LOCUS       NM_001169138            5728 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus thrombospondin 2 (Thbs2), mRNA.
ACCESSION   NM_001169138 XM_001055515 XM_214778
VERSION     NM_001169138.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5728)
  AUTHORS   Niu,J., Feng,F., Zhang,S., Zhu,Y., Song,R., Li,J., Zhao,L.,
            Wang,H., Zhao,Y. and Zhang,M.
  TITLE     Thrombospondin-2 Couples Pressure-Promoted Chondrogenesis through
            NF-kappaB Signaling
  JOURNAL   Tissue Eng Regen Med 20 (5), 753-766 (2023)
   PUBMED   37219820
  REMARK    GeneRIF: Thrombospondin-2 Couples Pressure-Promoted Chondrogenesis
            through NF-kappaB Signaling.
REFERENCE   2  (bases 1 to 5728)
  AUTHORS   Wang,S., Hu,T., Wang,Z., Li,N., Zhou,L., Liao,L., Wang,M., Liao,L.,
            Wang,H., Zeng,L., Fan,C., Zhou,H., Xiong,K., Huang,J. and Chen,D.
  TITLE     Macroglia-derived thrombospondin 2 regulates alterations of
            presynaptic proteins of retinal neurons following elevated
            hydrostatic pressure
  JOURNAL   PLoS One 12 (9), e0185388 (2017)
   PUBMED   28953973
  REMARK    GeneRIF: The expression levels of glial fibrillary acidic protein
            (the marker of activated macroglia cells), thrombospondin 2,
            alpha2delta-1 and presynaptic proteins were increased following
            elevated hydrostatic pressure in mixed cultures, but the expression
            levels of postsynaptic proteins were not changed.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5728)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 5728)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 5728)
  AUTHORS   Huang,J., Zhou,L., Wang,H., Luo,J., Zeng,L., Xiong,K. and Chen,D.
  TITLE     Distribution of thrombospondins and their neuronal receptor
            alpha2delta1 in the rat retina
  JOURNAL   Exp Eye Res 111, 36-49 (2013)
   PUBMED   23541831
  REMARK    GeneRIF: In the adult rat retina, TSP2, but not TSP1, secreted by
            glial cells may be involved in the synaptic plastic process after
            retinal injury through binding to its neuronal receptor
            alpha2delta1.
REFERENCE   6  (bases 1 to 5728)
  AUTHORS   Lin,T.N., Kim,G.M., Chen,J.J., Cheung,W.M., He,Y.Y. and Hsu,C.Y.
  TITLE     Differential regulation of thrombospondin-1 and thrombospondin-2
            after focal cerebral ischemia/reperfusion
  JOURNAL   Stroke 34 (1), 177-186 (2003)
   PUBMED   12511771
  REMARK    GeneRIF: Robust expression of TSP-1 and TSP-2, two major
            angiostatic factors, was noted in the ischemic brain with different
            temporal expression profiles from different cellular origins.
REFERENCE   7  (bases 1 to 5728)
  AUTHORS   Boekholdt,S.M., Trip,M.D., Peters,R.J., Engelen,M., Boer,J.M.,
            Feskens,E.J., Zwinderman,A.H., Kastelein,J.J. and Reitsma,P.H.
  TITLE     Thrombospondin-2 polymorphism is associated with a reduced risk of
            premature myocardial infarction
  JOURNAL   Arterioscler Thromb Vasc Biol 22 (12), e24-e27 (2002)
   PUBMED   12482844
REFERENCE   8  (bases 1 to 5728)
  AUTHORS   Sanders,J.E., Baker,A.B. and Golledge,S.L.
  TITLE     Control of in vivo microvessel ingrowth by modulation of
            biomaterial local architecture and chemistry
  JOURNAL   J Biomed Mater Res 60 (1), 36-43 (2002)
   PUBMED   11835157
REFERENCE   9  (bases 1 to 5728)
  AUTHORS   Melnick,M., Chen,H., Zhou,Y. and Jaskoll,T.
