LOCUS       NM_001398940            5702 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus thrombospondin 1 (Thbs1), transcript variant 2,
            mRNA.
ACCESSION   NM_001398940 XM_039105644
VERSION     NM_001398940.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5702)
  AUTHORS   Hassan,H.M., Liang,X., Xin,J., Lu,Y., Cai,Q., Shi,D., Ren,K.,
            Li,J., Chen,Q., Li,J., Li,P., Guo,B., Yang,H., Luo,J., Yao,H.,
            Zhou,X., Hu,W., Jiang,J. and Li,J.
  TITLE     Thrombospondin 1 enhances systemic inflammation and disease
            severity in acute-on-chronic liver failure
  JOURNAL   BMC Med 22 (1), 95 (2024)
   PUBMED   38439091
  REMARK    GeneRIF: Thrombospondin 1 enhances systemic inflammation and
            disease severity in acute-on-chronic liver failure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5702)
  AUTHORS   Zhang,L., Wang,Y., Tian,L., Li,L., Chen,Z., Ding,C., Tian,J.,
            Song,D., Yao,S. and Ren,W.
  TITLE     Thrombospondin-1-mediated crosstalk between autophagy and oxidative
            stress orchestrates repair of blast lung injury
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167026 (2024)
   PUBMED   38237742
  REMARK    GeneRIF: Thrombospondin-1-mediated crosstalk between autophagy and
            oxidative stress orchestrates repair of blast lung injury.
REFERENCE   3  (bases 1 to 5702)
  AUTHORS   Long,J., Yang,Y., Yang,J., Chen,L., Wang,S., Zhou,X., Su,Y. and
            Liu,C.
  TITLE     Targeting Thbs1 reduces bladder remodeling caused by partial
            bladder outlet obstruction via the FGFR3/p-FGFR3 pathway
  JOURNAL   Neurourol Urodyn 43 (2), 516-526 (2024)
   PUBMED   38108523
  REMARK    GeneRIF: Targeting Thbs1 reduces bladder remodeling caused by
            partial bladder outlet obstruction via the FGFR3/p-FGFR3 pathway.
REFERENCE   4  (bases 1 to 5702)
  AUTHORS   Song,A., Zhang,S., Zhao,X., Wu,S., Qi,X., Gao,S., Qi,J., Li,P. and
            Tan,J.
  TITLE     Exosomes derived from menstrual blood stromal cells ameliorated
            premature ovarian insufficiency and granulosa cell apoptosis by
            regulating SMAD3/AKT/MDM2/P53 pathway via delivery of
            thrombospondin-1
  JOURNAL   Biomed Pharmacother 166, 115319 (2023)
   PUBMED   37573658
  REMARK    GeneRIF: Exosomes derived from menstrual blood stromal cells
            ameliorated premature ovarian insufficiency and granulosa cell
            apoptosis by regulating SMAD3/AKT/MDM2/P53 pathway via delivery of
            thrombospondin-1.
REFERENCE   5  (bases 1 to 5702)
  AUTHORS   Lei,Y., Jin,X., Sun,M. and Ji,Z.
  TITLE     RNF7 Induces Skeletal Muscle Cell Apoptosis and Arrests Cell
            Autophagy via Upregulation of THBS1 and Inactivation of the
            PI3K/Akt Signaling Pathway in a Rat Sepsis Model
  JOURNAL   Infect Immun 91 (4), e0053522 (2023)
   PUBMED   36920202
  REMARK    GeneRIF: RNF7 Induces Skeletal Muscle Cell Apoptosis and Arrests
            Cell Autophagy via Upregulation of THBS1 and Inactivation of the
            PI3K/Akt Signaling Pathway in a Rat Sepsis Model.
REFERENCE   6  (bases 1 to 5702)
  AUTHORS   Asch,A.S., Barnwell,J., Silverstein,R.L. and Nachman,R.L.
  TITLE     Isolation of the thrombospondin membrane receptor
  JOURNAL   J Clin Invest 79 (4), 1054-1061 (1987)
   PUBMED   2435757
REFERENCE   7  (bases 1 to 5702)
  AUTHORS   Wolff,R., Plow,E.F. and Ginsberg,M.H.
