LOCUS       NM_001008340            1100 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus THAP domain containing 1 (Thap1), mRNA.
ACCESSION   NM_001008340 XM_224951
VERSION     NM_001008340.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1100)
  AUTHORS   Richter,A., Hollstein,R., Hebert,E., Vulinovic,F., Eckhold,J.,
            Osmanovic,A., Depping,R., Kaiser,F.J. and Lohmann,K.
  TITLE     In-depth Characterization of the Homodimerization Domain of the
            Transcription Factor THAP1 and Dystonia-Causing Mutations Therein
  JOURNAL   J Mol Neurosci 62 (1), 11-16 (2017)
   PUBMED   28299530
REFERENCE   2  (bases 1 to 1100)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   3  (bases 1 to 1100)
  AUTHORS   Zhao,Y., Xiao,J., Gong,S., Clara,J.A. and Ledoux,M.S.
  TITLE     Neural expression of the transcription factor THAP1 during
            development in rat
  JOURNAL   Neuroscience 231, 282-295 (2013)
   PUBMED   23219941
  REMARK    GeneRIF: The prominent cytoplasmic and developmentally regulated
            expression of THAP1 suggests that THAP1 may function as part of a
            cell surface-nucleus signaling cascade involved in terminal neural
            differentiation.
REFERENCE   4  (bases 1 to 1100)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   5  (bases 1 to 1100)
  AUTHORS   Kaiser,F.J., Osmanoric,A., Rakovic,A., Erogullari,A., Uflacker,N.,
            Braunholz,D., Lohnau,T., Orolicki,S., Albrecht,M.,
            Gillessen-Kaesbach,G., Klein,C. and Lohmann,K.
  TITLE     The dystonia gene DYT1 is repressed by the transcription factor
            THAP1 (DYT6)
  JOURNAL   Ann Neurol 68 (4), 554-559 (2010)
   PUBMED   20976771
REFERENCE   6  (bases 1 to 1100)
  AUTHORS   Sabogal,A., Lyubimov,A.Y., Corn,J.E., Berger,J.M. and Rio,D.C.
  TITLE     THAP proteins target specific DNA sites through bipartite
            recognition of adjacent major and minor grooves
  JOURNAL   Nat Struct Mol Biol 17 (1), 117-123 (2010)
   PUBMED   20010837
REFERENCE   7  (bases 1 to 1100)
  AUTHORS   Fuchs,T., Gavarini,S., Saunders-Pullman,R., Raymond,D.,
            Ehrlich,M.E., Bressman,S.B. and Ozelius,L.J.
  TITLE     Mutations in the THAP1 gene are responsible for DYT6 primary
            torsion dystonia
  JOURNAL   Nat Genet 41 (3), 286-288 (2009)
   PUBMED   19182804
REFERENCE   8  (bases 1 to 1100)
  AUTHORS   Bessiere,D., Lacroix,C., Campagne,S., Ecochard,V., Guillet,V.,
            Mourey,L., Lopez,F., Czaplicki,J., Demange,P., Milon,A.,
            Girard,J.P. and Gervais,V.
  TITLE     Structure-function analysis of the THAP zinc finger of THAP1, a
            large C2CH DNA-binding module linked to Rb/E2F pathways
  JOURNAL   J Biol Chem 283 (7), 4352-4363 (2008)
   PUBMED   18073205
REFERENCE   9  (bases 1 to 1100)
  AUTHORS   Cayrol,C., Lacroix,C., Mathe,C., Ecochard,V., Ceribelli,M.,
            Loreau,E., Lazar,V., Dessen,P., Mantovani,R., Aguilar,L. and
            Girard,J.P.
  TITLE     The THAP-zinc finger protein THAP1 regulates endothelial cell
            proliferation through modulation of pRB/E2F cell-cycle target genes
  JOURNAL   Blood 109 (2), 584-594 (2007)
   PUBMED   17003378
REFERENCE   10 (bases 1 to 1100)
  AUTHORS   Clouaire,T., Roussigne,M., Ecochard,V., Mathe,C., Amalric,F. and
            Girard,J.P.
  TITLE     The THAP domain of THAP1 is a large C2CH module with zinc-dependent
            sequence-specific DNA-binding activity
  JOURNAL   Proc Natl Acad Sci U S A 102 (19), 6907-6912 (2005)
   PUBMED   15863623
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086347.1.
            
            On Dec 16, 2004 this sequence version replaced XM_224951.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086347.1, EV775651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1100
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..1100
                     /gene="Thap1"
                     /note="THAP domain containing 1"
                     /db_xref="GeneID:306547"
                     /db_xref="RGD:1307589"
     exon            1..304
                     /gene="Thap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..866
                     /gene="Thap1"
                     /note="THAP domain-containing apoptosis-associated protein
                     1"
                     /codon_start=1
                     /product="THAP domain-containing protein 1"
                     /protein_id="NP_001008341.1"
                     /db_xref="GeneID:306547"
                     /db_xref="RGD:1307589"
                     /translation="MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKQWEAAVRRKN
                     FKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIFLYIEPHEKKEELEPQEQLPSP
                     SPPTSQVDAAVGLLMPPLQTPDNLSVFCDHNYTVEDTMHQRKRILHLEQQVEKLRKKL
                     KTAQQRCRRQERQLEKLKEVVHFQREKDDASERGYVILPNDYFEIVEVPA"
     exon            305..500
                     /gene="Thap1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..1076
                     /gene="Thap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgaagctg cctccgccat cttgaagatg ggagacgagc gacagctgtt gtctttctgc
       61 taaagcaaac accacaacgg accgggtggt caccccccac ggtgaggtaa tcgtccccat
      121 aactgctaac caaagccacc gaaagcggcg accgtatcaa agccgagcgc ggcggcaccg
      181 acggcccctt cacctgcctc ccgggcagag gggaagtgtg gagggccaga aggatggtgc
      241 agtcctgttc cgcctacggc tgcaagaacc ggtacgataa ggacaagccc gtctccttcc
      301 acaagtttcc tcttactcgt cccagtcttt gtaaacagtg ggaggcagct gttagaagga
      361 aaaacttcaa gcccactaag tacagcagta tctgttcgga gcactttact ccagactgct
      421 ttaagagaga gtgcaacaac aagctactga aggagaacgc tgtgcccact atttttctct
      481 atatagagcc acatgagaag aaggaagaac tggaacccca agagcagctt ccctctcctt
      541 caccccccac ttcccaggtt gacgccgctg ttgggttgct aatgcctcct ctccagaccc
      601 ctgataacct ctcagttttc tgtgaccaca actacactgt ggaggacaca atgcaccaga
      661 ggaagaggat ccttcacctg gagcagcagg ttgaaaagct caggaagaaa ctcaagaccg
      721 cccagcagcg gtgccgtcgg caggagagac agctcgagaa gctcaaggaa gttgtacact
      781 ttcagagaga gaaagacgac gcctcggaga ggggctatgt gattctacca aatgactact
      841 tcgaaattgt tgaagtgcca gcatgaaagg atgaggtgta ttagtggaca agactgtata
      901 ccttctttta gcctacatac aggagttcat ttgaaaaaaa taacaattac ttgtattaaa
      961 aaacaatatt tttttaaaat aaattagata tatactgtat aattgtaatt ttttgtttgt
     1021 aatttcagag tttctacatt ttaacaaaat atttaagaaa atccttaaac caccaaaaaa
     1081 aaaaaaaaaa aaaaaaaaaa
//
