LOCUS       NM_001013062            5699 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus thrombospondin 1 (Thbs1), transcript variant 1,
            mRNA.
ACCESSION   NM_001013062 XM_039105645
VERSION     NM_001013062.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5699)
  AUTHORS   Hassan,H.M., Liang,X., Xin,J., Lu,Y., Cai,Q., Shi,D., Ren,K.,
            Li,J., Chen,Q., Li,J., Li,P., Guo,B., Yang,H., Luo,J., Yao,H.,
            Zhou,X., Hu,W., Jiang,J. and Li,J.
  TITLE     Thrombospondin 1 enhances systemic inflammation and disease
            severity in acute-on-chronic liver failure
  JOURNAL   BMC Med 22 (1), 95 (2024)
   PUBMED   38439091
  REMARK    GeneRIF: Thrombospondin 1 enhances systemic inflammation and
            disease severity in acute-on-chronic liver failure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5699)
  AUTHORS   Zhang,L., Wang,Y., Tian,L., Li,L., Chen,Z., Ding,C., Tian,J.,
            Song,D., Yao,S. and Ren,W.
  TITLE     Thrombospondin-1-mediated crosstalk between autophagy and oxidative
            stress orchestrates repair of blast lung injury
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167026 (2024)
   PUBMED   38237742
  REMARK    GeneRIF: Thrombospondin-1-mediated crosstalk between autophagy and
            oxidative stress orchestrates repair of blast lung injury.
REFERENCE   3  (bases 1 to 5699)
  AUTHORS   Long,J., Yang,Y., Yang,J., Chen,L., Wang,S., Zhou,X., Su,Y. and
            Liu,C.
  TITLE     Targeting Thbs1 reduces bladder remodeling caused by partial
            bladder outlet obstruction via the FGFR3/p-FGFR3 pathway
  JOURNAL   Neurourol Urodyn 43 (2), 516-526 (2024)
   PUBMED   38108523
  REMARK    GeneRIF: Targeting Thbs1 reduces bladder remodeling caused by
            partial bladder outlet obstruction via the FGFR3/p-FGFR3 pathway.
REFERENCE   4  (bases 1 to 5699)
  AUTHORS   Song,A., Zhang,S., Zhao,X., Wu,S., Qi,X., Gao,S., Qi,J., Li,P. and
            Tan,J.
  TITLE     Exosomes derived from menstrual blood stromal cells ameliorated
            premature ovarian insufficiency and granulosa cell apoptosis by
            regulating SMAD3/AKT/MDM2/P53 pathway via delivery of
            thrombospondin-1
  JOURNAL   Biomed Pharmacother 166, 115319 (2023)
   PUBMED   37573658
  REMARK    GeneRIF: Exosomes derived from menstrual blood stromal cells
            ameliorated premature ovarian insufficiency and granulosa cell
            apoptosis by regulating SMAD3/AKT/MDM2/P53 pathway via delivery of
            thrombospondin-1.
REFERENCE   5  (bases 1 to 5699)
  AUTHORS   Lei,Y., Jin,X., Sun,M. and Ji,Z.
  TITLE     RNF7 Induces Skeletal Muscle Cell Apoptosis and Arrests Cell
            Autophagy via Upregulation of THBS1 and Inactivation of the
            PI3K/Akt Signaling Pathway in a Rat Sepsis Model
  JOURNAL   Infect Immun 91 (4), e0053522 (2023)
   PUBMED   36920202
  REMARK    GeneRIF: RNF7 Induces Skeletal Muscle Cell Apoptosis and Arrests
            Cell Autophagy via Upregulation of THBS1 and Inactivation of the
            PI3K/Akt Signaling Pathway in a Rat Sepsis Model.
REFERENCE   6  (bases 1 to 5699)
  AUTHORS   Asch,A.S., Barnwell,J., Silverstein,R.L. and Nachman,R.L.
  TITLE     Isolation of the thrombospondin membrane receptor
  JOURNAL   J Clin Invest 79 (4), 1054-1061 (1987)
   PUBMED   2435757
REFERENCE   7  (bases 1 to 5699)
  AUTHORS   Wolff,R., Plow,E.F. and Ginsberg,M.H.
