LOCUS       NM_001191756            7668 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus THO complex subunit 2 (Thoc2), mRNA.
ACCESSION   NM_001191756 XM_233081
VERSION     NM_001191756.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7668)
  AUTHORS   Kumar,R., Corbett,M.A., van Bon,B.W., Woenig,J.A., Weir,L.,
            Douglas,E., Friend,K.L., Gardner,A., Shaw,M., Jolly,L.A., Tan,C.,
            Hunter,M.F., Hackett,A., Field,M., Palmer,E.E., Leffler,M.,
            Rogers,C., Boyle,J., Bienek,M., Jensen,C., Van Buggenhout,G., Van
            Esch,H., Hoffmann,K., Raynaud,M., Zhao,H., Reed,R., Hu,H.,
            Haas,S.A., Haan,E., Kalscheuer,V.M. and Gecz,J.
  TITLE     THOC2 Mutations Implicate mRNA-Export Pathway in X-Linked
            Intellectual Disability
  JOURNAL   Am J Hum Genet 97 (2), 302-310 (2015)
   PUBMED   26166480
REFERENCE   2  (bases 1 to 7668)
  AUTHORS   Wang,L., Miao,Y.L., Zheng,X., Lackford,B., Zhou,B., Han,L., Yao,C.,
            Ward,J.M., Burkholder,A., Lipchina,I., Fargo,D.C., Hochedlinger,K.,
            Shi,Y., Williams,C.J. and Hu,G.
  TITLE     The THO complex regulates pluripotency gene mRNA export and
            controls embryonic stem cell self-renewal and somatic cell
            reprogramming
  JOURNAL   Cell Stem Cell 13 (6), 676-690 (2013)
   PUBMED   24315442
REFERENCE   3  (bases 1 to 7668)
  AUTHORS   Di Gregorio,E., Bianchi,F.T., Schiavi,A., Chiotto,A.M., Rolando,M.,
            Verdun di Cantogno,L., Grosso,E., Cavalieri,S., Calcia,A.,
            Lacerenza,D., Zuffardi,O., Retta,S.F., Stevanin,G., Marelli,C.,
            Durr,A., Forlani,S., Chelly,J., Montarolo,F., Tempia,F.,
            Beggs,H.E., Reed,R., Squadrone,S., Abete,M.C., Brussino,A.,
            Ventura,N., Di Cunto,F. and Brusco,A.
  TITLE     A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with
            THOC2 expression knockdown in a patient with psychomotor
            retardation and congenital cerebellar hypoplasia
  JOURNAL   J Med Genet 50 (8), 543-551 (2013)
   PUBMED   23749989
REFERENCE   4  (bases 1 to 7668)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   5  (bases 1 to 7668)
  AUTHORS   Folco,E.G., Lee,C.S., Dufu,K., Yamazaki,T. and Reed,R.
  TITLE     The proteins PDIP3 and ZC11A associate with the human TREX complex
            in an ATP-dependent manner and function in mRNA export
  JOURNAL   PLoS One 7 (8), e43804 (2012)
   PUBMED   22928037
REFERENCE   6  (bases 1 to 7668)
  AUTHORS   Boyne,J.R., Colgan,K.J. and Whitehouse,A.
  TITLE     Recruitment of the complete hTREX complex is required for Kaposi's
            sarcoma-associated herpesvirus intronless mRNA nuclear export and
            virus replication
  JOURNAL   PLoS Pathog 4 (10), e1000194 (2008)
   PUBMED   18974867
REFERENCE   7  (bases 1 to 7668)
  AUTHORS   Cheng,H., Dufu,K., Lee,C.S., Hsu,J.L., Dias,A. and Reed,R.
  TITLE     Human mRNA export machinery recruited to the 5' end of mRNA
  JOURNAL   Cell 127 (7), 1389-1400 (2006)
   PUBMED   17190602
REFERENCE   8  (bases 1 to 7668)
  AUTHORS   Masuda,S., Das,R., Cheng,H., Hurt,E., Dorman,N. and Reed,R.
  TITLE     Recruitment of the human TREX complex to mRNA during splicing
  JOURNAL   Genes Dev 19 (13), 1512-1517 (2005)
   PUBMED   15998806
REFERENCE   9  (bases 1 to 7668)
  AUTHORS   Guo,S., Hakimi,M.A., Baillat,D., Chen,X., Farber,M.J.,
            Klein-Szanto,A.J., Cooch,N.S., Godwin,A.K. and Shiekhattar,R.
