LOCUS       NM_138840               4713 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus trans-golgi network protein 2 (Tgoln2), mRNA.
ACCESSION   NM_138840
VERSION     NM_138840.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4713)
  AUTHORS   Gurth,C.M., Dankovich,T.M., Rizzoli,S.O. and D'Este,E.
  TITLE     Synaptic activity and strength are reflected by changes in the
            post-synaptic secretory pathway
  JOURNAL   Sci Rep 10 (1), 20576 (2020)
   PUBMED   33239744
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4713)
  AUTHORS   Zhang,D., Marlin,M.C., Liang,Z., Ahmad,M., Ashpole,N.M.,
            Sonntag,W.E., Zhao,Z.J. and Li,G.
  TITLE     The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and
            Signal Transduction of Tropomyosin Receptor Kinase A
  JOURNAL   J Biol Chem 291 (46), 23895-23905 (2016)
   PUBMED   27655914
REFERENCE   3  (bases 1 to 4713)
  AUTHORS   Banushi,B., Forneris,F., Straatman-Iwanowska,A., Strange,A.,
            Lyne,A.M., Rogerson,C., Burden,J.J., Heywood,W.E., Hanley,J.,
            Doykov,I., Straatman,K.R., Smith,H., Bem,D., Kriston-Vizi,J.,
            Ariceta,G., Risteli,M., Wang,C., Ardill,R.E., Zaniew,M.,
            Latka-Grot,J., Waddington,S.N., Howe,S.J., Ferraro,F., Gjinovci,A.,
            Lawrence,S., Marsh,M., Girolami,M., Bozec,L., Mills,K. and
            Gissen,P.
  TITLE     Regulation of post-Golgi LH3 trafficking is essential for collagen
            homeostasis
  JOURNAL   Nat Commun 7, 12111 (2016)
   PUBMED   27435297
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4713)
  AUTHORS   Urresti,J., Ruiz-Meana,M., Coccia,E., Arevalo,J.C., Castellano,J.,
            Fernandez-Sanz,C., Galenkamp,K.M., Planells-Ferrer,L.,
            Moubarak,R.S., Llecha-Cano,N., Reix,S., Garcia-Dorado,D.,
            Barneda-Zahonero,B. and Comella,J.X.
  TITLE     Lifeguard Inhibits Fas Ligand-mediated Endoplasmic
            Reticulum-Calcium Release Mandatory for Apoptosis in Type II
            Apoptotic Cells
  JOURNAL   J Biol Chem 291 (3), 1221-1234 (2016)
   PUBMED   26582200
REFERENCE   5  (bases 1 to 4713)
  AUTHORS   Ahmedli,N.B., Gribanova,Y., Njoku,C.C., Naidu,A., Young,A.,
            Mendoza,E., Yamashita,C.K., Ozgul,R.K., Johnson,J.E., Fox,D.A. and
            Farber,D.B.
  TITLE     Dynamics of the rhomboid-like protein RHBDD2 expression in mouse
            retina and involvement of its human ortholog in retinitis
            pigmentosa
  JOURNAL   J Biol Chem 288 (14), 9742-9754 (2013)
   PUBMED   23386608
REFERENCE   6  (bases 1 to 4713)
  AUTHORS   Roquemore,E.P. and Banting,G.
  TITLE     Efficient trafficking of TGN38 from the endosome to the trans-Golgi
            network requires a free hydroxyl group at position 331 in the
            cytosolic domain
  JOURNAL   Mol Biol Cell 9 (8), 2125-2144 (1998)
   PUBMED   9693371
REFERENCE   7  (bases 1 to 4713)
  AUTHORS   Aguilar,R.C., Ohno,H., Roche,K.W. and Bonifacino,J.S.
  TITLE     Functional domain mapping of the clathrin-associated adaptor medium
            chains mu1 and mu2
  JOURNAL   J Biol Chem 272 (43), 27160-27166 (1997)
   PUBMED   9341158
REFERENCE   8  (bases 1 to 4713)
  AUTHORS   Stephens,D.J., Crump,C.M., Clarke,A.R. and Banting,G.