  TITLE     Thrombospondin-2 gene expression and protein localization during
            embryonic mouse palate development
  JOURNAL   Arch Oral Biol 45 (1), 19-25 (2000)
   PUBMED   10669089
REFERENCE   10 (bases 1 to 5728)
  AUTHORS   Breton-Gorius,J., Clezardin,P., Guichard,J., Debili,N., Malaval,L.,
            Vainchenker,W., Cramer,E.M. and Delmas,P.D.
  TITLE     Localization of platelet osteonectin at the internal face of the
            alpha-granule membranes in platelets and megakaryocytes
  JOURNAL   Blood 79 (4), 936-941 (1992)
   PUBMED   1737102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 18, 2009 this sequence version replaced
            XM_001055515.1, XM_214778.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.795.1, SRR26643299.846.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               JAXUCZ010000001.1  64372790-64372918   c
            130-278             JAXUCZ010000001.1  64370111-64370259   c
            279-835             JAXUCZ010000001.1  64368473-64369029   c
            836-920             JAXUCZ010000001.1  64366366-64366450   c
            921-1117            JAXUCZ010000001.1  64364315-64364511   c
            1118-1258           JAXUCZ010000001.1  64362615-64362755   c
            1259-1355           JAXUCZ010000001.1  64361830-64361926   c
            1356-1526           JAXUCZ010000001.1  64360235-64360405   c
            1527-1703           JAXUCZ010000001.1  64359841-64360017   c
            1704-1877           JAXUCZ010000001.1  64358903-64359076   c
            1878-2005           JAXUCZ010000001.1  64358579-64358706   c
            2006-2158           JAXUCZ010000001.1  64358350-64358502   c
            2159-2377           JAXUCZ010000001.1  64357209-64357427   c
            2378-2485           JAXUCZ010000001.1  64355569-64355676   c
            2486-2645           JAXUCZ010000001.1  64354783-64354942   c
            2646-2764           JAXUCZ010000001.1  64352576-64352694   c
            2765-2999           JAXUCZ010000001.1  64351676-64351910   c
            3000-3227           JAXUCZ010000001.1  64349519-64349746   c
            3228-3499           JAXUCZ010000001.1  64348879-64349150   c
            3500-3597           JAXUCZ010000001.1  64348243-64348340   c
            3598-3737           JAXUCZ010000001.1  64346694-64346833   c
            3738-5728           JAXUCZ010000001.1  64343523-64345513   c
FEATURES             Location/Qualifiers
     source          1..5728
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..5728
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /note="thrombospondin 2"
                     /db_xref="GeneID:292406"
                     /db_xref="RGD:1310979"
     exon            1..129
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            130..278
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..3745
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /codon_start=1
                     /product="thrombospondin-2 precursor"
                     /protein_id="NP_001162609.1"
                     /db_xref="GeneID:292406"
                     /db_xref="RGD:1310979"
                     /translation="MLWALALLALGIGPRAYAGDHGEDTAFDLFSISNINRKTIGAKQ
                     FRGPDPGVPAYRFVRFDYVPPVNTDDLNRIVKLARRKEGFFLTAQLKQDRKSRGTLLV