  TITLE     Interaction of thrombospondin with resting and stimulated human
            platelets
  JOURNAL   J Biol Chem 261 (15), 6840-6846 (1986)
   PUBMED   3084490
REFERENCE   8  (bases 1 to 5702)
  AUTHORS   Bale,M.D., Westrick,L.G. and Mosher,D.F.
  TITLE     Incorporation of thrombospondin into fibrin clots
  JOURNAL   J Biol Chem 260 (12), 7502-7508 (1985)
   PUBMED   3997886
REFERENCE   9  (bases 1 to 5702)
  AUTHORS   Jaffe,E.A., Ruggiero,J.T., Leung,L.K., Doyle,M.J.,
            McKeown-Longo,P.J. and Mosher,D.F.
  TITLE     Cultured human fibroblasts synthesize and secrete thrombospondin
            and incorporate it into extracellular matrix
  JOURNAL   Proc Natl Acad Sci U S A 80 (4), 998-1002 (1983)
   PUBMED   6341993
REFERENCE   10 (bases 1 to 5702)
  AUTHORS   Lawler,J.W., Slayter,H.S. and Coligan,J.E.
  TITLE     Isolation and characterization of a high molecular weight
            glycoprotein from human blood platelets
  JOURNAL   J Biol Chem 253 (23), 8609-8616 (1978)
   PUBMED   101549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 28, 2021 this sequence version replaced XM_039105644.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.12704.1,
                                           SRR26643298.17621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000003.1  125510250-125510432
            184-278             JAXUCZ010000003.1  125510970-125511064
            279-838             JAXUCZ010000003.1  125511315-125511874
            839-914             JAXUCZ010000003.1  125512669-125512744
            915-1117            JAXUCZ010000003.1  125512976-125513178
            1118-1240           JAXUCZ010000003.1  125513270-125513392
            1241-1334           JAXUCZ010000003.1  125514116-125514209
            1335-1508           JAXUCZ010000003.1  125516039-125516212
            1509-1685           JAXUCZ010000003.1  125516732-125516908
            1686-1859           JAXUCZ010000003.1  125517221-125517394
            1860-1987           JAXUCZ010000003.1  125517644-125517771
            1988-2140           JAXUCZ010000003.1  125517887-125518039
            2141-2359           JAXUCZ010000003.1  125518377-125518595
            2360-2467           JAXUCZ010000003.1  125519004-125519111
            2468-2627           JAXUCZ010000003.1  125519627-125519786
            2628-2746           JAXUCZ010000003.1  125519908-125520026
            2747-2981           JAXUCZ010000003.1  125521215-125521449
            2982-3209           JAXUCZ010000003.1  125521634-125521861
            3210-3481           JAXUCZ010000003.1  125522025-125522296
            3482-3579           JAXUCZ010000003.1  125522664-125522761
            3580-3719           JAXUCZ010000003.1  125522876-125523015
            3720-5702           JAXUCZ010000003.1  125523420-125525402
FEATURES             Location/Qualifiers
     source          1..5702
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..5702
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /note="thrombospondin 1"
                     /db_xref="GeneID:445442"
                     /db_xref="RGD:1588455"
     exon            1..183
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..278
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..3727
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="thrombospondin-1 isoform 2 precursor"
                     /protein_id="NP_001385869.1"
