LOCUS       NM_022713               2868 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus transglutaminase 4 (Tgm4), mRNA.
ACCESSION   NM_022713 XM_346843
VERSION     NM_022713.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2868)
  AUTHORS   Dean,M.D.
  TITLE     Genetic disruption of the copulatory plug in mice leads to severely
            reduced fertility
  JOURNAL   PLoS Genet 9 (1), e1003185 (2013)
   PUBMED   23341775
REFERENCE   2  (bases 1 to 2868)
  AUTHORS   Jiang,W.G., Ye,L., Ablin,R.J., Kynaston,H.G. and Mason,M.D.
  TITLE     The prostate transglutaminase, TGase-4, coordinates with the
            HGFL/MSP-RON system in stimulating the migration of prostate cancer
            cells
  JOURNAL   Int J Oncol 37 (2), 413-418 (2010)
   PUBMED   20596668
REFERENCE   3  (bases 1 to 2868)
  AUTHORS   Cho,S.Y., Jeon,J.H., Kim,C.W., Shin,D.M., Jang,G.Y., Jeong,E.M.,
            Lee,S.E., Song,K.Y. and Kim,I.G.
  TITLE     Monoclonal antibodies to human transglutaminase 4
  JOURNAL   Hybridoma (Larchmt) 29 (3), 263-267 (2010)
   PUBMED   20569004
REFERENCE   4  (bases 1 to 2868)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2868)
  AUTHORS   Ho,K.C., Quarmby,V.E., French,F.S. and Wilson,E.M.
  TITLE     Molecular cloning of rat prostate transglutaminase complementary
            DNA. The major androgen-regulated protein DP1 of rat dorsal
            prostate and coagulating gland
  JOURNAL   J Biol Chem 267 (18), 12660-12667 (1992)
   PUBMED   1352290
REFERENCE   6  (bases 1 to 2868)
  AUTHORS   Ho,K.C., Wilson,E.M. and French,F.S.
  TITLE     Androgen regulated prostate genes: structural analysis and
            regulation
  JOURNAL   Prog Clin Biol Res 239, 125-153 (1987)
   PUBMED   3309953
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN934649.1, BC066665.1, DN931716.1 and CA339697.1.
            
            On Apr 18, 2007 this sequence version replaced NM_022713.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066665.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DN934649.1         32-42
            12-2273             BC066665.1         1-2262
            2274-2864           DN931716.1         58-648              c
            2865-2868           CA339697.1         341-344
FEATURES             Location/Qualifiers
     source          1..2868
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2868
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /note="transglutaminase 4"
                     /db_xref="GeneID:64679"
                     /db_xref="RGD:620785"
     exon            1..78
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2066
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /EC_number="2.3.2.13"
                     /note="TGase-4; dorsal prostate transglutaminase; dorsal
                     protein 1; transglutaminase 4 (prostate); glutamine
                     gamma-glutamyltransferase 4"
                     /codon_start=1
                     /product="protein-glutamine gamma-glutamyltransferase 4"
                     /protein_id="NP_073204.2"
                     /db_xref="GeneID:64679"
                     /db_xref="RGD:620785"
                     /translation="MDSRNMLVVYSVNLEKKLNAAAHHTIEYQTQKLVLRRGQIFSLK
                     VMLNRPLQSHDELKLIFNTGHNMPFYTVELDPMTSYRSKGWQVKIAKQSGVEVVLNVI
                     SAADAVVGRYTMNVNEFDAGVFFLLFNPWCSDDSVFMASEEDRAEYVLNDTGYMYMGF
                     AKQIKEKPWTFGQFEKYILNCCFRLLTHLEPKEMQSPVLVSRAICTMMCAANNFGVLV
                     GNWTGDYSNGTAPYVWASSVPILQQHYITRMPVRFGQCWVFSGVLTTALRAVGIPARS
                     VTNFESAHDTEKNLRVDIYLDESGKTIPHLTKDSVWNFHVWTDAWMKRQDLPQGHDGW
                     QVLDSTPQEISEGQFRIGPSPVSAIRQGLVQIMYDTTFVFTEVNGDKYIWLVKQNQER
                     EKNVLIAVETASIGKNISTKMVGENRRQDITLHYKFPEGSPEERKAMEKASGKRPDDK
                     LNSRTLHISVLQNSVELGHPINLTIVLKRKTATPQNVNISCSLDLQTYTGNKKTNLGV
                     IQKTVQIQGQESEVSLSMDSSFYIYKLGMVDDEMVIKGFIIAEIVDSGERVATDTTLC
                     FLYSAFSVEMPSTSKVNQPLTITCNFKNTLPIPLTNIKFSVESLGLNNMKSWEQETVP
                     PGKTINFQIECTPVKTGPRKFIVKFISRQVKEVHAEKVVLITK"
     exon            79..252
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..350
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..462
