LOCUS       NM_001305458            3155 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus thrombospondin 3 (Thbs3), mRNA.
ACCESSION   NM_001305458 XM_003753605 XM_008761238
VERSION     NM_001305458.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3155)
  AUTHORS   Eroglu,C., Allen,N.J., Susman,M.W., O'Rourke,N.A., Park,C.Y.,
            Ozkan,E., Chakraborty,C., Mulinyawe,S.B., Annis,D.S.,
            Huberman,A.D., Green,E.M., Lawler,J., Dolmetsch,R., Garcia,K.C.,
            Smith,S.J., Luo,Z.D., Rosenthal,A., Mosher,D.F. and Barres,B.A.
  TITLE     Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin
            receptor responsible for excitatory CNS synaptogenesis
  JOURNAL   Cell 139 (2), 380-392 (2009)
   PUBMED   19818485
REFERENCE   2  (bases 1 to 3155)
  AUTHORS   Posey,K.L., Hankenson,K., Veerisetty,A.C., Bornstein,P., Lawler,J.
            and Hecht,J.T.
  TITLE     Skeletal abnormalities in mice lacking extracellular matrix
            proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and
            type IX collagen
  JOURNAL   Am J Pathol 172 (6), 1664-1674 (2008)
   PUBMED   18467703
REFERENCE   3  (bases 1 to 3155)
  AUTHORS   Hankenson,K.D., Hormuzdi,S.G., Meganck,J.A. and Bornstein,P.
  TITLE     Mice with a disruption of the thrombospondin 3 gene differ in
            geometric and biomechanical properties of bone and have accelerated
            development of the femoral head
  JOURNAL   Mol Cell Biol 25 (13), 5599-5606 (2005)
   PUBMED   15964815
REFERENCE   4  (bases 1 to 3155)
  AUTHORS   Armstrong,D.J., Hiscott,P., Batterbury,M. and Kaye,S.
  TITLE     Corneal stromal cells (keratocytes) express thrombospondins 2 and 3
            in wound repair phenotype
  JOURNAL   Int J Biochem Cell Biol 34 (6), 588-593 (2002)
   PUBMED   11943589
REFERENCE   5  (bases 1 to 3155)
  AUTHORS   Qabar,A.N., Lin,Z., Wolf,F.W., O'Shea,K.S., Lawler,J. and
            Dixit,V.M.
  TITLE     Thrombospondin 3 is a developmentally regulated heparin binding
            protein
  JOURNAL   J Biol Chem 269 (2), 1262-1269 (1994)
   PUBMED   8288588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Mar 15, 2015 this sequence version replaced
            XM_008761238.1, XM_003753605.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.832282.1,
                                           SRR26643289.6678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000002.1  176919599-176919708
            111-317             JAXUCZ010000002.1  176920895-176921101
            318-574             JAXUCZ010000002.1  176922100-176922356
            575-677             JAXUCZ010000002.1  176922444-176922546
            678-704             JAXUCZ010000002.1  176923262-176923288
            705-787             JAXUCZ010000002.1  176923453-176923535
            788-839             JAXUCZ010000002.1  176923624-176923675
            840-988             JAXUCZ010000002.1  176923795-176923943
            989-1129            JAXUCZ010000002.1  176924252-176924392
            1130-1207           JAXUCZ010000002.1  176924531-176924608
            1208-1360           JAXUCZ010000002.1  176925164-176925316
            1361-1471           JAXUCZ010000002.1  176925521-176925631
            1472-1579           JAXUCZ010000002.1  176925729-176925836
            1580-1739           JAXUCZ010000002.1  176927592-176927751
            1740-1858           JAXUCZ010000002.1  176927993-176928111
            1859-1911           JAXUCZ010000002.1  176928192-176928244
            1912-2105           JAXUCZ010000002.1  176928544-176928737
            2106-2284           JAXUCZ010000002.1  176928834-176929012
            2285-2333           JAXUCZ010000002.1  176929129-176929177
            2334-2530           JAXUCZ010000002.1  176929374-176929570
            2531-2703           JAXUCZ010000002.1  176929812-176929984