                     /db_xref="GeneID:445442"
                     /db_xref="RGD:1588455"
                     /translation="MELLRGLGVLFLLHVCGSNRIPESGGDNGVFDIFELIGGARKVP
                     GRRLVKGQDLSSPAFRIENANLIPPVPDDKFQDLLDAVWADKGFIFLASLRQMKKTRG
                     TLLAVERKDNSGQIFSVVSNGKAGTLDLSLSLPGKQQVVSVEEALLATGQWKSITLFV
                     QEDRAQLYIDCDKMESAELDVPIQSIFTRDLANVARLRVAKGDVNDNFQGVLQNVRFV
                     FGTTPEDILRNKGCSSSATNVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGLSCD
                     ELSSMVLELRGLRTIVTTLQDSIRKVTEENRELASELRRPPLCFHNGVQYRNNEEWTV
                     DSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSC
                     SATCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSV
                     TCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWSPWSLWDICSVT
                     CGGGVQRRSRLCNNPTPQFGGKDCVGDVTENQVCNKQDCPIDGCLSNPCFAGAKCTSY
                     PDGSWKCGACPPGYSGNGIQCKDVDECKEVPDACFNHNGEHRCKNTDPGYNCLPCPPR
                     FTGSQPFGRGVEHAMANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPG
                     YAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACD
                     DDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDAC
                     AVDIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDT
                     CDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDRDNCRLV
                     PNPDQKDSDGDGRGDACKDDFDHDNVPDIDDICPENVDISETDFRRFQMIPLDPKGTS
                     QNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGY
                     QSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTP
                     GQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAG
                     GRLGLFVFSQEMVFFSDMKYECRDS"
     exon            279..838
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..914
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1117
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1240
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1334
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1508
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1685
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1859
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1987
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2140
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2359
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2467
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2627
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2746
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2981
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3209
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3481
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..3579
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3580..3719
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3720..5702
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccactgcc tggagtcagc cagcctcatc ggacttctgc aggcactcgc gacgcaacta
       61 cccagtcctg ccacggtcta tccggccgca ccagcaatct cagcgtcttt accggactcg
      121 aagtccttgt ccttcacttc gccttctcca ccactccggg ctgctgagct ccggtgcaca
      181 caggctccgc gttgggcaca aaggctccac catggagctc ctcaggggac taggcgtcct
      241 gttcctgttg catgtgtgtg gaagcaaccg cattccagag tctgggggag acaatggtgt
      301 gttcgacatt tttgaactca ttggaggtgc ccgcaaggtt ccgggtcgcc gactggtgaa
