LOCUS       NM_001107904            4305 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Rattus norvegicus trimethylguanosine synthase 1 (Tgs1), mRNA.
ACCESSION   NM_001107904 XM_001069069 XM_232648
VERSION     NM_001107904.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4305)
  AUTHORS   Sharma,R., Maity,S.K., Chakrabarti,P., Katika,M.R., Kapettu,S.,
            Parsa,K.V.L. and Misra,P.
  TITLE     PIMT Controls Insulin Synthesis and Secretion through PDX1
  JOURNAL   Int J Mol Sci 24 (9), 8084 (2023)
   PUBMED   37175791
  REMARK    GeneRIF: PIMT Controls Insulin Synthesis and Secretion through
            PDX1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4305)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 4305)
  AUTHORS   Lemm,I., Girard,C., Kuhn,A.N., Watkins,N.J., Schneider,M.,
            Bordonne,R. and Luhrmann,R.
  TITLE     Ongoing U snRNP biogenesis is required for the integrity of Cajal
            bodies
  JOURNAL   Mol Biol Cell 17 (7), 3221-3231 (2006)
   PUBMED   16687569
REFERENCE   4  (bases 1 to 4305)
  AUTHORS   Enunlu,I., Papai,G., Cserpan,I., Udvardy,A., Jeang,K.T. and
            Boros,I.
  TITLE     Different isoforms of PRIP-interacting protein with
            methyltransferase domain/trimethylguanosine synthase localizes to
            the cytoplasm and nucleus
  JOURNAL   Biochem Biophys Res Commun 309 (1), 44-51 (2003)
   PUBMED   12943661
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473984.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_232648.4, XM_001069069.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132292,
                              SAMD00132294 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4305
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..4305
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /note="trimethylguanosine synthase 1"
                     /db_xref="GeneID:312947"
                     /db_xref="RGD:1309953"
     exon            1..258
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2707
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /note="PIMT; PIPMT; PRIP-interacting protein with
                     methyltransferase motif; nuclear receptor coactivator 6
                     interacting protein; trimethylguanosine synthase homolog;
                     cap-specific guanine-N(2) methyltransferase"
                     /codon_start=1
                     /product="trimethylguanosine synthase"
                     /protein_id="NP_001101374.1"
                     /db_xref="GeneID:312947"
                     /db_xref="RGD:1309953"
                     /translation="MCCEKWSHVAEMLLFIEDREEEYKILCLCSRAFVEDRKLYNLGL
                     KGYYVKSSGNNAGDRVTEEEEDDHSSGTTESHSADEGDLDPEAKLMRSMGLPVRFGRM
                     STHGSFEVSMNARNKAKVRQKRRKHRKQYLDEIVREDWRNDCEEDDLVVSDDPSSVEH
                     CENNSACEIQSKTDAEAENLPVENTLAPKLEVTENWEKYWNEYGEGLLWQSWQEKYPD
                     QTLSSEPWNLPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFVASQNCDKDVCTSHTQ
                     VDQNAESSLKADGTTLSSSPNTAEDESLGSNDNDHNEIIAGINKITLSAEEVEQSQLD
                     SSEHCDKPLSEVTGKECPASGGSDSCHGTPKESDISENRSSDQPAQELQESSGTNTSK
                     HRPHHNGTDGNESEDDPPDHKPSKMKRSHELDIDENPDSEVDDNGFHLGFKHGSGQKY
                     GGIPNFSRRQVRYLEKNVKYKSKYLDMRKRMTVKNKHIVFSEESGKPFIRKSKVRSKV
                     EKFLKWVNEPVDEEISQEPLSHNKMQDTCTSSDSEEQDMSMEKTDGLMETRDPEPENC