  TITLE     Interaction of thrombospondin with resting and stimulated human
            platelets
  JOURNAL   J Biol Chem 261 (15), 6840-6846 (1986)
   PUBMED   3084490
REFERENCE   8  (bases 1 to 5699)
  AUTHORS   Bale,M.D., Westrick,L.G. and Mosher,D.F.
  TITLE     Incorporation of thrombospondin into fibrin clots
  JOURNAL   J Biol Chem 260 (12), 7502-7508 (1985)
   PUBMED   3997886
REFERENCE   9  (bases 1 to 5699)
  AUTHORS   Jaffe,E.A., Ruggiero,J.T., Leung,L.K., Doyle,M.J.,
            McKeown-Longo,P.J. and Mosher,D.F.
  TITLE     Cultured human fibroblasts synthesize and secrete thrombospondin
            and incorporate it into extracellular matrix
  JOURNAL   Proc Natl Acad Sci U S A 80 (4), 998-1002 (1983)
   PUBMED   6341993
REFERENCE   10 (bases 1 to 5699)
  AUTHORS   Lawler,J.W., Slayter,H.S. and Coligan,J.E.
  TITLE     Isolation and characterization of a high molecular weight
            glycoprotein from human blood platelets
  JOURNAL   J Biol Chem 253 (23), 8609-8616 (1978)
   PUBMED   101549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Dec 28, 2021 this sequence version replaced
            XM_039105645.1, NM_001013062.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3222613.1,
                                           SRR26643291.9797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000003.1  125510250-125510432
            184-278             JAXUCZ010000003.1  125510970-125511064
            279-838             JAXUCZ010000003.1  125511315-125511874
            839-914             JAXUCZ010000003.1  125512669-125512744
            915-1114            JAXUCZ010000003.1  125512979-125513178
            1115-1237           JAXUCZ010000003.1  125513270-125513392
            1238-1331           JAXUCZ010000003.1  125514116-125514209
            1332-1505           JAXUCZ010000003.1  125516039-125516212
            1506-1682           JAXUCZ010000003.1  125516732-125516908
            1683-1856           JAXUCZ010000003.1  125517221-125517394
            1857-1984           JAXUCZ010000003.1  125517644-125517771
            1985-2137           JAXUCZ010000003.1  125517887-125518039
            2138-2356           JAXUCZ010000003.1  125518377-125518595
            2357-2464           JAXUCZ010000003.1  125519004-125519111
            2465-2624           JAXUCZ010000003.1  125519627-125519786
            2625-2743           JAXUCZ010000003.1  125519908-125520026
            2744-2978           JAXUCZ010000003.1  125521215-125521449
            2979-3206           JAXUCZ010000003.1  125521634-125521861
            3207-3478           JAXUCZ010000003.1  125522025-125522296
            3479-3576           JAXUCZ010000003.1  125522664-125522761
            3577-3716           JAXUCZ010000003.1  125522876-125523015
            3717-5699           JAXUCZ010000003.1  125523420-125525402
FEATURES             Location/Qualifiers
     source          1..5699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..5699
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /note="thrombospondin 1"
                     /db_xref="GeneID:445442"
                     /db_xref="RGD:1588455"
     exon            1..183
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..278
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..3724
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="thrombospondin-1 isoform 1 precursor"
                     /protein_id="NP_001013080.2"