  TITLE     Linking transcriptional elongation and messenger RNA export to
            metastatic breast cancers
  JOURNAL   Cancer Res 65 (8), 3011-3016 (2005)
   PUBMED   15833825
REFERENCE   10 (bases 1 to 7668)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Apr 10, 2021 this sequence version replaced NM_001191756.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000021.1  125614987-125615087 c
            102-160             JAXUCZ010000021.1  125598085-125598143 c
            161-252             JAXUCZ010000021.1  125589846-125589937 c
            253-304             JAXUCZ010000021.1  125587897-125587948 c
            305-375             JAXUCZ010000021.1  125581820-125581890 c
            376-497             JAXUCZ010000021.1  125580679-125580800 c
            498-631             JAXUCZ010000021.1  125579803-125579936 c
            632-798             JAXUCZ010000021.1  125575955-125576121 c
            799-891             JAXUCZ010000021.1  125572049-125572141 c
            892-1047            JAXUCZ010000021.1  125570664-125570819 c
            1048-1220           JAXUCZ010000021.1  125569770-125569942 c
            1221-1416           JAXUCZ010000021.1  125568445-125568640 c
            1417-1458           JAXUCZ010000021.1  125558491-125558532 c
            1459-1589           JAXUCZ010000021.1  125557930-125558060 c
            1590-1691           JAXUCZ010000021.1  125557733-125557834 c
            1692-1776           JAXUCZ010000021.1  125551954-125552038 c
            1777-1870           JAXUCZ010000021.1  125550955-125551048 c
            1871-1951           JAXUCZ010000021.1  125550491-125550571 c
            1952-2048           JAXUCZ010000021.1  125548951-125549047 c
            2049-2166           JAXUCZ010000021.1  125544953-125545070 c
            2167-2346           JAXUCZ010000021.1  125542900-125543079 c
            2347-2511           JAXUCZ010000021.1  125541151-125541315 c
            2512-2787           JAXUCZ010000021.1  125537599-125537874 c
            2788-2929           JAXUCZ010000021.1  125536561-125536702 c
            2930-3087           JAXUCZ010000021.1  125535960-125536117 c
            3088-3216           JAXUCZ010000021.1  125534640-125534768 c
            3217-3348           JAXUCZ010000021.1  125534221-125534352 c
            3349-3533           JAXUCZ010000021.1  125533950-125534134 c
            3534-3712           JAXUCZ010000021.1  125533278-125533456 c
            3713-3815           JAXUCZ010000021.1  125532955-125533057 c
            3816-4246           JAXUCZ010000021.1  125518464-125518894 c
            4247-4305           JAXUCZ010000021.1  125518216-125518274 c
            4306-4341           JAXUCZ010000021.1  125516737-125516772 c
            4342-4479           JAXUCZ010000021.1  125512303-125512440 c
            4480-4549           JAXUCZ010000021.1  125511910-125511979 c
            4550-4710           JAXUCZ010000021.1  125511666-125511826 c
            4711-4787           JAXUCZ010000021.1  125509125-125509201 c
            4788-4833           JAXUCZ010000021.1  125508602-125508647 c
            4834-7668           JAXUCZ010000021.1  125500549-125503383 c
FEATURES             Location/Qualifiers
     source          1..7668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     gene            1..7668
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /note="THO complex subunit 2"
                     /db_xref="GeneID:313308"
                     /db_xref="RGD:1561623"
     exon            1..101
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..4815
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /note="THO complex 2"
