LOCUS       NM_001401407            2276 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus THO complex subunit 5 (Thoc5), transcript variant
            2, mRNA.
ACCESSION   NM_001401407 XM_006251338
VERSION     NM_001401407.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2276)
  AUTHORS   Wang,L., Miao,Y.L., Zheng,X., Lackford,B., Zhou,B., Han,L., Yao,C.,
            Ward,J.M., Burkholder,A., Lipchina,I., Fargo,D.C., Hochedlinger,K.,
            Shi,Y., Williams,C.J. and Hu,G.
  TITLE     The THO complex regulates pluripotency gene mRNA export and
            controls embryonic stem cell self-renewal and somatic cell
            reprogramming
  JOURNAL   Cell Stem Cell 13 (6), 676-690 (2013)
   PUBMED   24315442
REFERENCE   2  (bases 1 to 2276)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   3  (bases 1 to 2276)
  AUTHORS   Katahira,J.
  TITLE     mRNA export and the TREX complex
  JOURNAL   Biochim Biophys Acta 1819 (6), 507-513 (2012)
   PUBMED   22178508
  REMARK    Review article
REFERENCE   4  (bases 1 to 2276)
  AUTHORS   Dominguez-Sanchez,M.S., Barroso,S., Gomez-Gonzalez,B., Luna,R. and
            Aguilera,A.
  TITLE     Genome instability and transcription elongation impairment in human
            cells depleted of THO/TREX
  JOURNAL   PLoS Genet 7 (12), e1002386 (2011)
   PUBMED   22144908
REFERENCE   5  (bases 1 to 2276)
  AUTHORS   Mancini,A., Niemann-Seyde,S.C., Pankow,R., El Bounkari,O.,
            Klebba-Farber,S., Koch,A., Jaworska,E., Spooncer,E., Gruber,A.D.,
            Whetton,A.D. and Tamura,T.
  TITLE     THOC5/FMIP, an mRNA export TREX complex protein, is essential for
            hematopoietic primitive cell survival in vivo
  JOURNAL   BMC Biol 8, 1 (2010)
   PUBMED   20051105
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2276)
  AUTHORS   Sjoblom,T., Jones,S., Wood,L.D., Parsons,D.W., Lin,J., Barber,T.D.,
            Mandelker,D., Leary,R.J., Ptak,J., Silliman,N., Szabo,S.,
            Buckhaults,P., Farrell,C., Meeh,P., Markowitz,S.D., Willis,J.,
            Dawson,D., Willson,J.K., Gazdar,A.F., Hartigan,J., Wu,L., Liu,C.,
            Parmigiani,G., Park,B.H., Bachman,K.E., Papadopoulos,N.,
            Vogelstein,B., Kinzler,K.W. and Velculescu,V.E.
  TITLE     The consensus coding sequences of human breast and colorectal
            cancers
  JOURNAL   Science 314 (5797), 268-274 (2006)
   PUBMED   16959974
REFERENCE   7  (bases 1 to 2276)
  AUTHORS   Masuda,S., Das,R., Cheng,H., Hurt,E., Dorman,N. and Reed,R.
  TITLE     Recruitment of the human TREX complex to mRNA during splicing
  JOURNAL   Genes Dev 19 (13), 1512-1517 (2005)
   PUBMED   15998806
REFERENCE   8  (bases 1 to 2276)
  AUTHORS   Guo,S., Hakimi,M.A., Baillat,D., Chen,X., Farber,M.J.,
            Klein-Szanto,A.J., Cooch,N.S., Godwin,A.K. and Shiekhattar,R.
  TITLE     Linking transcriptional elongation and messenger RNA export to
            metastatic breast cancers
  JOURNAL   Cancer Res 65 (8), 3011-3016 (2005)
   PUBMED   15833825
REFERENCE   9  (bases 1 to 2276)
  AUTHORS   Mancini,A., Koch,A., Whetton,A.D. and Tamura,T.
  TITLE     The M-CSF receptor substrate and interacting protein FMIP is
            governed in its subcellular localization by protein kinase
            C-mediated phosphorylation, and thereby potentiates M-CSF-mediated
            differentiation
  JOURNAL   Oncogene 23 (39), 6581-6589 (2004)
   PUBMED   15221008
REFERENCE   10 (bases 1 to 2276)
  AUTHORS   Tamura,T., Mancini,A., Joos,H., Koch,A., Hakim,C., Dumanski,J.,
            Weidner,K.M. and Niemann,H.