                     LEGPGTSQRQFEIVSNGPGDTLDLNYWVEGHQHTNFLEDVGLADSQWKNVTVQVASDT
                     YSLYVGCDLIDSVTLEEPFYEQLEADKSRMYVAKGASRESHFRGLLQNVHLVFADSVE
                     DILSKKGCQHSQGAEVNTISEHTETLHLSPHITTDLVVQGVEKAQEVCTHSCEELSNM
                     MNELSGLHVMVNQLSKNLERVSSDNQFLLELIGGPLKTRNMSACVQEGRIFAENETWV
                     VDSCTTCTCKKFKTVCNQITCSPATCANPSLVEGECCPSCSHSADNDEGWSPWAEWTE
                     CSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRTCSLGKCDTRIRQNGGWSHWSPWSSCS
                     VTCGVGNVTRIRLCNSPVPQMGGKNCKGSGRETKACQRAPCPIDGRWSPWSPWSACTV
                     TCAGGIRERTRVCNSPEPQYGGKDCVGDVTEHQMCNKRSCPIDGCLSNPCFPGAKCNS
                     FPDGSWSCGSCPVGFLGNGTHCEDLDECAVVADICFSINKASRCVNTNPGFHCLPCPP
                     RYKGTQPFGIGLEDAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQT
                     GYAGDGLICGEDSDLDGWPNSNLVCATNATYHCVKDNCPKLPNSGQEDFDKDGIGDAC
                     DEDDDNDGVSDEKDNCPLLFNPRQLDYDKDEVGDRCDNCPYVHNQAQIDTDNNGEGDA
                     CSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQMDQDNDLVGD
                     QCDNNEDIDDDGHQNNQDNCPYISNSNQADHDNDGKGDACDSDDDNDGVPDDRDNCRL
                     VFNPDQEDSDGDGRGDICKDDFDNDNVPDIDDVCPENNAITETDFRNFQMVPLDPKGT
                     TQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFG
                     YQSSSRFYVVMWKQVTQTYWEDKPSRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNT
                     EGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGYMRVLVHEGKQVMADSGPIYDQTYA
                     GGRLGLFVFSQEMVYFSDLKYECRDA"
     exon            279..835
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..920
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1117
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1258
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1355
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1526
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1703
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1877
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2005
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2158
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2377
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2485
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2645
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2764
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2999
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3227
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3499
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3597
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..3737
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..5728
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcagagag agcaagtccg atgtctgcag cctccctggc caggcctctc ctctccagcg
       61 gcagctagtc cccctcagga cagactcaga gtactgacgt cggtcatcat tcatttccaa
      121 acacgccagg tcacgtgaac aaacttccca gtgacactcg ggctgtagct gtacactctt
      181 cgaccacgac attggttttc tcctaagtgt caccagtgga gacaggatgc tctgggcact
      241 ggccctgctg gctctgggca tagggccaag agcttacgct ggtgaccacg gcgaggacac
      301 agcatttgac cttttcagca tcagcaacat taaccggaag accatcggtg ccaagcagtt
      361 ccgagggccc gaccccggtg tgcccgccta ccgttttgtc cggtttgact acgtcccccc
      421 agtgaataca gacgacctca acaggatcgt taagcttgca aggagaaagg agggcttctt
