LOCUS       NM_031771               3680 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus thrombomodulin (Thbd), mRNA.
ACCESSION   NM_031771
VERSION     NM_031771.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3680)
  AUTHORS   Friedrich V, Bi W and Sehba FA.
  TITLE     Sexual dimorphism in gene expression after aneurysmal subarachnoid
            hemorrhage
  JOURNAL   Neurol Res 37 (12), 1054-1059 (2015)
   PUBMED   26923576
  REMARK    GeneRIF: This study demonstrated that Thbd increases in male rat
            with aneurysmal subarachnoid hemorrhage.
REFERENCE   2  (bases 1 to 3680)
  AUTHORS   Kaija H, Pakanen L, Uusitalo J, Nikkila S, Kortelainen ML and
            Porvari KS.
  TITLE     Changes in cardiac thrombomodulin and heat shock transcription
            factor 1 expression and peripheral thrombomodulin and
            catecholamines during hypothermia in rats
  JOURNAL   Stress 17 (6), 504-511 (2014)
   PUBMED   25109347
  REMARK    GeneRIF: Cellular and soluble levels of thrombomodulin are modified
            by cold stress in healthy rats, possibly via catecholamines and
            HSF1.
REFERENCE   3  (bases 1 to 3680)
  AUTHORS   Cao Y, Zhang Z, Xu J, Yuan W, Wang J, Huang X, Shen Y and Du J.
  TITLE     The association of idiopathic recurrent pregnancy loss with
            polymorphisms in hemostasis-related genes
  JOURNAL   Gene 530 (2), 248-252 (2013)
   PUBMED   23954867
REFERENCE   4  (bases 1 to 3680)
  AUTHORS   Tanaka J, Seki Y, Ishikura H, Tsubota M, Sekiguchi F, Yamaguchi K,
            Murai A, Umemura T and Kawabata A.
  TITLE     Recombinant human soluble thrombomodulin prevents peripheral
            HMGB1-dependent hyperalgesia in rats
  JOURNAL   Br J Pharmacol 170 (6), 1233-1241 (2013)
   PUBMED   24004409
REFERENCE   5  (bases 1 to 3680)
  AUTHORS   Nakahara M, Ito T, Kawahara K, Yamamoto M, Nagasato T, Shrestha B,
            Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A,
            Kakihana Y, Hashiguchi T, Kanmura Y and Maruyama I.
  TITLE     Recombinant thrombomodulin protects mice against histone-induced
            lethal thromboembolism
  JOURNAL   PLoS One 8 (9), e75961 (2013)
   PUBMED   24098750
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3680)
  AUTHORS   Wang J, Yao A, Wang JY, Sung CC, Fink LM, Hardin JW and
            Hauer-Jensen M.
  TITLE     cDNA cloning and sequencing, gene expression, and
            immunolocalization of thrombomodulin in the Sprague-Dawley rat
  JOURNAL   DNA Res 6 (1), 57-62 (1999)
   PUBMED   10231031
REFERENCE   7  (bases 1 to 3680)
  AUTHORS   Yao A, Wang J, Fink LM, Hardin JW and Hauer-Jensen M.
  TITLE     Molecular cloning and sequence analysis of the 5'-flanking region
            of the Sprague-Dawley rat thrombomodulin gene
  JOURNAL   DNA Seq 10 (1), 55-60 (1999)
   PUBMED   10565546
REFERENCE   8  (bases 1 to 3680)
  AUTHORS   Daimon T, Kazama M, Miyajima Y and Nakano M.
  TITLE     Immunocytochemical localization of thrombomodulin in the aqueous
            humor passage of the rat eye
  JOURNAL   Histochem Cell Biol 108 (2), 121-131 (1997)
   PUBMED   9272431
REFERENCE   9  (bases 1 to 3680)
  AUTHORS   Hasegawa N, Kandra TG, Husari AW, Veiss S, Hart WT, Hedgpeth J,
            Wydro R and Raffin TA.
  TITLE     The effects of recombinant human thrombomodulin on
            endotoxin-induced multiple-system organ failure in rats
  JOURNAL   Am J Respir Crit Care Med 153 (6 Pt 1), 1831-1837 (1996)
   PUBMED   8665042
REFERENCE   10 (bases 1 to 3680)
  AUTHORS   Healy AM, Rayburn HB, Rosenberg RD and Weiler H.
  TITLE     Absence of the blood-clotting regulator thrombomodulin causes
            embryonic lethality in mice before development of a functional
            cardiovascular system
  JOURNAL   Proc Natl Acad Sci U S A 92 (3), 850-854 (1995)
   PUBMED   7846065
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070903.1.