  TITLE     FMIP, a novel Fms-interacting protein, affects
            granulocyte/macrophage differentiation
  JOURNAL   Oncogene 18 (47), 6488-6495 (1999)
   PUBMED   10597251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Feb 11, 2022 this sequence version replaced XM_006251338.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.745237.1,
                                           SRR26360194.1866911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000014.1  83982397-83982436
            41-156              JAXUCZ010000014.1  83986401-83986516
            157-300             JAXUCZ010000014.1  83988557-83988700
            301-414             JAXUCZ010000014.1  83989575-83989688
            415-512             JAXUCZ010000014.1  83989826-83989923
            513-659             JAXUCZ010000014.1  83991711-83991857
            660-774             JAXUCZ010000014.1  83993539-83993653
            775-907             JAXUCZ010000014.1  83997500-83997632
            908-940             JAXUCZ010000014.1  83998311-83998343
            941-1018            JAXUCZ010000014.1  83999644-83999721
            1019-1059           JAXUCZ010000014.1  84001493-84001533
            1060-1159           JAXUCZ010000014.1  84001762-84001861
            1160-1268           JAXUCZ010000014.1  84002435-84002543
            1269-1370           JAXUCZ010000014.1  84005155-84005256
            1371-1467           JAXUCZ010000014.1  84006821-84006917
            1468-1582           JAXUCZ010000014.1  84007463-84007577
            1583-1686           JAXUCZ010000014.1  84009018-84009121
            1687-1774           JAXUCZ010000014.1  84009235-84009322
            1775-1890           JAXUCZ010000014.1  84012100-84012215
            1891-2081           JAXUCZ010000014.1  84013334-84013524
            2082-2276           JAXUCZ010000014.1  84015999-84016193
FEATURES             Location/Qualifiers
     source          1..2276
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2276
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /note="THO complex subunit 5"
                     /db_xref="GeneID:360972"
                     /db_xref="RGD:1304991"
     exon            1..40
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            41..156
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..2145
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /note="isoform 2 is encoded by transcript variant 2; THO
                     complex subunit 5 homolog; fms-interacting protein; Fms
                     interacting protein; THO complex 5"
                     /codon_start=1
                     /product="THO complex subunit 5 homolog isoform 2"
                     /protein_id="NP_001388336.1"
                     /db_xref="GeneID:360972"
                     /db_xref="RGD:1304991"
                     /translation="MSSESSKKRKPKVIRSDGTPTEGKRNRSDTEQEGRYYSEEAEVD
                     LRDPGRDYELYKYTCQELQRLMAEIQDLKSKGSKDVAIEIEERRIQSCVHFMTLKKLN
                     RLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLV
                     SLEEFYSEAPPNISKAEITMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKE
                     IEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQAT
                     AYGQACAHMTSSQPPRQDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTK
                     RRRPTLGVQLDDKRKEMLKRHPLSVLLDLKCKDNSVLHLTFFYLMNLNIMTVKAKVTT
                     AMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLRDYVLELGH
                     PYLWVQKLGGLHFPKEQPQHTVMADHSQSASHMETTMKLLKTRVQSRLALHKQFASLE
                     HGIVPVTSECQYLFPAKVVSRLVKWMIMAHEDYMELHFTKDIVEAGLAGDTNLYYLAL
                     IERGTAKLQAAVVLNPGYSSIPPVFRLCLNWKGEKTNSNDDNIRAMESEVNVCYRELC
                     GPRPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRMKPF
                     KYNHPQGFFSHR"
     exon            157..300
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            301..414
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            415..512