      481 cctcacagcc cagctgaagc aggaccgcaa gtctcgggga acactcctgg tgttggaagg
      541 tcccggcacc tcccagaggc agtttgagat tgtgtccaat ggcccagggg ataccttgga
      601 cctcaactac tgggtagaag gccaccagca taccaacttc ctggaggatg tgggtctggc
      661 tgactcccag tggaagaatg tgactgtgca ggtggccagt gacacctata gcctgtatgt
      721 gggctgtgat cttattgaca gtgtcaccct ggaagaaccc ttctatgagc agctggaagc
      781 agacaagagc aggatgtacg tggccaaggg tgcatctcga gagagtcact tcaggggctt
      841 gctgcagaat gtccatctcg tgtttgcaga ttctgtggaa gatattctaa gcaagaaagg
      901 ctgtcaacac agccagggag ctgaagtcaa caccatcagt gaacatacag agacactcca
      961 cctgagccct cacatcacca cagatctggt ggtccagggt gtggagaagg cacaggaggt
     1021 gtgtacgcac tcctgtgaag agctgagcaa catgatgaac gagctgtccg gattgcacgt
     1081 catggtgaac cagctgagca agaacctgga gagagtgtct agcgataacc agttcctttt
     1141 ggagctcatt gggggccctc tgaagacaag aaacatgtcg gcctgtgtgc aggagggacg
     1201 gatctttgca gaaaacgaaa cctgggttgt ggatagttgt accacctgca cctgcaagaa
     1261 atttaaaaca gtctgcaatc aaatcacctg ctcacctgca acttgtgcca acccatcttt
     1321 ggtggaaggc gagtgctgtc catcctgttc ccactctgca gacaacgatg agggctggtc
     1381 tccgtgggca gagtggaccg agtgttctgt cacctgtggc tctgggaccc agcagagagg
     1441 ccggtcttgt gatgtcacca gcaacacctg cctgggcccc tccattcaga caaggacatg
     1501 cagtttgggc aaatgtgata cgagaatccg tcagaatgga ggctggagtc actggtcacc
     1561 ctggtcttcg tgctccgtga cttgtggagt tggcaatgtc acccgcatac gtctctgcaa
     1621 ctcaccagtg ccccaaatgg gtggcaagaa ctgcaagggc agtggccggg aaaccaaggc
     1681 ctgccagcgt gctccatgcc caattgatgg ccgctggagc ccctggtccc cttggtcagc
     1741 ctgcacagtt acctgtgctg gagggatccg tgagcgcaca cgtgtttgca acagccctga
     1801 gccccagtat ggagggaagg attgtgtcgg ggatgtgaca gaacaccaaa tgtgcaacaa
     1861 gaggagctgc cctattgatg gatgcctatc caacccgtgt ttccctggag ccaagtgcaa
     1921 cagcttcccc gatggctcct ggtcctgtgg ttcctgccca gtgggctttc tgggcaatgg
     1981 cacccactgt gaggacctgg atgagtgtgc tgtggtcgca gatatctgct tctcaattaa
     2041 caaagcttcc cgctgtgtca acaccaaccc tggcttccac tgcctgcctt gtccgccacg
     2101 ctacaagggg acccaaccct tcgggattgg cctggaggat gctaaaacag aaaaacaagt
     2161 atgtgagcca gagaatccgt gcaaggacaa gactcacaac tgccacaagc atgcagagtg
     2221 catctacctg ggccacttca gtgaccccat gtacaagtgc gagtgccaga ctggctatgc
     2281 aggtgatggg ctcatctgcg gggaggactc agacctggac ggttggccca acagcaacct
     2341 ggtgtgtgct accaatgcca cctaccactg cgtcaaggac aactgcccca aactgccaaa
     2401 ttctgggcag gaggattttg ataaggacgg aatcggagat gcttgcgacg aggacgatga
     2461 taacgacggc gtgagcgatg agaaggacaa ttgcccactt ctcttcaatc cccgccaatt
     2521 agactatgat aaggatgagg ttggagaccg ctgtgacaat tgcccctatg tgcacaacca
     2581 agcacagatc gacacggaca acaacggtga aggggacgcc tgctctgtgg atatcgacgg
     2641 ggatgatgtt ttcaatgagc gagacaattg cccgtatgtc tacaacactg accagagaga
     2701 cacagacggt gacggcgttg gggaccactg tgacaactgt cctctgatgc ataacccaga
     2761 tcagatggat caggacaatg atctcgttgg agaccagtgt gataacaatg aggacataga
     2821 tgatgacggc caccagaaca accaagacaa ctgcccatac atctccaact ccaaccaggc
     2881 tgaccatgac aatgacggca agggggatgc ctgtgactcc gatgatgaca acgatggtgt
     2941 tccagatgac agggacaact gcaggcttgt gttcaacccc gaccaggaag actcggatgg
     3001 cgacggccga ggtgatattt gtaaagatga ctttgacaat gataatgtcc cagatattga
     3061 tgacgtgtgc cccgagaaca atgccatcac cgagacagac ttcagaaact ttcagatggt
