LOCUS       NP_001162609            1172 aa            linear   ROD 27-MAR-2024
DEFINITION  thrombospondin-2 precursor [Rattus norvegicus].
ACCESSION   NP_001162609 XP_001055515 XP_214778
VERSION     NP_001162609.1
DBSOURCE    REFSEQ: accession NM_001169138.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1172)
  AUTHORS   Niu,J., Feng,F., Zhang,S., Zhu,Y., Song,R., Li,J., Zhao,L.,
            Wang,H., Zhao,Y. and Zhang,M.
  TITLE     Thrombospondin-2 Couples Pressure-Promoted Chondrogenesis through
            NF-kappaB Signaling
  JOURNAL   Tissue Eng Regen Med 20 (5), 753-766 (2023)
   PUBMED   37219820
  REMARK    GeneRIF: Thrombospondin-2 Couples Pressure-Promoted Chondrogenesis
            through NF-kappaB Signaling.
REFERENCE   2  (residues 1 to 1172)
  AUTHORS   Wang,S., Hu,T., Wang,Z., Li,N., Zhou,L., Liao,L., Wang,M., Liao,L.,
            Wang,H., Zeng,L., Fan,C., Zhou,H., Xiong,K., Huang,J. and Chen,D.
  TITLE     Macroglia-derived thrombospondin 2 regulates alterations of
            presynaptic proteins of retinal neurons following elevated
            hydrostatic pressure
  JOURNAL   PLoS One 12 (9), e0185388 (2017)
   PUBMED   28953973
  REMARK    GeneRIF: The expression levels of glial fibrillary acidic protein
            (the marker of activated macroglia cells), thrombospondin 2,
            alpha2delta-1 and presynaptic proteins were increased following
            elevated hydrostatic pressure in mixed cultures, but the expression
            levels of postsynaptic proteins were not changed.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1172)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (residues 1 to 1172)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (residues 1 to 1172)
  AUTHORS   Huang,J., Zhou,L., Wang,H., Luo,J., Zeng,L., Xiong,K. and Chen,D.
  TITLE     Distribution of thrombospondins and their neuronal receptor
            alpha2delta1 in the rat retina
  JOURNAL   Exp Eye Res 111, 36-49 (2013)
   PUBMED   23541831
  REMARK    GeneRIF: In the adult rat retina, TSP2, but not TSP1, secreted by
            glial cells may be involved in the synaptic plastic process after
            retinal injury through binding to its neuronal receptor
            alpha2delta1.
REFERENCE   6  (residues 1 to 1172)
  AUTHORS   Lin,T.N., Kim,G.M., Chen,J.J., Cheung,W.M., He,Y.Y. and Hsu,C.Y.
  TITLE     Differential regulation of thrombospondin-1 and thrombospondin-2
            after focal cerebral ischemia/reperfusion
  JOURNAL   Stroke 34 (1), 177-186 (2003)
   PUBMED   12511771
  REMARK    GeneRIF: Robust expression of TSP-1 and TSP-2, two major
            angiostatic factors, was noted in the ischemic brain with different
            temporal expression profiles from different cellular origins.
REFERENCE   7  (residues 1 to 1172)
  AUTHORS   Boekholdt,S.M., Trip,M.D., Peters,R.J., Engelen,M., Boer,J.M.,
            Feskens,E.J., Zwinderman,A.H., Kastelein,J.J. and Reitsma,P.H.
  TITLE     Thrombospondin-2 polymorphism is associated with a reduced risk of
            premature myocardial infarction
  JOURNAL   Arterioscler Thromb Vasc Biol 22 (12), e24-e27 (2002)
   PUBMED   12482844
REFERENCE   8  (residues 1 to 1172)
  AUTHORS   Sanders,J.E., Baker,A.B. and Golledge,S.L.
  TITLE     Control of in vivo microvessel ingrowth by modulation of
            biomaterial local architecture and chemistry
  JOURNAL   J Biomed Mater Res 60 (1), 36-43 (2002)
   PUBMED   11835157
REFERENCE   9  (residues 1 to 1172)
  AUTHORS   Melnick,M., Chen,H., Zhou,Y. and Jaskoll,T.
  TITLE     Thrombospondin-2 gene expression and protein localization during
            embryonic mouse palate development
  JOURNAL   Arch Oral Biol 45 (1), 19-25 (2000)
   PUBMED   10669089
REFERENCE   10 (residues 1 to 1172)
  AUTHORS   Breton-Gorius,J., Clezardin,P., Guichard,J., Debili,N., Malaval,L.,
            Vainchenker,W., Cramer,E.M. and Delmas,P.D.