                     /codon_start=1
                     /product="THO complex subunit 2"
                     /protein_id="NP_001178685.1"
                     /db_xref="GeneID:313308"
                     /db_xref="RGD:1561623"
                     /translation="MAAATVVVPAEWIKNWEKSGRGDFLHLCRILSENKSHDSSTYRD
                     FQQALYELSYHVIKGNLKHEQASSVLNDISEFREDMPSILADVFCILDIETNCLEEKS
                     KRDYFTQLVLACLYLVSDTVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQ
                     KFNLLREENEGYAKLIAELGQDLSGTITSDLILENIKSLIGCFNLDPNRVLDVILEVF
                     ECRPEHDDFFISLLESYMSMCEPQTLCHILGFKFKFYQEPSGETPSSLYRVAAVLLQF
                     NLIDLDDLYVHLLPADNCIMDEYKREIVEAKQIVRKLTMVVLSSEKLDERDKEKDKDD
                     EKVEKPPDNQKLGLLEALLKIGDWQHAQNIMDQMPPYYAASHKLIALAICKLIHITVE
                     PLYRRVGVPKGAKGSPVSALQNKRAPKQVESFEDLRRDVFNMFCYLGPHLSHDPILFA
                     KVVRIGKSFMKEFQSDGSKQEDKEKTEVILSCLLSITDQVLLPSLSLMDCNACMSEEL
                     WGMFKTFPYQHRYRLYGQWKNETYNGHPLLVKVKAQTIDRAKYIMKRLTKENVKPSGR
                     QIGKLSHSNPTILFDYILSQIQKYDNLITPVVDSLKYLTSLNYDVLAYCIIEALANPE
                     KERMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEV
                     VQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLAL
                     PLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQFGGFLASNLSTEDYIKRVP
                     SIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGSKQQHKVHKYITSCEMV
                     MAPVHEAVVSLHVAKVWDDISPQFYATFWSLTMYDLAVPHTSYEREVNKLKVQMKAID
                     DNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEKDNWLLAKSTKNE
                     TITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRVFSDIIYTVAS
                     CTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFDGGNKADQL
                     DYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALER
                     RVNKICQEEKEKRPDLYALAMGYSGQLKSRKSHMIPENEFHHKDPPPRNAVASVQNGP
                     GGGTSSSSIGSASKSDESGAEETDKSRERSQCGTKAVNKASSTTPKGNSSNGNSGSNS
                     NKAVKENDKEKVKEKEKEKKEKTPATTPEARVLGKESKEKPKEERPNKDDKARETKER
                     TPKSDKEKEKFKKEEKAKDEKFKTTVPSVESKSTQEREREKEPSRERDVAKEMKSKEN
                     VKGGEKPPVSGSLKSPVPRSDISEPDREQKRRKIDTHPSPSHSSTVKDSLIDLKDSSA
                     KLYINHNPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPP
                     DITKRRKEENGTMGVSKHKSESPCESQYPNEKDKEKNKSKSSGKEKGSSDSFKSEKMD
                     KISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR"
     exon            102..160
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            161..252
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            253..304
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            305..375
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            376..497
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            498..631
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            632..798
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            799..891
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1047
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1220
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1416
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1458
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1589
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1691
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1776
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1870
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1951
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2048