                     /db_xref="GeneID:445442"
                     /db_xref="RGD:1588455"
                     /translation="MELLRGLGVLFLLHVCGSNRIPESGGDNGVFDIFELIGGARKVP
                     GRRLVKGQDLSSPAFRIENANLIPPVPDDKFQDLLDAVWADKGFIFLASLRQMKKTRG
                     TLLAVERKDNSGQIFSVVSNGKAGTLDLSLSLPGKQQVVSVEEALLATGQWKSITLFV
                     QEDRAQLYIDCDKMESAELDVPIQSIFTRDLANVARLRVAKGDVNDNFQGVLQNVRFV
                     FGTTPEDILRNKGCSSSTNVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGLSCDE
                     LSSMVLELRGLRTIVTTLQDSIRKVTEENRELASELRRPPLCFHNGVQYRNNEEWTVD
                     SCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCS
                     ATCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVT
                     CGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWSPWSLWDICSVTC
                     GGGVQRRSRLCNNPTPQFGGKDCVGDVTENQVCNKQDCPIDGCLSNPCFAGAKCTSYP
                     DGSWKCGACPPGYSGNGIQCKDVDECKEVPDACFNHNGEHRCKNTDPGYNCLPCPPRF
                     TGSQPFGRGVEHAMANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGY
                     AGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDD
                     DDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACA
                     VDIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTC
                     DNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDRDNCRLVP
                     NPDQKDSDGDGRGDACKDDFDHDNVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQ
                     NDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQ
                     SSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPG
                     QVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGG
                     RLGLFVFSQEMVFFSDMKYECRDS"
     exon            279..838
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..914
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1114
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1237
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1331
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1505
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1682
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1856
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1984
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2137
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2356
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2464
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2624
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2743
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2978
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3206
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3478
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3576
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3716
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..5699
                     /gene="Thbs1"
                     /gene_synonym="TSP-1; Tsp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccactgcc tggagtcagc cagcctcatc ggacttctgc aggcactcgc gacgcaacta
       61 cccagtcctg ccacggtcta tccggccgca ccagcaatct cagcgtcttt accggactcg
      121 aagtccttgt ccttcacttc gccttctcca ccactccggg ctgctgagct ccggtgcaca
      181 caggctccgc gttgggcaca aaggctccac catggagctc ctcaggggac taggcgtcct
      241 gttcctgttg catgtgtgtg gaagcaaccg cattccagag tctgggggag acaatggtgt
