LOCUS       NM_012740               1763 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus tyrosine hydroxylase (Th), mRNA.
ACCESSION   NM_012740
VERSION     NM_012740.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1763)
  AUTHORS   Yamaguchi,H., Hara,S., Ichinose,H., Nagasaki,H. and Nakashima,A.
  TITLE     Role of NT5DC2 in tyrosine hydroxylase phosphorylation based on the
            analysis of NT5DC2-binding proteins
  JOURNAL   Biochem Biophys Res Commun 703, 149698 (2024)
   PUBMED   38382359
REFERENCE   2  (bases 1 to 1763)
  AUTHORS   Zhang,Y., Tsai,T.H., Ezrokhi,M., Stoelzel,C. and Cincotta,A.H.
  TITLE     Tyrosine Hydroxylase Knockdown at the Hypothalamic Supramammillary
            Nucleus Area Induces Obesity and Glucose Intolerance
  JOURNAL   Neuroendocrinology 114 (5), 483-510 (2024)
   PUBMED   38128505
  REMARK    GeneRIF: Tyrosine Hydroxylase Knockdown at the Hypothalamic
            Supramammillary Nucleus Area Induces Obesity and Glucose
            Intolerance.
REFERENCE   3  (bases 1 to 1763)
  AUTHORS   Leem,K.H., Kim,S., Kim,H.W. and Park,H.J.
  TITLE     Downregulation of microRNA-330-5p induces manic-like behaviors in
            REM sleep-deprived rats by enhancing tyrosine hydroxylase
            expression
  JOURNAL   CNS Neurosci Ther 29 (6), 1525-1536 (2023)
   PUBMED   36794530
  REMARK    GeneRIF: Downregulation of microRNA-330-5p induces manic-like
            behaviors in REM sleep-deprived rats by enhancing tyrosine
            hydroxylase expression.
REFERENCE   4  (bases 1 to 1763)
  AUTHORS   Cassinotti,L., Guil,M., Bianciotti,L. and Vatta,M.
  TITLE     Role of Brain Endothelin Receptor Type B (ETB) in the Regulation of
            Tyrosine Hydroxylase in the Olfactory Bulb of DOCA-Salt
            Hypertensive Rats
  JOURNAL   Curr Vasc Pharmacol 21 (4), 246-256 (2023)
   PUBMED   37349999
  REMARK    GeneRIF: Role of Brain Endothelin Receptor Type B (ETB) in the
            Regulation of Tyrosine Hydroxylase in the Olfactory Bulb of
            DOCA-Salt Hypertensive Rats.
REFERENCE   5  (bases 1 to 1763)
  AUTHORS   Jimenez,A., Herrera-Gonzalez,A., Organista-Juarez,D., Estudillo,E.,
            Velasco,I., Guerrero-Vargas,N.N., Guzman-Ruiz,M.A. and
            Guevara-Guzman,R.
  TITLE     Diabetes Induces Permanent Deleterious Effects in the Olfactory
            Bulb Associated with Increased Tyrosine Hydroxylase Expression and
            ERK1/2 Phosphorylation
  JOURNAL   ACS Chem Neurosci 13 (19), 2821-2828 (2022)
   PUBMED   36122168
  REMARK    GeneRIF: Diabetes Induces Permanent Deleterious Effects in the
            Olfactory Bulb Associated with Increased Tyrosine Hydroxylase
            Expression and ERK1/2 Phosphorylation.
REFERENCE   6  (bases 1 to 1763)
  AUTHORS   Haycock,J.W. and Haycock,D.A.
  TITLE     Tyrosine hydroxylase in rat brain dopaminergic nerve terminals.
            Multiple-site phosphorylation in vivo and in synaptosomes
  JOURNAL   J Biol Chem 266 (9), 5650-5657 (1991)
   PUBMED   1672315
REFERENCE   7  (bases 1 to 1763)
  AUTHORS   Wolff,J.A., Fisher,L.J., Xu,L., Jinnah,H.A., Langlais,P.J.,
            Iuvone,P.M., O'Malley,K.L., Rosenberg,M.B., Shimohama,S.,
            Friedmann,T. et al.
  TITLE     Grafting fibroblasts genetically modified to produce L-dopa in a
            rat model of Parkinson disease
  JOURNAL   Proc Natl Acad Sci U S A 86 (22), 9011-9014 (1989)
   PUBMED   2573072
REFERENCE   8  (bases 1 to 1763)
  AUTHORS   Horellou,P., Guibert,B., Leviel,V. and Mallet,J.
  TITLE     A single RNA species injected in Xenopus oocyte directs the
            synthesis of active tyrosine hydroxylase
  JOURNAL   FEBS Lett 205 (1), 6-10 (1986)
   PUBMED   2427363
REFERENCE   9  (bases 1 to 1763)
  AUTHORS   Grima,B., Lamouroux,A., Blanot,F., Biguet,N.F. and Mallet,J.
  TITLE     Complete coding sequence of rat tyrosine hydroxylase mRNA
  JOURNAL   Proc Natl Acad Sci U S A 82 (2), 617-621 (1985)
   PUBMED   2857492
REFERENCE   10 (bases 1 to 1763)
  AUTHORS   Joh,T.H., Park,D.H. and Reis,D.J.
