LOCUS       NM_001398637            3013 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus THO complex subunit 1 (Thoc1), transcript variant
            1, mRNA.
ACCESSION   NM_001398637 XM_006254399
VERSION     NM_001398637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3013)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   2  (bases 1 to 3013)
  AUTHORS   Katahira,J.
  TITLE     mRNA export and the TREX complex
  JOURNAL   Biochim Biophys Acta 1819 (6), 507-513 (2012)
   PUBMED   22178508
  REMARK    Review article
REFERENCE   3  (bases 1 to 3013)
  AUTHORS   Dominguez-Sanchez,M.S., Barroso,S., Gomez-Gonzalez,B., Luna,R. and
            Aguilera,A.
  TITLE     Genome instability and transcription elongation impairment in human
            cells depleted of THO/TREX
  JOURNAL   PLoS Genet 7 (12), e1002386 (2011)
   PUBMED   22144908
REFERENCE   4  (bases 1 to 3013)
  AUTHORS   Boyne,J.R., Colgan,K.J. and Whitehouse,A.
  TITLE     Recruitment of the complete hTREX complex is required for Kaposi's
            sarcoma-associated herpesvirus intronless mRNA nuclear export and
            virus replication
  JOURNAL   PLoS Pathog 4 (10), e1000194 (2008)
   PUBMED   18974867
REFERENCE   5  (bases 1 to 3013)
  AUTHORS   Cheng,H., Dufu,K., Lee,C.S., Hsu,J.L., Dias,A. and Reed,R.
  TITLE     Human mRNA export machinery recruited to the 5' end of mRNA
  JOURNAL   Cell 127 (7), 1389-1400 (2006)
   PUBMED   17190602
REFERENCE   6  (bases 1 to 3013)
  AUTHORS   Masuda,S., Das,R., Cheng,H., Hurt,E., Dorman,N. and Reed,R.
  TITLE     Recruitment of the human TREX complex to mRNA during splicing
  JOURNAL   Genes Dev 19 (13), 1512-1517 (2005)
   PUBMED   15998806
REFERENCE   7  (bases 1 to 3013)
  AUTHORS   Li,Y., Wang,X., Zhang,X. and Goodrich,D.W.
  TITLE     Human hHpr1/p84/Thoc1 regulates transcriptional elongation and
            physically links RNA polymerase II and RNA processing factors
  JOURNAL   Mol Cell Biol 25 (10), 4023-4033 (2005)
   PUBMED   15870275
REFERENCE   8  (bases 1 to 3013)
  AUTHORS   Guo,S., Hakimi,M.A., Baillat,D., Chen,X., Farber,M.J.,
            Klein-Szanto,A.J., Cooch,N.S., Godwin,A.K. and Shiekhattar,R.
  TITLE     Linking transcriptional elongation and messenger RNA export to
            metastatic breast cancers
  JOURNAL   Cancer Res 65 (8), 3011-3016 (2005)
   PUBMED   15833825
REFERENCE   9  (bases 1 to 3013)
  AUTHORS   Gasparri,F., Sola,F., Locatelli,G. and Muzio,M.
  TITLE     The death domain protein p84N5, but not the short isoform p84N5s,
            is cell cycle-regulated and shuttles between the nucleus and the
            cytoplasm
  JOURNAL   FEBS Lett 574 (1-3), 13-19 (2004)
   PUBMED   15358532
REFERENCE   10 (bases 1 to 3013)
  AUTHORS   Doostzadeh-Cizeron,J., Evans,R., Yin,S. and Goodrich,D.W.