            
            On May 24, 2004 this sequence version replaced NM_031771.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC070903.1, AF022743.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3680
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..3680
                     /gene="Thbd"
                     /note="thrombomodulin"
                     /db_xref="GeneID:83580"
                     /db_xref="RGD:621299"
     exon            1..3653
                     /gene="Thbd"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1887
                     /gene="Thbd"
                     /note="thrombomdulin"
                     /codon_start=1
                     /product="thrombomodulin precursor"
                     /protein_id="NP_113959.1"
                     /db_xref="GeneID:83580"
                     /db_xref="RGD:621299"
                     /translation="MLGVFLLGVLAPAGLGISALAKLQPKGSQCVGNECFALFQDPVT
                     FLDASQACQRLQGHLMTVRSSVAADVISLLVSDSSMDSRPWIGLQLPQGCGDPVHLGP
                     LRGFQWVTGDNHTSYSRWARPNDQSPPLCGPLCVTVSTATEAAPGEPAWEEKPCENET
                     KGFLCEFYFAAFCRPLRVNTRDPEGAHISSTYNTPLGVSGADFQTLPIGSSATVAPFG
                     LELVCRALPGTSEGHWTREVTGAWNCSVENGGCEYMCNRSANGPRCVCPSGGDLQADG
                     RSCAKPVAQLCNELCQHFCVNNSDVPGSYSCMCETGYQLAADGHRCEDVDDCKQGPNP
                     CPQLCSNTEGGFECRCYDGYELVDGECVEQLDPCFRSKCEYQCQPVNSTHYNCICAEG
                     FAPKLDDPDRCEMFCNETSCPADCDPNSPSFCQCPEGFILDEGSICTDIDECSQGECL
                     TNECRNLPGSYECICGPDTALAGQISKDCDPIPVLEDSEDGGSGEHPSSNPTVVSSTV
                     PPSARPMHSGVLIGISIASLSLVVALLALLCHLRKKQGTARAELEYKCTSSAKEVVLQ
                     HVRTDRTLQKF"
ORIGIN      
        1 agggactacg aacctgggct agaaaagtct aggctgagac agaggctaac tgctgtcgcc
       61 gcagacgtac gaaaccctct gccgggactg ggtgcctgca ccatcgcagt gctagcgttt
      121 tctcgtagct tgcacggtgt tctcctgaac agcatgcttg gggttttcct tctgggtgtg
      181 ctggctccag ctggcctggg gatctctgca ctagccaagc tgcagcccaa aggcagtcaa
      241 tgcgtgggga atgagtgctt cgcgcttttc caggaccccg tgaccttcct cgatgccagc
      301 caggcctgcc agcgcctgca gggacatttg atgacagtgc gctcctcggt ggctgcggat
      361 gtcatctccc ttctggtgag cgacagtagt atggactcac ggccctggat cggtttacag
      421 ctccctcagg gctgtggtga cccggtgcat ctcgggcccc tgcgcggctt ccagtgggtt
      481 actggggata accacaccag ttacagcagg tgggcgcggc ccaacgacca gtcgcctcca
      541 ctttgcggtc cgctgtgcgt cacggtctca acagcaacag aagctgcacc aggcgagccg
      601 gcctgggaag agaagccgtg cgagaacgag accaagggtt ttctctgcga gttttacttc
      661 gcagctttct gcaggccttt acgggtgaat acccgagatc ctgagggtgc ccacatctct
      721 agcacctaca ataccccatt gggggtcagc ggcgcggatt ttcagacgct gccgataggc
      781 agttctgcta ccgtggcgcc ctttggcttg gagctggtgt gcagggccct gcccggaact
      841 tcagagggac actggactcg ggaagtgaca ggagcttgga actgcagcgt ggagaatggt
      901 ggctgcgagt acatgtgcaa caggagcgct aacggaccca gatgcgtctg ccccagcggc
      961 ggggacctgc aggctgatgg ccgttcgtgc gcaaaacctg tggctcaatt gtgcaacgaa
     1021 ctctgccagc atttttgcgt caacaactct gatgtgccag gctcttattc ctgtatgtgc
     1081 gaaacaggct accagttggc ggcagacgga catcggtgtg aggacgtgga tgactgtaag