                     QTISSASELEAEKSEGGSLVAAVPENCSTEGVANSPRAEAEVEIKKKKKKKKKNKNKK
                     INGLPPEIASVPELAKYWAQRYRLFSRFDDGIKLDKEGWFSVTPEKIAEHIAGRVSQS
                     FNCDIIVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEVYGVADKIEFICG
                     DFLLLAPCLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSQKITNNIVYF
                     LPRNADVDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRPALRSAEA"
     exon            259..323
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     exon            324..481
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     exon            482..1295
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1413
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1500
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1675
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1976
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2135
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2279
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2496
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2575
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..4305
                     /gene="Tgs1"
                     /gene_synonym="Ncoa6ip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgcttcc ggtggcgcgc ctggccggct ccgggctcga gcgtccccag gcgcgttccg
       61 ctcctctgcc cgcgcgggtt acgcctctct gtgtccagca acagagcaga ggcccggccc
      121 cgccgcggac aaaagagcga gcccggataa caaaatgtgt tgcgagaagt ggagccacgt
      181 ggccgaaatg ctgctcttca ttgaagaccg cgaggaggag tacaagatcc tttgcctctg
      241 ctcccgagca tttgtagagg atcggaaatt atacaacttg ggattaaaag gctactatgt
      301 caaaagcagt ggcaataatg caggagaccg agttacagaa gaggaggaag atgatcattc
      361 cagtggcact acggagtcac acagcgcaga tgaaggtgac cttgaccccg aggccaaact
      421 catgagaagt atgggcttac cagtccggtt tggtaggatg tctacgcatg ggagttttga
      481 ggtgtccatg aatgcaagaa ataaagctaa agtgaggcag aagaggagaa agcaccgcaa
      541 gcagtattta gatgaaattg tgcgggagga ctggagaaat gactgtgaag aagatgacct
      601 tgtagtctcc gatgacccat cctcagttga acactgtgag aacaacagcg catgtgaaat
      661 tcagagcaaa acagatgctg aagcagaaaa ccttcctgtt gaaaatacac tggctccaaa
      721 gctagaggtc acagagaatt gggaaaagta ctggaatgaa tacggagaag ggctgttgtg
      781 gcaaagctgg caagaaaaat atccagacca gacactgtct tctgaaccct ggaaccttcc
      841 tgatacaaag gaagaatggg agcagcacta cagtcagctt tattggtatt acttggagca
      901 gttccagtac tgggaagctc agggctggac tttcgttgcc tcacaaaact gtgataaaga
      961 tgtttgcaca tctcatacac aggttgacca gaacgctgag agcagcctga aagcagatgg
     1021 aacgactttg tcatcttcac ctaacacagc tgaggatgaa agccttggct caaatgacaa
     1081 tgaccacaat gaaattattg ctgggattaa taagataact ctgagtgcag aggaagtaga
     1141 acagagccag ttagattcct ctgaacactg tgacaagcca ctcagtgaag tcactgggaa
     1201 agagtgccct gcctctggag gaagtgactc ctgtcatgga acacccaagg aaagtgacat
     1261 atctgagaac agaagctcag accaaccagc tcaagagttg caggaatctt caggaacgaa
     1321 tacaagtaaa catagaccac accataacgg gactgatgga aacgagagtg aagatgaccc
     1381 ccctgatcat aagcctagca aaatgaagag aagccatgag ttggacattg atgaaaaccc
     1441 agattcggaa gttgatgaca atggtttcca tctaggattc aagcatggct caggacaaaa
     1501 atatggtgga attccaaatt tcagtcgtcg acaggtcagg tatctagaga agaatgtgaa
     1561 atacaagtca aagtacctgg acatgcgcaa gcggatgact gtgaagaaca agcacatcgt