  TITLE     Apoptosis induced by the nuclear death domain protein p84N5 is
            inhibited by association with Rb protein
  JOURNAL   Mol Biol Cell 10 (10), 3251-3261 (1999)
   PUBMED   10512864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 21, 2021 this sequence version replaced XM_006254399.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2009039.1,
                                           SRR26643286.43711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000018.1  1256660-1256730
            72-145              JAXUCZ010000018.1  1258978-1259051
            146-206             JAXUCZ010000018.1  1259139-1259199
            207-273             JAXUCZ010000018.1  1260491-1260557
            274-392             JAXUCZ010000018.1  1262471-1262589
            393-441             JAXUCZ010000018.1  1264819-1264867
            442-537             JAXUCZ010000018.1  1265197-1265292
            538-620             JAXUCZ010000018.1  1270010-1270092
            621-694             JAXUCZ010000018.1  1271595-1271668
            695-803             JAXUCZ010000018.1  1275681-1275789
            804-935             JAXUCZ010000018.1  1278635-1278766
            936-1036            JAXUCZ010000018.1  1282893-1282993
            1037-1103           JAXUCZ010000018.1  1285087-1285153
            1104-1154           JAXUCZ010000018.1  1285350-1285400
            1155-1225           JAXUCZ010000018.1  1285485-1285555
            1226-1321           JAXUCZ010000018.1  1285826-1285921
            1322-1387           JAXUCZ010000018.1  1286492-1286557
            1388-1471           JAXUCZ010000018.1  1288365-1288448
            1472-1619           JAXUCZ010000018.1  1289544-1289691
            1620-1695           JAXUCZ010000018.1  1290209-1290284
            1696-3013           JAXUCZ010000018.1  1290639-1291956
FEATURES             Location/Qualifiers
     source          1..3013
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..3013
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /note="THO complex subunit 1"
                     /db_xref="GeneID:291797"
                     /db_xref="RGD:1308657"
     exon            1..71
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1991
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /note="isoform 1 is encoded by transcript variant 1; THO
                     complex 1"
                     /codon_start=1
                     /product="THO complex subunit 1 isoform 1"
                     /protein_id="NP_001385566.1"
                     /db_xref="GeneID:291797"
                     /db_xref="RGD:1308657"
                     /translation="MSPTPALFSLPEARTRFTKSTREALNNKTIKPLLNAFSQLPGSE
                     NEKKCTLDQAFRGVLEEEIINHSACENVLAIISLAIGGVTESVCTASTPFVLLGDVLD
                     CLPLDQCDTIFTFVEKNVATWKSNTFYSAGKNYLLRMCNDLLRRLSKSQNTVFCGRIQ
                     LFLARLFPLSEKSGLNLQSQFNLENITVFNTNEQESTLGQKHTEDREEGMDVEEGEMG
                     DDEAPTTCSIPIDYNLYRKFWSLQDYFRNPVQCYEKISWKTFLKYSEEVLAVFKSYKL
                     DDTQASRKKMEELKTGGEHVYFAKFLTSEKLMDLQLSDSNFRRHILLQYLILFQYLKG
                     QVKFKSSNYVLTDEQSLWIEDTTKSVYQLLSENPPDGERFSKMVEHILNTEENWNSWK
                     NEGCPSFVKERASDTKPTRVVRKRAAPEDFLGKGPNKKILIGNEELTRLWNLCPDNME
                     ACKSETREYMPTLEEFFEEAIEQADPENMVESEYKAVNNSNYGWRALRLLARRSPHFF
                     QPTNQQFKSLPEYLENMVIKLAKELPPPSEEIKTGEDEDEEDNDALLKENESPDVRRD
                     KPLTGEQIESFANKLGEQWKILAPYLEIKDSDIRQIECDSEDMKMRAKQLLVAWQDQE
                     GVHATTDNLIGALNKSGLSDLAESLTNDTETNS"
     exon            72..145
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            146..206
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            207..273
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            274..392
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            393..441
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            442..537
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            538..620
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            621..694
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            695..803
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            804..935
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1036
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1103