  TITLE     Serine 331 and tyrosine 333 are both involved in the interaction
            between the cytosolic domain of TGN38 and the mu2 subunit of the
            AP2 clathrin adaptor complex
  JOURNAL   J Biol Chem 272 (22), 14104-14109 (1997)
   PUBMED   9162036
REFERENCE   9  (bases 1 to 4713)
  AUTHORS   Reaves,B., Wilde,A. and Banting,G.
  TITLE     Identification, molecular characterization and immunolocalization
            of an isoform of the trans-Golgi-network (TGN)-specific integral
            membrane protein TGN38
  JOURNAL   Biochem J 283 (Pt 2) (Pt 2), 313-316 (1992)
   PUBMED   1575675
REFERENCE   10 (bases 1 to 4713)
  AUTHORS   Luzio,J.P., Brake,B., Banting,G., Howell,K.E., Braghetta,P. and
            Stanley,K.K.
  TITLE     Identification, sequencing and expression of an integral membrane
            protein of the trans-Golgi network (TGN38)
  JOURNAL   Biochem J 270 (1), 97-102 (1990)
   PUBMED   2204342
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138840.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098512.1, SRR26360172.1618465.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000004.1  106229204-106229262 c
            60-997              JAXUCZ010000004.1  106228009-106228946 c
            998-1081            JAXUCZ010000004.1  106226873-106226956 c
            1082-4713           JAXUCZ010000004.1  106221509-106225140 c
FEATURES             Location/Qualifiers
     source          1..4713
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..4713
                     /gene="Tgoln2"
                     /gene_synonym="Tgn38; Tgoln1; Ttgn1"
                     /note="trans-golgi network protein 2"
                     /db_xref="GeneID:192152"
                     /db_xref="RGD:620445"
     exon            1..59
                     /gene="Tgoln2"
                     /gene_synonym="Tgn38; Tgoln1; Ttgn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1087
                     /gene="Tgoln2"
                     /gene_synonym="Tgn38; Tgoln1; Ttgn1"
                     /note="trans-Golgi network integral membrane protein
                     TGN38; trans-golgi network protein 1"
                     /codon_start=1
                     /product="trans-Golgi network integral membrane protein
                     TGN38 precursor"
                     /protein_id="NP_620195.1"
                     /db_xref="GeneID:192152"
                     /db_xref="RGD:620445"
                     /translation="MQFLVALLLLSVAVARALPSASKPNNTSSENNPPIQPSTPLPPG
                     VDISQQVKTNRPTDQRLESDKEGQDKTVARTSASVSSGVESATNLNLDDSKKHPETAD
                     AKLKETLQQLLPVDPKQEKSGQKFTKDSGSPTGGDSDNTTGGDSNKTTGVDSDKTSGG
                     DSNKPTGSDNDKPTGGDSNKPTSKVPSNTETPKIDKVQLTEKGQKPTLISKTESGEKL
                     AGDSDFSLKPEKGDKSSEPTEDVETKEIEEGDTEPEEGSPLEEENEKVLGPSSSENQE
                     GTLTDSMKDEKDDHYKDNSGNTSAESSHFFAYLVTAAVLVAVLYIAYHNKRKIIAFAL
                     EGKRSKVTRRPKASDYQRLNLKL"
     exon            60..997
                     /gene="Tgoln2"
                     /gene_synonym="Tgn38; Tgoln1; Ttgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1081