      301 gttcgacatt tttgaactca ttggaggtgc ccgcaaggtt ccgggtcgcc gactggtgaa
      361 gggccaagat ctatccagcc ccgccttccg gatcgagaat gccaacctga tcccccctgt
      421 gccagatgac aagttccaag acctactgga cgctgtgtgg gccgacaaag gcttcatctt
      481 cctggcttcc ttgaggcaga tgaagaagac tcggggcaca ctcctggccg tggaacggaa
      541 agacaattct ggccagatct tcagtgtggt ctccaatggc aaagccggca ccctcgatct
      601 gagtctgagc ctgcccggga agcagcaagt ggtgtcagtg gaggaagctc tcctggccac
      661 tggccagtgg aagagcatca cgctgtttgt ccaagaagac agggcccagc tctacattga
      721 ctgtgacaag atggagagcg cagagctgga tgttcccatc cagagcatct tcaccaggga
      781 tttggccaat gtcgccaggc tccgagtcgc aaagggagat gtcaatgaca attttcaggg
      841 ggtgctgcag aatgtgaggt ttgtctttgg aaccacccca gaagacattc tcaggaacaa
      901 aggctgctcc agttctacca acgtccttct cacccttgac aacaacgtgg tgaacggttc
      961 cagccctgcc atccgcacca actacatcgg ccacaaaaca aaggacctcc aagccatctg
     1021 tggcctctcc tgtgacgaac tatccagcat ggtcctggaa ctgaggggcc tgcgtaccat
     1081 cgtgaccacg ctacaggaca gcattcgaaa agtgacggaa gagaacagag agctggctag
     1141 cgagctgagg cggcctcccc tctgcttcca caatggagtc caatacagga acaacgagga
     1201 gtggactgta gatagttgca cagagtgtca ctgccagaac tcagttacca tctgcaaaaa
     1261 ggtgtcctgt cccatcatgc cctgctccaa tgccacagtt cctgatggtg aatgctgccc
     1321 acggtgctgg cccagtgact ctgctgacga tggctggtct ccctggtctg agtggacctc
     1381 ttgctctgcc acctgtggca atgggattca gcaacgtggt cgctcctgtg acagcctcaa
     1441 caacagatgt gagggctctt cagtacagac gaggacctgc cacattcagg agtgcgacaa
     1501 aagatttaaa caggatggtg gttggagtca ctggtccccg tggtcgtcct gttctgtgac
     1561 ctgtggtgac ggtgtgatca cgaggatccg actctgcaac tcccccagcc cccagatgaa
     1621 cgggaagccc tgtgaaggtg aagctcggga gaccaaagcc tgcaagaagg acgcctgccc
     1681 aatcaatgga ggctggagtc cctggtcact atgggacatc tgctctgtca cctgtggagg
     1741 aggagtacag agacgtagcc gactctgcaa caaccccaca ccccagtttg gaggcaaaga
     1801 ctgtgttggt gatgtgacgg aaaatcaagt ttgcaacaag caggactgtc cgattgatgg
     1861 atgcctgtcc aatccctgct ttgctggtgc caagtgtacg agctatcctg atggtagctg
     1921 gaaatgtggt gcgtgtcctc ctggctacag tggaaatggt atccagtgca aagacgtcga
     1981 cgagtgcaaa gaagtgcctg atgcttgctt caatcacaac ggagaacatc ggtgcaagaa
     2041 cacagatcct ggctacaact gcctgccctg cccaccacga ttcaccggct cacagccctt
     2101 cggcagaggt gtcgaacacg ctatggccaa caaacaggtg tgcaaacccc gaaacccctg
     2161 caccgacggg acacacgact gcaacaagaa cgccaagtgc aactacctgg gtcactacag
     2221 cgaccccatg taccgctgtg agtgcaagcc tggctacgca ggcaatggca tcatttgcgg
     2281 agaggacaca gaccttgacg gctggcctaa tgaaaacctg gtgtgtgtgg ccaacgcaac
     2341 ttaccactgc aaaaaggaca actgccccaa tcttcccaat tcggggcagg aagactatga
     2401 caaggatggg attggcgatg cctgtgatga cgatgatgac aacgacaaga ttcctgatga
     2461 cagggacaac tgtccattcc attacaaccc agcccagtat gactatgaca gagatgatgt
     2521 gggagaccgc tgtgacaatt gcccctacaa ccacaaccct gaccaggcag acacagacaa
     2581 caatggggag ggagatgcct gcgctgtgga catcgatggg gatggaatcc tcaatgaacg
     2641 agacaactgc cagtatgttt acaacgtgga tcagagggac acggacatgg atggggttgg
     2701 agaccagtgt gacaactgcc ccctggaaca caatccagac cagctggact ctgactcgga
     2761 ccgcataggg gacacctgtg acaacaatca ggacatcgat gaggatggcc atcagaacaa
     2821 cctggacaac tgtccctatg tgcccaatgc caaccaggcc gaccacgata aagatggtaa
     2881 aggagacgcc tgtgaccatg acgatgacaa cgacggcatc cctgatgaca gagacaactg
     2941 caggctggtg cccaatcctg accagaagga ctctgatggt gatggccgag gcgatgcctg