     3121 ccctctggat cccaagggga ccacacaaat tgatcccaac tgggtaattc gtcaccaagg
     3181 caaagagctg gtgcagacag caaactcgga ccctggcatc gccgtaggtt tcgatgagtt
     3241 tgggtctgtg gacttcagcg gcactttcta tgtcaacact gaccgggacg atgactacgc
     3301 cggcttcgtc tttggctatc agtcaagcag ccgcttctat gtggtgatgt ggaagcaggt
     3361 gacccagacc tactgggaag acaagcccag tcgggcttac ggctactctg gtgtgtcact
     3421 caaagtagta aactccacga ctggtactgg cgagcacctg aggaatgccc tgtggcacac
     3481 gggaaacacg gaaggccagg ttcgaactct atggcatgac cccaaaaaca ttggctggaa
     3541 ggactacacc gcctacaggt ggcatctgat tcacaggcct aagacaggct acatgagagt
     3601 cttagtgcat gaaggaaagc aggtcatggc tgactcagga ccaatttatg accaaactta
     3661 tgctggtgga cggctgggtc tgtttgtctt ctcccaagaa atggtctact tctcagacct
     3721 caagtatgag tgcagagatg cctagagagc agggttccag ctccagcagt gtgctgccaa
     3781 caccccttcc tggacgcatc ggtccatctt ggccctcgca gctcttctgc catgcagcat
     3841 ttcctgtttc ttggccttac ctgagtggat cttcacctcc ttcatcagca ctgaggtcca
     3901 gtgccttccg aggctaagca cctagggagc cccaagagga gcatcaagcc tgctgctggg
     3961 gaacagttgg aggagactga ggctccctgc ggagcggaca cggagctgtc gctgcattgc
     4021 cctttcttgt ttgtttaaaa agaatgacgt ttacatggaa aatgtaatta cttgcagtat
     4081 ttatgtgtat atggagttga agggaatatt gtgtataagt cattctcata aattaagcat
     4141 gaaaaataat cgctcaccta cttccagtgc ttaatgttgt caactgttct tggattcgtg
     4201 ctgttctaca ataacacaca aatcctgtga ggctgattag gaagaaagac caggtgaacc
     4261 cggctgcagt aaggaagaag ccagaaggca gtcacctgag actgtggccc cttgtccagt
     4321 gatttgaaac attaacgaat tagaacatgg aaagggattg caaagttaga agcaaagcag
     4381 ttcttctttg gccgcagtta aagatgactt gacagagaca gagaagctat gtccttgcaa
     4441 aggggaatat ttcagggttc cagccgtagg cttctcagtg ctttcagaag aaaggctcag
     4501 cagagacaat gtccctttaa actggctgcc tgggttgggc ctttccgaaa gcatactgac
     4561 tgctgggatc tctgtctggg catccttccc tgtccctact actaggaaac agactggcag
     4621 ataggttggt ggatgcactt tggtacccta ctcctactct aggctttgga atgatgcaaa
     4681 cgttgctttt gccaagtttg gtaacacgtt tcattaaggt tccaggtaca ggtttcgtta
     4741 ctatttatta aatgatttgg aatatagctc cactcaccaa taatttattt taaacatatg
     4801 aagtaacaag catgtagtat ggtttctgga actaagcgta tgacaaggat ataatgatat
     4861 aaagacatgc aaatatctgc tgtttgaaat acaaggcttt atgtcatgat aaaatggaac
     4921 cttaatatgc atacttacca acaattttaa ttcagttctt tttaatatga tcaatttgct
     4981 gtatataggt ttggtttttt ttttttttta ttttaacgct gaaggaaacg tcattttttc
     5041 cagacacatc cattaatcag tcacaccatt acaggcatag gctcgattta ttttatttta
     5101 ttttgttttt tgctttaagc tgcatgatct cccagcagga agtactatct ctctcactcc
     5161 acatgagttc agcggaagta tatcttgtcc ctctggggag cagggctcac aatccccttt
     5221 ctggtgatgg caactgaatt tctaagtcag atagaaagaa tccatgattt tgatctgagt
     5281 ttccacaatt tgtcttgctg cagttacttg tgttgaaatc actgaggggg agtttccttg
     5341 tgacttgtta tcctgcacgt tttagatttt ttgtggagct gtattcccaa ggccagcaca
     5401 gaattgggag acttctgacc atgaggatgt gaagaacatt taggtctcac ttgggcattt
     5461 ggtacaatgg tacaaggtgg tgggggcgat gtgaatacat tcaatgtacc atattatttt
     5521 tgtaaattat ttatgtagtt ttttttaaaa aaaacaaaag cttctcaata cattaatgaa
     5581 acattgtttt tgccaaagat tgtaaatatt tatttatttg ttcattgggt taaatttcac
     5641 caccaaaacc ctgcatttag ctagagcttc atttttttat accgaagatt atcaacagca
     5701 aataaattat aaaaaggttt ctataaat
//