                     /gene="Tgoln2"
                     /gene_synonym="Tgn38; Tgoln1; Ttgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..4713
                     /gene="Tgoln2"
                     /gene_synonym="Tgn38; Tgoln1; Ttgn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagactac aggatgcagt tcctggttgc gttgctcctg ctgagtgtcg cggtggcgag
       61 agctctgcca tccgcttcta agccaaacaa cacatcaagt gaaaataatc ctccgattca
      121 accttccacg cccctgcctc ctggggttga tatttctcaa caggtaaaga ctaacagacc
      181 gactgatcag aggctggagt cggataaaga aggccaggac aagacggtgg ctaggacttc
      241 ggcatcagtt tccagtgggg tggaatctgc gaccaatctc aatttggatg attccaaaaa
      301 gcaccccgaa acagcagatg ccaaattgaa ggaaactttg cagcagcttt tgcctgtgga
      361 ccccaaacag gaaaagtcag gtcagaagtt tacaaaagat tcaggcagcc ccacaggagg
      421 tgattccgac aataccacag gaggtgattc taacaagacc acaggagttg attctgacaa
      481 gacatcagga ggtgattcta acaagcccac aggaagtgat aatgacaagc ccacaggagg
      541 tgattctaac aagcccacct ccaaagtccc ctccaataca gagactccaa aaattgacaa
      601 agtccagcta actgaaaaag gacagaaacc aacacttatt tccaaaactg aatctgggga
      661 aaaactggca ggggactctg acttctcttt aaagccagag aaaggagata agtcttcaga
      721 gcctactgaa gatgtggaaa ccaaggagat tgaagagggt gatacagagc ccgaagaagg
      781 ttcaccactt gaagaagaga atgaaaaggt gttgggccct tcctccagtg agaaccaaga
      841 ggggacactt acagattcta tgaaggatga gaaggatgac cattataagg acaattctgg
      901 aaacaccagt gcagaaagca gccacttctt tgcttatctg gtgaccgctg ctgttcttgt
      961 tgctgtcctc tatattgctt accacaacaa acgaaagatt attgcttttg ccctggaagg
     1021 aaaaagatcc aaagtcactc ggaggccaaa ggccagtgac taccaacgtt tgaacctaaa
     1081 gctttgattt tgattttgtc tgcaagaacc ttgtcctccc tgctgatttg tttccgaatc
     1141 aagagaaatg aaaagactga cctgtggggt ttggtggcaa gtctgggctg gcagagatgg
     1201 gattgcttca ggttttgcac ctgcactttg atgacattgt cctctggtgg tgttttattt
     1261 acttttgtgt tccctttatg tgatgtgtcc atcttccttc cattcttgga gtacaagcag
     1321 agggagtgtg tggaaacatg gctgtgacca aaggaagacc ccaccttcct taggcaggcc
     1381 acactatgga ccaccctccc ataacccctt tatctttgca actctaggag caaactacag
     1441 aggtgctttc tagacaagat gtagaagatg attctgtggg atgctgatgg gcagagacag
     1501 ggttgaaatc ttctccacag aggcctcagc tgcagaccag actagcaagt taaagagtgt
     1561 caaggtccag tccgtctgac agtctgtata tctctctgaa atttgcactc gagttgtgct
     1621 agcacaaaag ggactcactg cttctgaaag taaaatcact gtgccatggg attttttttt
     1681 tttaaatatg gtgatgatta ttgaactgaa ccagtgtgtt cttgcataca gtcaccccaa
     1741 taggaacttc ctggaaagaa gcaggtttat gccttgtgga agaaaacaca tagggctttg
     1801 gtatacagga aagagtttct cacagtcagt tttgctttca tggtctgcag taggtaagat
     1861 agacatttag aaactccgtg cgttctccac attcctccac actgtttaag atgccaggga
     1921 atgagtaata tctttcctat cctgtcatag ctactcatga aattgtaaga aaccaagtag
     1981 gttccctgag ataaccaaaa atgtcttgga ttatgctgtg tctaaagttt tattccagtc
     2041 tatatggtta cacctaaaga gagaaaactc ttaactaatc tcagggatat aaaaggaaga
     2101 aaaatctgag tcctgtgcag ttggagaagt tgaagaagac ctggtcttgg agctctttct
     2161 ccatgctgac tgtagcatgt gcctgaagtt tgtatgcttg gcaggtggca ttctagaaat
