LOCUS       NP_001178685            1594 aa            linear   ROD 29-MAR-2024
DEFINITION  THO complex subunit 2 [Rattus norvegicus].
ACCESSION   NP_001178685 XP_233081
VERSION     NP_001178685.1
DBSOURCE    REFSEQ: accession NM_001191756.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1594)
  AUTHORS   Kumar,R., Corbett,M.A., van Bon,B.W., Woenig,J.A., Weir,L.,
            Douglas,E., Friend,K.L., Gardner,A., Shaw,M., Jolly,L.A., Tan,C.,
            Hunter,M.F., Hackett,A., Field,M., Palmer,E.E., Leffler,M.,
            Rogers,C., Boyle,J., Bienek,M., Jensen,C., Van Buggenhout,G., Van
            Esch,H., Hoffmann,K., Raynaud,M., Zhao,H., Reed,R., Hu,H.,
            Haas,S.A., Haan,E., Kalscheuer,V.M. and Gecz,J.
  TITLE     THOC2 Mutations Implicate mRNA-Export Pathway in X-Linked
            Intellectual Disability
  JOURNAL   Am J Hum Genet 97 (2), 302-310 (2015)
   PUBMED   26166480
REFERENCE   2  (residues 1 to 1594)
  AUTHORS   Wang,L., Miao,Y.L., Zheng,X., Lackford,B., Zhou,B., Han,L., Yao,C.,
            Ward,J.M., Burkholder,A., Lipchina,I., Fargo,D.C., Hochedlinger,K.,
            Shi,Y., Williams,C.J. and Hu,G.
  TITLE     The THO complex regulates pluripotency gene mRNA export and
            controls embryonic stem cell self-renewal and somatic cell
            reprogramming
  JOURNAL   Cell Stem Cell 13 (6), 676-690 (2013)
   PUBMED   24315442
REFERENCE   3  (residues 1 to 1594)
  AUTHORS   Di Gregorio,E., Bianchi,F.T., Schiavi,A., Chiotto,A.M., Rolando,M.,
            Verdun di Cantogno,L., Grosso,E., Cavalieri,S., Calcia,A.,
            Lacerenza,D., Zuffardi,O., Retta,S.F., Stevanin,G., Marelli,C.,
            Durr,A., Forlani,S., Chelly,J., Montarolo,F., Tempia,F.,
            Beggs,H.E., Reed,R., Squadrone,S., Abete,M.C., Brussino,A.,
            Ventura,N., Di Cunto,F. and Brusco,A.
  TITLE     A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with
            THOC2 expression knockdown in a patient with psychomotor
            retardation and congenital cerebellar hypoplasia
  JOURNAL   J Med Genet 50 (8), 543-551 (2013)
   PUBMED   23749989
REFERENCE   4  (residues 1 to 1594)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   5  (residues 1 to 1594)
  AUTHORS   Folco,E.G., Lee,C.S., Dufu,K., Yamazaki,T. and Reed,R.
  TITLE     The proteins PDIP3 and ZC11A associate with the human TREX complex
            in an ATP-dependent manner and function in mRNA export
  JOURNAL   PLoS One 7 (8), e43804 (2012)
   PUBMED   22928037
REFERENCE   6  (residues 1 to 1594)
  AUTHORS   Boyne,J.R., Colgan,K.J. and Whitehouse,A.
  TITLE     Recruitment of the complete hTREX complex is required for Kaposi's
            sarcoma-associated herpesvirus intronless mRNA nuclear export and
            virus replication
  JOURNAL   PLoS Pathog 4 (10), e1000194 (2008)
   PUBMED   18974867
REFERENCE   7  (residues 1 to 1594)
  AUTHORS   Cheng,H., Dufu,K., Lee,C.S., Hsu,J.L., Dias,A. and Reed,R.
  TITLE     Human mRNA export machinery recruited to the 5' end of mRNA
  JOURNAL   Cell 127 (7), 1389-1400 (2006)
   PUBMED   17190602
REFERENCE   8  (residues 1 to 1594)
  AUTHORS   Masuda,S., Das,R., Cheng,H., Hurt,E., Dorman,N. and Reed,R.
  TITLE     Recruitment of the human TREX complex to mRNA during splicing
  JOURNAL   Genes Dev 19 (13), 1512-1517 (2005)
   PUBMED   15998806
REFERENCE   9  (residues 1 to 1594)
  AUTHORS   Guo,S., Hakimi,M.A., Baillat,D., Chen,X., Farber,M.J.,
            Klein-Szanto,A.J., Cooch,N.S., Godwin,A.K. and Shiekhattar,R.