      361 gggccaagat ctatccagcc ccgccttccg gatcgagaat gccaacctga tcccccctgt
      421 gccagatgac aagttccaag acctactgga cgctgtgtgg gccgacaaag gcttcatctt
      481 cctggcttcc ttgaggcaga tgaagaagac tcggggcaca ctcctggccg tggaacggaa
      541 agacaattct ggccagatct tcagtgtggt ctccaatggc aaagccggca ccctcgatct
      601 gagtctgagc ctgcccggga agcagcaagt ggtgtcagtg gaggaagctc tcctggccac
      661 tggccagtgg aagagcatca cgctgtttgt ccaagaagac agggcccagc tctacattga
      721 ctgtgacaag atggagagcg cagagctgga tgttcccatc cagagcatct tcaccaggga
      781 tttggccaat gtcgccaggc tccgagtcgc aaagggagat gtcaatgaca attttcaggg
      841 ggtgctgcag aatgtgaggt ttgtctttgg aaccacccca gaagacattc tcaggaacaa
      901 aggctgctcc agttcagcta ccaacgtcct tctcaccctt gacaacaacg tggtgaacgg
      961 ttccagccct gccatccgca ccaactacat cggccacaaa acaaaggacc tccaagccat
     1021 ctgtggcctc tcctgtgacg aactatccag catggtcctg gaactgaggg gcctgcgtac
     1081 catcgtgacc acgctacagg acagcattcg aaaagtgacg gaagagaaca gagagctggc
     1141 tagcgagctg aggcggcctc ccctctgctt ccacaatgga gtccaataca ggaacaacga
     1201 ggagtggact gtagatagtt gcacagagtg tcactgccag aactcagtta ccatctgcaa
     1261 aaaggtgtcc tgtcccatca tgccctgctc caatgccaca gttcctgatg gtgaatgctg
     1321 cccacggtgc tggcccagtg actctgctga cgatggctgg tctccctggt ctgagtggac
     1381 ctcttgctct gccacctgtg gcaatgggat tcagcaacgt ggtcgctcct gtgacagcct
     1441 caacaacaga tgtgagggct cttcagtaca gacgaggacc tgccacattc aggagtgcga
     1501 caaaagattt aaacaggatg gtggttggag tcactggtcc ccgtggtcgt cctgttctgt
     1561 gacctgtggt gacggtgtga tcacgaggat ccgactctgc aactccccca gcccccagat
     1621 gaacgggaag ccctgtgaag gtgaagctcg ggagaccaaa gcctgcaaga aggacgcctg
     1681 cccaatcaat ggaggctgga gtccctggtc actatgggac atctgctctg tcacctgtgg
     1741 aggaggagta cagagacgta gccgactctg caacaacccc acaccccagt ttggaggcaa
     1801 agactgtgtt ggtgatgtga cggaaaatca agtttgcaac aagcaggact gtccgattga
     1861 tggatgcctg tccaatccct gctttgctgg tgccaagtgt acgagctatc ctgatggtag
     1921 ctggaaatgt ggtgcgtgtc ctcctggcta cagtggaaat ggtatccagt gcaaagacgt
     1981 cgacgagtgc aaagaagtgc ctgatgcttg cttcaatcac aacggagaac atcggtgcaa
     2041 gaacacagat cctggctaca actgcctgcc ctgcccacca cgattcaccg gctcacagcc
     2101 cttcggcaga ggtgtcgaac acgctatggc caacaaacag gtgtgcaaac cccgaaaccc
     2161 ctgcaccgac gggacacacg actgcaacaa gaacgccaag tgcaactacc tgggtcacta
     2221 cagcgacccc atgtaccgct gtgagtgcaa gcctggctac gcaggcaatg gcatcatttg
     2281 cggagaggac acagaccttg acggctggcc taatgaaaac ctggtgtgtg tggccaacgc
     2341 aacttaccac tgcaaaaagg acaactgccc caatcttccc aattcggggc aggaagacta
     2401 tgacaaggat gggattggcg atgcctgtga tgacgatgat gacaacgaca agattcctga
     2461 tgacagggac aactgtccat tccattacaa cccagcccag tatgactatg acagagatga
     2521 tgtgggagac cgctgtgaca attgccccta caaccacaac cctgaccagg cagacacaga
     2581 caacaatggg gagggagatg cctgcgctgt ggacatcgat ggggatggaa tcctcaatga
     2641 acgagacaac tgccagtatg tttacaacgt ggatcagagg gacacggaca tggatggggt
     2701 tggagaccag tgtgacaact gccccctgga acacaatcca gaccagctgg actctgactc
     2761 ggaccgcata ggggacacct gtgacaacaa tcaggacatc gatgaggatg gccatcagaa
     2821 caacctggac aactgtccct atgtgcccaa tgccaaccag gccgaccacg ataaagatgg
     2881 taaaggagac gcctgtgacc atgacgatga caacgacggc atccctgatg acagagacaa
     2941 ctgcaggctg gtgcccaatc ctgaccagaa ggactctgat ggtgatggcc gaggcgatgc