     2221 gaggtcattg tcttcccgac tgtgcataag tctgctgtta ctttttccta gctgagaagc
     2281 cgttttcagt ctccctcagc tttccgtaac tcttcttcag ttccccacct cttccattct
     2341 ctcttcctct ttagccctgt ttgtacacct ctgatgaaaa cctttccttc tagcctacgt
     2401 gcatgccatc cctaccccgt tccagttggt gttgcttcta ttcccttccc tctctccctg
     2461 acatttgcag gtttgccttg gtctgttttc ctcctgtttc tcaaggttac tcagttaaca
     2521 gatcaccaaa taaaacagcc cattttcaca gcttataaca cttggtaatg atagatgctg
     2581 gggtctgtgc atgttgacat tctaggtgtc tcttgcaaac tgtcctttgc cttatcttat
     2641 ggcgttgggg gagggtgccc aggtctctct tgctttgact gtcgcatcca ttctttatcc
     2701 tttctgtgac tctcacattt tctttggtct ccttcccaag aacccagttc tgctatatgc
     2761 taaataactc agccacattg tctggttgtc attcaaccag agtttccctc ttgtacctat
     2821 taagttcctc tatccttcgg gttttttaat tatctgaaaa ctctacacta taaactaatt
     2881 acagtggtca tcacagaagt cctatttgtt ttttcttttt ttaagaaatt atatatctag
     2941 gtatattctc cattaatttt caggaaccag gtgaattgac cttaccagtt ttggaaacct
     3001 tgattattcc agaacactcc ctggtctgaa gctcctgtct gatgctatat tctagactac
     3061 agggtccctc atgtcttcat ggtctggcac tccatctctg cctctgccct cctcgtctcc
     3121 tttgtattcc agcttctcca ggttgctctg cggtgagcat tccctttcct tcaccttagc
     3181 aggtcctttg gttccggatg tgcagtgttc cttcttagag tcaacacact tgcttggctt
     3241 ccattcctca ctgtcactgt ctcttactgt cactctcatc ttggaacttc agtgtgacat
     3301 agttctgatg ttctatgatc tcccccaaga aaaccaagct ctgagacaca gccattggca
     3361 tcgtttatca gccagggacc ttaggggtca aatttcttgt tggaggtgta gctgaactgg
     3421 ggctcgcata gctcttcctg gctactgctt gctatgacct tatacttgtt gatttttttg
     3481 cttttgaaga gcaggaagga aggttgattt ttagtaacaa agtgagtgga cagacacatg
     3541 aaggattgcc agaggctaca gagcctcgcc ctcttgggct gctgaccgat gtttcttgtg
     3601 tgacagagta cagttgaatt tgttttcact tggaaagttg cattgaagga gatggctccc
     3661 accaaagaaa agttattttt aggatttttt tgttttgtgt tagttttttg aaggtagaat
     3721 acttacttga agcatatctc ctagagtgtg tgtggatgat tatggtccag ctgaggtgtc
     3781 tataccaagg acggggctgg catgtgagaa gtacatgaag ccttaactag gactcctgta
     3841 gacttttctg agcttgctct cctgctcagt gtctggctaa aggcaatttc ctaagaggag
     3901 cctgcctgag gcacaactgt taaccgtttg ctctctatgg attatagaca ccaggtctgg
     3961 acaacagcta agaaacgtgc taacgtattt tcccctagaa acagctctgt gcccttcaga
     4021 attccccata ctgatgctct ttctttttct tcggggagtg gtgtgctttg cacatatcct
     4081 gagccattcg aaggcagaga agggtgtgcc aggccctgtg ccctgtgaga cagtttggta
     4141 ttgccttaag aaagctgtaa agagtcagca ctcaggaggc agaggcagaa ggatctctgt
     4201 gagtatgagg ccagcttagt ctagaattca ggtagccaga gttacatagt gatagcttgt
     4261 ctcaaaaaca aagacaaagg aaagctgtaa ggagatgttg aaattaactc catcatgatg
     4321 gctcagttcc tttagttccc tgctcagatg tgactaagta gtttatcttg aaactgtagt
     4381 gtggacctca gtttgcacag cagagcaaac tacccatgaa gctggcctcc tcccactctt
     4441 aggaatttaa tttagactac catgttaagg aaatgagtaa atgttgaaat tattttcttt
     4501 gtcttgttta cccagttaga tcaccactgt tagccatgtt ttgtgttttc accttttttg
     4561 taacttaact gtaatggctt aattttattt ttttaaagct tactgtggta taataagtat
     4621 ttttcagtat attttatcaa gcttctgtaa atggcatcac agtgtagttt catgtcattg
     4681 aacaaaaatc aataaatttc agatatcaaa gca
//
