LOCUS       NP_001385869            1171 aa            linear   ROD 30-MAR-2024
DEFINITION  thrombospondin-1 isoform 2 precursor [Rattus norvegicus].
ACCESSION   NP_001385869 XP_038961572
VERSION     NP_001385869.1
DBSOURCE    REFSEQ: accession NM_001398940.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1171)
  AUTHORS   Hassan,H.M., Liang,X., Xin,J., Lu,Y., Cai,Q., Shi,D., Ren,K.,
            Li,J., Chen,Q., Li,J., Li,P., Guo,B., Yang,H., Luo,J., Yao,H.,
            Zhou,X., Hu,W., Jiang,J. and Li,J.
  TITLE     Thrombospondin 1 enhances systemic inflammation and disease
            severity in acute-on-chronic liver failure
  JOURNAL   BMC Med 22 (1), 95 (2024)
   PUBMED   38439091
  REMARK    GeneRIF: Thrombospondin 1 enhances systemic inflammation and
            disease severity in acute-on-chronic liver failure.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1171)
  AUTHORS   Zhang,L., Wang,Y., Tian,L., Li,L., Chen,Z., Ding,C., Tian,J.,
            Song,D., Yao,S. and Ren,W.
  TITLE     Thrombospondin-1-mediated crosstalk between autophagy and oxidative
            stress orchestrates repair of blast lung injury
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167026 (2024)
   PUBMED   38237742
  REMARK    GeneRIF: Thrombospondin-1-mediated crosstalk between autophagy and
            oxidative stress orchestrates repair of blast lung injury.
REFERENCE   3  (residues 1 to 1171)
  AUTHORS   Long,J., Yang,Y., Yang,J., Chen,L., Wang,S., Zhou,X., Su,Y. and
            Liu,C.
  TITLE     Targeting Thbs1 reduces bladder remodeling caused by partial
            bladder outlet obstruction via the FGFR3/p-FGFR3 pathway
  JOURNAL   Neurourol Urodyn 43 (2), 516-526 (2024)
   PUBMED   38108523
  REMARK    GeneRIF: Targeting Thbs1 reduces bladder remodeling caused by
            partial bladder outlet obstruction via the FGFR3/p-FGFR3 pathway.
REFERENCE   4  (residues 1 to 1171)
  AUTHORS   Song,A., Zhang,S., Zhao,X., Wu,S., Qi,X., Gao,S., Qi,J., Li,P. and
            Tan,J.
  TITLE     Exosomes derived from menstrual blood stromal cells ameliorated
            premature ovarian insufficiency and granulosa cell apoptosis by
            regulating SMAD3/AKT/MDM2/P53 pathway via delivery of
            thrombospondin-1
  JOURNAL   Biomed Pharmacother 166, 115319 (2023)
   PUBMED   37573658
  REMARK    GeneRIF: Exosomes derived from menstrual blood stromal cells
            ameliorated premature ovarian insufficiency and granulosa cell
            apoptosis by regulating SMAD3/AKT/MDM2/P53 pathway via delivery of
            thrombospondin-1.
REFERENCE   5  (residues 1 to 1171)
  AUTHORS   Lei,Y., Jin,X., Sun,M. and Ji,Z.
  TITLE     RNF7 Induces Skeletal Muscle Cell Apoptosis and Arrests Cell
            Autophagy via Upregulation of THBS1 and Inactivation of the
            PI3K/Akt Signaling Pathway in a Rat Sepsis Model
  JOURNAL   Infect Immun 91 (4), e0053522 (2023)
   PUBMED   36920202
  REMARK    GeneRIF: RNF7 Induces Skeletal Muscle Cell Apoptosis and Arrests
            Cell Autophagy via Upregulation of THBS1 and Inactivation of the
            PI3K/Akt Signaling Pathway in a Rat Sepsis Model.
REFERENCE   6  (residues 1 to 1171)
  AUTHORS   Asch,A.S., Barnwell,J., Silverstein,R.L. and Nachman,R.L.
  TITLE     Isolation of the thrombospondin membrane receptor
  JOURNAL   J Clin Invest 79 (4), 1054-1061 (1987)
   PUBMED   2435757
REFERENCE   7  (residues 1 to 1171)
  AUTHORS   Wolff,R., Plow,E.F. and Ginsberg,M.H.
  TITLE     Interaction of thrombospondin with resting and stimulated human
            platelets
  JOURNAL   J Biol Chem 261 (15), 6840-6846 (1986)
   PUBMED   3084490
REFERENCE   8  (residues 1 to 1171)
  AUTHORS   Bale,M.D., Westrick,L.G. and Mosher,D.F.
  TITLE     Incorporation of thrombospondin into fibrin clots
  JOURNAL   J Biol Chem 260 (12), 7502-7508 (1985)
   PUBMED   3997886
REFERENCE   9  (residues 1 to 1171)
  AUTHORS   Jaffe,E.A., Ruggiero,J.T., Leung,L.K., Doyle,M.J.,
            McKeown-Longo,P.J. and Mosher,D.F.