            2704-2843           JAXUCZ010000002.1  176930824-176930963
            2844-3155           JAXUCZ010000002.1  176931046-176931357
FEATURES             Location/Qualifiers
     source          1..3155
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3155
                     /gene="Thbs3"
                     /note="thrombospondin 3"
                     /db_xref="GeneID:681309"
                     /db_xref="RGD:1596780"
     exon            1..110
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2902
                     /gene="Thbs3"
                     /codon_start=1
                     /product="thrombospondin-3 precursor"
                     /protein_id="NP_001292387.1"
                     /db_xref="GeneID:681309"
                     /db_xref="RGD:1596780"
                     /translation="MEKPELWVALALLLCSYTCGSQDLQVIDLLTVSESRQMAAVAEK
                     VRTALLTAGDIYLLSTFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQRE
                     DGKVHAVNLQQAGLADGRTHTALLRLRGPSRPSPGLQLYVDCKLGDQHAGLPALAPIP
                     PAEVSGLEIRTGQKAYLRMQGFVESMKIILGGSMARVGALSECPFQGDESIHNAVTSA
                     LQSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSH
                     CSPSPCFRGVDCMEVYEYPGYRCGPCPPGLRGNGTHCEDIDECAHADPCFLGSSCINT
                     MPGFHCEACPQGYKGTRVSGVGIDYARASKQVCSDIDECNDGNNGGCDPNSICTNTVG
                     SFKCGPCRLGFLGNQSQGCTPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGN
                     GNVCGPDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADG
                     DGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVD
                     GDGIPNGLDNCPKVPNPLQTDRDEDGVGDTCDSCPEMSNPTQTDADSDLVGDVCDTNE
                     DSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDSDDDNDGVPDYVPPGPDNCRLVP
                     NPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVILDPEGDAQ
                     IDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQ
                     DSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSISGPGEHLRNALWHTGHTPD
                     QVRLLWTDPRNVGWRDKTSYRWRLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGG
                     RLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV"
     exon            111..317
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            318..574
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            575..677
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            678..704
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            705..787
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            788..839
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            840..988
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1129
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1207
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1360
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1471
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1579
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1739
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1858
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1911
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2105
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2284
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2333
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2530
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2703
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2843
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..3155
                     /gene="Thbs3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgcctgcca ggggtagtga accggctaag cggcatggag aagccggaac tttgggttgc
       61 cctggctctc ctcctttgct cttacacatg tggcagtcag gaccttcagg taattgacct