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..581
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..683
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..858
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..997
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1101
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1353
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1617
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1787
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1924
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2868
                     /gene="Tgm4"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctggcagcg ccgctggcat cagactggag acttgacagg gttggagaga ggcagcagga
       61 ccatggactc caggaacatg cttgtcgttt actctgtgaa cttggagaaa aagctgaacg
      121 ctgctgccca ccacacgatt gagtaccaaa ctcagaagct cgtgctcagg cgtggacaga
      181 tattctccct gaaggtgatg ctaaacagac cgctccaatc tcatgatgaa ctgaagctga
      241 tattcaatac tggacacaac atgccattct acactgtgga gcttgatcca atgacatcct
      301 accgttccaa gggctggcag gtgaagattg ctaaacagtc tggtgtagag gttgtattga
      361 atgtcatcag tgctgccgac gccgtggtgg ggaggtacac gatgaacgtg aacgaatttg
      421 acgctggagt gttcttcctt ctcttcaatc cgtggtgctc agatgacagt gtcttcatgg
      481 ctagtgagga agaccgagca gagtacgtcc ttaatgatac cggttacatg tacatgggtt
      541 ttgccaaaca gattaaagag aagccctgga cctttggtca gtttgagaag tacatcttga
      601 actgctgctt ccgattgttg acccatttgg agcccaagga aatgcagagc ccagtgcttg
      661 tgtccagggc catttgtact atgatgtgtg ctgcaaacaa ttttggagtg ctggtgggga
      721 actggacagg agactatagc aatggcactg ccccgtatgt gtgggccagc agtgtaccca
      781 ttctccagca gcactacatc accaggatgc ctgtacgctt tggccagtgc tgggttttct
      841 ctggagtcct gaccacagca ctgagagcag tgggcatccc agctcgcagc gtgactaact
      901 ttgagtcagc ccacgataca gaaaagaacc tcagagtaga catctacctg gatgaatcgg
      961 gcaagacaat tccacatctg accaaagact ctgtctggaa tttccatgtg tggacagatg
     1021 cctggatgaa aagacaggat ctaccccagg gccatgatgg ttggcaggtc ctggattcta
     1081 caccacagga aatcagtgaa ggacaattcc gcattggacc ttcaccggtg tctgctatcc
     1141 gccagggatt ggtccaaatc atgtatgaca ccacatttgt gttcacggag gtgaacggtg
     1201 acaagtacat ctggctggtg aagcagaacc aggaaaggga gaagaatgtc ctcatcgctg
     1261 tggagactgc tagcatcggc aagaacatca gcaccaagat ggtgggcgag aacaggcgtc
     1321 aagatattac cttgcattac aagttcccag aaggcagccc agaggagagg aaggccatgg
     1381 agaaggcctc tgggaaacgt cctgatgaca agctcaactc tcggacactt cacatatctg
     1441 tcctccagaa ctctgtggag ctaggacatc ctatcaattt gaccatagtg ttgaaaagga
     1501 aaacggccac accacagaat gtcaacattt catgctccct tgacctacag acttacacag
     1561 gcaacaagaa gacaaacctg ggagtcatcc agaagactgt gcagattcaa ggccaagaat
     1621 cagaggtgtc tctcagcatg gattccagtt tctacatcta taaactgggc atggttgatg
     1681 atgagatggt cattaaaggg ttcatcattg cagaaattgt tgattctggt gaacgggtag
     1741 ccactgatac gaccctgtgt ttcctgtact ctgccttctc tgtagagatg ccgagcacaa
     1801 gcaaggtcaa ccagcctctg accatcacct gcaacttcaa gaacaccctg cccatccctt
     1861 tgactaacat caagttctca gtggaaagcc tgggcctcaa taacatgaag tcctgggagc
     1921 aagagacggt gccgcccgga aagaccatca atttccagat agaatgcacc ccagtgaaaa
     1981 ctggacccag gaagttcatt gtcaagttta tttccagaca agtgaaagag gttcatgccg
     2041 agaaggtcgt tctcatcaca aagtagccca tctgatacca ttgagatgga ggcaggagcc
     2101 ctgattggct ctgagccttg gtaagcatgt tagcatttcc taaattgcat ttagctctca
     2161 ggtcagaaat gattaaattt taggggttgg ggatttagct cagtggtaga gcgcttgcct
     2221 aggaagcgca aggccctggg ttcggtcccc agctccggga aaaaaaaaaa aaaaagaaat
     2281 gattaaattt tgattactca tatgaaggca gattcaagag ccagcccagc aaaagacaga
     2341 gctcaaaggc caatgtaacc accggcagta gctccaggga gccaggttac ctaagcacat
     2401 gtcatacata ggcagacatc tcaaatacat atttaggaac tgtggcctca gaagacagtg
     2461 ccactgtcat ctggattcag aaccatatcc agagcccaga tagagaagtg ccagaggcat
     2521 cttccatcta caccatggat tctatcaagt ccaggggtgc ctggaggctg tgctggaagt
     2581 cctgtaggaa gcatcgtgga gctggtcctt gaccaggtgc tacaagctct taccctaggg
     2641 ctccgtcctc tcggaagcag gccccacgct ggcgtgaggc ccctcttgct ctagatgggc
     2701 caggggaggg aggccctttc cttaagtaag agtctatggc cagtgacaac atctgaagaa
     2761 gcaaggtatc cttccctgtt ccctggagtc tgtgctttac tatgctgtaa agggatctgc
     2821 tcatgtatca ctgtgctttg aattaaactc tggcaacttt aagatggc
//