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2166
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2346
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2511
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2787
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2929
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3087
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3216
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3348
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3533
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..3712
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3815
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..4246
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            4247..4305
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4341
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            4342..4479
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            4480..4549
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            4550..4710
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            4711..4787
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            4788..4833
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
     exon            4834..7668
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccgggcca ctgttactag cgaggggaag atggcggccg cgactgtggt ggttcccgca
       61 gagtggataa agaactggga gaaatcaggg agaggcgatt ttttgcattt atgccggatt
      121 ctcagtgaaa acaaaagcca tgacagttcg acctacagag attttcagca agctctctat
      181 gagttgtcat accatgtcat taagggaaat ttaaagcacg aacaggcatc cagtgttctt
      241 aatgacatta gtgaattccg tgaggatatg ccttctatcc ttgctgacgt gttctgcata
      301 ttagatattg agacaaattg tttagaagaa aaaagcaaga gagactattt tacacaattg
      361 gtattagcat gtttgtattt agtttcagac acagttctga aggaacgatt ggatccagaa
      421 actttggaat ctttagggct tatcaaacaa tcacagcagt tcaaccaaaa gtcagttaaa
      481 atcaagacaa aactctttta taagcagcaa aaattcaatt tattaagaga agaaaatgaa
      541 ggttatgcca agctgattgc tgaactgggg caagatttat ctggaactat tactagtgat
      601 ttaatattag aaaatatcaa atctttaata ggatgcttta atctggatcc caatagagtt
      661 ttggatgtca ttttagaagt atttgaatgc aggccagaac atgatgactt ctttatatcg
      721 ttattagagt cttacatgag tatgtgtgaa ccacaaacac tgtgtcatat tcttggattc
      781 aaattcaagt tttatcagga accaagtggt gagacgccct cgtctttgta cagagttgca
      841 gcagtccttc tgcaatttaa tctcattgat ctagatgatc tttatgtaca tctcctccca
      901 gctgataatt gtattatgga tgaatacaaa cgagaaattg tggaagctaa gcaaattgta
      961 agaaaactca caatggttgt actgtcttct gaaaaacttg atgaacgaga caaagaaaag
     1021 gataaagatg acgagaaagt agaaaagcca cctgacaacc aaaaacttgg tttgttggaa
     1081 gctttgttaa agattggtga ttggcagcat gcacagaaca tcatggatca gatgcctccg
     1141 tactatgcag cttcacataa gctaatagct cttgctattt gcaagctcat tcacataact
     1201 gtcgagcctc tctaccgaag agttggtgtt cctaaaggtg ctaaaggctc acccgttagt
     1261 gctttgcaaa ataagagagc accgaagcaa gtagagagct ttgaagattt gaggagggat
     1321 gtattcaata tgttctgcta ccttggtcct cacctctcac atgatcccat tttatttgca
     1381 aaagtcgtgc gcataggcaa gtcatttatg aaggagtttc agtctgatgg aagcaaacaa
     1441 gaagataaag agaaaacgga agttatcctt agctgtttac ttagcattac tgaccaggta
     1501 ttacttccat ctctctcttt gatggactgc aatgcttgca tgtctgagga actgtgggga
     1561 atgttcaaga catttcccta tcagcataga tatcgtctat atggccagtg gaagaatgaa
     1621 acttataatg ggcacccact tttagtaaaa gttaaagctc aaacaataga ccgagccaag
     1681 tatatcatga agcgtctaac caaggaaaat gtgaagcctt cgggaagaca aattggcaag
     1741 ctgagccata gtaatccaac aattttgttt gattatatct tgtcacaaat ccagaaatat
     1801 gataacttaa taacacctgt agtagattca ttgaaatacc tcacttcatt gaattatgat