  TITLE     Cultured human fibroblasts synthesize and secrete thrombospondin
            and incorporate it into extracellular matrix
  JOURNAL   Proc Natl Acad Sci U S A 80 (4), 998-1002 (1983)
   PUBMED   6341993
REFERENCE   10 (residues 1 to 1171)
  AUTHORS   Lawler,J.W., Slayter,H.S. and Coligan,J.E.
  TITLE     Isolation and characterization of a high molecular weight
            glycoprotein from human blood platelets
  JOURNAL   J Biol Chem 253 (23), 8609-8616 (1978)
   PUBMED   101549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 28, 2021 this sequence version replaced XP_038961572.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.12704.1,
                                           SRR26643298.17621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1171
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     Protein         1..1171
                     /product="thrombospondin-1 isoform 2 precursor"
                     /calculated_mol_wt=127868
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1957
     Region          26..221
                     /region_name="TSPN"
                     /note="Thrombospondin N-terminal -like domains;
                     smart00210"
                     /db_xref="CDD:214560"
     Region          319..373
                     /region_name="VWC"
                     /note="von Willebrand factor type C domain; pfam00093"
                     /db_xref="CDD:278520"
     Region          384..429
                     /region_name="TSP_1"
                     /note="Thrombospondin type 1 domain; pfam00090"
                     /db_xref="CDD:459668"
     Region          439..491
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          496..548
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          651..690
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          692..727
                     /region_name="TSP3 repeat_1C"
                     /note="TSP3 repeat_1C [structural motif]"
                     /db_xref="CDD:275367"
     Region          764..786
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275365"
     Region          787..822
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          788..822
                     /region_name="TSP3 repeat_long"
                     /note="TSP3 repeat_long [structural motif]"
                     /db_xref="CDD:275366"
     Region          823..845
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275366"
     Region          846..883
                     /region_name="TSP3 repeat_long"
                     /note="TSP3 repeat_long [structural motif]"
                     /db_xref="CDD:275365"
     Region          847..883
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          884..919
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275366"
     Region          920..953
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          973..1170
                     /region_name="TSP_C"
                     /note="Thrombospondin C-terminal region; pfam05735"
                     /db_xref="CDD:461725"
     CDS             1..1171
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /coded_by="NM_001398940.1:212..3727"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="GeneID:445442"
                     /db_xref="RGD:1588455"
ORIGIN      
        1 mellrglgvl fllhvcgsnr ipesggdngv fdifeligga rkvpgrrlvk gqdlsspafr
       61 ienanlippv pddkfqdlld avwadkgfif laslrqmkkt rgtllaverk dnsgqifsvv
      121 sngkagtldl slslpgkqqv vsveeallat gqwksitlfv qedraqlyid cdkmesaeld
      181 vpiqsiftrd lanvarlrva kgdvndnfqg vlqnvrfvfg ttpedilrnk gcsssatnvl
      241 ltldnnvvng sspairtnyi ghktkdlqai cglscdelss mvlelrglrt ivttlqdsir
      301 kvteenrela selrrpplcf hngvqyrnne ewtvdsctec hcqnsvtick kvscpimpcs
      361 natvpdgecc prcwpsdsad dgwspwsewt scsatcgngi qqrgrscdsl nnrcegssvq
      421 trtchiqecd krfkqdggws hwspwsscsv tcgdgvitri rlcnspspqm ngkpcegear
      481 etkackkdac pinggwspws lwdicsvtcg ggvqrrsrlc nnptpqfggk dcvgdvtenq
      541 vcnkqdcpid gclsnpcfag akctsypdgs wkcgacppgy sgngiqckdv deckevpdac
      601 fnhngehrck ntdpgynclp cpprftgsqp fgrgvehama nkqvckprnp ctdgthdcnk
      661 nakcnylghy sdpmyrceck pgyagngiic gedtdldgwp nenlvcvana tyhckkdncp
      721 nlpnsgqedy dkdgigdacd ddddndkipd drdncpfhyn paqydydrdd vgdrcdncpy
      781 nhnpdqadtd nngegdacav didgdgilne rdncqyvynv dqrdtdmdgv gdqcdncple
      841 hnpdqldsds drigdtcdnn qdidedghqn nldncpyvpn anqadhdkdg kgdacdhddd
      901 ndgipddrdn crlvpnpdqk dsdgdgrgda ckddfdhdnv pdiddicpen vdisetdfrr
      961 fqmipldpkg tsqndpnwvv rhqgkelvqt vncdpglavg ydefnavdfs gtffinterd
     1021 ddyagfvfgy qsssrfyvvm wkqvtqsywd tnptraqgys glsvkvvnst tgpgehlrna
     1081 lwhtgntpgq vrtlwhdprh igwkdftayr wrlshrpktg firvvmyegk kimadsgpiy
     1141 dktyaggrlg lfvfsqemvf fsdmkyecrd s
//