     1141 caggggccca atccatgccc tcagctctgt tctaacaccg agggcggctt cgaatgccgc
     1201 tgctatgatg gctatgagtt ggtggacgga gagtgcgtgg agcaactgga tccgtgcttc
     1261 agatctaaat gcgagtatca gtgccagcca gtaaactcca cgcactacaa ttgcatctgt
     1321 gctgagggct tcgcacctaa gctggatgat cccgacaggt gcgaaatgtt ctgcaatgaa
     1381 acttcgtgcc cagcagactg tgaccccaac tccccaagct tttgtcaatg ccctgagggc
     1441 ttcatcctgg acgagggttc catatgcaca gacattgatg agtgcagtca aggcgaatgc
     1501 ctcaccaatg aatgtcgaaa ccttcctggc tcctatgagt gcatctgcgg acctgacaca
     1561 gcccttgctg gtcagattag caaggactgt gaccccatcc ctgttctgga ggactcagag
     1621 gatggtggct ctggggagca cccatcaagc aatccgacgg tagtctcttc gacagttccc
     1681 ccttctgcaa gaccaatgca ctctggtgtg ctcattggga tctccattgc cagcctgtcc
     1741 ctggtggtgg cgcttttggc gcttctttgt cacctgcgca agaagcaggg cactgctcgc
     1801 gcagagctgg agtacaagtg tacctcttca gccaaggagg tagtactgca gcacgtgagg
     1861 actgatcgga cgctgcagaa gttctgaggg atttactcca gagaccaagg tggcctttgt
     1921 ctttccgggc tctgtacctc tcctttctct ctcttcagcc tcccagctgt gctctctggc
     1981 aatgtaaaag cattctggct ggtataataa ccagagaaga gctcatcctc ttatgacaag
     2041 cgagggtagg gaggacttga agccggagag cccagtttct tccaagtaga gactggacaa
     2101 ctgggcggag gtgacaaata cagtgaagat cccagagtgt cccagtccct cacctcgggg
     2161 tgcaggatgt gtgggtgctg ctgatctgta ggcttggagg caaaccttga ccctatggac
     2221 tggagatgac ccagatattt atttttttaa aagtatttag tattttcttc ccttcagctt
     2281 tattctgctt gtaagtctcc agtccctcac ccttttctgt gtccctccat tcctttccct
     2341 cccctccccc tctccatcat tctcctcccc gaacctgatc atagtttgcc tttacccttg
     2401 tctccaaact cttatgtgaa acagaaaaaa aaaaaacact aaacgcagaa aaatattttt
     2461 tttcgctagc tttggcaatt taatcgggga tttcaggtaa ccagagcaaa agaatttaaa
     2521 caaaagttaa aatgtttcaa ctgaacacta actagttaat agtgctggaa tatcacagaa
     2581 tttaaactca aggaagtagg gttttgattt tttttaatct ttgtttttga aagggtgagc
     2641 ctgggtttta tgattgttgc tgttgttttt tttttattta gaatgacaaa agaggtaata
     2701 attattaaac tttttatgcc ggcttctaca gtgttattaa tttttgacag tgtttcaaat
     2761 gtgcagagga tcctttgtcc aaccctttga cattccaata ggacattgcc atcttcagac
     2821 atattgggcc acattcatag ctatccaaga atgtatgtgg tccttagcct ggacatatct
     2881 gagacggatg gatggaagca tcttccagta aagcttgagc tgtatgcttc gtgcctggct
     2941 gactctccac tgtgtttgcc atttgtagtc ccaaaataaa agcaatgtgc tgcttaggga
     3001 gatatggcaa cttgggaaag gagtctgggg ggtgactaga tgggactttg ctttaatgaa
     3061 actctggaac gatatcttgt acttcagaga gatctactag ccctggccta tacacaagaa
     3121 ttgggacctc ccttgggatc tggctagaat tgcaaaatcc taacccccac cctaccccac
     3181 tcccacccca gtgagccagt tcataagaag ctgcattttg acaacatcca cagggcattg
     3241 tccagtcatt tcaggacaac tggtctaaag agtttccaac ttcttgagaa catttaaatg
     3301 tcacttaata ataagtagca ggccatatgc aggccatttt ttaataaaga aactgaggaa
     3361 ttttctctgc atagctttgc tttctggata aaataaaagg accaggtaca tgcctctaga
     3421 tattggcata cagagtccag aagggttttg ttttaagtaa gctaggaatg agttcatatg
     3481 tcagtgtaag gaacaaatgt atcatatgtg tatcttttgt gaagaaaagg ttttctttac
     3541 tgttttgtag gctcagcata tctgtacata tttatttatt ggagtttagc tagaacacaa
     3601 gcaaagcctt tgcttatgac gtcacgtgta taaaataaat agattacaat gtaaaaaaaa
     3661 aaaaaaaaaa aaaaaaaaaa
//
