LOCUS       NM_001025017            1756 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus thioesterase superfamily member 4 (Them4), mRNA.
ACCESSION   NM_001025017 XM_342292
VERSION     NM_001025017.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1756)
  AUTHORS   Zhao,H., Lim,K., Choudry,A., Latham,J.A., Pathak,M.C.,
            Dominguez,D., Luo,L., Herzberg,O. and Dunaway-Mariano,D.
  TITLE     Correlation of structure and function in the human hotdog-fold
            enzyme hTHEM4
  JOURNAL   Biochemistry 51 (33), 6490-6492 (2012)
   PUBMED   22871024
REFERENCE   2  (bases 1 to 1756)
  AUTHORS   Piao,L., Li,Y., Yang,K.J., Park,K.A., Byun,H.S., Won,M., Hong,J.,
            Kim,J.L., Kweon,G.R., Hur,G.M., Seok,J.H., Cho,J.Y., Chun,T.,
            Hess,D., Sack,R., Maira,S.M., Brazil,D.P., Hemmings,B.A. and
            Park,J.
  TITLE     Heat shock protein 70-mediated sensitization of cells to apoptosis
            by Carboxyl-Terminal Modulator Protein
  JOURNAL   BMC Cell Biol 10, 53 (2009)
   PUBMED   19604401
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1756)
  AUTHORS   Miyawaki,T., Ofengeim,D., Noh,K.M., Latuszek-Barrantes,A.,
            Hemmings,B.A., Follenzi,A. and Zukin,R.S.
  TITLE     The endogenous inhibitor of Akt, CTMP, is critical to
            ischemia-induced neuronal death
  JOURNAL   Nat Neurosci 12 (5), 618-626 (2009)
   PUBMED   19349976
  REMARK    GeneRIF: CTMP is important in the neurodegeneration that is
            associated with stroke and identify CTMP as a therapeutic target
            for the amelioration of hippocampal injury and cognitive deficits.
REFERENCE   4  (bases 1 to 1756)
  AUTHORS   Parcellier,A., Tintignac,L.A., Zhuravleva,E., Cron,P., Schenk,S.,
            Bozulic,L. and Hemmings,B.A.
  TITLE     Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial
            protein that sensitizes cells to apoptosis
  JOURNAL   Cell Signal 21 (4), 639-650 (2009)
   PUBMED   19168129
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC093385.1.
            
            On Jun 25, 2005 this sequence version replaced XM_342292.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093385.1, CV075202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132278, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1756
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1756
                     /gene="Them4"
                     /gene_synonym="RGD1304723"
                     /note="thioesterase superfamily member 4"
                     /db_xref="GeneID:361992"
                     /db_xref="RGD:1304723"
     exon            1..150
                     /gene="Them4"
                     /gene_synonym="RGD1304723"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..771
                     /gene="Them4"
                     /gene_synonym="RGD1304723"
                     /EC_number="3.1.2.2"
                     /note="acyl-CoA thioesterase THEM4"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase THEM4"
                     /protein_id="NP_001020188.1"
                     /db_xref="GeneID:361992"
                     /db_xref="RGD:1304723"
                     /translation="MLRSCAMRLRTLGATPARRPEATRRLFSSEEVVCKDYALPNPSW
                     TKDLRLLFDQFMKKCEDGSWKRLPSYRQNPPQALQEFQTHFVDSKFKKEEQMSKAQQF
                     TRSLEEGLGFEYAMFYNKAEKRIVCLFQGGLHLQGMPGFVHGGAIATIIDITAGMCAF
                     SEGIVMTANLNIDYKKPIPLLSVVVVNSQLQKIEGRKLFVSCTIQSTDEKTLHTQATA
                     LFIKLDPDKPLT"
     exon            151..337
                     /gene="Them4"
                     /gene_synonym="RGD1304723"
                     /inference="alignment:Splign:2.1.0"
     exon            338..497
                     /gene="Them4"
                     /gene_synonym="RGD1304723"
                     /inference="alignment:Splign:2.1.0"
     exon            498..605
                     /gene="Them4"
                     /gene_synonym="RGD1304723"
                     /inference="alignment:Splign:2.1.0"
     exon            606..730
                     /gene="Them4"
                     /gene_synonym="RGD1304723"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1731
                     /gene="Them4"
                     /gene_synonym="RGD1304723"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccggaatc cgcgtgccgg gtagtgtggc tctttctggt tgagaggaca ttgcagcgtc
       61 ctgccctcgg cttgaacgat gttgagaagc tgcgctatgc gcctgcgcac tcttggggcc
      121 acgcctgcaa ggcggcctga agcaacgagg aggttatttt cttctgagga agtcgtctgt
      181 aaggactatg ctctccctaa ccccagctgg actaaggacc taagactcct ttttgaccag
      241 ttcatgaaga aatgtgaaga tggctcctgg aaacgtttgc cttcatacag acaaaaccct
      301 cctcaagccc ttcaagagtt ccaaacccac tttgttgact caaagtttaa gaaagaagaa
      361 caaatgtcaa aggcacaaca gttcaccaga agcttagaag aaggactagg ctttgagtac
      421 gcgatgttct ataataaggc tgagaagaga attgtctgct tgtttcaagg aggtcttcac
      481 ctgcaaggaa tgcctggatt tgttcatgga ggtgccattg caaccatcat cgacatcact
      541 gccggcatgt gtgcattttc tgagggcatt gtcatgactg ccaatctcaa catcgactat
      601 aaaaaaccta tcccccttct ttctgttgtt gtggtaaata gccaacttca aaaaattgaa
      661 ggaaggaaac tttttgtttc ctgtactatt caaagtactg atgagaagac tttacataca
      721 caggcaacag ccttatttat aaagctggat cctgacaaac ctttgacata aaagaactct
      781 ggtgagttcc acaccgttct gcatgaggtc cccgccccct ccagaagtag cacctatctc
      841 cactcctgtc acagctgctg aatcccccag ggaaagtctg ctctcacagc tccttcagcg
      901 cagcctctga cgtggctgca ggaactcact ctcaccttcc agagttatca taagaagtac
      961 tgcccggggg cgtctcagca gtaatctgta tgtccacgtg acaactgtgt ggttctaact
     1021 cgtgaacaga cttcaaagct aacaagcata ggacctgctc tgctgtgggc tgcagaaaaa
     1081 aacaaaagac catattgaga cttgggctgc aaatgtggaa atgcacgaaa accacaggca
     1141 gggatagatc cacagagcgt tgagtgacgt gcgtgtgtgc acaagccgcg ccgggtctta
     1201 cagaactaag tttgttgtat ctgaacaaac tctctttggc cacatcagga acacagctca
     1261 ttgctgtggg aatggccccc acacatcatt gtctggggcc ctagagatta aaatactgtt
     1321 catttttctg gcctgtgctg ctgtagctta gaacactgta gtctgtcacc cctggaagaa
     1381 ggctttgtta catttctggg actgtaatga agagctacaa gctgggtggt ttaaacaaat
     1441 aaaaaacgtc actggcacag ccccaggggc cagcagtcta aaagtattaa caaaacgttg
     1501 cttcttaagg ttctgggcgg gcactttcac atctctcctg gcttctacca aggaagcatc
     1561 cagctttcct tggtttttag acacagcata attcctaatt gcatctcttt tatcatcttc
     1621 tctcggttgt atccacattt ccctttgtga atgtttattt atttatttgt ctgggtgggt
     1681 gtgtgtgttc aggtgctaaa ataaattggg agattagtgt tctacaaagt gaaaaaaaaa
     1741 aaaaaaaaaa aaaaaa
//