  TITLE     Localization of platelet osteonectin at the internal face of the
            alpha-granule membranes in platelets and megakaryocytes
  JOURNAL   Blood 79 (4), 936-941 (1992)
   PUBMED   1737102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 18, 2009 this sequence version replaced
            XP_001055515.1, XP_214778.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.795.1, SRR26643299.846.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1172
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     Protein         1..1172
                     /product="thrombospondin-2 precursor"
                     /calculated_mol_wt=127846
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1900
     Region          22..213
                     /region_name="TSPN"
                     /note="Thrombospondin N-terminal -like domains;
                     smart00210"
                     /db_xref="CDD:214560"
     Region          320..374
                     /region_name="VWC"
                     /note="von Willebrand factor type C domain; pfam00093"
                     /db_xref="CDD:278520"
     Region          385..430
                     /region_name="TSP_1"
                     /note="Thrombospondin type 1 domain; pfam00090"
                     /db_xref="CDD:459668"
     Region          440..492
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          497..549
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          652..691
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          693..728
                     /region_name="TSP3 repeat_1C"
                     /note="TSP3 repeat_1C [structural motif]"
                     /db_xref="CDD:275367"
     Region          729..764
                     /region_name="TSP3 repeat_long"
                     /note="TSP3 repeat_long [structural motif]"
                     /db_xref="CDD:275366"
     Region          765..787
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275365"
     Region          789..823
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          789..823
                     /region_name="TSP3 repeat_long"
                     /note="TSP3 repeat_long [structural motif]"
                     /db_xref="CDD:275366"
     Region          824..846
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275366"
     Region          847..884
                     /region_name="TSP3 repeat_long"
                     /note="TSP3 repeat_long [structural motif]"
                     /db_xref="CDD:275365"
     Region          848..884
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          885..920
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275366"
     Region          921..951
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          974..1171
                     /region_name="TSP_C"
                     /note="Thrombospondin C-terminal region; pfam05735"
                     /db_xref="CDD:461725"
     CDS             1..1172
                     /gene="Thbs2"
                     /gene_synonym="TSP-2"
                     /coded_by="NM_001169138.1:227..3745"
                     /db_xref="GeneID:292406"
                     /db_xref="RGD:1310979"
ORIGIN      
        1 mlwalallal gigprayagd hgedtafdlf sisninrkti gakqfrgpdp gvpayrfvrf
       61 dyvppvntdd lnrivklarr kegffltaql kqdrksrgtl lvlegpgtsq rqfeivsngp
      121 gdtldlnywv eghqhtnfle dvgladsqwk nvtvqvasdt yslyvgcdli dsvtleepfy
      181 eqleadksrm yvakgasres hfrgllqnvh lvfadsvedi lskkgcqhsq gaevntiseh
      241 tetlhlsphi ttdlvvqgve kaqevcthsc eelsnmmnel sglhvmvnql sknlervssd
      301 nqflleligg plktrnmsac vqegrifaen etwvvdsctt ctckkfktvc nqitcspatc
      361 anpslvegec cpscshsadn degwspwaew tecsvtcgsg tqqrgrscdv tsntclgpsi
      421 qtrtcslgkc dtrirqnggw shwspwsscs vtcgvgnvtr irlcnspvpq mggknckgsg
      481 retkacqrap cpidgrwspw spwsactvtc aggirertrv cnspepqygg kdcvgdvteh
      541 qmcnkrscpi dgclsnpcfp gakcnsfpdg swscgscpvg flgngthced ldecavvadi
      601 cfsinkasrc vntnpgfhcl pcpprykgtq pfgigledak tekqvcepen pckdkthnch
      661 khaeciylgh fsdpmykcec qtgyagdgli cgedsdldgw pnsnlvcatn atyhcvkdnc
      721 pklpnsgqed fdkdgigdac dedddndgvs dekdncpllf nprqldydkd evgdrcdncp
      781 yvhnqaqidt dnngegdacs vdidgddvfn erdncpyvyn tdqrdtdgdg vgdhcdncpl
      841 mhnpdqmdqd ndlvgdqcdn nedidddghq nnqdncpyis nsnqadhdnd gkgdacdsdd
      901 dndgvpddrd ncrlvfnpdq edsdgdgrgd ickddfdndn vpdiddvcpe nnaitetdfr
      961 nfqmvpldpk gttqidpnwv irhqgkelvq tansdpgiav gfdefgsvdf sgtfyvntdr
     1021 dddyagfvfg yqsssrfyvv mwkqvtqtyw edkpsraygy sgvslkvvns ttgtgehlrn
     1081 alwhtgnteg qvrtlwhdpk nigwkdytay rwhlihrpkt gymrvlvheg kqvmadsgpi
     1141 ydqtyaggrl glfvfsqemv yfsdlkyecr da
//