     1861 gtcttggcct attgtatcat tgaagcttta gctaatccag aaaaggagag aatgaaacat
     1921 gatgacacaa ccatctcaag ctggcttcaa agtctggcaa gtttctgtgg tgcagtattc
     1981 cgtaaatacc caatcgatct tgctggtctt cttcagtatg tagccaatca attaaaggca
     2041 ggcaaaagtt ttgacctact aatattgaaa gaagtggtac aaaaaatggc aggaatcgaa
     2101 attacagagg agatgacgat ggagcagtta gaggccatga ctggtgggga gcagctgaag
     2161 gctgagggtg gttatttcgg ccagatcaga aacactaaaa aatcttctca gagattaaag
     2221 gatgcactac tggaccatga tcttgctctt cctctctgtt tgctcatggc acaacagagg
     2281 aatggggtaa tttttcagga gggtggagag aaacacttga aacttgtggg gaagctctat
     2341 gaccagtgtc atgataccct agtacagttt ggtgggtttt tagcatcaaa tctaagtaca
     2401 gaagattata taaaacgagt gccttcaatt gatgtgctct gtaatgaatt tcatacacct
     2461 cacgatgcag cattttttct gtctaggcca atgtatgcac accatatttc atcaaaatac
     2521 gatgaactta aaaaatcaga aaagggaagt aaacagcaac ataaagtcca taaatacatt
     2581 acatcatgtg aaatggtgat ggcacctgtc catgaagcag tggtctcctt gcatgttgcc
     2641 aaagtctggg atgatatcag ccctcagttc tatgctacat tttggtcgtt gacaatgtat
     2701 gaccttgcag ttccacatac cagctatgaa agagaagtca ataaacttaa agtccagatg
     2761 aaagcgattg atgacaatca ggaaatgcct ccaaataaaa agaagaaaga aaaggagcgt
     2821 tgcacggccc ttcaggacaa gctccttgaa gaagaaaaga agcagatgga acatgttcag
     2881 agagtacttc agagactgaa actagagaaa gacaactggc ttttagcaaa gtctaccaaa
     2941 aatgagacca tcacaaaatt tttacagctg tgtatatttc ctcgatgcat tttttcagca
     3001 attgatgctg tttattgtgc tcgttttgtt gaattggtac atcaacagaa aactccaaat
     3061 ttttccacac ttctttgcta tgatcgagtt ttttctgaca taatttacac ggttgcaagc
     3121 tgcactgaaa atgaagctag tcggtatggg agattccttt gctgtatgtt agagacagtg
     3181 accaggtggc atagtgatag agccacttat gagaaggaat gtggaaacta tccaggattc
     3241 cttaccatat tacgggcaac tggatttgat ggtggaaaca aagctgatca gttagattat
     3301 gaaaattttc gacatgttgt ccacaaatgg cattacaaat taaccaaggc ctcggttcat
     3361 tgccttgaga caggcgaata tactcacatc aggaatatat tgattgtgct aacaaaaata
     3421 cttccttggt acccaaaagt tttgaatctg ggtcaggctt tggaaagaag agtgaataaa
     3481 atatgccaag aagaaaaaga gaagaggcca gatctttatg cattggctat gggctactcg
     3541 gggcagttga aaagtagaaa gtcacacatg atacctgaaa atgaatttca tcacaaggat
     3601 cctcctccaa ggaatgctgt tgccagtgta caaaatgggc ctggtggtgg gacttcttca
     3661 tcatccatag gaagtgcgtc taaatcagat gaaagcggtg ctgaggagac tgataaatca
     3721 agggagagat ctcagtgtgg tacaaaagct gttaataagg cttctagtac cacaccaaaa
     3781 gggaattcaa gcaatggaaa tagtggctct aacagcaaca aagctgttaa ggaaaatgac
     3841 aaagaaaaag taaaagagaa agaaaaagag aaaaaagaga agactccagc tacaactcca
     3901 gaggccaggg tacttggtaa agaaagtaaa gaaaaaccga aggaagagcg gccaaataaa
     3961 gatgacaaag caagagagac aaaggaaaga acacctaaat ctgacaaaga gaaggagaag
     4021 ttcaagaagg aagaaaaagc aaaagatgag aaattcaaga ccactgtccc cagcgtagaa
     4081 tcaaaatcga ctcaagaaag ggaaagagag aaggagccat ccagagaaag agatgtagca
     4141 aaggaaatga agtcaaagga aaatgttaaa ggaggagaaa aaccaccagt ttcagggtcc
     4201 ttgaagtcac ctgttccccg atcagatatc tcggagcctg acagagaaca aaaacgccgc
     4261 aaaattgata ctcatccttc tccatcacat tcctccactg taaaggacag tctcatcgat
     4321 ctcaaggact cttcagcaaa gctctacatt aaccataatc ctccaccact gtccaagagt
     4381 aaggagagag aaatggacaa gaaagatttg gacaagtcaa gggaaagatc cagagaaaga
     4441 gagaaaaaag atgaaaagga caggaaagag cggaaaaggg atcattcaaa caatgaccgt
     4501 gaagtgccac cggacataac aaagaggcgg aaagaggaga atggaacaat gggggtttca
     4561 aaacacaaaa gtgaaagtcc atgtgagtct caatatccaa atgagaaaga caaagagaaa
     4621 aataagtcaa aatcttcagg caaagaaaaa ggcagtagtg attcgtttaa atctgagaag
     4681 atggataaaa tctcctctgg tggcaaaaag gaatccaggc atgataaaga aaagatagaa