     3001 ctgcaaagac gactttgacc atgacaatgt gccagacatt gatgacatct gtcctgagaa
     3061 tgttgacatc agtgaaaccg atttccgccg attccagatg attcctctag atcccaaagg
     3121 aacctcccaa aatgacccta actgggttgt ccgccatcag ggcaaagaac ttgtccagac
     3181 tgtaaactgt gaccctggac ttgctgtagg ttatgatgag tttaatgccg tggacttcag
     3241 tggtaccttc ttcatcaaca ctgagaggga tgacgactat gctggctttg ttttcggcta
     3301 ccagtccagc agccgcttct acgttgtgat gtggaaacaa gtcacccagt cctactggga
     3361 caccaacccc acaagggctc agggatactc aggcctgtct gtaaaggttg taaactccac
     3421 cactggcccc ggcgagcacc tgcggaatgc actgtggcac acaggaaaca cccctggcca
     3481 ggtgcgcacc ctgtggcatg accctcgtca cattggctgg aaagatttca ctgcatacag
     3541 atggcgtctc agccacaggc caaagaccgg ttttatcaga gtggtgatgt atgaaggaaa
     3601 gaaaatcatg gctgactcag gacccatcta tgacaaaacc tacgctggcg gtagactagg
     3661 cctgttcgtc ttctctcaag aaatggtgtt cttctcggac atgaaatacg agtgccgaga
     3721 ctcctaatca ccaccccgat cataaccagc ctggcattgc accttccgaa accaagggct
     3781 agagaaaaac ccctccagga tcgcttctcc tcgccttccc tgcctctctt cttgcatagt
     3841 gtgggcttct agagtctgtg acctgcctca agaaaatgca gttttcaaac ctagccagac
     3901 tcagaacttg gcctgtaagg agtgagaatg catcttctaa gaacatgaag aattactttg
     3961 gtttgctttt gagaaagcaa aagcgactat ttacttccca ctgggaaggt gcccactcca
     4021 ctctgcctta ctcacagagc cagagcttct gcgaggccat ctccgagctg cacactcaga
     4081 agcattttcg ggcctgtcaa agaaaaaaca acatggctca ctagaactca ctgccaaacc
     4141 acctctgaca taagtcctca gcaggggaga ggcaggagcc aaagcactag gagccatgaa
     4201 cccaagagat gattgtgcaa agaaaagatg gaggagctgt tacttggtcg gtactaatca
     4261 ttttcagggg acagagaagg cttgctgctt tcctcatgct gcccctgaga gctgactacc
     4321 cagtcttcca caggcacctg agtgagcagg ggagggaggg aaatcctggc tcctggactt
     4381 cctccacact gaaactgtgg gcgtcttctg catgtataac atgcgtgtct aaggacagca
     4441 agagagccct gccgtctcgg tgagctctag ctgcctccgc aggaggggca gtgcgccttc
     4501 attttatggt tagaaaggca caaaattttt atcaacctga aacattcctt tttctttttg
     4561 cctcaattat catggagttt tccaattctc ttctggtttt tgtttaacaa acgctttaac
     4621 aatgtaatat atttattttt ccccctattc tggaggattc gtctgaagga ttgttattga
     4681 aacaggatgc gtgggactct ctgaatcatc ttcatagtga gtctttatga ctgtaagatt
     4741 gtaaatacag attatttatt aaccctgttc tacctggaat taaactgcat agagcaaatg
     4801 tttgcaagca ggtagctgag gctgtcagca aatctctcca aaactagtgt ggaagtcagc
     4861 aggagctgct ggctttcatt tgggggctta gagcgaatga tttggactcc tttggctttt
     4921 ccccttggtt ttctctgtct tttcaagtgg gaatgggtgg ctgcccattt gcatttgcct
     4981 ctcctgcaaa ggaagcctga gccctccaag gctcacccac cccacccctt ctgcctattt
     5041 ccagggagaa gaaaacacaa tcaacttttt atttcatttt cccaaaagag acaaaggtgg
     5101 aacttatata caaatattac ctcatttgtt gtgtgactga gtaaagaatt ttggatcaag
     5161 aagaaagagt ttaagtgtca ataaacttaa aactactgtc gtgtctaaaa agtcagtgtt
     5221 gtacatagca taaaaatcct ttgcagagaa tgatcccaat acagaaatag ctttgaaatg
     5281 ttaaatacaa ctcctcaaag ttctggtttt gttctatcat cttgtacacc attgctttta
     5341 tttttataaa ttattttctc attgccattg gaatagagat ctcagactat gtagatatgc
     5401 tatttaaata atttatcagg aaatactgcc tgtagagtta gtatttctgt tttttatatg
     5461 ttgcacactg aattgaagaa atgttggttt ttcttgtttt gttttagttt gtttctttgg
     5521 ttttgttttt ggttttgctt tttacttccc aggtttgact atttgccaat gccctgtgtt
     5581 ctaggaacgt gcttttttgt acacatttta tccattttac attctaaagc agtgtaactt
     5641 gtatattact gtttcttgtg tacaaggaac aacaataaat catatggaag tttatattta
     5701 ta
//