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            513..659
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            660..774
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            775..907
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            908..940
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1018
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1059
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1159
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1268
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1370
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1467
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1582
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1686
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1774
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1890
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2081
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2276
                     /gene="Thoc5"
                     /gene_synonym="Fmip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtggat gcctggctgg aaggcgtgag gatcgttctg ctctctgacc tggaagcaca
       61 atgtcatcag aatccagcaa aaaaaggaaa cccaaagtga tccgaagtga tggaacccca
      121 actgaaggga aacggaatcg atctgacaca gagcaggaag gcagatacta tagcgaggag
      181 gctgaggttg acctgcggga ccccggcaga gactatgagt tgtacaagta cacttgccag
      241 gagctacaga ggttgatggc tgagatccag gacctgaaga gcaagggcag caaggacgtg
      301 gccattgaaa tagaagaacg aaggatccag agctgtgtgc atttcatgac tctaaagaag
      361 cttaaccgat tagcccatat caggttaaag aaaggaagag atcagaccca cgaggccaag
      421 cagaaagtcg atgcctacca cctacagctg cagaacctgc tctacgaagt gatgcacctg
      481 cagaaggaga tcaccaagtg tctggagttc aagtcaaagc atgaagaaat cgatctggtc
      541 agtttagagg aattttattc agaagctcca ccaaacatca gcaaggccga gatcaccatg
      601 ggagaccctc accaacagac gctggcacgt ttggactggg agctggagca gcggaaaagg
      661 ctggcagaga agtaccgaga gtgtctgtcc aacaaggaga agatcctgaa ggagatcgag
      721 gtgaagaagg agtatctcag cagcctccag ccccgcctca acagcatcat gcaggcttcc
      781 ctgccggtgc aagagtacct gttcatgcca ttcgaccagg ctcacaagca gtacgagacc
      841 gccaggcacc tgccgcctcc cctctacgtg ctctttgtgc aggccaccgc atacgggcag
      901 gcctgtgctc atatgacctc ctcccagccc cctagacagg ataagacgtt gtctgtggcg
      961 attgaaggca gtgtggatga agccaaagcc cttttcaagc cccccgagga ctcccaagat
     1021 gatgagagtg actcggatgc tgaagaggag cagaccacga agaggcgtcg gcccacactc
     1081 ggggttcagt tggatgataa gcgcaaggag atgctgaaaa ggcacccgct gtctgtcctg
     1141 ctggatctga agtgcaaaga caacagtgtg ctccatctga ctttcttcta tctcatgaac
     1201 ctcaacatca tgacagtgaa agccaaagtg acgaccgcca tggagctgat cacccccatc
     1261 agtgcaggcg acttactgtc tcctgactcg gtcttgagct gcttgtatcc tggagatcat
     1321 ggaaagaaaa ctccaaatcc agccaatcag tatcagtttg ataaagttgg catcctgact
     1381 ttgagagact atgtacttga gttaggtcac ccctacttgt gggtacagaa gctgggtggc
     1441 ctccacttcc ccaaagagca gccccagcac acggtgatgg ctgaccactc acagagcgct
     1501 agccacatgg agaccaccat gaaactgctc aagactaggg tacagtcccg cctggctctc
     1561 cacaaacagt tcgcatctct ggaacatggc attgtgccag tcaccagcga gtgccagtac
     1621 ctcttccctg ccaaggttgt ttcccgactg gtaaagtgga tgataatggc ccatgaagat
     1681 tacatggagc tgcacttcac taaggacatt gtagaggccg gcctggctgg ggacaccaac
     1741 ctctactacc tggcgcttat cgaaagggga acagctaagc ttcaggctgc tgtggtactg
     1801 aaccctggct actcctccat cccacctgtt ttccgactct gtctaaactg gaaaggggag
     1861 aaaaccaaca gcaacgatga caacattcgg gctatggaga gtgaagtcaa tgtgtgctat
     1921 cgggagctct gcggccctcg gcccagtcac cagctcttga ccaaccagct gcagaggctg
     1981 tgtgtgctgc tggatgtcta cctggagacc gagagccatg atgacagtgt agagggcccc
     2041 aaggaatttc cccaggagaa gatgtgcctg cggctcttta ggggtccaag taggatgaag
     2101 ccgtttaaat ataaccaccc tcagggattc ttcagccacc gctgacagac ttccctctct
     2161 acctgtcagc ccccaagccc tgccctgact cctgggtatc tgagttttgc tttggccgcc
     2221 tgtggttctt gatattttcc aaagacaccg gctaattaaa atgtcgtgtg accaaa
//