     4741 aagaaagaaa aacgggatag ttcaggagga aaagaagaga agaaacatca taagtcctct
     4801 gacaagcaca gataatgaac aatttcaacc aagggtgtgg acagacccct aagctgaccg
     4861 tctccccgtg gaggatgcca aagctccatg agtcactctc agaatgacat ctcccataat
     4921 taagagcttc tggtgctgtc cattttatgg gaatttgctt taagtcagaa gatgcataca
     4981 caccaccatc cttttgacaa gacattccaa agtcactgat ttttcagaac attttcacct
     5041 gcaggcaatt tcttggagca aggtccctgt gcatacagtt tttatgtggg atacgccatc
     5101 cagaagcagc atctaatgga aagttcacta actgactttt agttcatctt tctttctcag
     5161 aaaggaaagg aaattgcctc ttggaaccaa ttccttaatg atgtagatag gttgcctttg
     5221 tgtgtgaatt ctataagtgt gaaaacattg gggtgattat gttgcttgga gggttttggc
     5281 ttcttaaaaa attttaattt taattccagt tcatgggaaa gatgtttgtg gtttaatggc
     5341 aaaaacattt tttatcattt aatgtaccct taaatatgtc cacaaaagtt ttcttgtccc
     5401 taaggtattc tcatagtgtg acatgatcat gattgagacc ccatttctta ttctgaatat
     5461 tgtcatatgg ataccatgat gttctttttc ttttttggaa cattacatag acatgattaa
     5521 tgacccagtt cttattctca cgagtatggt catgtgaata ccatgaagtt ctttattgga
     5581 acattgttca ttttcagtct aaaaccctga gatgcagtca gcattttaaa gtggacagtc
     5641 cagtggttgt tagtatactc actgtgtggt gcagtcatcc acagtctagt ctcaaagtgc
     5701 aggttagcag tcattcttat ttctcctcgt tcttcagcca ctggaagcta ctgacacatt
     5761 ttctgcctat gaatttgcct gttttgggac atttcatata aatggaattg tgcaatatca
     5821 tgtcctgggg gccagggttc tttcaactac catcatgtta tcaagactta tccatggtgt
     5881 agcatgtgtc aacaatccat tccttcacaa ggttaaatat tccacagaat gaatgtgtat
     5941 catgttttgt ttacccattt attcattgag ggacagaaac aattatattt taagtaataa
     6001 aattagaagg ttaacagcag tgtatccaaa attataattg atggtgtcaa cattatacac
     6061 agtatgcaca gaatgctgtg tagaaatgat gtgtaaatta cttgtcagca tttcatgcaa
     6121 gtgtaattat tttctaaggc cccttctagc tatgattttt tggaactgtg tgaatgtagt
     6181 atattcatta ataaagttta atgcattaag cattaattta aaatttgaga acaatgttag
     6241 gcagataaat tatttgccac atgctgtaat gatcatgttt tgaatttatt tcattatgca
     6301 gtatttgaaa aatgtctaca taaaggaaag gaaatgagta taattgagtc aatatatttt
     6361 taaagcaatt tttataattt agcagacatt gcatcttaat ataattcact attaaaattg
     6421 tgtccttgtg gaaaaatcga tatcattttc tatttctttt gatgatcatg taaaatagat
     6481 tcctttcctt tgttaaatgt tctgtttatt tttgatacat tattccttgc acctgtagaa
     6541 tctacctgtt actctttaat ctttttctct accccagaat ccttccaccc tatcacacac
     6601 agaaaatgtt tcaatgtttc ttaaaattca tagtgtcttt atgatttcta agaatagaca
     6661 cagacacaga atatatttcc tcattttctg ggaactttct gcaagtcttt gttattgata
     6721 gaattcactg aagtttcttc ctaaatgggt cttttccttt cccctttctt tccctttgat
     6781 cactccccgg ccttctctca atggcctctt cttaccttgc tttggccttc ctcctcattc
     6841 tcccttagtc actccctcct tgtctatctg tataaccagt ttgtttcttt taggtggaaa
     6901 gtatgaaatg aaatcataca gctgtgacca gaattgtatt ttctcgagta gatttctgag
     6961 aattgtgaat gaagcgggcc cattttcagt tacctgcttt attgctccat gcagaaaacc
     7021 taaaactgtt gtgttgtatg ttattgtact ttaacttgtt gcttaatttc tacatgttta
     7081 ttttcagtaa tggctgaaag tgttaattat tccatatttt agcacaatgt gctgcatata
     7141 cttcccaata agcaaataag gttacatgtg tacagaattt cacttttgat taaatattgc
     7201 ctgggtttca agtccctccc cccatttgaa atgcttcctt tttaatgttg aaactgaaaa
     7261 taaacagtta ctgaatgatt ttgaatttac ctcatcttag agctcagttt taatttattt
     7321 ggcctgtttt taatatgagt cactaaaaat aaagtggagc actgtcttat gcagtgccta
     7381 agaattgttt tatatagtat gtgtacaaca ttaaaacatg ttcgacaaag aaaaatatac
     7441 cagcgctcac ttgtcccttg ccattttttt cttgtaatta ggacattttg ggggtagaag
     7501 agaaaaaaat taattgtgtt ttaattttac agctaccgga gctttgtatt gctaaactta
     7561 catctggaaa cgtttcacgt gacattttta agagaatttt ttatctactg aattctacca
     7621 gtgtaaccat tttttctaaa taaacaatag ttttctcaaa tgactata
//