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1154
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1225
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1321
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1387
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1471
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1619
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1695
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..3013
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcacgcgc aaccaagatg tctccgacgc cggcgctttt cagtttgccc gaggcgcgga
       61 cgcggtttac gaaatctacc agagaagcct tgaataacaa aactatcaag ccattgttga
      121 atgccttcag tcagttacct ggcagtgaaa atgaaaaaaa atgtaccctt gaccaagctt
      181 tcagaggcgt tctggaagaa gaaattataa atcattcagc atgtgagaac gttttagcta
      241 ttatttctct tgccattggg ggagtaacag aaagtgtctg tactgcgtcc acaccatttg
      301 tgctattggg agatgtcttg gactgccttc ctttggatca gtgtgacaca atattcactt
      361 ttgtcgaaaa aaatgttgcc acttggaagt caaatacatt ctattctgct ggcaaaaatt
      421 atttactgcg tatgtgcaat gatctcctca gaagattgtc taaatctcag aatacagttt
      481 tctgtggaag aattcagctc tttttggcca gactttttcc actatccgag aaatcaggtc
      541 ttaatttgca aagtcagttt aacctggaaa acatcactgt tttcaataca aatgaacagg
      601 agagcaccct gggtcaaaag catactgagg atagagagga agggatggat gtagaagaag
      661 gtgaaatggg agatgatgaa gcccccacga cttgttctat tccaattgat tacaacctgt
      721 acagaaaatt ctggtcactt caggattact tcaggaaccc agtacaatgc tatgagaaga
      781 tttcttggaa aacttttctc aagtattctg aagaagtttt agctgtcttt aaaagttata
      841 aattagatga tactcaagcc tccaggaaga agatggaaga actgaaaaca ggaggggagc
      901 acgtgtactt cgcaaagttc ttaacaagcg agaagttgat ggatttacaa ctgagtgaca
      961 gtaactttcg tcgacacatc ctgttgcagt atctcatttt atttcagtat ctcaagggac
     1021 aggtcaaatt caaaagttca aattatgttt taactgatga gcaatcactc tggattgaag
     1081 atactaccaa gtcagtctac caactgctat ctgaaaatcc ccctgatgga gaaagatttt
     1141 caaagatggt agagcatata ttaaacactg aagaaaattg gaactcatgg aaaaatgaag
     1201 gttgcccaag ttttgtgaaa gaaagagcat cagataccaa gcccacaaga gtggtacgga
     1261 agagagcagc cccagaagac ttcttaggca aagggcccaa taagaaaatc ctgattggaa
     1321 atgaggagct aacaaggctt tggaatctct gtcctgataa catggaagcc tgtaaatcag
     1381 agacaagaga atacatgcca actttggagg agttctttga agaagccatt gaacaagcag
     1441 atcctgaaaa catggttgaa agtgaatata aagccgtaaa taattcaaat tatggatgga
     1501 gagctctcag actcttagcc cggagaagcc ctcacttctt ccagccaact aaccagcagt
     1561 ttaagagtct gccagagtat cttgaaaaca tggtgataaa gctagccaag gaactaccac
     1621 ccccttctga agaaataaaa acaggtgagg atgaagatga ggaagataat gatgctttac
     1681 taaaggaaaa tgaaagtcct gatgttcggc gagataaacc tctaacaggg gaacagatag
     1741 agtcatttgc caacaaactt ggtgagcagt ggaagatttt ggctccttac ctggaaatta
     1801 aagactctga cattaggcag attgaatgtg acagtgagga catgaagatg agagccaaac
     1861 agctccttgt tgcctggcaa gatcaagaag gagttcacgc aacaactgat aacctgattg
     1921 gtgcactgaa caagtctggg ttaagtgacc ttgcagaaag tctaactaat gacactgaaa
     1981 caaacagtta gctttctttc tttctctcct tttttattga acagtgatta agattttgtt
     2041 accaagcagc atttgataaa aggttcactg gttttggtaa acaataaaca cttttataac
     2101 agctgttgta cagttagctg gtgctcaaaa aaccacatac cgaacaggca ttggagtata
     2161 ggaggacagg gtgggaaaat ggccaaagta aaaggaccac aagatcacag acgacttttt
     2221 gtaagtattt ttataatgaa gttaaatgag tactatttat gagtatgtta gagtcctgtc
     2281 ccaaattagt ttcctgcatg ctatcagtta taaaatgtat tctgaaatca caagatgaca
     2341 cttctgaaac cttaggactg gaaagctgga aagcagagga ttggcaaagg atggatagtt
     2401 taagtgtttt actggcagtc tgccatgttt actctactac agcaagagtc cagactgata
     2461 gccaggggcc ctgcaaacca tttgctgttt ggccaataca gaaaatgttt gctagcctct
     2521 aactttatgt gaagtggagt ctaagaccca actactcctt tagctttata aagattactt
     2581 gacatcctca agtctctaaa cacccaggga ttcctgtcag ttgacttgtg aaaatacact
     2641 gtatgtagca gagcatgtgc ggtgctggct gaaggttcat gttctgttcc catacaacat
     2701 ttcctgtggg tgtttggtgt ctggtgaagg ttaaaagtgt ccttgcctgg accatgcaca
     2761 ctccactagc tggggaagca gtggctgcgc acagctccag cttcctggta ccctctgcac
     2821 taagcaaatt aaggcatgct caggaactga aagggagaat ggattttttg cctcttctct
     2881 cttacattca aggatgcatt ctaaaatact aaacacctta tttaaaacaa cactggaaat
     2941 ccaatttcta ctttaaagaa ttctctttgg aatgcttttc taggtcaaat aaactatcga
     3001 gaagcttttt gta
//