     3001 caaagacgac tttgaccatg acaatgtgcc agacattgat gacatctgtc ctgagaatgt
     3061 tgacatcagt gaaaccgatt tccgccgatt ccagatgatt cctctagatc ccaaaggaac
     3121 ctcccaaaat gaccctaact gggttgtccg ccatcagggc aaagaacttg tccagactgt
     3181 aaactgtgac cctggacttg ctgtaggtta tgatgagttt aatgccgtgg acttcagtgg
     3241 taccttcttc atcaacactg agagggatga cgactatgct ggctttgttt tcggctacca
     3301 gtccagcagc cgcttctacg ttgtgatgtg gaaacaagtc acccagtcct actgggacac
     3361 caaccccaca agggctcagg gatactcagg cctgtctgta aaggttgtaa actccaccac
     3421 tggccccggc gagcacctgc ggaatgcact gtggcacaca ggaaacaccc ctggccaggt
     3481 gcgcaccctg tggcatgacc ctcgtcacat tggctggaaa gatttcactg catacagatg
     3541 gcgtctcagc cacaggccaa agaccggttt tatcagagtg gtgatgtatg aaggaaagaa
     3601 aatcatggct gactcaggac ccatctatga caaaacctac gctggcggta gactaggcct
     3661 gttcgtcttc tctcaagaaa tggtgttctt ctcggacatg aaatacgagt gccgagactc
     3721 ctaatcacca ccccgatcat aaccagcctg gcattgcacc ttccgaaacc aagggctaga
     3781 gaaaaacccc tccaggatcg cttctcctcg ccttccctgc ctctcttctt gcatagtgtg
     3841 ggcttctaga gtctgtgacc tgcctcaaga aaatgcagtt ttcaaaccta gccagactca
     3901 gaacttggcc tgtaaggagt gagaatgcat cttctaagaa catgaagaat tactttggtt
     3961 tgcttttgag aaagcaaaag cgactattta cttcccactg ggaaggtgcc cactccactc
     4021 tgccttactc acagagccag agcttctgcg aggccatctc cgagctgcac actcagaagc
     4081 attttcgggc ctgtcaaaga aaaaacaaca tggctcacta gaactcactg ccaaaccacc
     4141 tctgacataa gtcctcagca ggggagaggc aggagccaaa gcactaggag ccatgaaccc
     4201 aagagatgat tgtgcaaaga aaagatggag gagctgttac ttggtcggta ctaatcattt
     4261 tcaggggaca gagaaggctt gctgctttcc tcatgctgcc cctgagagct gactacccag
     4321 tcttccacag gcacctgagt gagcagggga gggagggaaa tcctggctcc tggacttcct
     4381 ccacactgaa actgtgggcg tcttctgcat gtataacatg cgtgtctaag gacagcaaga
     4441 gagccctgcc gtctcggtga gctctagctg cctccgcagg aggggcagtg cgccttcatt
     4501 ttatggttag aaaggcacaa aatttttatc aacctgaaac attccttttt ctttttgcct
     4561 caattatcat ggagttttcc aattctcttc tggtttttgt ttaacaaacg ctttaacaat
     4621 gtaatatatt tatttttccc cctattctgg aggattcgtc tgaaggattg ttattgaaac
     4681 aggatgcgtg ggactctctg aatcatcttc atagtgagtc tttatgactg taagattgta
     4741 aatacagatt atttattaac cctgttctac ctggaattaa actgcataga gcaaatgttt
     4801 gcaagcaggt agctgaggct gtcagcaaat ctctccaaaa ctagtgtgga agtcagcagg
     4861 agctgctggc tttcatttgg gggcttagag cgaatgattt ggactccttt ggcttttccc
     4921 cttggttttc tctgtctttt caagtgggaa tgggtggctg cccatttgca tttgcctctc
     4981 ctgcaaagga agcctgagcc ctccaaggct cacccacccc accccttctg cctatttcca
     5041 gggagaagaa aacacaatca actttttatt tcattttccc aaaagagaca aaggtggaac
     5101 ttatatacaa atattacctc atttgttgtg tgactgagta aagaattttg gatcaagaag
     5161 aaagagttta agtgtcaata aacttaaaac tactgtcgtg tctaaaaagt cagtgttgta
     5221 catagcataa aaatcctttg cagagaatga tcccaataca gaaatagctt tgaaatgtta
     5281 aatacaactc ctcaaagttc tggttttgtt ctatcatctt gtacaccatt gcttttattt
     5341 ttataaatta ttttctcatt gccattggaa tagagatctc agactatgta gatatgctat
     5401 ttaaataatt tatcaggaaa tactgcctgt agagttagta tttctgtttt ttatatgttg
     5461 cacactgaat tgaagaaatg ttggtttttc ttgttttgtt ttagtttgtt tctttggttt
     5521 tgtttttggt tttgcttttt acttcccagg tttgactatt tgccaatgcc ctgtgttcta
     5581 ggaacgtgct tttttgtaca cattttatcc attttacatt ctaaagcagt gtaacttgta
     5641 tattactgtt tcttgtgtac aaggaacaac aataaatcat atggaagttt atatttata
//