  TITLE     Direct phosphorylation of brain tyrosine hydroxylase by cyclic
            AMP-dependent protein kinase: mechanism of enzyme activation
  JOURNAL   Proc Natl Acad Sci U S A 75 (10), 4744-4748 (1978)
   PUBMED   33381
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012740.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M10244.1, SRR26360194.681303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000001.1  207508118-207508218 c
            102-326             JAXUCZ010000001.1  207506075-207506299 c
            327-501             JAXUCZ010000001.1  207505030-207505204 c
            502-590             JAXUCZ010000001.1  207504680-207504768 c
            591-658             JAXUCZ010000001.1  207504497-207504564 c
            659-709             JAXUCZ010000001.1  207504177-207504227 c
            710-855             JAXUCZ010000001.1  207503687-207503832 c
            856-991             JAXUCZ010000001.1  207503481-207503616 c
            992-1061            JAXUCZ010000001.1  207503253-207503322 c
            1062-1118           JAXUCZ010000001.1  207502806-207502862 c
            1119-1214           JAXUCZ010000001.1  207502572-207502667 c
            1215-1348           JAXUCZ010000001.1  207502185-207502318 c
            1349-1763           JAXUCZ010000001.1  207500965-207501379 c
FEATURES             Location/Qualifiers
     source          1..1763
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1763
                     /gene="Th"
                     /gene_synonym="The"
                     /note="tyrosine hydroxylase"
                     /db_xref="GeneID:25085"
                     /db_xref="RGD:3853"
     exon            1..101
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1508
                     /gene="Th"
                     /gene_synonym="The"
                     /EC_number="1.14.16.2"
                     /note="tyrosine 3-hydroxylase"
                     /codon_start=1
                     /product="tyrosine 3-monooxygenase"
                     /protein_id="NP_036872.1"
                     /db_xref="GeneID:25085"
                     /db_xref="RGD:3853"
                     /translation="MPTPSAPSPQPKGFRRAVSEQDAKQAEAVTSPRFIGRRQSLIED
                     ARKEREAAAAAAAAAVASSEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRAVK
                     VFETFEAKIHHLETRPAQRPLAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSAR
                     EDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGE
                     PIPHVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLLERYCGYREDSIPQLEDV
                     SRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELL
                     GHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAG
                     LLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYAS
                     RIQRPFSVKFDPYTLAIDVLDSPHTIQRSLEGVQDELHTLAHALSAIS"
     exon            102..326
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            327..501
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            502..590
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            591..658
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            659..709
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            710..855
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            856..991
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1061
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1118
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1214
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1348
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1763
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcttgcac tatgcccacc cccagcgccc cctcgccaca gcccaagggc ttcagaaggg
       61 ccgtctcaga gcaggatgcc aagcaggccg aggctgtcac gtccccaagg ttcatcggac
      121 ggcgacagag tctcatcgag gatgcccgca aggagcggga ggcggcggca gctgcagcag
      181 cagcagcggt agcctcctcg gaacctggga acccactgga ggctgtggta tttgaggaga
      241 gggatgggaa tgctgttctc aacctgctct tctccctgag gggtacaaaa ccctcctcct
      301 tgtctcgggc tgtaaaagta tttgagacat ttgaagccaa aattcaccac ttagagaccc
      361 ggcctgccca gaggccactg gcaggaagcc cccacctgga gtattttgtg cgcttcgagg
      421 tgcccagtgg agacctggct gccctcctca gctctgtgcg tcgggtgtct gacgacgtgc
      481 gcagtgctag agaggacaag gtcccctggt tcccaagaaa agtgtcggaa ttggacaagt
      541 gtcaccacct ggtcaccaag tttgaccctg atctggacct ggaccacccg ggcttctctg
      601 accaggtgta tcgccagcgt cggaagctga ttgcagagat tgccttccag tacaagcacg
      661 gtgaaccaat tccccatgtg gaatacacag cggaagagat tgctacctgg aaggaggtat
      721 atgtcacgct gaagggcctc tatgctaccc atgcctgccg ggagcacctg gagggtttcc
      781 agcttctgga acggtactgt ggctaccgag aggacagcat cccacagctg gaggacgtgt
      841 cccgcttctt gaaggagcgg actggcttcc agctgcgacc cgtggccggt ctactgtccg
      901 cccgtgattt tctggccagt ctggccttcc gcgtgtttca atgcacccag tatatccgcc
      961 atgcctcctc acctatgcat tcacctgagc cggactgctg ccatgagctg ttgggacatg
     1021 tacccatgtt ggctgaccgc acatttgccc agttctccca ggacattgga cttgcatctc
     1081 tgggggcctc agatgaagaa attgaaaaac tctccacggt gtactggttc actgtggaat
     1141 tcgggctatg taaacagaat ggggagctga aggcttatgg tgcagggctg ctgtcttcct
     1201 acggagagct cctgcactcc ctgtcagagg agcctgaggt ccgagccttt gacccagaca
     1261 cagcagctgt gcagccctac caagatcaaa cctaccagcc tgtgtacttt gtgtccgaga
     1321 gcttcaatga cgccaaggac aagctcagga actatgcctc tcgtatccag cgcccattct
     1381 ctgtgaagtt tgacccgtac acactggcca ttgacgtact ggacagccct cacaccatcc
     1441 agcgctcctt ggagggggtc caggatgagc tgcacaccct ggcccacgca ctgagtgcca
     1501 ttagctaaat gcatagggta ccacccacag gtgccagggg cctttcccaa agtctccatc
     1561 cccttctcca acctttcctg gcccagaggc tttcccatgt gtgtggctgg gccctttgat
     1621 gggctcctct tggaccccca tcctcccaac actgcttctc aaccatgtct tactactgca
     1681 tgcactccag ggtggtcctg cattcctcct gccctccatg ctctatacta ccctgattat
     1741 tctctcaata aaggaaggaa aga
//