  TITLE     Linking transcriptional elongation and messenger RNA export to
            metastatic breast cancers
  JOURNAL   Cancer Res 65 (8), 3011-3016 (2005)
   PUBMED   15833825
REFERENCE   10 (residues 1 to 1594)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jul 17, 2010 this sequence version replaced XP_233081.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1594
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     Protein         1..1594
                     /product="THO complex subunit 2"
                     /note="THO complex 2"
                     /calculated_mol_wt=182599
     Region          11..566
                     /region_name="THOC2_N"
                     /note="THO complex subunit 2 N-terminus; pfam16134"
                     /db_xref="CDD:465032"
     Region          568..642
                     /region_name="Thoc2"
                     /note="Transcription- and export-related complex subunit;
                     pfam11732"
                     /db_xref="CDD:463334"
     Region          874..1173
                     /region_name="Tho2"
                     /note="Transcription factor/nuclear export subunit protein
                     2; pfam11262"
                     /db_xref="CDD:463251"
     Region          1448..>1550
                     /region_name="U2AF_lg"
                     /note="U2 snRNP auxilliary factor, large subunit, splicing
                     factor; TIGR01642"
                     /db_xref="CDD:273727"
     CDS             1..1594
                     /gene="Thoc2"
                     /gene_synonym="RGD1561623"
                     /coded_by="NM_001191756.2:31..4815"
                     /db_xref="GeneID:313308"
                     /db_xref="RGD:1561623"
ORIGIN      
        1 maaatvvvpa ewiknweksg rgdflhlcri lsenkshdss tyrdfqqaly elsyhvikgn
       61 lkheqassvl ndisefredm psiladvfci ldietnclee kskrdyftql vlaclylvsd
      121 tvlkerldpe tleslglikq sqqfnqksvk iktklfykqq kfnllreene gyakliaelg
      181 qdlsgtitsd lileniksli gcfnldpnrv ldvilevfec rpehddffis llesymsmce
      241 pqtlchilgf kfkfyqepsg etpsslyrva avllqfnlid lddlyvhllp adncimdeyk
      301 reiveakqiv rkltmvvlss eklderdkek dkddekvekp pdnqklglle allkigdwqh
      361 aqnimdqmpp yyaashklia laicklihit veplyrrvgv pkgakgspvs alqnkrapkq
      421 vesfedlrrd vfnmfcylgp hlshdpilfa kvvrigksfm kefqsdgskq edkektevil
      481 scllsitdqv llpslslmdc nacmseelwg mfktfpyqhr yrlygqwkne tynghpllvk
      541 vkaqtidrak yimkrltken vkpsgrqigk lshsnptilf dyilsqiqky dnlitpvvds
      601 lkyltslnyd vlayciieal anpekermkh ddttisswlq slasfcgavf rkypidlagl
      661 lqyvanqlka gksfdllilk evvqkmagie iteemtmeql eamtggeqlk aeggyfgqir
      721 ntkkssqrlk dalldhdlal plcllmaqqr ngvifqegge khlklvgkly dqchdtlvqf
      781 ggflasnlst edyikrvpsi dvlcnefhtp hdaafflsrp myahhissky delkksekgs
      841 kqqhkvhkyi tscemvmapv heavvslhva kvwddispqf yatfwsltmy dlavphtsye
      901 revnklkvqm kaiddnqemp pnkkkkeker ctalqdklle eekkqmehvq rvlqrlklek
      961 dnwllakstk netitkflql cifprcifsa idavycarfv elvhqqktpn fstllcydrv
     1021 fsdiiytvas cteneasryg rflccmletv trwhsdraty ekecgnypgf ltilratgfd
     1081 ggnkadqldy enfrhvvhkw hykltkasvh cletgeythi rnilivltki lpwypkvlnl
     1141 gqalerrvnk icqeekekrp dlyalamgys gqlksrkshm ipenefhhkd ppprnavasv
     1201 qngpgggtss ssigsasksd esgaeetdks rersqcgtka vnkassttpk gnssngnsgs
     1261 nsnkavkend kekvkekeke kkektpattp earvlgkesk ekpkeerpnk ddkaretker
     1321 tpksdkekek fkkeekakde kfkttvpsve skstqerere kepsrerdva kemkskenvk
     1381 ggekppvsgs lkspvprsdi sepdreqkrr kidthpspsh sstvkdslid lkdssaklyi
     1441 nhnppplsks keremdkkdl dksrersrer ekkdekdrke rkrdhsnndr evppditkrr
     1501 keengtmgvs khksespces qypnekdkek nkskssgkek gssdsfksek mdkissggkk
     1561 esrhdkekie kkekrdssgg keekkhhkss dkhr
//