      121 gctgacggtg agtgagtcca ggcagatggc agctgtagca gagaaggtcc ggacagcttt
      181 actcactgct ggggacatct acctcttgtc cactttccgc ctccctccaa agcaaggtgg
      241 tgtcctcttt ggcctctact ctcgccaaga caacacacga tggctggagg cctctgttgt
      301 tggcaagatc aacaaagtgc tggtgcggta ccagcgggaa gatggcaaag tgcacgcagt
      361 gaaccttcag caagcaggct tggctgacgg gcgcacgcac accgctctcc tgcgactccg
      421 aggaccttct cgacccagcc ctggcctgca actgtatgtg gactgtaaac tgggtgacca
      481 acacgctggc ctcccagccc tagcgcccat tcctccagcg gaggtcagcg gactggagat
      541 tagaacagga caaaaggctt acctgaggat gcagggcttt gtggaatcga tgaagattat
      601 tttgggtgga tcgatggctc gggtgggagc cctgagcgaa tgtccgttcc aaggagatga
      661 atccattcac aatgcagtga ccagcgcgct gcagtccatt ctaggagagc agaccaaggc
      721 actggtcact cagctcacac tcttcaacca gatcctagtg gagctccggg atgacatccg
      781 ggaccaggtg aaggaaatgt ccctcatccg gaacaccatc atggagtgtc aggtgtgcgg
      841 tttccacgag cagcgttcac actgcagccc cagcccctgc ttcagaggtg tggactgcat
      901 ggaagtgtat gagtacccag gctaccgctg tgggccctgc ccacctggcc tgcgcggcaa
      961 tggcacccac tgtgaagaca tcgacgagtg tgctcacgct gacccctgtt tcctggggtc
     1021 cagctgcatc aacaccatgc ctggcttcca ctgcgaggcc tgtcctcaag ggtacaaggg
     1081 cacccgagtg tctggagtgg gcattgacta tgctagagcc agcaaacagg tctgcagtga
     1141 cattgacgaa tgtaacgacg gtaacaatgg aggctgtgac ccaaattcca tctgcaccaa
     1201 cactgtgggg tctttcaaat gtggtccctg ccgcctgggt ttcctgggga accagagcca
     1261 gggctgcact ccagccagga cgtgccacag ccccgcccac agcccctgcc acatccacgc
     1321 tcattgtctt tttgaacgca acggtgcagt gtcatgccag tgtaacgtgg gctgggcagg
     1381 gaacgggaac gtgtgtggac ctgacacgga catagacggc tatccagacc aggcgcttcc
     1441 ctgcatggac aacaacaaac actgcaagca ggacaattgc cttttgacac ccaactctgg
     1501 gcaagaagat gctgataatg atggtgtcgg ggaccagtgt gatgacgacg ctgatgggga
     1561 tggtatcaag aatgttgagg acaactgccg actgttcccc aacaaggacc agcagaattc
     1621 agacacagat tcatttggtg acgcctgtga caactgtccc aatgttccca acaatgacca
     1681 gaaggacacg gatggcaatg gagaaggaga cgcctgtgac aacgatgtgg acggggacgg
     1741 catccccaat ggcttggaca attgccctaa agtacccaac ccactgcaga cagaccggga
     1801 tgaagatgga gtcggagaca cttgcgacag ctgccctgag atgagcaatc ctacccagac
     1861 agatgcagac agtgacctgg taggggatgt ctgtgacacc aacgaagaca gcgatggaga
     1921 cgggcaccag gacaccaagg acaactgtcc tcagctgccc aacagctctc agctggactc
     1981 ggacaacgac gggcttggag atgagtgtga cagcgacgat gacaatgacg gggtgcccga
     2041 ttacgtgcct cccgggcctg ataactgtcg cctggtaccc aatcctaacc agaaggactc
     2101 agacggcaac ggtgttggtg atgtctgtga ggatgacttt gacaatgatg cagtggttga
     2161 ccctctggat gtgtgcccag aaagtgcaga agttaccctc acggacttcc gggcctatca
     2221 gaccgtgatt ctggatccgg agggtgacgc tcagatcgat ccaaactggg tagtgctcaa
     2281 ccagggcatg gaaattgttc agactatgaa cagtgaccca ggtcttgcag ttggatacac
     2341 agccttcaat ggtgtagact ttgaaggcac tttccacgtg aacacagtca ctgatgatga
     2401 ctatgcaggc ttcctcttca gttaccagga cagtggccgc ttctatgtgg tcatgtggaa
     2461 acagacggag cagacctact ggcaggccac gcctttccga gcagtggccc aaccagggct
     2521 gcagctcaag gcagtgacat caatatctgg cccaggtgag cacctccgga atgctctgtg
     2581 gcacactggc cacacccctg atcaggtacg actgctgtgg actgatccac ggaatgtggg
     2641 ttggcgagac aagacatcct atagatggcg gctgctccac cggccccaag tcggctacat
     2701 tcgggtgaag ctctatgagg gtccccagct agtggcggac tctggggtga ttattgatac
     2761 gtccatgcga ggggggcgtc ttggtgtatt ctgcttctcc caagaaaaca tcatttggtc
     2821 taatctccag taccgatgca atgacacagt gcctgaggac tttgagccat tcaggaggca
     2881 actgctccag ggaagggtgt gaggaggtgg ccataggatt cagatcctga ttggagaccc
     2941 tttgccgttg gactctgttc tggagaccct ggggtctaac ctacagcccc tcagcctaac
     3001 agatggttct ctggtaccca tcagggagct cagccctaga ggggtagtga ccccattgtg
     3061 caggggttgg gagcctttca aggggtatta ctactcaggt tttaacccca ggaaagacaa
     3121 caacacattg ccataaagtt tcagttattt tctaa
//