     1621 cttctccgag gagtcaggga aaccctttat caggaagagt aaagtacgga gtaaggtgga
     1681 aaaattccta aaatgggtta atgagcctgt agatgaggag atatcacagg agcctctctc
     1741 tcacaacaaa atgcaagaca cttgcacaag cagtgactct gaggaacaag acatgtccat
     1801 ggagaaaact gatggtctga tggagaccag agatccagaa cctgaaaact gtcagaccat
     1861 ctcttcagcc agtgaacttg aagcagaaaa gagtgaaggg ggctccttag tagcagctgt
     1921 tccagagaac tgttcaactg aaggagtagc aaactctccc cgtgcagaag cagaagtaga
     1981 aataaagaag aaaaagaaga agaagaagaa gaacaagaac aaaaagataa atggcctacc
     2041 acctgaaata gcttctgttc cggagctggc aaaatactgg gcccagagat acaggctttt
     2101 ctctcgcttt gatgatggga tcaaattgga caaagagggc tggttttcag tcactcctga
     2161 gaagattgct gagcacatag ctggccgcgt cagtcagtct ttcaactgtg acatcatagt
     2221 agatgctttc tgtggggttg gaggaaatac cattcagttt gccttgacag gaaaaagagt
     2281 gattgccatt gatatcgacc ctgttaaaat tgatcttgct cggaataatg ctgaagttta
     2341 tggggtagca gataaaatag agtttatctg cggagatttc ctgctcttgg ctccatgttt
     2401 aaaggctgac gttgtgttcc tgagtccacc gtgggggggc ccagattatg ccactgcgga
     2461 gacctttgac attaggacca tgatgtctcc tgatggcttt gaaattttca ggctttccca
     2521 gaagatcact aataatattg tttattttct tccaagaaat gctgatgttg accaggtggc
     2581 atcgttggct gggcctggag gacaagtaga aatagaacag aactttctta acaacaagtt
     2641 aaagacaatc actgcatatt ttggtgacct gatcagaaga ccagcacttc gaagtgctga
     2701 ggcgtgatgc tgtaaagcac agagatcatg aggagagagg atggatgtat ggactgacag
     2761 acagccttcg agtgggagac acgaggaaga tcttcctaag ctccttgata ctgtgtgtgc
     2821 atgtgatgaa aagctgagct ttaaagaatg ctaatgaagt ggtttgagat cttggtaatg
     2881 ttaactgatc tgtgttctgt actttaaaac agcatcagga caaggtgatg gtgggggcct
     2941 gcatcccagc ccttgaaaaa gatcatgagt tcaaggccat gctgtgctgc ataacaattc
     3001 aaggctggcc tgggctacat gctgtcttgc ctcagaataa acatcataaa gagtctaggc
     3061 atatccctgt gcttacatta agtgcatatg tggttgtggg tgttttcatt ctttaactgt
     3121 tttagtttat catctttgtg tctgtgtaaa taataattga ttttttcaaa tgcaaagaaa
     3181 aacaaagcag ttctacctac acatttaacc cctattgaaa taatgttacc aatttaatgc
     3241 taaaacaaga aaagtaaagt tcccaccacc ttttactcaa ctatctaaag ctaatcacag
     3301 ttaacaatgc tatccttttt aattttttat tacattttta ttttgtctgt atgtgcatgc
     3361 atgtgtgtgt gtgtagaggt cagaggacaa tttgtggggt tcccttctct acttacacca
     3421 tgtgggttcc tgggaatcaa gttaaggtca tcaggcttta taacctgagc catcccattg
     3481 gtcccctgtt aattcttctg gagaaaagat tgcattatag cagtatgctc tggtgcactt
     3541 tcccatgatg cactcgctgt tcgttcattg ctgttcgtaa tggatagtat ataaaataaa
     3601 tgcttttgtg agagaaatgt atgtgagaaa gtgtgtgtgt gtgtgtgtgt gtacacgtat
     3661 gtacgtacgt gtgtacgtag gtgtgtacgt aggtgtgttc gtgcactgta cccactatgc
     3721 ccacagagtc cagggaagag tgttggattc cttggagctg gagttacagg tggctgtgag
     3781 ctgccaagtg taggcactga gaaatgcact tgggtcttct ggaagcagaa gtaagttctc
     3841 tctccagccc aagatgcttt ttttaatcag tatttttaca tttctgtttt ggtatggttt
     3901 gttttttcag ataatctcac ataacccaca ctggcctcaa cctttgtgtg actgagagac
     3961 tgagctccta ggcccttctg gctccagcac tgcacctggc ttgtcagtgt ctggaaggcc
     4021 atttcagttc atacatgtca atctacctcg tgttctaaac ggcagtcttg tattttatca
     4081 catgtgcata taaaatagtt ccctactgag gcacacaggc tgtttttatg gttttatcat
     4141 taccgattgt tccatactgt ctttccttac aatatttgct gttgaacaaa tatttgttgg
     4201 taagtttcta gcagttggac tgctaggctt ttgtacattt cagtcttgat aaaaagacca
     4261 aattgcttca ataaagttga acttgctttt agtcatattt atctc
//
