LOCUS       NP_001385566             657 aa            linear   ROD 31-MAR-2024
DEFINITION  THO complex subunit 1 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001385566 XP_006254461
VERSION     NP_001385566.1
DBSOURCE    REFSEQ: accession NM_001398637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 657)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   2  (residues 1 to 657)
  AUTHORS   Katahira,J.
  TITLE     mRNA export and the TREX complex
  JOURNAL   Biochim Biophys Acta 1819 (6), 507-513 (2012)
   PUBMED   22178508
  REMARK    Review article
REFERENCE   3  (residues 1 to 657)
  AUTHORS   Dominguez-Sanchez,M.S., Barroso,S., Gomez-Gonzalez,B., Luna,R. and
            Aguilera,A.
  TITLE     Genome instability and transcription elongation impairment in human
            cells depleted of THO/TREX
  JOURNAL   PLoS Genet 7 (12), e1002386 (2011)
   PUBMED   22144908
REFERENCE   4  (residues 1 to 657)
  AUTHORS   Boyne,J.R., Colgan,K.J. and Whitehouse,A.
  TITLE     Recruitment of the complete hTREX complex is required for Kaposi's
            sarcoma-associated herpesvirus intronless mRNA nuclear export and
            virus replication
  JOURNAL   PLoS Pathog 4 (10), e1000194 (2008)
   PUBMED   18974867
REFERENCE   5  (residues 1 to 657)
  AUTHORS   Cheng,H., Dufu,K., Lee,C.S., Hsu,J.L., Dias,A. and Reed,R.
  TITLE     Human mRNA export machinery recruited to the 5' end of mRNA
  JOURNAL   Cell 127 (7), 1389-1400 (2006)
   PUBMED   17190602
REFERENCE   6  (residues 1 to 657)
  AUTHORS   Masuda,S., Das,R., Cheng,H., Hurt,E., Dorman,N. and Reed,R.
  TITLE     Recruitment of the human TREX complex to mRNA during splicing
  JOURNAL   Genes Dev 19 (13), 1512-1517 (2005)
   PUBMED   15998806
REFERENCE   7  (residues 1 to 657)
  AUTHORS   Li,Y., Wang,X., Zhang,X. and Goodrich,D.W.
  TITLE     Human hHpr1/p84/Thoc1 regulates transcriptional elongation and
            physically links RNA polymerase II and RNA processing factors
  JOURNAL   Mol Cell Biol 25 (10), 4023-4033 (2005)
   PUBMED   15870275
REFERENCE   8  (residues 1 to 657)
  AUTHORS   Guo,S., Hakimi,M.A., Baillat,D., Chen,X., Farber,M.J.,
            Klein-Szanto,A.J., Cooch,N.S., Godwin,A.K. and Shiekhattar,R.
  TITLE     Linking transcriptional elongation and messenger RNA export to
            metastatic breast cancers
  JOURNAL   Cancer Res 65 (8), 3011-3016 (2005)
   PUBMED   15833825
REFERENCE   9  (residues 1 to 657)
  AUTHORS   Gasparri,F., Sola,F., Locatelli,G. and Muzio,M.
  TITLE     The death domain protein p84N5, but not the short isoform p84N5s,
            is cell cycle-regulated and shuttles between the nucleus and the
            cytoplasm
  JOURNAL   FEBS Lett 574 (1-3), 13-19 (2004)
   PUBMED   15358532
REFERENCE   10 (residues 1 to 657)
  AUTHORS   Doostzadeh-Cizeron,J., Evans,R., Yin,S. and Goodrich,D.W.
  TITLE     Apoptosis induced by the nuclear death domain protein p84N5 is
            inhibited by association with Rb protein
  JOURNAL   Mol Biol Cell 10 (10), 3251-3261 (1999)
   PUBMED   10512864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 21, 2021 this sequence version replaced XP_006254461.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2009039.1,
                                           SRR26643286.43711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     Protein         1..657
                     /product="THO complex subunit 1 isoform 1"
                     /note="THO complex 1"
                     /calculated_mol_wt=75289
     Region          74..539
                     /region_name="efThoc1"
                     /note="THO complex subunit 1 transcription elongation
                     factor; pfam11957"
                     /db_xref="CDD:463412"
     Region          565..650
                     /region_name="Death_NMPP84"
                     /note="Death domain of Nuclear Matrix Protein P84;
                     cd08318"
                     /db_xref="CDD:260030"
     CDS             1..657
                     /gene="Thoc1"
                     /gene_synonym="LRRGT00070"
                     /coded_by="NM_001398637.1:18..1991"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:291797"
                     /db_xref="RGD:1308657"
ORIGIN      
        1 msptpalfsl peartrftks trealnnkti kpllnafsql pgsenekkct ldqafrgvle
       61 eeiinhsace nvlaiislai ggvtesvcta stpfvllgdv ldclpldqcd tiftfveknv
      121 atwksntfys agknyllrmc ndllrrlsks qntvfcgriq lflarlfpls eksglnlqsq
      181 fnlenitvfn tneqestlgq khtedreegm dveegemgdd eapttcsipi dynlyrkfws
      241 lqdyfrnpvq cyekiswktf lkyseevlav fksyklddtq asrkkmeelk tggehvyfak
      301 fltseklmdl qlsdsnfrrh illqylilfq ylkgqvkfks snyvltdeqs lwiedttksv
      361 yqllsenppd gerfskmveh ilnteenwns wknegcpsfv kerasdtkpt rvvrkraape
      421 dflgkgpnkk iligneeltr lwnlcpdnme acksetreym ptleeffeea ieqadpenmv
      481 eseykavnns nygwralrll arrsphffqp tnqqfkslpe ylenmvikla kelpppseei
      541 ktgededeed ndallkenes pdvrrdkplt geqiesfank lgeqwkilap yleikdsdir
      601 qiecdsedmk mrakqllvaw qdqegvhatt dnligalnks glsdlaeslt ndtetns
//
