58; THO complex 6
                     homolog"
                     /codon_start=1
                     /product="THO complex subunit 6 homolog"
                     /protein_id="NP_077360.2"
                     /db_xref="GeneID:79227"
                     /db_xref="RGD:708553"
                     /translation="MEHATPLAVPLGQAEVFQALQRLHMTIFSQSVSPCGKFLAAGNN
                     YGQIAIFSLSAALSSEAKEESKKPMVTFHAHDGPVYSMVSTDRHLLSAGDGEVKGWLW
                     AEILKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTF
                     TRALRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRIAKEVQTIEVYKHEECSRPH
                     NGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTVFPIRAPQKHVTFYQDLILSAGQ
                     GCCVNHWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTASGNSCRVDVFTNLGY
                     RAFSLSF"
     exon            279..394
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            395..459
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            460..563
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            564..601
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            602..650
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            651..722
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            723..825
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            826..875
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            876..938
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1049
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1184
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1450
                     /gene="Thoc6"
                     /gene_synonym="Pdrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtggctg gacagctctg ggagctgctt agcataaggg tgcttcgtgg agttctccta
       61 ggtttctgtg gttcgagaca gcacggacct gccgtcttag ttgttgagcg ataggcagtg
      121 ccaggtcttg gggcgcaacg agaagagcca cactcaggca cgtccggagt cgagaggttg
      181 tgtcgcgcgt cgagagattg tgtcacacgt agagccttct gggacttgta gttctcaaga
      241 tggaacatgc cacaccgctc gcggtgcctc tgggtcaggc tgaggtattt caggccttgc
      301 agcggctgca catgaccatc ttttcccaga gtgtctcgcc ctgtgggaag ttcctggcag
      361 ctggcaacaa ttatgggcag attgccatct tcagtttgtc tgctgcctta agttcagaag
      421 ccaaagaaga aagcaaaaag cctatggtga ccttccacgc ccatgacgga cctgtctaca
      481 gcatggtctc cacggaccga catctactca gtgctgggga cggagaggtc aagggctggc
      541 tttgggcaga aatactgaag aagggctgta aggaactgtg gcgtcgccag cctccataca
      601 ggaccagcct ggaagttcct gaaatcaacg ccttgctgct tgtccccaag gagaattcac
      661 ttatcctagc tgggggagat tgtcagctgc acaccatgga tctggaaact gggaccttca
      721 cacgggccct ccggggccac acagactaca tccattgcct ggcactgagg gaacgcagcc
      781 ctgaggtatt gtccggtggc gaggatggag ctgtacggct ttgggatctc cgtatagcca
      841 aagaggtcca gaccatcgaa gtctacaagc atgaggagtg ctcaaggccc cacaatgggc
      901 gctggattgg atgcttggca actgactcag actggatggt ctgtggaggg ggcccagccc
      961 tcaccctctg gcacctcagg tcttccacac ccactacggt ctttcccatt cgagcaccac
     1021 agaaacatgt caccttctac caggacctga tcctgtctgc tggccagggc tgttgtgtca
     1081 atcactggca actgagtggg gagcttaagg cccaggtgcc tggctcctcc ccaggactgc
     1141 tcagcctgag cctcaaccag cagccagcag ccccagagtg taaggtcctg actgcatcag
     1201 gcaacagctg tcgagtagac gtctttacca acctgggcta ccgagccttc tccctgtcct
     1261 tctgacatca caatcctcca ttccaggagc tggacgggtg tttgtgtttt ggatgggggt
     1321 cttatacttt agcccaggct ggcctggaac tctgtggctt agcttggtct cagactcctg
     1381 tctgagattt agatctgtga accataacat ccagcttttg ttttcctgtc aaaataaaat
     1441 tttaggcttt aaaaaaaaaa aaaaaaaaaa aaaaa
//
